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MXPA04003594A - Azaindoles e indolinas tetraciclicas que tienen actividad en serotonina 5-ht-2. - Google Patents

Azaindoles e indolinas tetraciclicas que tienen actividad en serotonina 5-ht-2.

Info

Publication number
MXPA04003594A
MXPA04003594A MXPA04003594A MXPA04003594A MXPA04003594A MX PA04003594 A MXPA04003594 A MX PA04003594A MX PA04003594 A MXPA04003594 A MX PA04003594A MX PA04003594 A MXPA04003594 A MX PA04003594A MX PA04003594 A MXPA04003594 A MX PA04003594A
Authority
MX
Mexico
Prior art keywords
compounds
azaindoles
indolines
tetracyclic
serotonin
Prior art date
Application number
MXPA04003594A
Other languages
English (en)
Inventor
Fu Jian-Min
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of MXPA04003594A publication Critical patent/MXPA04003594A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains four or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Psychiatry (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

La presente invencion proporciona compuestos de la Formula (I):(ver formula I),en donde R1, R2, R3, R4, R5 y R6, tienen cualquiera de los valores definidos en la especificacion, asi como tambien las composiciones farmaceuticas que comprenden los compuestos. La invencion tambien proporciona los metodos terapeuticos, asi como tambien los procesos e intermediarios utiles para preparar los compuestos de la Formula (I). Los compuestos son ligandos 5-HT y son utiles para tratar enfermedades en donde se desea la modulacion de la actividad 5-HT2c.
MXPA04003594A 2001-10-18 2002-10-15 Azaindoles e indolinas tetraciclicas que tienen actividad en serotonina 5-ht-2. MXPA04003594A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US33508101P 2001-10-18 2001-10-18
PCT/US2002/033176 WO2003033497A1 (en) 2001-10-18 2002-10-15 Tetracyclic azaindoles and -indolines having serotonin 5-ht2c activity

Publications (1)

Publication Number Publication Date
MXPA04003594A true MXPA04003594A (es) 2004-07-30

Family

ID=23310182

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA04003594A MXPA04003594A (es) 2001-10-18 2002-10-15 Azaindoles e indolinas tetraciclicas que tienen actividad en serotonina 5-ht-2.

Country Status (7)

Country Link
US (1) US6930105B2 (es)
EP (1) EP1436294A1 (es)
JP (1) JP2005508969A (es)
BR (1) BR0213417A (es)
CA (1) CA2464412A1 (es)
MX (1) MXPA04003594A (es)
WO (1) WO2003033497A1 (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CL2004000826A1 (es) * 2003-04-25 2005-03-04 Pfizer Uso de un agonista para el receptor 5-ht2c para preparar un medicamento util en el tratamiento de la incontinencia urinaria provocada por estres, con la condicion de que el agonista no sea 1-[6-cloro-5-(trifluorometil)-2-piridinil]piperazina (org-129
US20050052815A1 (en) * 2003-09-09 2005-03-10 Smc Corporation Static eliminating method and apparatus therefor
JP5173190B2 (ja) 2004-08-25 2013-03-27 武田薬品工業株式会社 腹圧性尿失禁の予防・治療剤及びそのスクリーニング方法
GT200500317A (es) * 2004-11-05 2006-10-27 Proceso para preparar compuestos de quinolina y productos obtenidos de los mismos
WO2006117218A2 (en) * 2005-05-04 2006-11-09 Charite Universitätsmedizin - Berlin Serotonin-transport-protein binding radiopharmaceutical for the production of a diagnostic medicament for the diagnosis of headache
EP1728520A1 (de) * 2005-05-04 2006-12-06 Charité - Universitätsmedizin Berlin Verwendung von spezifisch an das Serotonin-Transport-Protein (SERT) bindenden Radiopharmaka zur Herstellung eines Diagnostikums zur Untersuchung von Kopfschmerzerkrankungen
AR054849A1 (es) * 2005-07-26 2007-07-18 Wyeth Corp Diazepinoquinolinas, sintesis de las mismas, e intermediarios para obtenerlas
TW200734334A (en) * 2006-01-13 2007-09-16 Wyeth Corp Treatment of substance abuse
KR20080105105A (ko) * 2006-03-24 2008-12-03 와이어쓰 인지 장애 및 기타 장애의 치료방법
CA2644656A1 (en) * 2006-03-24 2007-10-04 Wyeth Treatment of pain
KR20080105104A (ko) * 2006-03-24 2008-12-03 와이어쓰 우울증 치료를 위한 신규한 치료학적 병용제
WO2007132841A1 (ja) 2006-05-16 2007-11-22 Takeda Pharmaceutical Company Limited 縮合複素環化合物およびその用途
CL2008002777A1 (es) * 2007-09-21 2010-01-22 Wyeth Corp Metodo de preparacion de compuestos diazepinoquinolinicos quirales por recristalizacion en un sistema de solvente ternario.
WO2009063992A1 (ja) 2007-11-15 2009-05-22 Takeda Pharmaceutical Company Limited 縮合ピリジン誘導体およびその用途
EP2384328B1 (en) 2008-11-27 2013-02-13 Boehringer Ingelheim International GmbH 6,7,8,9-tetrahydro-5h-1,4,7,10a-tetraaza-cyclohept[f]indene derivatives, pharmaceutical compositions containing these compounds, their use and process for preparing them
JPWO2011071136A1 (ja) 2009-12-11 2013-04-22 アステラス製薬株式会社 線維筋痛症治療剤
JPWO2019131902A1 (ja) 2017-12-27 2020-12-10 武田薬品工業株式会社 腹圧性尿失禁および便失禁の治療薬

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20010052A1 (es) 1999-04-23 2001-01-27 Upjohn Co Compuestos de azepinindol tetraciclico como agonistas o antagonistas del receptor de 5-ht
ES2228549T3 (es) 1999-06-15 2005-04-16 Bristol-Myers Squibb Pharma Company Gamma-carbolinas condensadas con heterociclo sustituido.

Also Published As

Publication number Publication date
US6930105B2 (en) 2005-08-16
US20030091505A1 (en) 2003-05-15
JP2005508969A (ja) 2005-04-07
EP1436294A1 (en) 2004-07-14
CA2464412A1 (en) 2003-04-24
BR0213417A (pt) 2004-11-03
WO2003033497A1 (en) 2003-04-24

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