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MXPA04012630A - Proceso para preparar derivados de acido 5-(1,3-oxazol-2-il)benzoico. - Google Patents

Proceso para preparar derivados de acido 5-(1,3-oxazol-2-il)benzoico.

Info

Publication number
MXPA04012630A
MXPA04012630A MXPA04012630A MXPA04012630A MXPA04012630A MX PA04012630 A MXPA04012630 A MX PA04012630A MX PA04012630 A MXPA04012630 A MX PA04012630A MX PA04012630 A MXPA04012630 A MX PA04012630A MX PA04012630 A MXPA04012630 A MX PA04012630A
Authority
MX
Mexico
Prior art keywords
oxazol
preparing
benzoic acid
acid derivatives
formula iii
Prior art date
Application number
MXPA04012630A
Other languages
English (en)
Inventor
J Imbordino Rick
Original Assignee
Pharmacia & Upjohn Co Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia & Upjohn Co Llc filed Critical Pharmacia & Upjohn Co Llc
Publication of MXPA04012630A publication Critical patent/MXPA04012630A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Catalysts (AREA)

Abstract

Se describen compuestos de formula III y un proceso para preparar un compuesto de formula III, en donde R1, R2, R3 y R6 se define en la presente, utilizando un aducto de cloruro de zinc/oxazol opcionalmente sustituido y un compuesto de formula I. Se describen otros metodos para utilizar compuestos de formula III para preparar compuestos utiles en el tratamiento de la enfermedad de Alzheimer y condiciones relacionadas.
MXPA04012630A 2002-06-20 2003-06-20 Proceso para preparar derivados de acido 5-(1,3-oxazol-2-il)benzoico. MXPA04012630A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US39028502P 2002-06-20 2002-06-20
US45047803P 2003-02-27 2003-02-27
PCT/US2003/019585 WO2004000821A1 (en) 2002-06-20 2003-06-20 Process for preparing 5-(1, 3-oxazol-2-yl) benzoic acid derivatives

Publications (1)

Publication Number Publication Date
MXPA04012630A true MXPA04012630A (es) 2005-09-30

Family

ID=30003150

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA04012630A MXPA04012630A (es) 2002-06-20 2003-06-20 Proceso para preparar derivados de acido 5-(1,3-oxazol-2-il)benzoico.

Country Status (17)

