MXPA03010811A - Compuestos heterociclico y uso farmaceutico. - Google Patents
Compuestos heterociclico y uso farmaceutico.Info
- Publication number
- MXPA03010811A MXPA03010811A MXPA03010811A MXPA03010811A MXPA03010811A MX PA03010811 A MXPA03010811 A MX PA03010811A MX PA03010811 A MXPA03010811 A MX PA03010811A MX PA03010811 A MXPA03010811 A MX PA03010811A MX PA03010811 A MXPA03010811 A MX PA03010811A
- Authority
- MX
- Mexico
- Prior art keywords
- agent
- alkyl
- remedy
- same meaning
- heterocyclic compound
- Prior art date
Links
- 150000002391 heterocyclic compounds Chemical class 0.000 title abstract 2
- 239000003795 chemical substances by application Substances 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 206010012601 diabetes mellitus Diseases 0.000 abstract 2
- 230000003449 preventive effect Effects 0.000 abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- 125000004648 C2-C8 alkenyl group Chemical group 0.000 abstract 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 abstract 1
- 206010022489 Insulin Resistance Diseases 0.000 abstract 1
- 102000003728 Peroxisome Proliferator-Activated Receptors Human genes 0.000 abstract 1
- 108090000029 Peroxisome Proliferator-Activated Receptors Proteins 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 239000002260 anti-inflammatory agent Substances 0.000 abstract 1
- 229940121363 anti-inflammatory agent Drugs 0.000 abstract 1
- 239000003472 antidiabetic agent Substances 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000008103 glucose Substances 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229910052717 sulfur Chemical group 0.000 abstract 1
- 239000011593 sulfur Chemical group 0.000 abstract 1
- 208000011580 syndromic disease Diseases 0.000 abstract 1
- 125000003039 tetrahydroisoquinolinyl group Chemical group C1(NCCC2=CC=CC=C12)* 0.000 abstract 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Child & Adolescent Psychology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
El nuevo compuesto heterociclico de la presente invencion es un nuevo compuesto heterociclico que tiene la formula (I) (ver formula) donde R1 es H o alquilo C1-6, R7 es H, -CO-C(R4)=C(R4)-R5, donde R4 es H o alquilo C1-4, y R5 es alquilo C4-8, alquenilo C2-8 y similares, y otros, y es el siguiente grupo, donde X es O u S, R7, es el mismo que R4, R8 es R10-C(R9)=C(R9)-, donde R9 es el mismo que R4, R10 es C1-6 alquilo y similares, y otros, R14 es el mismo que R4 y R15 es arilo y similares, Y-(CH7)n-O- esta enlazado a la posicion 6 o 7 del esqueleto de la tetrahidroisoquinolina, y n es un numero entero de 1 a 4, o una sal farmaceuticamente aceptable del mismo. El compuesto (I) de la presente invencion es util como agente hipoglucemico, agente hipolipidemico, mejorador de la resistencia a la insulina, agente terapeutico de la diabetes, agente terapeutico de complicaciones diabeticas, mejorador de la tolerancia a la glucosa, agente antiarterioesclerosis, agente antiobesidad, agente antiinflamatorio, agente para la profilaxis o tratamiento de enfermedades mediadas por PPAR o agente para la profilaxis o el tratamiento del sindrome X.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2001161489 | 2001-05-29 | ||
