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MXPA03011652A - 5-(2-aminopirimidin-4-il) benzioxazoles como inhibidores de proteinas cinasa. - Google Patents

5-(2-aminopirimidin-4-il) benzioxazoles como inhibidores de proteinas cinasa.

Info

Publication number
MXPA03011652A
MXPA03011652A MXPA03011652A MXPA03011652A MXPA03011652A MX PA03011652 A MXPA03011652 A MX PA03011652A MX PA03011652 A MXPA03011652 A MX PA03011652A MX PA03011652 A MXPA03011652 A MX PA03011652A MX PA03011652 A MXPA03011652 A MX PA03011652A
Authority
MX
Mexico
Prior art keywords
compounds
protein kinase
benzisoxazoles
aminopyrimidin
kinase inhibitors
Prior art date
Application number
MXPA03011652A
Other languages
English (en)
Inventor
Green Jeremy
Original Assignee
Vertex Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharma filed Critical Vertex Pharma
Publication of MXPA03011652A publication Critical patent/MXPA03011652A/es

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P11/00—Drugs for disorders of the respiratory system
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    • A—HUMAN NECESSITIES
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    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
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    • A61P25/00—Drugs for disorders of the nervous system
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    • A61P9/00—Drugs for disorders of the cardiovascular system
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

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  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

En la presente se describen compuestos de benzisoxazol con la formula l o un derivado o profarmaco farmaceuticamente aceptable de los mismos, donde A-B es N-O u O-N; Ar es un grupo arilo de C5-10 opcionalmente sustituido; R2 es hidrogeno o un grupo opcionalmente sustituido, seleccionado de compuestos alifaticos de C1-10, arilo de C5-10, aralquilo de C6-12, heterociclilo de C3-10 o heterociclilalquilo de C4-12; y T, n, R2 y R3 son como se describe en la especificacion. Estos compuestos son inhibidores de proteinas cinasas, en particular, inhibidores de las proteinas cinasas GSK-3 y JAK de mamifero. La invencion tambien brinda composiciones farmaceuticamente aceptables que contienen los compuestos de la invencion, asi como metodos para utilizar esos compuestos y composiciones en el tratamiento de diversos trastornos mediados por la proteina cinasa.
MXPA03011652A 2001-06-15 2002-06-14 5-(2-aminopirimidin-4-il) benzioxazoles como inhibidores de proteinas cinasa. MXPA03011652A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US29864601P 2001-06-15 2001-06-15
PCT/US2002/019186 WO2002102800A1 (en) 2001-06-15 2002-06-14 5-(2-aminopyrimidin-4-yl) benzisoxazoles as protein kinase inhibitors

Publications (1)

Publication Number Publication Date
MXPA03011652A true MXPA03011652A (es) 2004-05-31

Family

ID=23151418

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA03011652A MXPA03011652A (es) 2001-06-15 2002-06-14 5-(2-aminopirimidin-4-il) benzioxazoles como inhibidores de proteinas cinasa.

Country Status (8)

Country Link
US (2) US6825190B2 (es)
EP (1) EP1399440B1 (es)
JP (2) JP4541695B2 (es)
AT (1) ATE432929T1 (es)
CA (1) CA2450769A1 (es)
DE (1) DE60232510D1 (es)
MX (1) MXPA03011652A (es)
WO (1) WO2002102800A1 (es)

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