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MXPA03004875A - Compuestos derivados de benzotiofeno, su procedimiento de obtencion y utilizacion de los mismos. - Google Patents

Compuestos derivados de benzotiofeno, su procedimiento de obtencion y utilizacion de los mismos.

Info

Publication number
MXPA03004875A
MXPA03004875A MXPA03004875A MXPA03004875A MXPA03004875A MX PA03004875 A MXPA03004875 A MX PA03004875A MX PA03004875 A MXPA03004875 A MX PA03004875A MX PA03004875 A MXPA03004875 A MX PA03004875A MX PA03004875 A MXPA03004875 A MX PA03004875A
Authority
MX
Mexico
Prior art keywords
preparation
derivative compounds
benzothiophene derivative
medicine
preparing
Prior art date
Application number
MXPA03004875A
Other languages
English (en)
Inventor
Aldaz Berta Esperanza Lasheras
Original Assignee
Lab Vita S A
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lab Vita S A filed Critical Lab Vita S A
Publication of MXPA03004875A publication Critical patent/MXPA03004875A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/56—Radicals substituted by oxygen atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Thin Film Transistor (AREA)

Abstract

La presente invencion proporciona nuevos derivados de benzotiofeno de formula general (I) asi como un procedimiento para su obtencion, las correspondientes composiciones y su utilizacion para la fabricacion de un medicamento destinado al tratamiento de trastornos neurologicos; estos nuevos compuestos se comportan como inhibidores de la receptacion de serotonina y muestran elevada afinidad hacia el receptor de 5-HT1A.
MXPA03004875A 2000-11-29 2001-11-19 Compuestos derivados de benzotiofeno, su procedimiento de obtencion y utilizacion de los mismos. MXPA03004875A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ES200002914A ES2188344B1 (es) 2000-11-29 2000-11-29 Compuestos derivados de benzotiofeno, su procedimiento de obtencion y utilizacion de los mismos.
PCT/IB2001/002211 WO2002044170A2 (en) 2000-11-29 2001-11-19 Benzothiophene derivative compounds, process of preparation and use thereof

Publications (1)

Publication Number Publication Date
MXPA03004875A true MXPA03004875A (es) 2005-02-14

Family

ID=8495887

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA03004875A MXPA03004875A (es) 2000-11-29 2001-11-19 Compuestos derivados de benzotiofeno, su procedimiento de obtencion y utilizacion de los mismos.

Country Status (35)