| PCT/JP2002/005097 WO2002096880A1 (en) | 2001-05-29 | 2002-05-27 | Novel heterocyclic compound and medicinal use thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MXPA03010811A true MXPA03010811A (es) | 2004-02-27 |
Family
ID=19004756
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MXPA03010811A MXPA03010811A (es) | 2001-05-29 | 2002-05-27 | Compuestos heterociclico y uso farmaceutico. |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US7557123B2 (es) |
| EP (1) | EP1403253A4 (es) |
| JP (1) | JP4279136B2 (es) |
| KR (2) | KR20040030647A (es) |
| CN (1) | CN1242994C (es) |
| AR (1) | AR036036A1 (es) |
| AU (1) | AU2002308889B2 (es) |
| BR (1) | BR0209711A (es) |
| CA (1) | CA2448634A1 (es) |
| CO (1) | CO5540342A2 (es) |
| CZ (1) | CZ20033450A3 (es) |
| HU (1) | HUP0401862A3 (es) |
| IL (1) | IL159085A0 (es) |
| MX (1) | MXPA03010811A (es) |
| NO (1) | NO326688B1 (es) |
| NZ (1) | NZ530358A (es) |
| PL (1) | PL367639A1 (es) |
| RU (1) | RU2299197C2 (es) |
| TW (1) | TWI297008B (es) |
| WO (1) | WO2002096880A1 (es) |
| YU (1) | YU94003A (es) |
| ZA (1) | ZA200309757B (es) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MXPA03010867A (es) | 2001-05-29 | 2004-02-27 | Kyoto Pharma Ind | Nuevos derivados heterociclicos y uso farmaceutico de los mismos. |
| US7816385B2 (en) * | 2002-12-20 | 2010-10-19 | High Point Pharmaceuticals, Llc | Dimeric dicarboxylic acid derivatives, their preparation and use |
| WO2004106542A1 (ja) * | 2003-05-29 | 2004-12-09 | Sankyo Company, Limited | インスリン抵抗性改善剤及びそのスクリーニング方法 |
| TWI359810B (en) * | 2004-11-04 | 2012-03-11 | Mitsubishi Tanabe Pharma Corp | Carboxylic acid derivative containing thiazole rin |
| US7790745B2 (en) | 2005-10-21 | 2010-09-07 | Bristol-Myers Squibb Company | Tetrahydroisoquinoline LXR Modulators |
| WO2007058504A1 (en) * | 2005-11-21 | 2007-05-24 | Lg Life Sciences, Ltd. | Novel compounds as agonist for ppar gamma and ppar alpha, method for preparation of the same, and pharmaceutical composition containing the same |
| RU2411936C2 (ru) * | 2009-01-11 | 2011-02-20 | Институт физиологии Коми научного центра Уральского отделения Российской академии наук. Государственное учреждение | Применение 2-морфолино-5-фенил-6н-1,3,4-тиадизин, гидробромида в качестве средства, обладающего гиполипидемическим и гипергликемическим эффектом |
| WO2012033195A1 (ja) * | 2010-09-10 | 2012-03-15 | 京都薬品工業株式会社 | 複素環化合物 |
| CN102807526B (zh) * | 2011-06-21 | 2015-12-02 | 寿光富康制药有限公司 | 组蛋白去乙酰化酶抑制剂ZYJ-D08a及其差向异构体的制备方法与应用 |
| WO2020013116A1 (ja) * | 2018-07-10 | 2020-01-16 | 京都薬品工業株式会社 | Ｐｔｐ－１ｂ阻害剤およびその用途 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6051189A (ja) * | 1983-08-30 | 1985-03-22 | Sankyo Co Ltd | チアゾリジン誘導体およびその製造法 |
| AR240698A1 (es) * | 1985-01-19 | 1990-09-28 | Takeda Chemical Industries Ltd | Procedimiento para preparar compuestos de 5-(4-(2-(5-etil-2-piridil)-etoxi)benzil)-2,4-tiazolidindiona y sus sales |
