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MXPA04001035A - Proceso para purificar n-[3-(3-cianopirazolo[1,5-a]pirimidin-7-il)fenil]-n-etilacetamida (zaleplon) y formas cristalinas de zaleplon accesibles con este proceso. - Google Patents

Proceso para purificar n-[3-(3-cianopirazolo[1,5-a]pirimidin-7-il)fenil]-n-etilacetamida (zaleplon) y formas cristalinas de zaleplon accesibles con este proceso.

Info

Publication number
MXPA04001035A
MXPA04001035A MXPA04001035A MXPA04001035A MXPA04001035A MX PA04001035 A MXPA04001035 A MX PA04001035A MX PA04001035 A MXPA04001035 A MX PA04001035A MX PA04001035 A MXPA04001035 A MX PA04001035A MX PA04001035 A MXPA04001035 A MX PA04001035A
Authority
MX
Mexico
Prior art keywords
zaleplon
purification
crystalline forms
regioisomer
byproduct
Prior art date
Application number
MXPA04001035A
Other languages
English (en)
Inventor
Singer Claude
Original Assignee
Biogal Gyogyszergyar
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/170,673 external-priority patent/US6884888B2/en
Application filed by Biogal Gyogyszergyar filed Critical Biogal Gyogyszergyar
Publication of MXPA04001035A publication Critical patent/MXPA04001035A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/145555—Hetero-N
    • Y10T436/147777—Plural nitrogen in the same ring [e.g., barbituates, creatinine, etc.]

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Anesthesiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Inorganic Compounds Of Heavy Metals (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Se revela un proceso de purificacion que es capaz de separar zaleplon y un regioisomero de zaleplon que tiende a formarse como un subproducto en la sintesis quimica de zaleplon, que deriva en zaleplon esencialmente puro. Ademas, formas cristalinas novedosas de zaleplon son accesibles con el proceso.
MXPA04001035A 2001-08-01 2002-08-01 Proceso para purificar n-[3-(3-cianopirazolo[1,5-a]pirimidin-7-il)fenil]-n-etilacetamida (zaleplon) y formas cristalinas de zaleplon accesibles con este proceso. MXPA04001035A (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US30939101P 2001-08-01 2001-08-01
US31790701P 2001-09-06 2001-09-06
US38819902P 2002-06-12 2002-06-12
US10/170,673 US6884888B2 (en) 2001-06-12 2002-06-12 Process for the production of N-[3-(3-cyanopyrazolo[1,5-a] pyrimidin-7-yl) phenyl]-N-ethylacetamide (zaleplon)
PCT/US2002/024553 WO2003011228A2 (en) 2001-08-01 2002-08-01 Purification and crystalline forms of zaleplon

Publications (1)

Publication Number Publication Date
MXPA04001035A true MXPA04001035A (es) 2004-06-22

Family

ID=27496922

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA04001035A MXPA04001035A (es) 2001-08-01 2002-08-01 Proceso para purificar n-[3-(3-cianopirazolo[1,5-a]pirimidin-7-il)fenil]-n-etilacetamida (zaleplon) y formas cristalinas de zaleplon accesibles con este proceso.

Country Status (14)

Country Link
US (2) US6852858B2 (es)
EP (1) EP1430054A4 (es)
JP (1) JP2005523874A (es)
CA (1) CA2453751A1 (es)
CZ (1) CZ200471A3 (es)
HR (1) HRP20040180A2 (es)
HU (1) HUP0402253A3 (es)
IL (1) IL160076A0 (es)
IS (1) IS7128A (es)
MX (1) MXPA04001035A (es)
NO (1) NO20040887L (es)
PL (1) PL374176A1 (es)
SK (1) SK472004A3 (es)
WO (1) WO2003011228A2 (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG125971A1 (en) * 2000-08-03 2006-10-30 Wyeth Corp Variable water hydrates of zaleplon and method forthe preparation thereof
CA2450384A1 (en) * 2001-06-12 2002-12-19 Biogal Gyogyszergyar Rt. Process for the production of zaleplon
US20050032818A1 (en) * 2001-06-12 2005-02-10 Entire Interest N-[3-(3-cyanopyrazolo[1,5-a]pyrimidin-5-yl)phenyl]-N-ethylacetamide and crystalline forms of zaleplon
PL374176A1 (en) * 2001-08-01 2005-10-03 Biogal Gyogyszergyar Rt Process for purifying n-[3-(3-cyanopyrazolo[1,5-a]pyrimidin-7-yl)phenyl]-n-ethylacetamide(zaleplon) and crystalline forms of zaleplon accessible with the process
AU2003218058A1 (en) * 2002-02-15 2003-09-04 Teva Gyogyszergyar Reszvenytarsasag Powder composition comprising zaleplon of defined particle size distribution and pharmaceutical products made therefrom
CZ293015B6 (cs) * 2002-10-25 2004-01-14 Léčiva, A.S. Způsob výroby N-ethyl-N-[3-(3-methyl-pyrazolo[1,5-a]pyrimidin-7-yl)-fenyl]-acetamidu (zaleplonu)
KR101248123B1 (ko) 2003-09-04 2013-03-27 씨아이피엘에이 엘티디. 잘레플론의 합성
WO2005070931A1 (en) * 2004-01-14 2005-08-04 Mallinckrodt Inc. Two-phase method for the synthesis of selected pyrazolopyrimidines
HUP0400325A3 (en) * 2004-02-02 2005-11-28 Richter Gedeon Vegyeszet Pure n-[3-(-cyanopyrazolo[1,5-a]pyrimidin-7-yl)phenyl]-n-ethyl-acetamide, process for its preparation and intermediates
WO2006062129A1 (ja) * 2004-12-08 2006-06-15 Kuraray Co., Ltd. （５α，７α）－３－スピロ－２’－（１’，３’－ジオキソラン）－２４－オキソコレスト－２２－エン－７－イル ベンゾアートの製造方法
WO2007043939A1 (en) * 2005-10-07 2007-04-19 Astrazeneca Ab Novel crystalline form of 3,5-dibromo-n- [(2s)-2-(-4-fluorophenyl)-4-(3-morpholin-4-ylazetidin-1-yl)butyl] -n-methylbenzamide, modification a
US7761955B1 (en) * 2007-08-30 2010-07-27 Hiltz Erik D Dual port cleaning and extraction apparatus
US8171598B1 (en) 2010-07-26 2012-05-08 Erik Daniel Hiltz Dual port cleaning and extraction apparatus
RU2021125455A (ru) 2013-11-15 2021-10-05 Экебиа Терапьютикс, Инк. Твердые формы { [5-(3-хлорфенил)-3-гидроксипиридин-2-карбонил]амино} уксусной кислоты, их композиции и применения