Country Link
US (2) US7115747B2 (es)
EP (1) EP1532123B1 (es)
JP (1) JP2005533811A (es)
CN (1) CN1324017C (es)
AT (1) ATE370131T1 (es)
AU (1) AU2003249344A1 (es)
BR (1) BR0312439A (es)
CA (1) CA2489988A1 (es)
CO (1) CO5670350A2 (es)
DE (1) DE60315664D1 (es)
EA (1) EA008389B1 (es)
IL (1) IL165763A0 (es)
MX (1) MXPA04012630A (es)
NO (1) NO20045497L (es)
NZ (1) NZ537390A (es)
PL (1) PL374999A1 (es)
WO (1) WO2004000821A1 (es)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004050609A1 (en) * 2002-11-27 2004-06-17 Elan Pharmaceutical, Inc. Substituted ureas and carbamates
TW200738701A (en) 2005-07-26 2007-10-16 Du Pont Fungicidal carboxamides
US7872009B2 (en) 2005-11-21 2011-01-18 Amgen Inc. Beta-Secretase modulators and methods of use
JP5274258B2 (ja) 2005-11-21 2013-08-28 アムジエン・インコーポレーテツド β−セクレターゼ調節物質及び使用方法
US7745484B2 (en) * 2005-11-21 2010-06-29 Amgen Inc. Beta-secretase modulators and methods of use
US7838676B2 (en) * 2005-11-21 2010-11-23 Amgen Inc. Beta-secretase modulators and methods of use
WO2008137954A2 (en) * 2007-05-07 2008-11-13 Environmental Packaging Technologies Limited Universal shipping container
TW200901991A (en) 2007-05-25 2009-01-16 Amgen Inc Substituted hydroxyethyl amine compounds as beta-secretase modulators and methods of use
EP2167471B1 (en) * 2007-05-25 2013-10-16 Amgen Inc. Substituted hydroxyethyl amine compounds as beta-secretase modulators and methods of use
US7803809B2 (en) 2008-11-12 2010-09-28 Amgen Inc. Substituted pyrano [2,3-b] pyridinamine compounds as beta-secretase modulators and methods of use
TWI385175B (zh) 2008-09-11 2013-02-11 Amgen Inc 作為β-分泌酶調節劑之螺旋-三環化合物及其使用方法
WO2011063272A1 (en) 2009-11-23 2011-05-26 Amgen Inc. Amino heteroaryl compounds as beta-secretase modulators and methods of use
WO2011063233A1 (en) 2009-11-23 2011-05-26 Amgen Inc. Amino heteroaryl compounds as beta-secretase modulators and methods of use
US8735384B2 (en) 2010-01-19 2014-05-27 Amgen Inc. Amino heteroaryl compounds as beta-secretase modulators and methods of use
CA2791281A1 (en) 2010-03-15 2011-09-22 Amgen Inc. Spiro-tetracyclic ring compounds as beta-secretase modulators
JP5584352B2 (ja) 2010-03-15 2014-09-03 アムジエン・インコーポレーテツド β−セクレターゼ調節剤としてのアミノ−ジヒドロオキサジン系およびアミノ−ジヒドロチアジン系スピロ化合物ならびにそれらの医学的用途
EP2673279A1 (en) 2011-02-07 2013-12-18 Amgen Inc. 5-amino-oxazepine and 5-amino-thiazepane compounds as beta-secretase antagonists and methods of use
JP2014526560A (ja) 2011-09-21 2014-10-06 アムジエン・インコーポレーテツド β‐セクレターゼ調節因子としてのアミノオキサジン化合物およびアミノジヒドロチアジン化合物および使用方法
WO2014078314A1 (en) 2012-11-15 2014-05-22 Amgen Inc. Amino-oxazine and amino-dihydrothiazine compounds as beta-secretase modulators and methods of use
US11272751B2 (en) 2016-03-01 2022-03-15 Nicholas Popejoy Protective headgear, impact diffusing systems and methods
US9462841B1 (en) 2016-03-01 2016-10-11 William Popejoy Protective headgear and shoulder pad apparatus and methods

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20020276A1 (es) * 2000-06-30 2002-04-06 Elan Pharm Inc COMPUESTOS DE AMINA SUSTITUIDA COMO INHIBIDORES DE ß-SECRETASA PARA EL TRATAMIENTO DE ALZHEIMER
US7244755B2 (en) 2001-10-04 2007-07-17 Pharmacia & Upjohn Company Hydroxypropylamines
EP1453789A2 (en) * 2001-11-08 2004-09-08 Elan Pharmaceuticals, Inc. N,n'-substituted-1,3-diamino-2-hydroxypropane derivatives
GB0325830D0 (en) * 2003-11-05 2003-12-10 Novartis Ag Organic compounds

Also Published As

Publication number Publication date
JP2005533811A (ja) 2005-11-10
DE60315664D1 (de) 2007-09-27
EP1532123A1 (en) 2005-05-25
US7115747B2 (en) 2006-10-03
NO20045497D0 (no) 2004-12-16
AU2003249344A1 (en) 2004-01-06
US20070105921A1 (en) 2007-05-10
CN1324017C (zh) 2007-07-04
US20040063965A1 (en) 2004-04-01
CO5670350A2 (es) 2006-08-31
PL374999A1 (en) 2005-11-14
IL165763A0 (en) 2006-01-15
EA200401510A1 (ru) 2005-06-30
ATE370131T1 (de) 2007-09-15
NZ537390A (en) 2006-07-28
WO2004000821A1 (en) 2003-12-31
CN1662510A (zh) 2005-08-31
EP1532123B1 (en) 2007-08-15
CA2489988A1 (en) 2003-12-31
NO20045497L (no) 2005-03-07
BR0312439A (pt) 2005-05-10
HK1081543A1 (zh) 2006-05-19
EA008389B1 (ru) 2007-04-27

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