Country Link
US (1) US20040034219A1 (es)
EP (1) EP1337528B1 (es)
JP (1) JP2004514719A (es)
KR (1) KR20030066689A (es)
CN (1) CN1478088A (es)
AP (1) AP2003002801A0 (es)
AR (1) AR034009A1 (es)
AT (1) ATE272634T1 (es)
AU (1) AU2002215157A1 (es)
BG (1) BG107851A (es)
BR (1) BR0115708A (es)
CA (1) CA2429892A1 (es)
CZ (1) CZ20031398A3 (es)
DE (1) DE60104717T2 (es)
EA (1) EA200300519A1 (es)
EE (1) EE200300245A (es)
ES (2) ES2188344B1 (es)
GE (1) GEP20043366B (es)
HR (1) HRP20030407A2 (es)
HU (1) HUP0303568A3 (es)
IL (1) IL155966A0 (es)
IS (1) IS6824A (es)
MA (1) MA26963A1 (es)
MX (1) MXPA03004875A (es)
NO (1) NO20032332L (es)
NZ (1) NZ525950A (es)
OA (1) OA12536A (es)
PE (1) PE20020692A1 (es)
PL (1) PL362982A1 (es)
PT (1) PT1337528E (es)
SI (1) SI1337528T1 (es)
SK (1) SK6202003A3 (es)
TR (1) TR200402779T4 (es)
WO (1) WO2002044170A2 (es)
ZA (1) ZA200303858B (es)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE424825T1 (de) * 2001-07-20 2009-03-15 Psychogenics Inc Behandlung von hyperaktivitätsstörungen und aufmerksamkeitsdefiziten
PT1956004E (pt) 2002-03-27 2012-08-31 Glaxo Group Ltd Derivados de quinolina e sua utilização como ligandos 5-ht6
MXPA05007379A (es) 2003-01-13 2006-02-10 Dynogen Pharmaceuticals Inc Metodo para tratar nauseas, vomito, esfuerzo por vomitar o cualquier combinacion de los mismos.
US7276603B2 (en) 2003-05-02 2007-10-02 Wyeth Benzofuranyl-and benzothienyl-piperazinyl quinolines and methods of their use
PL1558582T3 (pl) 2003-07-22 2006-05-31 Arena Pharm Inc Diarylowe i aryloheteroarylowe pochodne mocznika jako modulatory receptora serotoninowego 5-HT2A użyteczne w profilaktyce i w leczeniu zaburzeń związanych z tym receptorem
DE102004023501A1 (de) * 2004-05-10 2005-12-01 Grünenthal GmbH Oxosubstituierte Cyclohexyl-1,4-diamin-Derivate
DE102004023632A1 (de) * 2004-05-10 2005-12-08 Grünenthal GmbH Substituierte Cyclohexylcarbonsäure-Derivate
DE102004023522A1 (de) * 2004-05-10 2005-12-01 Grünenthal GmbH Substituierte Cyclohexyl-1,4-diamin-Derivate
DE102004023635A1 (de) * 2004-05-10 2006-04-13 Grünenthal GmbH Heteroarylsubstituierte Cyclohexyl-1,4-diamin-Derivate
DE102004023506A1 (de) * 2004-05-10 2005-12-01 Grünenthal GmbH Kettenverlängerte substituierte Cyclohexyl-1,4-diamin-Derivate
DE102004023507A1 (de) * 2004-05-10 2005-12-01 Grünenthal GmbH Substituierte Cyclohexylessigsäure-Derivate
DE102004023508A1 (de) * 2004-05-10 2005-12-08 Grünenthal GmbH Säurederivate substituierter Cyclohexyl-1,4-diamine
US7881267B2 (en) * 2004-06-04 2011-02-01 Hewlett-Packard Development Company, L.P. Portable computing device for wireless communications and method of operation
DE102004063797A1 (de) * 2004-12-30 2006-07-13 Schwarz Pharma Ag Sauerstoffhaltige annelierte Phenylpiperazin- und Phenyldiazepancarboxamide
US7538113B2 (en) 2005-02-18 2009-05-26 Wyeth 4-substituted imidazo[4,5-c]pyridine antagonists of gonadotropin releasing hormone receptor
US7534796B2 (en) 2005-02-18 2009-05-19 Wyeth Imidazo[4,5-b]pyridine antagonists of gonadotropin releasing hormone receptor
US7582634B2 (en) 2005-02-18 2009-09-01 Wyeth 7-substituted imidazo[4,5-c]pyridine antagonists of gonadotropin releasing hormone receptor
TWI320783B (en) 2005-04-14 2010-02-21 Otsuka Pharma Co Ltd Heterocyclic compound
US7531542B2 (en) 2005-05-18 2009-05-12 Wyeth Benzooxazole and benzothiazole antagonists of gonadotropin releasing hormone receptor
US7582636B2 (en) 2005-05-26 2009-09-01 Wyeth Piperazinylimidazopyridine and piperazinyltriazolopyridine antagonists of Gonadotropin Releasing Hormone receptor
US9084742B2 (en) 2007-12-12 2015-07-21 Axovant Sciences Ltd. Combinations comprising 3-phenylsulfonyl-8-piperazinyl-1yl-Quinoline
WO2009123714A2 (en) 2008-04-02 2009-10-08 Arena Pharmaceuticals, Inc. Processes for the preparation of pyrazole derivatives useful as modulators of the 5-ht2a serotonin receptor
CN101619056B (zh) * 2008-07-02 2013-07-17 石药集团中奇制药技术（石家庄）有限公司 苯并噻吩烷醇哌嗪衍生物及其作为抗抑郁症药物的应用
WO2010062321A1 (en) 2008-10-28 2010-06-03 Arena Pharmaceuticals, Inc. Processes useful for the preparation of 1-[3-(4-bromo-2-methyl-2h-pyrazol-3-yl)-4-methoxy-phenyl]-3-(2,4-difluoro-phenyl)-urea and crystalline forms related thereto
WO2015014256A1 (en) 2013-07-29 2015-02-05 Sunshine Lake Pharma Co., Ltd. Substituted heteroaryl compounds and methods of use thereof
WO2016192657A1 (en) 2015-06-03 2016-12-08 Sunshine Lake Pharma Co., Ltd. Substituted piperazine compounds and methods of use and use thereof
MX388281B (es) 2015-06-12 2025-03-11 Axovant Sciences Gmbh Derivados de diaril y arilheteroaril urea como moduladores del receptor 5ht2a de serotonina útiles para la profilaxis y el tratamiento de un trastorno conductual del sueño rem.
CA2992518A1 (en) 2015-07-15 2017-01-19 Axovant Sciences Gmbh Diaryl and arylheteroaryl urea derivatives as modulators of the 5-ht2a serotonin receptor useful for the prophylaxis and treatment of hallucinations associated with a neurodegenerative disease

