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MXPA04001976A - Hormona de crecimiento humano modificada. - Google Patents

Hormona de crecimiento humano modificada.

Info

Publication number
MXPA04001976A
MXPA04001976A MXPA04001976A MXPA04001976A MXPA04001976A MX PA04001976 A MXPA04001976 A MX PA04001976A MX PA04001976 A MXPA04001976 A MX PA04001976A MX PA04001976 A MXPA04001976 A MX PA04001976A MX PA04001976 A MXPA04001976 A MX PA04001976A
Authority
MX
Mexico
Prior art keywords
growth hormone
human growth
modified human
immunogenic
relates
Prior art date
Application number
MXPA04001976A
Other languages
English (en)
Inventor
Carter Graham
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of MXPA04001976A publication Critical patent/MXPA04001976A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/61—Growth hormone [GH], i.e. somatotropin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Endocrinology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

La invencion se refiere a la modificacion de la hormona del crecimiento humano (alta) para resultar en proteinas en la hormona del crecimiento humano que son substancialmente no inmunogenicas o menos inmunogenicas que cualquier contraparte no modificada cuando se usa in vivo. La invencion se refiere ademas a las secuencias del epitopo de celulas T que derivan de la alta, que son inmunogenicas.
MXPA04001976A 2001-09-04 2002-08-30 Hormona de crecimiento humano modificada. MXPA04001976A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01121153 2001-09-04
PCT/EP2002/009716 WO2003020761A1 (en) 2001-09-04 2002-08-30 Modified human growth hormone

Publications (1)

Publication Number Publication Date
MXPA04001976A true MXPA04001976A (es) 2004-06-07

Family

ID=8178533

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA04001976A MXPA04001976A (es) 2001-09-04 2002-08-30 Hormona de crecimiento humano modificada.

Country Status (13)

Country Link
US (1) US20050020494A1 (es)
EP (1) EP1427756A1 (es)
JP (1) JP2005501546A (es)
KR (1) KR20040039323A (es)
CN (1) CN1551888A (es)
BR (1) BR0211991A (es)
CA (1) CA2459138A1 (es)
HU (1) HUP0402334A3 (es)
MX (1) MXPA04001976A (es)
PL (1) PL369066A1 (es)
RU (1) RU2004110238A (es)
WO (1) WO2003020761A1 (es)
ZA (1) ZA200402602B (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1539960B1 (en) * 2002-09-09 2010-04-28 Hanall Pharmaceutical Co., Ltd. Protease-resistant modified interferon alpha polypeptides
SG135176A1 (en) * 2004-02-02 2007-09-28 Ambrx Inc Modified human four helical bundle polypeptides and their uses
EP1640382A1 (en) * 2004-08-16 2006-03-29 Université de Liège Anti-angiogenic peptides
US7998930B2 (en) 2004-11-04 2011-08-16 Hanall Biopharma Co., Ltd. Modified growth hormones
US20080260820A1 (en) * 2007-04-19 2008-10-23 Gilles Borrelly Oral dosage formulations of protease-resistant polypeptides
US20090010966A1 (en) * 2007-06-21 2009-01-08 Angelica Therapeutics, Inc. Modified diphtheria toxins
WO2009110944A1 (en) * 2008-02-29 2009-09-11 Angelica Therapeutics, Inc. Modified toxins
JP2016519651A (ja) 2013-03-15 2016-07-07 アンジェリカ セラピューティックス，インク． 改質された毒素
US11396254B2 (en) 2017-09-07 2022-07-26 Custom Truck & Equipment LLC Railcar-mover vehicle

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100237968B1 (ko) * 1990-12-05 2000-01-15 한센 핀 베네드 변화된 에피토프를 지닌 단백질 및 그 제조방법
US5686268A (en) * 1992-06-19 1997-11-11 Pfizer Inc. Fused proteins
ATE319745T1 (de) * 1997-05-21 2006-03-15 Biovation Ltd Verfahren zur herstellung von nicht-immunogenen proteinen
GB9712892D0 (en) * 1997-06-20 1997-08-20 Eclagen Ltd Identification of mhc binding peptides
CA2342967A1 (en) * 1998-12-08 2000-06-15 Biovation Limited Modifying protein immunogenicity

Also Published As

Publication number Publication date
BR0211991A (pt) 2004-09-28
RU2004110238A (ru) 2005-10-20
HUP0402334A2 (hu) 2005-02-28
WO2003020761A1 (en) 2003-03-13
PL369066A1 (en) 2005-04-18
CN1551888A (zh) 2004-12-01
CA2459138A1 (en) 2003-03-13
ZA200402602B (en) 2005-05-06
EP1427756A1 (en) 2004-06-16
JP2005501546A (ja) 2005-01-20
KR20040039323A (ko) 2004-05-10
US20050020494A1 (en) 2005-01-27
HUP0402334A3 (en) 2007-03-28

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Legal Events

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FA Abandonment or withdrawal