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MXPA03008984A - D-hidantoinasa de ochrobactrum anthropi. - Google Patents

D-hidantoinasa de ochrobactrum anthropi.

Info

Publication number
MXPA03008984A
MXPA03008984A MXPA03008984A MXPA03008984A MXPA03008984A MX PA03008984 A MXPA03008984 A MX PA03008984A MX PA03008984 A MXPA03008984 A MX PA03008984A MX PA03008984 A MXPA03008984 A MX PA03008984A MX PA03008984 A MXPA03008984 A MX PA03008984A
Authority
MX
Mexico
Prior art keywords
hydantoinase
ochrobactrum anthropi
enzyme
nucleic acids
anthropi
Prior art date
Application number
MXPA03008984A
Other languages
English (en)
Inventor
John J Usher
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of MXPA03008984A publication Critical patent/MXPA03008984A/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/78Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • C12N9/86Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in cyclic amides, e.g. penicillinase (3.5.2)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y305/00Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5)
    • C12Y305/02Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5) in cyclic amides (3.5.2)
    • C12Y305/02002Dihydropyrimidinase (3.5.2.2), i.e. hydantoinase

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

La presente invencion se refiere a una nueva D-hidantoinasa de Ochrobactrun anthropi que hidroliza enantio-selectivamente D-hidantoinas a sus D,N-carbamoil-aminoacidos correspondientes; a acidos nucleicos que codifican la enzima; a vectores de expresion que incluyen los acidos nucleicos y a celulas huesped capaces de expresar la enzima.
MXPA03008984A 2001-04-03 2002-04-03 D-hidantoinasa de ochrobactrum anthropi. MXPA03008984A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US28115001P 2001-04-03 2001-04-03
PCT/US2002/010437 WO2002081626A2 (en) 2001-04-03 2002-04-03 D-hydantoinase from ochrobactrum anthropi

Publications (1)

Publication Number Publication Date
MXPA03008984A true MXPA03008984A (es) 2004-02-18

Family

ID=23076145

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA03008984A MXPA03008984A (es) 2001-04-03 2002-04-03 D-hidantoinasa de ochrobactrum anthropi.

Country Status (11)

Country Link
US (1) US6800465B2 (es)
EP (1) EP1383886B1 (es)
JP (1) JP4118689B2 (es)
AT (1) ATE402998T1 (es)
AU (1) AU2002254519B2 (es)
CA (1) CA2443377C (es)
DE (1) DE60227936D1 (es)
ES (1) ES2307746T3 (es)
IL (2) IL157937A0 (es)
MX (1) MXPA03008984A (es)
WO (1) WO2002081626A2 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4561009B2 (ja) * 2001-07-10 2010-10-13 味の素株式会社 D−ヒダントインハイドロラーゼをコードするdna、n−カルバミル−d−アミノ酸ハイドロラーゼをコードするdna、該遺伝子を含む組み換えdna、該組み換えdnaにより形質転換された細胞、該形質転換細胞を用いるタンパク質の製造方法、および、d−アミノ酸の製造方法
JP4561010B2 (ja) * 2001-07-10 2010-10-13 味の素株式会社 D−ヒダントインハイドロラーゼをコードするdna、n−カルバミル−d−アミノ酸ハイドロラーゼをコードするdna、該遺伝子を含む組み換えdna、該組み換えdnaにより形質転換された細胞、該形質転換細胞を用いるタンパク質の製造方法、および、d−アミノ酸の製造方法
US7741082B2 (en) 2004-04-14 2010-06-22 Bristol-Myers Squibb Company Process for preparing dipeptidyl peptidase IV inhibitors and intermediates therefor
AU2005290337A1 (en) * 2004-09-28 2006-04-06 Cytogenix, Inc. Single-stranded antimicrobial oligonucleotides and uses thereof
CN102482661A (zh) * 2009-07-09 2012-05-30 中化帝斯曼制药有限公司荷兰公司 经稳定化的酶组合物
WO2011003702A1 (en) * 2009-07-09 2011-01-13 Dsm Ip Assets B.V. Stabilized enzyme compositions

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4316928C2 (de) 1993-05-19 1995-03-16 Degussa Neue Mikroorganismen, deren Verwendung und Verfahren zur Herstellung von L-alpha-Aminosäuren
KR100244066B1 (ko) 1994-12-28 2000-02-01 후루따 다케시 D-N-카르바모일-α-아미노산의 제조법
EP0739978A2 (en) 1995-04-28 1996-10-30 W.R. Grace & Co.-Conn. Hydantoinase from agrobacterium tumefaciens and its use for the preparation of optically pure N-carbamyl-D-amino acids from racemic hydantoins
DE19519717C1 (de) 1995-05-30 1996-08-22 Degussa Neuer Mikroorganismus, dessen Verwendung und Verfahren zur Herstellung von L-alpha-Aminosäuren
US6524837B1 (en) 1999-03-29 2003-02-25 California Institute Of Technology Hydantoinase variants with improved properties and their use for the production of amino acids

Also Published As

Publication number Publication date
EP1383886B1 (en) 2008-07-30
CA2443377C (en) 2014-05-27
AU2002254519B2 (en) 2006-08-31
CA2443377A1 (en) 2002-10-17
IL157937A (en) 2008-04-13
EP1383886A4 (en) 2005-09-07
US20030013102A1 (en) 2003-01-16
DE60227936D1 (de) 2008-09-11
JP4118689B2 (ja) 2008-07-16
JP2004525641A (ja) 2004-08-26
IL157937A0 (en) 2004-03-28
ATE402998T1 (de) 2008-08-15
WO2002081626A3 (en) 2003-12-04
WO2002081626A2 (en) 2002-10-17
ES2307746T3 (es) 2008-12-01
US6800465B2 (en) 2004-10-05
EP1383886A2 (en) 2004-01-28

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