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4626538A (en) 1983-06-23 1986-12-02 American Cyanamid Company [7-(3-disubstituted amino)phenyl]pyrazolo[1,5-a]pyrimidines
US5714607A (en) * 1995-12-01 1998-02-03 American Cyanamid Company Process improvement in the synthesis of N- 3-(3-cyano-pyrazolo 1,5-a!pyrimidin-7-yl)phenyl!-N-ethylacetamide
US6485746B1 (en) * 2000-08-25 2002-11-26 Neurocrine Biosciences, Inc. Controlled-release sedative-hypnotic compositions and methods related thereto
DE10004790B4 (de) 2000-02-01 2004-09-09 Lts Lohmann Therapie-Systeme Ag Transdermales therapeutisches System zur Verabreichung von Zaleplon, Verfahren zu seiner Herstellung und seine Verwendung
EP1272181A2 (en) 2000-04-13 2003-01-08 Synthon B.V. Modified release formulations containing a hypnotic agent
SG125971A1 (en) * 2000-08-03 2006-10-30 Wyeth Corp Variable water hydrates of zaleplon and method forthe preparation thereof
AR029780A1 (es) * 2000-12-13 2003-07-16 Gador Sa Procedimiento mejorado para la obtencion de n-[3(3-ciano-pirazolo[1,5-a]pirimidin-7-il)fenil]-n-etil-acetamida
CA2450384A1 (en) * 2001-06-12 2002-12-19 Biogal Gyogyszergyar Rt. Process for the production of zaleplon
PL374176A1 (en) * 2001-08-01 2005-10-03 Biogal Gyogyszergyar Rt Process for purifying n-[3-(3-cyanopyrazolo[1,5-a]pyrimidin-7-yl)phenyl]-n-ethylacetamide(zaleplon) and crystalline forms of zaleplon accessible with the process
US7034155B2 (en) * 2002-02-14 2006-04-25 Cilag Ag Method for producing n-ethyl-n-[3-(3-cyanopyrazolo[1,5a]pyrimidine-7-yl)phenyl]acetamide
PL207322B1 (pl) 2002-05-14 2010-11-30 Adamed Społka Z Ograniczoną Odpowiedzialnością Sposób wytwarzania zaleplonu
CZ293015B6 (cs) * 2002-10-25 2004-01-14 Léčiva, A.S. Způsob výroby N-ethyl-N-[3-(3-methyl-pyrazolo[1,5-a]pyrimidin-7-yl)-fenyl]-acetamidu (zaleplonu)

Also Published As

Publication number Publication date
HUP0402253A2 (hu) 2005-02-28
US7348429B2 (en) 2008-03-25
EP1430054A4 (en) 2005-06-22
IL160076A0 (en) 2004-06-20
SK472004A3 (en) 2004-12-01
CZ200471A3 (cs) 2004-11-10
WO2003011228A2 (en) 2003-02-13
IS7128A (is) 2004-01-28
EP1430054A2 (en) 2004-06-23
NO20040887L (no) 2004-02-27
HUP0402253A3 (en) 2005-12-28
CA2453751A1 (en) 2003-02-13
US20030130291A1 (en) 2003-07-10
PL374176A1 (en) 2005-10-03
US20050065168A1 (en) 2005-03-24
US6852858B2 (en) 2005-02-08
WO2003011228A3 (en) 2003-10-30
HRP20040180A2 (en) 2004-12-31
JP2005523874A (ja) 2005-08-11

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