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MXPA04012779A - Profarmacos de 2'- y 3'-nucleosido para tratar infecciones por flaviviridae. - Google Patents

Profarmacos de 2'- y 3'-nucleosido para tratar infecciones por flaviviridae.

Info

Publication number
MXPA04012779A
MXPA04012779A MXPA04012779A MXPA04012779A MXPA04012779A MX PA04012779 A MXPA04012779 A MX PA04012779A MX PA04012779 A MXPA04012779 A MX PA04012779A MX PA04012779 A MXPA04012779 A MX PA04012779A MX PA04012779 A MXPA04012779 A MX PA04012779A
Authority
MX
Mexico
Prior art keywords
prodrugs
flaviviridae infections
derivatives
pharmaceutically acceptable
acceptable salts
Prior art date
Application number
MXPA04012779A
Other languages
English (en)
Inventor
Sommadossi Jean-Pierre
Original Assignee
Idenix Cayman Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Idenix Cayman Ltd filed Critical Idenix Cayman Ltd
Publication of MXPA04012779A publication Critical patent/MXPA04012779A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

Se describen profarmacos 2' y 3' de °-D o °- L- nucleosidos ramificados en las posiciones 1',2', 3 o 4' o sus sales y derivados farmaceuticamente aceptables, los cuales son utiles en la prevencion y tratamiento de infecciones por Flaviviridea y otras condiciones relacionadas. Estos nucleosidos modificados proveen resultados superiores contra flavivirus y pestivirus, incluyendo el virus de la hepatitis C y en general virus que se replican a traves de un ARN transcriptasa inversa dependiente de ARN. Se proveen compuestos, composiciones, metodos y usos para el tratamiento de infeccion por Flaviviridae, incluyendo infeccion por VHC, que incluye la administracion de una cantidad efectiva de los pro farmacos de la presente invencion, o sus sales o derivados farmaceuticamente aceptables. Estos farmacos se pueden administrar opcionalmente en combinacion o alteracion con agentes antivirales adicionales para prevenir o tratar infecciones por flaviviridae y otras condiciones relacionadas.
MXPA04012779A 2002-06-28 2003-06-27 Profarmacos de 2'- y 3'-nucleosido para tratar infecciones por flaviviridae. MXPA04012779A (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US39235102P 2002-06-28 2002-06-28
US39235002P 2002-06-28 2002-06-28
US46619403P 2003-04-28 2003-04-28
US47094903P 2003-05-14 2003-05-14
PCT/IB2003/003901 WO2004003000A2 (en) 2002-06-28 2003-06-27 1’-, 2'- and 3'- modified nucleoside derivatives for treating flaviviridae infections

Publications (1)

Publication Number Publication Date
MXPA04012779A true MXPA04012779A (es) 2005-08-19

Family

ID=38337686

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA04012779A MXPA04012779A (es) 2002-06-28 2003-06-27 Profarmacos de 2'- y 3'-nucleosido para tratar infecciones por flaviviridae.

Country Status (13)

Country Link
EP (1) EP1525209B1 (es)
JP (1) JP5087211B2 (es)
KR (1) KR20050055630A (es)
AP (1) AP2005003211A0 (es)
AU (1) AU2003263412A1 (es)
CA (1) CA2490200C (es)
IL (1) IL165891A0 (es)
MA (1) MA27329A1 (es)
MX (1) MXPA04012779A (es)
NO (1) NO20050466L (es)
PL (1) PL374792A1 (es)
RS (1) RS114104A (es)
WO (1) WO2004003000A2 (es)

Families Citing this family (127)

* Cited by examiner, † Cited by third party
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