[go: up one dir, main page]

MXPA03007037A - Ligandos del antigeno de membrana especifico de prostata (amep) y usos relacionados del mismo. - Google Patents

Ligandos del antigeno de membrana especifico de prostata (amep) y usos relacionados del mismo.

Info

Publication number
MXPA03007037A
MXPA03007037A MXPA03007037A MXPA03007037A MXPA03007037A MX PA03007037 A MXPA03007037 A MX PA03007037A MX PA03007037 A MXPA03007037 A MX PA03007037A MX PA03007037 A MXPA03007037 A MX PA03007037A MX PA03007037 A MXPA03007037 A MX PA03007037A
Authority
MX
Mexico
Prior art keywords
psma ligands
uses related
modified psma
diagnosis
detection
Prior art date
Application number
MXPA03007037A
Other languages
English (en)
Inventor
John V Frangioni
Original Assignee
Beth Israel Hospital
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beth Israel Hospital filed Critical Beth Israel Hospital
Publication of MXPA03007037A publication Critical patent/MXPA03007037A/es

Links

Classifications

    • G01N33/5759—
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/005—Compounds of elements of Group 5 of the Periodic Table without metal-carbon linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
    • C07F9/301—Acyclic saturated acids which can have further substituents on alkyl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
    • C07F9/32—Esters thereof
    • C07F9/3205—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/3211—Esters of acyclic saturated acids which can have further substituents on alkyl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/572—Five-membered rings
    • C07F9/5728—Five-membered rings condensed with carbocyclic rings or carbocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6596—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having atoms other than oxygen, sulfur, selenium, tellurium, nitrogen or phosphorus as ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/66—Arsenic compounds
    • C07F9/70—Organo-arsenic compounds
    • C07F9/72—Aliphatic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
    • G01N33/57505—
    • G01N33/57555—

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Urology & Nephrology (AREA)
  • Genetics & Genomics (AREA)
  • Reproductive Health (AREA)
  • Hematology (AREA)
  • Neurosurgery (AREA)
  • Endocrinology (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • Neurology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Catalysts (AREA)
MXPA03007037A 2001-02-07 2002-02-07 Ligandos del antigeno de membrana especifico de prostata (amep) y usos relacionados del mismo. MXPA03007037A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US26705501P 2001-02-07 2001-02-07
PCT/US2002/021996 WO2002098885A1 (en) 2001-02-07 2002-02-07 Modified psma ligands and uses related thereto

Publications (1)

Publication Number Publication Date
MXPA03007037A true MXPA03007037A (es) 2003-11-18

Family

ID=23017130

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA03007037A MXPA03007037A (es) 2001-02-07 2002-02-07 Ligandos del antigeno de membrana especifico de prostata (amep) y usos relacionados del mismo.

Country Status (8)

Country Link
US (4) US6875886B2 (es)
EP (1) EP1363920B1 (es)
JP (1) JP2005507857A (es)
AT (1) ATE337011T1 (es)
CA (1) CA2436408A1 (es)
DE (1) DE60214134T2 (es)
MX (1) MXPA03007037A (es)
WO (1) WO2002098885A1 (es)

