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MXPA02006863A - Compuestos de pirrol fusionados, composiciones farmaceuticas que los comprenden y su uso. - Google Patents

Compuestos de pirrol fusionados, composiciones farmaceuticas que los comprenden y su uso.

Info

Publication number
MXPA02006863A
MXPA02006863A MXPA02006863A MXPA02006863A MXPA02006863A MX PA02006863 A MXPA02006863 A MX PA02006863A MX PA02006863 A MXPA02006863 A MX PA02006863A MX PA02006863 A MXPA02006863 A MX PA02006863A MX PA02006863 A MXPA02006863 A MX PA02006863A
Authority
MX
Mexico
Prior art keywords
pharmaceutical agents
same
compounds
agents containing
pyrrole compounds
Prior art date
Application number
MXPA02006863A
Other languages
English (en)
Inventor
Stefan Laufer
Original Assignee
Merckle Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merckle Gmbh filed Critical Merckle Gmbh
Publication of MXPA02006863A publication Critical patent/MXPA02006863A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyrrole Compounds (AREA)

Abstract

La presente invencion se refiere a compuestos de pirrol fusionados de la formula 1 (ver formula) en donde por lo menos uno de los radicales R1, R2, R3 es fenilo sustituido por azufre en la posicion 4. Estos compuestos son en particular pirrolizinas, indolizinas y heteroanalogos que tienen una accion inhibidora selectiva sobre la isoenzima-2 de la prostaglandina H sintasa (COX-2). La invencion se refiere tambien a composiciones farmaceuticas que contienen estos compuestos; y al uso de estos compuestos para el tratamiento de trastornos del tipo reumatico.
MXPA02006863A 2000-01-13 2001-01-12 Compuestos de pirrol fusionados, composiciones farmaceuticas que los comprenden y su uso. MXPA02006863A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10001166A DE10001166A1 (de) 2000-01-13 2000-01-13 Anellierte Pyrrolverbindungen, diese enthaltende pharmazeutische Mittel und deren Verwendung
PCT/EP2001/000332 WO2001051491A1 (de) 2000-01-13 2001-01-12 Anellierte pyrrolverbindungen, diese enthaltende pharmazeutische mittel und deren verwendung

Publications (1)

Publication Number Publication Date
MXPA02006863A true MXPA02006863A (es) 2004-04-05

Family

ID=7627401

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA02006863A MXPA02006863A (es) 2000-01-13 2001-01-12 Compuestos de pirrol fusionados, composiciones farmaceuticas que los comprenden y su uso.

Country Status (16)

Country Link
US (1) US6936632B2 (es)
EP (1) EP1246825B1 (es)
JP (1) JP2003525875A (es)
KR (1) KR20020081254A (es)
CN (1) CN1191254C (es)
AT (1) ATE256685T1 (es)
AU (1) AU2001230180A1 (es)
CA (1) CA2396413A1 (es)
DE (2) DE10001166A1 (es)
DK (1) DK1246825T3 (es)
ES (1) ES2213102T3 (es)
MX (1) MXPA02006863A (es)
NO (1) NO323238B1 (es)
PT (1) PT1246825E (es)
TR (1) TR200400270T4 (es)
WO (1) WO2001051491A1 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10004157A1 (de) 2000-02-01 2001-08-02 Merckle Gmbh Chem Pharm Fabrik 4-Pyridyl-und 2,4-Pyrimidinyl-substituierte Pyrrolderivate und ihre Anwendung in der Pharmazie
WO2003020267A1 (en) * 2001-08-30 2003-03-13 Merckle Gmbh Use of annellated pyrrole compounds in the treatment of articular cartilage or subchondral bone degeneration
US20060068009A1 (en) * 2004-09-30 2006-03-30 Scolr Pharma, Inc. Modified release ibuprofen dosage form
US20070077297A1 (en) 2004-09-30 2007-04-05 Scolr Pharma, Inc. Modified release ibuprofen dosage form
US7749537B2 (en) * 2006-12-04 2010-07-06 Scolr Pharma, Inc. Method of forming a tablet
US20190060286A1 (en) 2016-02-29 2019-02-28 University Of Florida Research Foundation, Incorpo Chemotherapeutic Methods
CN117756811A (zh) * 2023-12-29 2024-03-26 贵州民族大学 一种合成多取代基吡咯化合物的方法

