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MXPA04004056A - Oligonucleotidos que contienen enlazador aciclico y usos de los mismos. - Google Patents

Oligonucleotidos que contienen enlazador aciclico y usos de los mismos.

Info

Publication number
MXPA04004056A
MXPA04004056A MXPA04004056A MXPA04004056A MXPA04004056A MX PA04004056 A MXPA04004056 A MX PA04004056A MX PA04004056 A MXPA04004056 A MX PA04004056A MX PA04004056 A MXPA04004056 A MX PA04004056A MX PA04004056 A MXPA04004056 A MX PA04004056A
Authority
MX
Mexico
Prior art keywords
nucleic acid
target nucleic
prevention
acyclic linker
function
Prior art date
Application number
MXPA04004056A
Other languages
English (en)
Inventor
Min Kyung-Lyum
Original Assignee
Univ Mcgill
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Mcgill filed Critical Univ Mcgill
Publication of MXPA04004056A publication Critical patent/MXPA04004056A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)

Abstract

Se describe oligonucleotidos que tienen un residuo enlazador aciclico interno, y la preparacion y usos de los mismos. Tales usos incluyen la preparacion de oligonucleotidos antisentido que contienen enlazador aciclico, y su uso para la prevencion o deplecion de funcion de un acido nucleico objetivo de interes, tal como ARN; en un sistema. Tal prevencion o deplecion de funcion incluye, por ejemplo, la prevencion o inhibicion de la expresion, transcripcion inversa y/o replica del acido nucleico objetivo, asi como tambien la separacion/degradacion del acido nucleico objetivo. De acuerdo con lo anterior, un oligonucleotido de la invencion es util para metodos analiticos y terapeuticos y usos en los cuales la funcion de un acido nucleico objetivo se implica, asi como tambien un componente de paquetes comerciales que corresponden a tales metodos y usos.
MXPA04004056A 2001-10-29 2002-10-29 Oligonucleotidos que contienen enlazador aciclico y usos de los mismos. MXPA04004056A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US33071901P 2001-10-29 2001-10-29
PCT/CA2002/001628 WO2003037909A1 (en) 2001-10-29 2002-10-29 Acyclic linker-containing oligonucleotides and uses thereof

Publications (1)

Publication Number Publication Date
MXPA04004056A true MXPA04004056A (es) 2004-09-10

Family

ID=23291016

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA04004056A MXPA04004056A (es) 2001-10-29 2002-10-29 Oligonucleotidos que contienen enlazador aciclico y usos de los mismos.

Country Status (9)

Country Link
US (1) US20050233455A1 (es)
EP (1) EP1440079B1 (es)
JP (1) JP2005508634A (es)
AT (1) ATE348104T1 (es)
CA (1) CA2465129A1 (es)
DE (1) DE60216798T2 (es)
MX (1) MXPA04004056A (es)
NZ (1) NZ532610A (es)
WO (1) WO2003037909A1 (es)

