[go: up one dir, main page]

MXPA04000310A - Procedimiento para la preparacion de 2,4-didesoxihexosas y 2,4,6-tridesoxihexosas. - Google Patents

Procedimiento para la preparacion de 2,4-didesoxihexosas y 2,4,6-tridesoxihexosas.

Info

Publication number
MXPA04000310A
MXPA04000310A MXPA04000310A MXPA04000310A MXPA04000310A MX PA04000310 A MXPA04000310 A MX PA04000310A MX PA04000310 A MXPA04000310 A MX PA04000310A MX PA04000310 A MXPA04000310 A MX PA04000310A MX PA04000310 A MXPA04000310 A MX PA04000310A
Authority
MX
Mexico
Prior art keywords
preparation
substituted
trideoxyhexose
dideoxyhexose
unsubstituted
Prior art date
Application number
MXPA04000310A
Other languages
English (en)
Inventor
Mink Daniel
Original Assignee
Dsm Ip Assets Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from NL1018525A external-priority patent/NL1018525C2/nl
Priority claimed from NL1019622A external-priority patent/NL1019622C2/nl
Application filed by Dsm Ip Assets Bv filed Critical Dsm Ip Assets Bv
Publication of MXPA04000310A publication Critical patent/MXPA04000310A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/02—Monosaccharides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La invencion se refiere a un procedimiento para la preparacion de una 2,4-didesoxihexosa o una 2,4,6-tridesoxihexosa a partir de un compuesto carbonilo sustituido o no sustituido con al menos dos atomos de carbono y al menos un atomo de hidrogeno a y un aldehido sustituido o no sustituido, en presencia de una aldolasa y agua, llevandose a cabo la reaccion entre el compuesto carbonilo sustituido o no sustituido con al menos dos atomos de carbono y al menos un atomo de hidrogeno a y el aldehido sustituido o no sustituido, a una concentracion de carbonilo de cuando mucho 6 moles/l de mezcla de reaccion, y la concentracion final de la 2,4-didesoxihexosa o la 2,4,6-tridesoxihexosa es de al menos 2% en masa de la mezcla de reaccion; la invencion tambien se refiere al uso de una didesoxihexosa o una 2,4,6-tridesoxihexosa obtenida por medio de un procedimiento de acuerdo con la invencion, en la preparacion de un medicamento, particularmente en la preparacion de una estatina.
MXPA04000310A 2001-07-12 2002-07-09 Procedimiento para la preparacion de 2,4-didesoxihexosas y 2,4,6-tridesoxihexosas. MXPA04000310A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
NL1018525A NL1018525C2 (nl) 2001-07-12 2001-07-12 Werkwijze voor de bereiding van 2,4-dideoxyhexosen en 2,4,6-trideoxyhexosen.
NL1019622A NL1019622C2 (nl) 2001-12-20 2001-12-20 Werkwijze voor de bereiding van 2,4-dideoxyhexosen en 2,4,6-trideoxyhexosen.
PCT/NL2002/000450 WO2003006656A2 (en) 2001-07-12 2002-07-09 Process for the preparation of 2,4-dideoxyhexoses and 2,4,6-trideoxyhexoses

Publications (1)

Publication Number Publication Date
MXPA04000310A true MXPA04000310A (es) 2004-05-04

Family

ID=26643375

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA04000310A MXPA04000310A (es) 2001-07-12 2002-07-09 Procedimiento para la preparacion de 2,4-didesoxihexosas y 2,4,6-tridesoxihexosas.

Country Status (12)

Country Link
US (2) US6964863B2 (es)
EP (1) EP1404844B1 (es)
JP (1) JP4248392B2 (es)
CN (1) CN1300132C (es)
AT (1) ATE356215T1 (es)
CA (1) CA2448517A1 (es)
DE (1) DE60218678T2 (es)
DK (1) DK1404844T3 (es)
ES (1) ES2282433T3 (es)
HU (1) HU228734B1 (es)
MX (1) MXPA04000310A (es)
WO (1) WO2003006656A2 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003263031A1 (en) 2002-09-20 2004-04-08 Diversa Corporation Chemoenzymatic methods for the synthesis of statins and stain intermediates
JP4272231B2 (ja) * 2004-03-29 2009-06-03 三井化学株式会社 キラルなヒドロキシアルデヒド化合物の製造方法
KR100807523B1 (ko) 2004-12-31 2008-02-26 주식회사유한양행 광학 활성 디올 유도체의 신규 제조방법
WO2007137816A1 (en) * 2006-05-30 2007-12-06 Dsm Ip Assets B.V. Process for the preparation of epoxide intermediates for pharmaceutical compounds such as statins
EP2185713B1 (en) 2007-08-03 2014-09-10 Pfizer Products Inc. Process for preparing chiral compounds
JP5731826B2 (ja) * 2008-01-23 2015-06-10 レツク・フアーマシユーテイカルズ・デー・デー （（２ｓ，４ｒ）−４，６−ジヒドロキシテトラヒドロ−２ｈ−ピラン−２−イル）メチルカルボキシラート及び２−デオキシリボース−５−リン酸アルドラーゼを使用の製造方法
WO2013083719A1 (en) 2011-12-09 2013-06-13 Dsm Sinochem Pharmaceuticals Netherlands B.V. Process for the preparation of a thioprecursor for statins
EP2788342B1 (en) 2011-12-09 2018-01-24 DSM Sinochem Pharmaceuticals Netherlands B.V. Process for the preparation of a statin precursor