| EP0306228B1 (en) * | 1987-09-04 | 1999-11-17 | Beecham Group Plc | Substituted thiazolidinedione derivatives |
| US5246943A (en) * | 1992-05-19 | 1993-09-21 | Warner-Lambert Company | Substituted 1,2,3,4-tetahydroisoquinolines with angiotensin II receptor antagonist properties |
| GB9604242D0 (en) | 1996-02-28 | 1996-05-01 | Glaxo Wellcome Inc | Chemical compounds |
| CA2259431A1 (en) * | 1996-07-01 | 1998-01-08 | Eli Lilly And Company | Hypoglycemic and hypolipidemic compounds |
| JP2000515133A (ja) | 1996-07-01 | 2000-11-14 | イーライ・リリー・アンド・カンパニー | 血糖降下性および脂質低下性の化合物 |
| GB9817118D0 (en) * | 1998-08-07 | 1998-10-07 | Glaxo Group Ltd | Pharmaceutical compounds |
| CZ20021911A3 (cs) | 1999-12-03 | 2002-10-16 | Kyoto Pharmaceutical Industries, Ltd. | Nové heterocyklické sloučeniny a jejich soli a jejich vyuľití v lékařství |
| US20020037897A1 (en) * | 2000-08-07 | 2002-03-28 | 3-Dimensional Pharmaceuticals, Inc. | Tetrahydroisoquinoline-3-carboxylic acid alkoxyguanidines as integrin antagonists |
| MXPA03010867A (es) * | 2001-05-29 | 2004-02-27 | Kyoto Pharma Ind | Nuevos derivados heterociclicos y uso farmaceutico de los mismos. |
-
2002
- 2002-05-27 PL PL02367639A patent/PL367639A1/xx unknown
- 2002-05-27 US US10/478,862 patent/US7557123B2/en not_active Expired - Fee Related
- 2002-05-27 KR KR10-2003-7015611A patent/KR20040030647A/ko not_active Withdrawn
- 2002-05-27 YU YU94003A patent/YU94003A/sh unknown
- 2002-05-27 CA CA002448634A patent/CA2448634A1/en not_active Abandoned
- 2002-05-27 BR BR0209711-7A patent/BR0209711A/pt not_active IP Right Cessation
- 2002-05-27 HU HU0401862A patent/HUP0401862A3/hu unknown
- 2002-05-27 JP JP2003500060A patent/JP4279136B2/ja not_active Expired - Fee Related
- 2002-05-27 CN CNB028109643A patent/CN1242994C/zh not_active Expired - Fee Related
- 2002-05-27 AU AU2002308889A patent/AU2002308889B2/en not_active Ceased
- 2002-05-27 RU RU2003137574/04A patent/RU2299197C2/ru not_active IP Right Cessation
- 2002-05-27 KR KR1020087023698A patent/KR100898358B1/ko not_active Expired - Fee Related
- 2002-05-27 MX MXPA03010811A patent/MXPA03010811A/es active IP Right Grant
- 2002-05-27 ZA ZA200309757A patent/ZA200309757B/en unknown
- 2002-05-27 NZ NZ530358A patent/NZ530358A/en unknown
- 2002-05-27 WO PCT/JP2002/005097 patent/WO2002096880A1/ja not_active Ceased
- 2002-05-27 IL IL15908502A patent/IL159085A0/xx unknown
- 2002-05-27 EP EP02774070A patent/EP1403253A4/en not_active Withdrawn
- 2002-05-27 CZ CZ20033450A patent/CZ20033450A3/cs unknown
- 2002-05-28 TW TW091111315A patent/TWI297008B/zh active
- 2002-05-29 AR ARP020102002A patent/AR036036A1/es unknown
-
2003
- 2003-11-28 NO NO20035331A patent/NO326688B1/no not_active IP Right Cessation
- 2003-12-29 CO CO03112806A patent/CO5540342A2/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| TWI297008B (en) | 2008-05-21 |
| HUP0401862A3 (en) | 2009-03-30 |
| EP1403253A1 (en) | 2004-03-31 |
| EP1403253A4 (en) | 2005-03-30 |
| CZ20033450A3 (cs) | 2004-05-12 |
| HK1069385A1 (en) | 2005-05-20 |