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4232038A (en) * 1979-08-31 1980-11-04 Syntex (U.S.A.) Inc. 5-Alkylsulfinylbenzoyl- and 5-alkylsulfonylbenzoyl-1,2-dihydro-3H-pyrrolo[1,]pyrrole-1-carboxylic acids
DE3361812D1 (en) 1982-03-03 1986-02-27 Du Pont Antiinflammatory and/or analgesic 2,3-diaryl-5-halo thiophenes
DE3915450A1 (de) * 1989-05-11 1990-11-15 Gerd Prof Dr Dannhardt Substituierte pyrrolverbindungen und deren anwendung in der pharmazie
US5260451A (en) 1989-05-11 1993-11-09 Merckle Gmbh Substituted pyrrole compounds and use thereof in pharmaceutical compositions
EP0759432A1 (en) 1993-01-15 1997-02-26 G.D. Searle & Co. Use of medicaments containing 3,4-diaryl furans and analogs thereof for treating a skin-related condition
US5380738A (en) 1993-05-21 1995-01-10 Monsanto Company 2-substituted oxazoles further substituted by 4-fluorophenyl and 4-methylsulfonylphenyl as antiinflammatory agents
US5474995A (en) 1993-06-24 1995-12-12 Merck Frosst Canada, Inc. Phenyl heterocycles as cox-2 inhibitors
US5344991A (en) 1993-10-29 1994-09-06 G.D. Searle & Co. 1,2 diarylcyclopentenyl compounds for the treatment of inflammation
US5475018A (en) 1993-11-30 1995-12-12 G. D. Searle & Co. 1,5-diphenyl pyrazole compounds for treatment of inflammation
CA2182950A1 (en) 1994-02-10 1995-08-17 David B. Reitz Substituted spiro compounds for the treatment of inflammation
US5418254A (en) 1994-05-04 1995-05-23 G. D. Searle & Co. Substituted cyclopentadienyl compounds for the treatment of inflammation
DE4419246A1 (de) * 1994-06-01 1995-12-07 Merckle Gmbh Heteroarylsubstituierte Pyrrolizinverbindungen und deren Anwendung in der Pharmazie
DE4419247A1 (de) * 1994-06-01 1995-12-07 Merckle Gmbh Sulfonylierte Pyrrolizincarbonsäureamide und deren Anwendung in der Pharmazie
DE4419315A1 (de) 1994-06-01 1995-12-07 Merckle Gmbh Heteropyrrolizinverbindungen und deren Anwendung in der Pharmazie
US5593994A (en) 1994-09-29 1997-01-14 The Dupont Merck Pharmaceutical Company Prostaglandin synthase inhibitors
AU6111796A (en) * 1995-06-12 1997-01-09 G.D. Searle & Co. Compositions comprising a cyclooxygenase-2 inhibitor and a 5 -lipoxygenase inhibitor
DE19624289A1 (de) * 1996-06-18 1998-01-02 Merckle Gmbh Pyrrolizin-Verbindungen und deren Verwendung
DE19624290A1 (de) 1996-06-18 1998-01-02 Merckle Gmbh Verwendungen von Pyrrolizin-Verbindungen in der Pharmazie
WO1999061016A1 (fr) * 1998-05-27 1999-12-02 Nippon Shinyaku Co., Ltd. Inhibiteurs de cyclo-oxygenase-2
DE19845446A1 (de) 1998-10-02 2000-04-06 Merckle Gmbh Antiinflammatorische Oxo- und Hydroxyderivate von Pyrrolizinen und deren Verwendung in der Pharmazie
SK286082B6 (sk) 1999-11-23 2008-03-05 Merckle Gmbh Protizápalové oxo- a hydroxyderiváty pyrolizínov a ich použitie vo farmácii
DE10004157A1 (de) 2000-02-01 2001-08-02 Merckle Gmbh Chem Pharm Fabrik 4-Pyridyl-und 2,4-Pyrimidinyl-substituierte Pyrrolderivate und ihre Anwendung in der Pharmazie

Also Published As

Publication number Publication date
US20040122002A1 (en) 2004-06-24
TR200400270T4 (tr) 2004-03-22
EP1246825A1 (de) 2002-10-09
DE10001166A1 (de) 2001-07-19
CN1418217A (zh) 2003-05-14
US6936632B2 (en) 2005-08-30
ES2213102T3 (es) 2004-08-16
DE50101187D1 (de) 2004-01-29
KR20020081254A (ko) 2002-10-26
NO323238B1 (no) 2007-02-05
PT1246825E (pt) 2004-04-30
CA2396413A1 (en) 2001-07-19
AU2001230180A1 (en) 2001-07-24
CN1191254C (zh) 2005-03-02
WO2001051491A1 (de) 2001-07-19
EP1246825B1 (de) 2003-12-17
ATE256685T1 (de) 2004-01-15
JP2003525875A (ja) 2003-09-02
NO20023363L (no) 2002-09-10
NO20023363D0 (no) 2002-07-12
DK1246825T3 (da) 2004-04-13

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