Families Citing this family (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002043773A2 (en) * 2000-12-01 2002-06-06 The Johns Hopkins University Tissue specific prodrugs
US7771953B2 (en) 2003-01-10 2010-08-10 Millenium Pharmaceuticals, Inc. Methods of diagnosing and treating cancer
WO2007001448A2 (en) 2004-11-04 2007-01-04 Massachusetts Institute Of Technology Coated controlled release polymer particles as efficient oral delivery vehicles for biopharmaceuticals
CA2593574A1 (en) * 2005-01-14 2006-07-20 Cytogen Corporation Combination cancer therapy with anti-psma antibodies
US20060264414A1 (en) * 2005-04-08 2006-11-23 The Board of Regents, University and Community College System of Nevada on behalf of the Fluorous 2,2'-bipyridines and fluorinated biphasic sysems for ligand design
JP2008535865A (ja) * 2005-04-08 2008-09-04 サイトジェン コーポレーション 抗ｐｓｍａコンジュゲート抗体
WO2006121920A2 (en) * 2005-05-05 2006-11-16 Beth Israel Deaconess Medical Center, Inc. Micro-scale resonant devices and methods of use
EP2662096A1 (en) 2005-08-24 2013-11-13 ImmunoGen, Inc. Process for preparing maytansinoid antibody conjugates
EP1937699A2 (en) * 2005-10-18 2008-07-02 Centre National De La Recherche Scientifique (Cnrs) Hypophosphorous acid derivatives and their therapeutical applications
US9267937B2 (en) 2005-12-15 2016-02-23 Massachusetts Institute Of Technology System for screening particles
WO2007106869A1 (en) 2006-03-14 2007-09-20 Cancer Targeted Technology Llc Peptidomimetic inhibitors of psma,compounds comprising them, and methods of use
CA2648099C (en) 2006-03-31 2012-05-29 The Brigham And Women's Hospital, Inc System for targeted delivery of therapeutic agents
US9381477B2 (en) * 2006-06-23 2016-07-05 Massachusetts Institute Of Technology Microfluidic synthesis of organic nanoparticles
WO2008006006A1 (en) 2006-07-03 2008-01-10 Beth Israel Deaconess Medical Center, Inc. Histology methods
US20100144845A1 (en) * 2006-08-04 2010-06-10 Massachusetts Institute Of Technology Oligonucleotide systems for targeted intracellular delivery
WO2008027995A2 (en) * 2006-08-29 2008-03-06 Beth Israel Deaconess Medical Center, Inc. Radio-labeled materials and methods of making and using the same
EP2087337A4 (en) * 2006-11-03 2010-09-08 Purdue Research Foundation METHOD AND DEVICE FOR EX-VIVO FLOW CYTOMETRY
EP2134830A2 (en) 2007-02-09 2009-12-23 Massachusetts Institute of Technology Oscillating cell culture bioreactor
EP2144600A4 (en) * 2007-04-04 2011-03-16 Massachusetts Inst Technology POLY (AMINIC ACID) TARGET MOLECULES
US9044468B2 (en) 2007-06-26 2015-06-02 The Johns Hopkins University Labeled inhibitors of prostate specific membrane antigen (PSMA), biological evaluation, and use as imaging agents
JP2010535193A (ja) * 2007-08-01 2010-11-18 サーントゥル ナシオナル ドゥ ラ ルシェルシュ シャーンティフィク セエンエールエス チオホスフィン（チオホスホン）酸誘導体およびそれらの治療適用
NZ583931A (en) 2007-08-17 2012-06-29 Purdue Research Foundation Psma binding ligand-linker conjugates and methods for using
FR2920086A1 (fr) 2007-08-24 2009-02-27 Univ Grenoble 1 Systeme et procede d'analyse pour une operation chirurgicale par endoscopie
EP2644594B1 (en) * 2007-09-28 2017-08-23 Pfizer Inc Cancer Cell Targeting Using Nanoparticles
EP3424525A1 (en) 2007-10-12 2019-01-09 Massachusetts Institute Of Technology Vaccine nanotechnology
ES2721850T3 (es) 2008-06-16 2019-08-05 Pfizer Nanopartículas poliméricas terapéuticas que comprenden alcaloides vinca y procedimientos de fabricación y uso de las mismas
WO2010005726A2 (en) * 2008-06-16 2010-01-14 Bind Biosciences Inc. Therapeutic polymeric nanoparticles with mtor inhibitors and methods of making and using same
WO2010005723A2 (en) 2008-06-16 2010-01-14 Bind Biosciences, Inc. Drug loaded polymeric nanoparticles and methods of making and using same
US8277812B2 (en) 2008-10-12 2012-10-02 Massachusetts Institute Of Technology Immunonanotherapeutics that provide IgG humoral response without T-cell antigen
US8591905B2 (en) 2008-10-12 2013-11-26 The Brigham And Women's Hospital, Inc. Nicotine immunonanotherapeutics
WO2010045598A2 (en) * 2008-10-17 2010-04-22 Purdue Research Foundation Psma binding ligand-linker conjugates and methods for using
US8563041B2 (en) * 2008-12-12 2013-10-22 Bind Therapeutics, Inc. Therapeutic particles suitable for parenteral administration and methods of making and using same
EP2379064B1 (en) * 2008-12-15 2020-02-26 Pfizer Inc. Long circulating nanoparticles for sustained release of therapeutic agents
US10493169B2 (en) 2009-02-06 2019-12-03 Beth Israel Deaconess Medical Center Use of charge-balanced imaging agents for determining renal function
ES2684697T3 (es) 2009-02-06 2018-10-04 Beth Israel Deaconess Medical Center, Inc. Agentes de obtención de imágenes de carga equilibrada
CA2769444A1 (en) 2009-05-19 2010-11-25 Aic Blab Company Composite current collector and methods therefor
PT2437790T (pt) 2009-06-03 2019-06-04 Immunogen Inc Métodos de conjugação
JP5891175B2 (ja) 2009-12-11 2016-03-22 バインド セラピューティックス インコーポレイテッド 治療用粒子の凍結乾燥に対する安定製剤
JP5965844B2 (ja) 2009-12-15 2016-08-10 バインド セラピューティックス インコーポレイテッド 高いガラス転移温度または高分子量のコポリマーを有する治療用ポリマーナノ粒子組成物
US9951324B2 (en) 2010-02-25 2018-04-24 Purdue Research Foundation PSMA binding ligand-linker conjugates and methods for using
CN107537040A (zh) * 2011-03-29 2018-01-05 伊缪诺金公司 通过一步法制备类美登素抗体缀合物
CA2865282A1 (en) * 2012-02-24 2013-08-29 Cornell University Elevated psma identifies lethal prostate cancers
JP2015508903A (ja) * 2012-02-28 2015-03-23 コーネル ユニヴァーシティー 前立腺癌におけるアンドロゲン活性のバイオマーカーとしてのｐｓｍａ
MX356097B (es) 2012-09-17 2018-05-14 Pfizer Inc Star Proceso para la preparacion de nanoparticulas terapeuticas.
AU2013326881B2 (en) 2012-10-04 2018-08-02 Immunogen, Inc. Use of a PVDF membrane to purify cell-binding agent cytotoxic agent conjugates
EP3875082A1 (en) 2012-11-15 2021-09-08 Endocyte, Inc. Conjugates for treating diseases caused by psma expressing cells
US20170232119A1 (en) 2013-03-15 2017-08-17 Purdue Research Foundation Synthesis and composition of amino acid linking groups conjugated to compounds used for the targeted imaging of tumors
CA2903994C (en) 2013-03-15 2017-08-22 Philip S. Low Synthesis and composition of amino acid linking groups conjugated to compounds used for the targeted imaging of tumors
EP2842578B1 (en) * 2013-08-27 2018-06-27 GILUPI GmbH Diagnostic device for the detection of biomarkers
TN2016000137A1 (en) 2013-10-18 2017-10-06 Deutsches Krebsforsch Labeled inhibitors of prostate specific membrane antigen (psma), their use as imaging agents and pharmaceutical agents for the treatment of prostate cancer.
ES3013992T3 (en) 2013-11-14 2025-04-16 Endocyte Inc Compounds for positron emission tomography
DK3116547T3 (da) 2014-03-14 2019-07-15 Pfizer Terapeutiske nanopartikler omfattende et terapeutisk middel og fremgangsmåder til fremstilling og anvendelse deraf
WO2016040179A1 (en) * 2014-09-08 2016-03-17 Molecular Insight Pharmaceuticals, Inc. Organ protection in psma-targeted radionuclide therapy of prostate cancer
US10188759B2 (en) 2015-01-07 2019-01-29 Endocyte, Inc. Conjugates for imaging
WO2019204335A1 (en) 2018-04-17 2019-10-24 Endocyte, Inc. Methods of treating cancer
EP3972627A4 (en) 2019-05-20 2023-06-21 Endocyte, Inc. Methods for preparing psma conjugates
DE102019215585B4 (de) * 2019-10-10 2022-02-17 KCM Egészségügyi és Tudományos Korlátolt Felelösségü Társaság Verfahren zur prävention von strahlenschäden in humanen drüsen
CN118852044A (zh) 2021-09-03 2024-10-29 晶核生物医药科技(南京)有限公司 一种肽脲素衍生物、含其的药物组合物及其应用
TW202426433A (zh) 2022-09-23 2024-07-01 瑞士商紐利迪姆股份公司 成纖維細胞活化蛋白（ｆａｐ）抑制劑、ｆａｐ結合物及其診斷與治療用途
JP2025532104A (ja) 2022-09-23 2025-09-29 ヌクリディウム アクチェンゲゼルシャフト 高純度銅放射性医薬組成物ならびにその診断および治療用途
WO2025167998A1 (zh) * 2024-02-06 2025-08-14 北京昌平实验室 膦酸酯骨架的psma靶向偶联物

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1757694A3 (en) 1992-11-05 2008-02-27 Sloan Kettering Institute For Cancer Research Prostate-specific membrane antigen
US5804602A (en) * 1996-06-17 1998-09-08 Guilford Pharmaceuticals Inc. Methods of cancer treatment using naaladase inhibitors
US5902817A (en) 1997-04-09 1999-05-11 Guilford Pharmaceuticals Inc. Certain sulfoxide and sulfone derivatives
US6025345A (en) * 1996-06-17 2000-02-15 Guilford Pharmaceuticals Inc. Inhibitors of NAALADase enzyme activity
US6384022B1 (en) * 1996-06-17 2002-05-07 Guilford Pharmaceuticals Inc. Prodrugs of NAALAdase inhibitors
US6046180A (en) 1996-06-17 2000-04-04 Guilford Pharmaceuticals Inc. NAALADase inhibitors
TR199802638T2 (xx) 1996-06-17 1999-03-22 Guilford Pharmaceuticals, Inc. Kanser tedavisinde naaladase inhibit�rleri kullan�m�.
US6071965A (en) * 1996-06-17 2000-06-06 Guilford Pharmaceuticals Inc. Phosphinic alkanoic acid derivatives
US6025344A (en) 1996-06-17 2000-02-15 Guilford Pharmaceuticals Inc. Certain dioic acid derivatives useful as NAALADase inhibitors
US6054444A (en) 1997-04-24 2000-04-25 Guilford Pharmaceuticals Inc. Phosphonic acid derivatives
WO1998013046A1 (en) 1996-09-27 1998-04-02 Guilford Pharmaceuticals Inc. Naaladase compositions and methods for treating glutamate abnormality and effecting neuronal activity in animals
US5962521A (en) 1997-04-04 1999-10-05 Guilford Pharmaceuticals Inc. Hydroxamic acid derivatives
US5981209A (en) 1997-12-04 1999-11-09 Guilford Pharmaceuticals Inc. Use of NAALADase activity to identify prostate cancer and benign prostatic hyperplasia
US6444657B1 (en) * 1998-12-31 2002-09-03 Guilford Pharmaceuticals Inc. Methods for treating certain diseases using naaladase inhibitors
US6348464B1 (en) 1999-11-12 2002-02-19 Guilford Pharmaceuticals, Inc. Pyrrolecarbonylimino derivatives as naaladase inhibitors
US7254409B2 (en) * 2000-04-14 2007-08-07 Ntt Docomo, Inc. Multicast service providing system, multicast service providing method, information distributor, radio terminal, and radio base station
AU2001265111A1 (en) 2000-05-30 2001-12-11 Guilford Pharmaceuticals Inc. Benzenedicarboxylic acid derivatives
US6594498B1 (en) * 2000-08-14 2003-07-15 Vesuvius, Inc. Communique system for cellular communication networks
US6907023B2 (en) * 2000-08-14 2005-06-14 Vesuvius, Inc. Communique system with dynamic bandwidth allocation in cellular communication networks
US6684076B2 (en) * 2000-08-14 2004-01-27 Vesuvius Inc. Communique system with hierarchical communique coverage areas in cellular communication networks
US6687498B2 (en) * 2000-08-14 2004-02-03 Vesuvius Inc. Communique system with noncontiguous communique coverage areas in cellular communication networks
US7024200B2 (en) * 2000-08-14 2006-04-04 Vesuvius, Inc. Communique system with active feedback for cellular communication networks
US6829486B2 (en) * 2000-08-14 2004-12-07 Vesuvius Communique system for combined cellular and wireline communication networks
US6741856B2 (en) * 2000-08-14 2004-05-25 Vesuvius Inc. Communique system for virtual private narrowcasts in cellular communication networks
US6954641B2 (en) * 2000-08-14 2005-10-11 Vesivius, Inc. Communique wireless subscriber device for a cellular communication network
US6681115B1 (en) * 2000-08-14 2004-01-20 Vesuvius Inc. Communique subscriber handoff between a narrowcast cellular communication network and a point-to-point cellular communication network
EP1341557A2 (en) * 2000-10-27 2003-09-10 Beth Israel Deaconess Medical Center Non-isotopic detection of osteoblastic activity in vivo using modified bisphosphonates
JP4234430B2 (ja) 2001-01-17 2009-03-04 エムジーアイ ジーピー インコーポレイティッド チオールを含むｎａａｌａｄアーゼ抑制物質

Also Published As

Publication number Publication date
US6875886B2 (en) 2005-04-05
EP1363920B1 (en) 2006-08-23
DE60214134D1 (de) 2006-10-05
US20040110723A1 (en) 2004-06-10
JP2005507857A (ja) 2005-03-24
EP1363920A1 (en) 2003-11-26
ATE337011T1 (de) 2006-09-15
EP1363920A4 (en) 2004-04-21
US20080175789A1 (en) 2008-07-24
CA2436408A1 (en) 2002-12-12
US20040229845A1 (en) 2004-11-18
DE60214134T2 (de) 2007-07-19
US20050245486A1 (en) 2005-11-03
WO2002098885A1 (en) 2002-12-12

Similar Documents

Publication Publication Date Title
MXPA03007037A (es) Ligandos del antigeno de membrana especifico de prostata (amep) y usos relacionados del mismo.
WO2007016548A3 (en) Micro-rna-based methods and compositions for the diagnosis, prognosis and treatment of breast cancer
WO2003048301A3 (en) Anti-hla-dr antibodies and the methods of using thereof
WO2004067570A3 (en) Prostate cancer diagnosis and treatment
WO2003008583A3 (en) Novel compositions and methods for cancer
WO1998035693A3 (en) Detection and modulation of the iaps and naip for the diagnosis and treatment of proliferative disease
EP1441766A4 (en) ANTIBODIES BONDING TO THE CANCER ASSOCIATED ANTIGEN CD46 AND METHOD OF USE THEREOF
WO2004074320A3 (en) Therapeutic targets in cancer
WO2005031001A3 (en) Novel therapeutic targets in cancer
AU2003205077A1 (en) Imaging agents and methods of imaging naaladase of psma
MXPA04006517A (es) Conjugados que comprenden un anticuerpo especifico para el dominio ed-b de fibronectina y sus usos para la deteccion y tratamiento de tumores.
ATE489108T1 (de) Flt4 (vegfr-3) als ziel für tumornachweis (imaging) und antitumortherapie
WO2003046581A3 (en) Methods for diagnosis and treatment of epithelial-derived cancers,such as colorectal cancers and kidney cancers
WO2004058146A3 (en) Novel compositions and methods in cancer
WO2004060304A3 (en) Novel compositions and methods in cancer
WO2003033731A3 (en) Methods for detecting ovarian cancer
AU4927501A (en) Prostate cancer markers
WO2001072775A3 (en) Polynucleotides and polypeptides as well as methods for diagnosing and treating lung cancer
AU8727201A (en) Genes involved in intestinal inflammatory diseases and use thereof
WO2005053604A3 (en) Antibodies specific for cancer associated antigen sm5-1 and uses thereof
WO2003093794A3 (en) Methods for discovering tumor biomarkers and diagnosing tumors
WO2005070456A8 (en) Diagnosing and treating female reproductive tract or chilhood cancer with pmsa antibodies
WO2003057146A3 (en) Novel compositions and methods for cancer
WO2001075169A3 (en) Compositions and methods for diagnosing, monitoring, staging, imaging and treating stomach cancer
IL139852A0 (en) Monoclonal antibodies directed against the g3bp protein, and uses