| KR20040030647A (ko) | 2004-04-09 |
| US7557123B2 (en) | 2009-07-07 |
| WO2002096880A1 (en) | 2002-12-05 |
| AU2002308889B2 (en) | 2007-09-06 |
| CN1527819A (zh) | 2004-09-08 |
| NZ530358A (en) | 2005-04-29 |
| NO326688B1 (no) | 2009-01-26 |
| JP4279136B2 (ja) | 2009-06-17 |
| KR100898358B1 (ko) | 2009-05-20 |
| NO20035331D0 (no) | 2003-11-28 |
| CA2448634A1 (en) | 2002-12-05 |
| KR20080093076A (ko) | 2008-10-17 |
| CN1242994C (zh) | 2006-02-22 |
| AR036036A1 (es) | 2004-08-04 |
| PL367639A1 (en) | 2005-03-07 |
| BR0209711A (pt) | 2004-11-03 |
| ZA200309757B (en) | 2004-12-22 |
| JPWO2002096880A1 (ja) | 2004-09-09 |
| RU2299197C2 (ru) | 2007-05-20 |
| RU2003137574A (ru) | 2005-05-20 |
| YU94003A (sh) | 2006-08-17 |
| HUP0401862A2 (hu) | 2004-12-28 |
| IL159085A0 (en) | 2004-05-12 |
| US20040220215A1 (en) | 2004-11-04 |
| CO5540342A2 (es) | 2005-07-29 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP1357115A4 (en) | ALKANOIC ACID DERIVATIVES, PROCESS FOR THE PRODUCTION AND USE THEREOF | |
| NZ508066A (en) | Oxyiminoalkanoic acid derivatives with hypoglycemic and hypolipidemic activity | |
| YU50302A (sh) | Nova heterociklična jedinjenja, njihove soli i njihova primena u medicini | |
| CA2316902A1 (en) | Alpha-aminoamide derivatives useful as analgesic agents | |
| HUP0203165A2 (hu) | Nitrogént tartalmazó, öttagú heterociklusos vegyületek | |
| IE44246L (en) | Heterocyclyloxypropanolamines | |
| WO2004073611A3 (en) | Compounds for the treatment of metabolic disorders | |
| MXPA03010811A (es) | Compuestos heterociclico y uso farmaceutico. | |
| MXPA05011592A (es) | Compuestos para el tratamiento de trastornos metabolicos. | |
| ATE487474T1 (de) | Verbindungen zur behandlung von stoffwechselstörungen | |
| ATE450496T1 (de) | Verbindungen zur behandlung von stoffwechselstörungen | |
| MXPA03010867A (es) | Nuevos derivados heterociclicos y uso farmaceutico de los mismos. | |
| AU3381389A (en) | Derivative of caffeic acid and pharmaceutical composition containing the same | |
| NZ501785A (en) | 4-(3,4-dihydro-2-naphthylmethyl)- or 4-(2H-3-chromenylmethyl)-4,5-dihydro-1H-imidazole derivatives | |
| EP1156057A4 (en) | MALTO-OLIGOSACCHARID DERIVATIVES AND THEIR APPLICATIONS | |
| AU4301189A (en) | New thienyloxy-alkylamine derivates, their process of production and medicaments containing these compounds | |
| NZ511572A (en) | Eudesmadienolide derivatives useful as glucose and lipid lowering compounds | |
| FI892685A0 (fi) | Menetelmä uusien, sytostaattisesti vaikuttavien antrasykliinijohdannaisten valmistamiseksi | |
| EP1627866A4 (en) | CARBONIC ACID CONNECTION AND MEDICAMENT CONTAINING THIS | |
| AU2224795A (en) | Ameliorant or remedy for paraneoplastic syndrome | |
| NO950827L (no) | Fosfonsubstituerte tetrazolderivater | |
| ES2007784A6 (es) | Procedimiento para la preparacion de derivados de 1-alquil-ergolinil-tiourea> | |
| IE782313L (en) | Naphthalene derivatives | |
| KR920017661A (ko) | 진행성 당뇨병의 진전 억제용 제약 조성물 | |
| KR940021526A (ko) | 카르복실산 유도체 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |