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MXPA04005099A - Derivados de 5-sulfanil-4h-1,2,4-triazol y su uso como medicamento. - Google Patents

Derivados de 5-sulfanil-4h-1,2,4-triazol y su uso como medicamento.

Info

Publication number
MXPA04005099A
MXPA04005099A MXPA04005099A MXPA04005099A MXPA04005099A MX PA04005099 A MXPA04005099 A MX PA04005099A MX PA04005099 A MXPA04005099 A MX PA04005099A MX PA04005099 A MXPA04005099 A MX PA04005099A MX PA04005099 A MXPA04005099 A MX PA04005099A
Authority
MX
Mexico
Prior art keywords
sulphanyl
medicine
triazole derivatives
preparing
somatostatin receptors
Prior art date
Application number
MXPA04005099A
Other languages
English (en)
Inventor
Roubert Pierre
Original Assignee
Sod Conseils Rech Applic
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR0115342A external-priority patent/FR2832710B1/fr
Application filed by Sod Conseils Rech Applic filed Critical Sod Conseils Rech Applic
Publication of MXPA04005099A publication Critical patent/MXPA04005099A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
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    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D249/12—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
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  • Hematology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Dermatology (AREA)
  • Pulmonology (AREA)
  • Emergency Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La invencion es concerniente con nuevos derivados de 5-sulfanil-4H-1,2,4-triazoles de formula (I), en la cual R1, R2 y R3 representan grupos variables y metodos para su preparacion mediante procesos de sintesis en paralelo en fase liquida. Tal producto exhibe buena afinidad por ciertos subtipos de receptores de somatostatina; son particularmente utiles para tratar enfermedades o condiciones patologicas en donde uno (o mas) receptores de somatostatina esta (n) involucrado (s). La invencion tambien es concerniente con composiciones farmaceuticas que contienen tales productos y su uso para preparar un medicamento.
MXPA04005099A 2001-11-28 2002-11-27 Derivados de 5-sulfanil-4h-1,2,4-triazol y su uso como medicamento. MXPA04005099A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR0115342A FR2832710B1 (fr) 2001-11-28 2001-11-28 Derives de 5-sulfanyl-4h-1,2,4-triazoles et leur utilisation en tant que medicaments
FR0207697 2002-06-21
PCT/FR2002/004055 WO2003045926A1 (fr) 2001-11-28 2002-11-27 Derives de 5-sulfanyl-4h-1,2,4-triazoles et leur utilisation en tant que medicament

Publications (1)

Publication Number Publication Date
MXPA04005099A true MXPA04005099A (es) 2004-08-19

Family

ID=26213278

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA04005099A MXPA04005099A (es) 2001-11-28 2002-11-27 Derivados de 5-sulfanil-4h-1,2,4-triazol y su uso como medicamento.

Country Status (22)

Country Link
US (1) US20050154039A1 (es)
EP (1) EP1465880B1 (es)
JP (1) JP2005513035A (es)
KR (1) KR100961332B1 (es)
CN (1) CN100462359C (es)
AR (1) AR037465A1 (es)
AT (1) ATE438630T1 (es)
AU (1) AU2002361345B8 (es)
BR (1) BR0214553A (es)
CA (1) CA2468184A1 (es)
CZ (1) CZ2004760A3 (es)
DE (1) DE60233265D1 (es)
ES (1) ES2330927T3 (es)
HU (1) HUP0402489A3 (es)
MX (1) MXPA04005099A (es)
MY (1) MY133406A (es)
NO (1) NO20042635L (es)
NZ (1) NZ533397A (es)
PL (1) PL370140A1 (es)
RU (1) RU2367655C2 (es)
TW (1) TWI283670B (es)
WO (1) WO2003045926A1 (es)

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TWI330079B (en) * 2003-01-15 2010-09-11 Synta Pharmaceuticals Corp Treatment for cancers
US7385084B2 (en) 2004-06-23 2008-06-10 Synta Pharmaceutical Corp. Bis(thio-hydrazide amide) salts for treatment of cancers
ES2399241T3 (es) 2004-11-18 2013-03-26 Synta Pharmaceuticals Corporation Compuestos de triazol que modulan la actividad de HSP90
JP2008536875A (ja) * 2005-04-15 2008-09-11 シンタ ファーマシューティカルズ コーポレーション ビス（チオヒドラジド）アミド化合物による併用癌療法
TWI446910B (zh) * 2005-08-18 2014-08-01 Synta Pharmaceuticals Corp 調節ｈｓｐ９０活性的三唑化合物
CA2653327A1 (en) * 2006-05-25 2007-12-06 Synta Pharmaceuticals Corp. Compounds that modulate hsp90 activity and methods for identifying same
JP5441690B2 (ja) * 2006-05-25 2014-03-12 シンタ ファーマシューティカルズ コーポレーション Ｈｓｐ９０活性を調節するトリアゾール化合物
CA2653217A1 (en) 2006-05-25 2007-12-06 Synta Pharmaceuticals Corp. Method for treating proliferative disorders associated with protooncogene products
AU2007288338B2 (en) 2006-08-21 2012-05-03 Synta Pharmaceuticals Corp. Compounds for treating proliferative disorders
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KR100980328B1 (ko) * 2007-12-14 2010-09-06 한국생명공학연구원 단백질 포스파타제의 활성을 억제하는트리아졸릴-티오-에타논 유도체 또는 이의 약학적으로 허용가능한 염을 유효성분으로 함유하는 암 예방 및 치료용조성물
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CA2468184A1 (fr) 2003-06-05
AU2002361345A1 (en) 2003-06-10
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ATE438630T1 (de) 2009-08-15
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