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MXPA04000953A - Derivados sustituidos del acido 5,6,6a,11b-tetrahidro-7-oxa-aza-benzo[c]fluoren-6-carboxilico como antagonista de nmda. - Google Patents

Derivados sustituidos del acido 5,6,6a,11b-tetrahidro-7-oxa-aza-benzo[c]fluoren-6-carboxilico como antagonista de nmda.

Info

Publication number
MXPA04000953A
MXPA04000953A MXPA04000953A MXPA04000953A MXPA04000953A MX PA04000953 A MXPA04000953 A MX PA04000953A MX PA04000953 A MXPA04000953 A MX PA04000953A MX PA04000953 A MXPA04000953 A MX PA04000953A MX PA04000953 A MXPA04000953 A MX PA04000953A
Authority
MX
Mexico
Prior art keywords
aza
oxa
fluorene
benzo
tetrahydro
Prior art date
Application number
MXPA04000953A
Other languages
English (en)
Inventor
Guenter Englberger Werner
Original Assignee
Gruenenthal Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruenenthal Gmbh filed Critical Gruenenthal Gmbh
Publication of MXPA04000953A publication Critical patent/MXPA04000953A/es

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
    • A—HUMAN NECESSITIES
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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Pulmonology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Urology & Nephrology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Hematology (AREA)
  • Psychology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Obesity (AREA)
  • Hospice & Palliative Care (AREA)
  • Emergency Medicine (AREA)
  • Dermatology (AREA)
  • Anesthesiology (AREA)
  • Endocrinology (AREA)
  • Immunology (AREA)

Abstract

La presente invencion se refiere a derivados sustituidos del acido 5,6,6a,11b-tetrahidro-7-oxa-aza-benzo[c]fluoren-6-carboxilico, asi como procedimientos para su preparacion, medicamentos conteniendo estos compuestos y su uso para la preparacion de medicamentos para determinadas indicaciones, particularmente para el tratamiento de dolor.
MXPA04000953A 2001-08-03 2002-08-05 Derivados sustituidos del acido 5,6,6a,11b-tetrahidro-7-oxa-aza-benzo[c]fluoren-6-carboxilico como antagonista de nmda. MXPA04000953A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10137487A DE10137487A1 (de) 2001-08-03 2001-08-03 Substituierte 5,6,6a,11b-Tetrahydro-7-oxa-6-aza- benzo[c]fluoren-6-carbonsäurederivate
PCT/EP2002/008886 WO2003014124A1 (de) 2001-08-03 2002-08-05 SUBSTITUIERTE 5,6,6a,11b-TETRAHYDRO-7-OXA-5-AZA-BENZO'C!FLUOREN-6-CARBONSÄUREDERIVATE ALS NMDA-ANTAGONISTEN

Publications (1)

Publication Number Publication Date
MXPA04000953A true MXPA04000953A (es) 2004-04-20

Family

ID=7693857

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA04000953A MXPA04000953A (es) 2001-08-03 2002-08-05 Derivados sustituidos del acido 5,6,6a,11b-tetrahidro-7-oxa-aza-benzo[c]fluoren-6-carboxilico como antagonista de nmda.

Country Status (21)

Country Link
US (1) US7199130B2 (es)
EP (1) EP1412361B1 (es)
JP (1) JP2005500374A (es)
KR (1) KR20040020078A (es)
CN (1) CN1697836A (es)
AT (1) ATE402178T1 (es)
BR (1) BR0211734A (es)
CA (1) CA2456124A1 (es)
CO (1) CO5550438A2 (es)
DE (2) DE10137487A1 (es)
EC (1) ECSP044968A (es)
ES (1) ES2310211T3 (es)
HU (1) HUP0400800A3 (es)
IL (1) IL160160A0 (es)
MX (1) MXPA04000953A (es)
NO (1) NO20040471L (es)
NZ (1) NZ531372A (es)
PL (1) PL368073A1 (es)
RU (1) RU2004106533A (es)
WO (1) WO2003014124A1 (es)
ZA (1) ZA200401725B (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10304950A1 (de) * 2003-02-06 2004-08-19 Grünenthal GmbH Herstellung von Tetrahydrochinolinbenzofuranen
KR20050021629A (ko) * 2003-08-25 2005-03-07 학교법인 이화학당 신규한 벤조플루오렌 디온계 화합물

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69029668T2 (de) * 1989-03-08 1997-08-07 Merck Sharp & Dohme Tetrahydroquinolin-Derivate, verwendbar bei neurodegenerativen Krankheiten
DE19536809A1 (de) * 1995-10-02 1997-04-03 Basf Ag Heterocyclisch substituierte Salicylsäurederivate
US5925527A (en) * 1997-02-04 1999-07-20 Trega Biosciences, Inc. Tricyclic Tetrahydroquinoline derivatives and tricyclic tetrahydroquinoline combinatorial libraries
GB9706294D0 (en) * 1997-03-26 1997-05-14 Glaxo Wellcome Spa Heterocyclic compound
MY125037A (en) * 1998-06-10 2006-07-31 Glaxo Wellcome Spa 1,2,3,4 tetrahydroquinoline derivatives
DE10005302A1 (de) * 2000-02-07 2002-01-17 Gruenenthal Gmbh Substituierte 1,2,3,4-Tetrahydrochinolin-2-carbonsäurederivate

Also Published As

Publication number Publication date
KR20040020078A (ko) 2004-03-06
JP2005500374A (ja) 2005-01-06
ECSP044968A (es) 2004-03-23
US20040248889A1 (en) 2004-12-09
HUP0400800A2 (hu) 2004-07-28
ATE402178T1 (de) 2008-08-15
ES2310211T3 (es) 2009-01-01
RU2004106533A (ru) 2005-07-27
IL160160A0 (en) 2004-07-25
HUP0400800A3 (en) 2007-09-28
DE50212538D1 (de) 2008-09-04
EP1412361A1 (de) 2004-04-28
ZA200401725B (en) 2005-01-31
NO20040471L (no) 2004-02-02
CO5550438A2 (es) 2005-08-31
DE10137487A1 (de) 2003-03-27
WO2003014124A1 (de) 2003-02-20
NZ531372A (en) 2005-03-24
PL368073A1 (en) 2005-03-21
CN1697836A (zh) 2005-11-16
BR0211734A (pt) 2004-09-21
EP1412361B1 (de) 2008-07-23
US7199130B2 (en) 2007-04-03
CA2456124A1 (en) 2003-02-20

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