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MXPA03011898A - Ensayo de seleccion in vitro para ?- secretasa. - Google Patents

Ensayo de seleccion in vitro para ?- secretasa.

Info

Publication number
MXPA03011898A
MXPA03011898A MXPA03011898A MXPA03011898A MXPA03011898A MX PA03011898 A MXPA03011898 A MX PA03011898A MX PA03011898 A MXPA03011898 A MX PA03011898A MX PA03011898 A MXPA03011898 A MX PA03011898A MX PA03011898 A MXPA03011898 A MX PA03011898A
Authority
MX
Mexico
Prior art keywords
gamma
secretase
vitro
substrate
secretase activity
Prior art date
Application number
MXPA03011898A
Other languages
English (en)
Spanish (es)
Inventor
Fuchs Klaus
Original Assignee
Boehringer Ingelheim Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Pharma
Publication of MXPA03011898A publication Critical patent/MXPA03011898A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Hospice & Palliative Care (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Psychiatry (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
MXPA03011898A 2001-07-04 2002-06-27 Ensayo de seleccion in vitro para ?- secretasa. MXPA03011898A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10131899A DE10131899A1 (de) 2001-07-04 2001-07-04 In vitro-Screening-Assay für gamma-Secretase
PCT/EP2002/007095 WO2003008635A2 (fr) 2001-07-04 2002-06-27 Essai de criblage in vitro de $g(g)-secretase

Publications (1)

Publication Number Publication Date
MXPA03011898A true MXPA03011898A (es) 2004-03-26

Family

ID=7690254

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA03011898A MXPA03011898A (es) 2001-07-04 2002-06-27 Ensayo de seleccion in vitro para ?- secretasa.

Country Status (6)

Country Link
EP (1) EP1407043A2 (fr)
JP (1) JP2004535206A (fr)
CA (1) CA2452832A1 (fr)
DE (1) DE10131899A1 (fr)
MX (1) MXPA03011898A (fr)
WO (1) WO2003008635A2 (fr)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0229582D0 (en) * 2002-12-19 2003-01-22 Merck Sharp & Dohme Novel assay
DK1849762T3 (da) 2006-04-21 2009-10-12 Cellzome Ltd Substituerede biphenylcarboxylsyrer og derivater deraf
SI2132188T1 (sl) 2007-03-07 2012-04-30 Janssen Pharmaceutica Nv Substituiran fenoksi n-alkilirani tiazoldinedioni kot z estrogenom povezani receptor-alfa modulatorji
CN101679327A (zh) 2007-03-07 2010-03-24 詹森药业有限公司 用作雌激素相关受体-α调节剂的取代的苯氧基氨基噻唑酮
WO2009012237A1 (fr) * 2007-07-13 2009-01-22 Elan Pharmaceuticals, Inc. Compositions et procédés permettant d'identifier la spécificité de substrat des inhibiteurs de la gamma secrétase
CA2702832A1 (fr) 2007-10-17 2009-04-23 Janssen Pharmaceutica N.V. Acides biphenylcarboxyliques et leurs derives
NZ584721A (en) 2007-10-19 2011-11-25 Janssen Pharmaceutica Nv AMIDE LINKED MODULATORS OF gamma-SECRETASE
JP5439381B2 (ja) 2007-10-19 2014-03-12 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ γ−セクレターゼのピペリジニル及びピペラジニル調節物質
KR20100082351A (ko) 2007-10-19 2010-07-16 얀센 파마슈티카 엔.브이. γ-세크레타아제의 아민 결합된 조절제
EA019710B1 (ru) 2007-10-19 2014-05-30 Янссен Фармацевтика, Н.В. ПРОИЗВОДНЫЕ 2-АРИЛ-4-МЕТИЛПЕНТАНОВОЙ КИСЛОТЫ В КАЧЕСТВЕ МОДУЛЯТОРОВ γ-СЕКРЕТАЗЫ
US7968725B2 (en) 2008-07-22 2011-06-28 Janssen Pharmaceutica N.V. Pyridinyl modulators of γ-secretase
US9023767B2 (en) 2009-05-07 2015-05-05 Memorial Sloan-Kettering Cancer Center γ-Secretase substrates and methods of use
CN103502466A (zh) 2010-09-07 2014-01-08 斯隆－凯特林纪念癌症中心 用于γ-分泌酶测定的方法和组合物
WO2014062771A1 (fr) * 2012-10-16 2014-04-24 The Johns Hopkins University Reconstitution inductible et système cinétique quantitatif en temps réel pour l'étude d'enzymes intramembranaires

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998015828A1 (fr) * 1996-10-07 1998-04-16 Scios Inc. METHODE D'IDENTIFICATION DES INHIBITEURS DIRECTS DE L'ENZYME η-SECRETASE PRODUISANT LE β-AMYLOIDE
DE19941039A1 (de) * 1999-08-28 2001-03-01 Boehringer Ingelheim Pharma gamma-Sekretase in vitro Testsystem

Also Published As

Publication number Publication date
WO2003008635A8 (fr) 2003-10-30
EP1407043A2 (fr) 2004-04-14
CA2452832A1 (fr) 2003-01-30
WO2003008635A2 (fr) 2003-01-30
JP2004535206A (ja) 2004-11-25
DE10131899A1 (de) 2003-02-27
WO2003008635A3 (fr) 2004-01-29

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