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5278313A (en) 1992-03-27 1994-01-11 E. R. Squibb & Sons, Inc. Process for the preparation of 1,3-dioxane derivatives useful in the preparation of HMG-COA reductase inhibitors
US5795749A (en) 1995-04-05 1998-08-18 The Scripps Research Institution Use of 2-deoxyribose-5-phosphate aldolase to prepare 2-deoxyfucose, analogues and derivatives
DE69937374T2 (de) 1998-08-05 2008-07-24 Kaneka Corp. Verfahren zur Herstellung von 3,5-dihydroxy substituierten Estern als Zwischenprodukte zur Herstellung optisch aktiver 2-(6-(Hydroxymethyl)-1,3-dioxan-4-yl)-essigsäure-Derivate

Also Published As

Publication number Publication date
US7439046B2 (en) 2008-10-21
CA2448517A1 (en) 2003-01-23
DK1404844T3 (da) 2007-06-04
WO2003006656A3 (en) 2003-12-11
JP4248392B2 (ja) 2009-04-02
HUP0401577A3 (en) 2010-03-29
EP1404844A2 (en) 2004-04-07
DE60218678D1 (de) 2007-04-19
US20040171125A1 (en) 2004-09-02
CN1526019A (zh) 2004-09-01
WO2003006656A2 (en) 2003-01-23
EP1404844B1 (en) 2007-03-07
HU228734B1 (hu) 2013-05-28
HUP0401577A2 (hu) 2004-11-29
ATE356215T1 (de) 2007-03-15
CN1300132C (zh) 2007-02-14
US6964863B2 (en) 2005-11-15
US20050287650A1 (en) 2005-12-29
ES2282433T3 (es) 2007-10-16
DE60218678T2 (de) 2008-02-14
JP2005500838A (ja) 2005-01-13

Similar Documents

Publication Publication Date Title
BR0112812A (pt) Titanato de potássio e magnésio lepidocrocìtico, método para fabricar o mesmo e material de fricção
EP2201945A3 (en) Use of substituted 2-aminoacetamides for treating or ameliorating anxiety
MXPA04001348A (es) NUEVOS COMPUESTOS DE FOSFITOS Y SUS COMPLEJOS METaLICOS.
TW200633967A (en) Process for the hydroformylation of olefins
WO2003016321A3 (de) Neue phosphitverbindungen und neue phosphitmetallkomplexe
MY126903A (en) Sulfonyl-pyrrolidine derivatives.
MXPA04000210A (es) Conjugados quelantes mejorados.
EA200401622A1 (ru) Способы лечения ангиогенеза, роста опухолей и метастазов
MXPA04000310A (es) Procedimiento para la preparacion de 2,4-didesoxihexosas y 2,4,6-tridesoxihexosas.
DE50303819D1 (de) Verfahren zur aktivierung von doppelmetallcyanid-verbindungen
ATE180669T1 (de) Verwendung von pregnanderivaten zur behandlung von tumoren
TW200633977A (en) Novel process for the manufacture of 3-pyrrolidin-2-yl-propionic acid derivatives
EP0943620A3 (en) Betulinic acid derivatives for inhibiting cancer growth
AP2003002776A0 (en) A process for the removal of heavy metals by actinomycete
DE69902816D1 (de) Synthese von heteropolysäuren
ES2057289T3 (es) Procedimiento para la obtencion de octadienoles.
IL179832A0 (en) A process for the synthesis of terbinafine and derivatives thereof
PL1877370T3 (pl) Sposób wytwarzania pochodnych hydrazonu
EP1199308A3 (en) Process for the preparation of imidazodiazepine intermediates
BG103858A (en) Method for heavy metals elimination
MXPA05013604A (es) Procedimiento para preparar acilsulfamoilbenzamidas.
MXPA02008460A (es) Proceso catalizado con metal de transicion para la adicion de aminas a enlaces dobles carbono-carbono.
MY134242A (en) Process for catalytically hydrogenating nitriles using an iron-containing material
MXPA05008108A (es) Exo-(2r)(+))-2-amino-7-azabiciclo[2.2.1]heptan-7-carboxilato de terc-butilo, compuestos intermedios y procedimiento para prepararlos y aislarlos.
PL363012A1 (en) Method for producing chiral compounds

Legal Events

Date Code Title Description
FG Grant or registration
GB Transfer or rights
HC Change of company name or juridical status