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WO2008054834A2 (en) * 2006-02-03 2008-05-08 Columbia University Binary deoxyribozyme probes for nucleic acid analysis
KR20090035662A (ko) 2006-05-19 2009-04-10 토피겐 파마슈티컬스 인코포레이티드 포스포디에스테라아제의 발현에 영향을 미치는 올리고누클레오티드
EP3034083B1 (en) * 2006-09-21 2020-12-09 University of Rochester Antisense oligonucleotides for use in treating myotonic dystrophy
CA2687850C (en) 2007-05-22 2017-11-21 Mdrna, Inc. Oligomers for therapeutics
EP2285961A4 (en) 2008-05-15 2012-10-17 Topigen Pharmaceuticals Inc OLIGONUCLEOTIDES FOR THE TREATMENT OF INFLAMMATION AND NEOPLASTIC CELL REPRODUCTION
AU2009322290B2 (en) 2008-12-03 2016-06-16 Arcturus Therapeutics, Inc. Una oligomer structures for therapeutic agents
US20110262989A1 (en) * 2010-04-21 2011-10-27 Nanomr, Inc. Isolating a target analyte from a body fluid
US10913767B2 (en) 2010-04-22 2021-02-09 Alnylam Pharmaceuticals, Inc. Oligonucleotides comprising acyclic and abasic nucleosides and analogs
WO2011139387A1 (en) * 2010-05-03 2011-11-10 Opko Curna, Llc Treatment of sirtuin (sirt) related diseases by inhibition of natural antisense transcript to a sirtuin (sirt)
KR20130137160A (ko) * 2010-08-24 2013-12-16 머크 샤프 앤드 돔 코포레이션 내부의 비－핵산 스페이서를 함유하는 단일－가닥 ＲＮＡｉ 작용제
ES2646716T3 (es) * 2011-09-05 2017-12-15 Stichting Katholieke Universiteit Oligonucleótidos antisentido para el tratamiento de amaurosis congénita de Leber
CA2848753C (en) 2011-09-14 2022-07-26 Rana Therapeutics, Inc. Multimeric oligonucleotide compounds
CN110055247A (zh) * 2012-01-07 2019-07-26 株式会社博纳克 具有氨基酸骨架的单链核酸分子
EP2850188A4 (en) 2012-05-16 2016-01-20 Rana Therapeutics Inc COMPOSITIONS AND METHOD FOR MODULATING THE EXPRESSION OF THE HEMOGLOBIN GENE FAMILIES
AU2013262709A1 (en) 2012-05-16 2015-01-22 Rana Therapeutics, Inc. Compositions and methods for modulating MECP2 expression
US10837014B2 (en) 2012-05-16 2020-11-17 Translate Bio Ma, Inc. Compositions and methods for modulating SMN gene family expression
US10059941B2 (en) 2012-05-16 2018-08-28 Translate Bio Ma, Inc. Compositions and methods for modulating SMN gene family expression
EA201492122A1 (ru) 2012-05-16 2015-10-30 Рана Терапьютикс, Инк. Композиции и способы для модулирования экспрессии utrn
US10174323B2 (en) 2012-05-16 2019-01-08 The General Hospital Corporation Compositions and methods for modulating ATP2A2 expression
US9663784B2 (en) 2012-05-26 2017-05-30 Bonac Corporation Single-stranded nucleic acid molecule for regulating expression of gene having delivering function
AU2013315225B2 (en) 2012-09-14 2018-11-08 Translate Bio Ma, Inc. Multimeric oligonucleotide compounds
US10174328B2 (en) 2013-10-04 2019-01-08 Translate Bio Ma, Inc. Compositions and methods for treating amyotrophic lateral sclerosis
JP6486836B2 (ja) 2013-12-26 2019-03-20 学校法人東京医科大学 遺伝子発現制御のための人工ミミックｍｉＲＮＡおよびその用途
KR102357337B1 (ko) 2013-12-27 2022-01-28 가부시키가이샤 보낙 유전자 발현 제어를 위한 인공 매치형 miRNA 및 그 용도
CN106460025A (zh) 2014-03-25 2017-02-22 阿克丘勒斯治疗公司 在基因沉默中具有降低的脱靶效应的una寡聚物
JP6771387B2 (ja) 2014-03-25 2020-10-21 アークトゥラス・セラピューティクス・インコーポレイテッドＡｒｃｔｕｒｕｓ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． 遺伝子サイレンシング用トランスサイレチン対立遺伝子選択的ｕｎａオリゴマー
US9856475B2 (en) 2014-03-25 2018-01-02 Arcturus Therapeutics, Inc. Formulations for treating amyloidosis
BR112017004056A2 (pt) 2014-09-12 2017-12-05 Biogen Ma Inc composições e métodos para detecção da proteína smn em um indivíduo e tratamento de um indivíduo
MX381947B (es) 2014-12-27 2025-03-11 Bonac Corp Mirna natural para controlar la expresion de gen y uso del mismo.
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JP6602847B2 (ja) 2015-03-27 2019-11-06 株式会社ボナック デリバリー機能と遺伝子発現制御能を有する一本鎖核酸分子
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US6468983B2 (en) * 1997-04-21 2002-10-22 The Cleveland Clinic Foundation RNase L activators and antisense oligonucleotides effective to treat telomerase-expressing malignancies
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EP0978561A1 (en) * 1998-08-07 2000-02-09 Hoechst Marion Roussel Deutschland GmbH Antisense oligonucleotides for the inhibition of VEGF expression

Also Published As

Publication number Publication date
WO2003037909A1 (en) 2003-05-08
EP1440079B1 (en) 2006-12-13
ATE348104T1 (de) 2007-01-15
NZ532610A (en) 2008-03-28
JP2005508634A (ja) 2005-04-07
DE60216798T2 (de) 2007-10-18
CA2465129A1 (en) 2003-05-08
EP1440079A1 (en) 2004-07-28
DE60216798D1 (de) 2007-01-25
US20050233455A1 (en) 2005-10-20

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