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4487773A (en) * 1981-03-16 1984-12-11 Mead Johnson & Company 1,2,4-Triazol-3-one antidepressants
ZA929008B (en) * 1991-12-13 1993-05-21 Bristol Myers Squibb Co Piperazinyl- and piperidinyl-cyclohexanols.
FR2692264B1 (fr) * 1992-06-12 1994-08-05 Adir Nouvelles piperazines 1,4-disubstituees, leur procede de preparation et les compositions pharmaceutiques les contenant.
US5693804A (en) * 1994-11-17 1997-12-02 Molecular Geriatrics Corporation Substituted 1-aryl-3-piperazin-1'-yl propanones
US5658909A (en) * 1994-11-17 1997-08-19 Molecular Geriatrics Corporation Certain substituted 1-aryl-3-piperazin-1'-yl propanones to treat Alzheimer's Disease
ES2128266B1 (es) * 1997-07-08 2000-01-16 Vita Invest Sa Compuestos derivados de tiofeno y benzotiofeno y utilizacion y composicion correspondientes.

Also Published As

Publication number Publication date
ES2225623T3 (es) 2005-03-16
ES2188344B1 (es) 2004-09-16
ES2188344A1 (es) 2003-06-16
HUP0303568A3 (en) 2005-02-28
EE200300245A (et) 2003-08-15
WO2002044170A2 (en) 2002-06-06
NO20032332D0 (no) 2003-05-22
JP2004514719A (ja) 2004-05-20
DE60104717D1 (de) 2004-09-09
EP1337528B1 (en) 2004-08-04
US20040034219A1 (en) 2004-02-19
DE60104717T2 (de) 2006-04-06
ATE272634T1 (de) 2004-08-15
SI1337528T1 (en) 2005-02-28
WO2002044170A3 (en) 2002-09-06
HRP20030407A2 (en) 2004-08-31
PL362982A1 (en) 2004-11-02
BG107851A (bg) 2004-06-30
AP2003002801A0 (en) 2003-06-30
IS6824A (is) 2003-05-22
NZ525950A (en) 2004-11-26
NO20032332L (no) 2003-05-22
EP1337528A2 (en) 2003-08-27
AU2002215157A1 (en) 2002-06-11
GEP20043366B (en) 2004-04-13
AR034009A1 (es) 2004-01-21
PE20020692A1 (es) 2002-09-02
SK6202003A3 (en) 2004-05-04
BR0115708A (pt) 2004-02-03
OA12536A (en) 2006-06-05
PT1337528E (pt) 2004-11-30
TR200402779T4 (tr) 2004-11-22
IL155966A0 (en) 2003-12-23
MA26963A1 (fr) 2004-12-20
HUP0303568A2 (hu) 2004-03-01
EA200300519A1 (ru) 2003-12-25
CZ20031398A3 (cs) 2004-01-14
KR20030066689A (ko) 2003-08-09
CN1478088A (zh) 2004-02-25
ZA200303858B (en) 2004-05-19
CA2429892A1 (en) 2002-06-06

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