[go: up one dir, main page]

MXPA02006647A - Microagujas mejoradas y metodos de fabricacion y uso de las mismas. - Google Patents

Microagujas mejoradas y metodos de fabricacion y uso de las mismas.

Info

Publication number
MXPA02006647A
MXPA02006647A MXPA02006647A MXPA02006647A MXPA02006647A MX PA02006647 A MXPA02006647 A MX PA02006647A MX PA02006647 A MXPA02006647 A MX PA02006647A MX PA02006647 A MXPA02006647 A MX PA02006647A MX PA02006647 A MXPA02006647 A MX PA02006647A
Authority
MX
Mexico
Prior art keywords
micro
needle
fluid
distal end
needles
Prior art date
Application number
MXPA02006647A
Other languages
English (en)
Inventor
Lorin Olson
Original Assignee
Lifescan Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lifescan Inc filed Critical Lifescan Inc
Publication of MXPA02006647A publication Critical patent/MXPA02006647A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/14—Devices for taking samples of blood ; Measuring characteristics of blood in vivo, e.g. gas concentration within the blood, pH-value of blood
    • A61B5/1405—Devices for taking blood samples
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/14507—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue specially adapted for measuring characteristics of body fluids other than blood
    • A61B5/1451—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue specially adapted for measuring characteristics of body fluids other than blood for interstitial fluid
    • A61B5/14514—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue specially adapted for measuring characteristics of body fluids other than blood for interstitial fluid using means for aiding extraction of interstitial fluid, e.g. microneedles or suction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150015—Source of blood
    • A61B5/150022—Source of blood for capillary blood or interstitial fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150206—Construction or design features not otherwise provided for; manufacturing or production; packages; sterilisation of piercing element, piercing device or sampling device
    • A61B5/150274—Manufacture or production processes or steps for blood sampling devices
    • A61B5/150282—Manufacture or production processes or steps for blood sampling devices for piercing elements, e.g. blade, lancet, canula, needle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150977—Arrays of piercing elements for simultaneous piercing
    • A61B5/150984—Microneedles or microblades
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Instruments for taking body samples for diagnostic purposes; Other methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determination; Throat striking implements
    • A61B10/0045—Devices for taking samples of body liquids
    • A61B2010/008—Interstitial fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/003—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles having a lumen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0053—Methods for producing microneedles

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Medical Informatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Surgery (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Optics & Photonics (AREA)
  • Manufacturing & Machinery (AREA)
  • Anesthesiology (AREA)
  • Dermatology (AREA)
  • Emergency Medicine (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

Se provee una microaguja la cual es particularmente util para el muestreo minimamente invasivo de un fluido biologico y/o el suministro minimamente invasivo de un farmaco u otra formulacion a traves de la piel; la microaguja tiene una estructura que tiene una base en un extremo proximo y un vertice en un extremo distal, y un lumen abierto que se extiende a traves de los mismos y a traves del cual se puede transferir fluido; la estructura define un eje estructural que hace interseccion con el eje lumenal definido por el lumen abierto; el punto de interseccion entre estos ejes esta en un punto debajo del vertice de la microaguja para proveer un apice agudo en el extremo distal de la microaguja y define la configuracion general del extremo distal de la microaguja, la cual se puede seleccionar o adaptar dependiendo del uso destinado de la microaguja; la microaguja puede ser integral con un dispositivo de medicion para medir la concentracion de un constituyente dentro de fluido biologico muestreado y/o con un deposito de fluido para contener un fluido que sera suministrado, tambien se puede utilizar junto con un medio de control remoto; tambien se proveen metodos para hacer y utilizar la microaguja de la presente invencion, asi como equipos que comprenden una o mas de las microagujas.
MXPA02006647A 2001-07-09 2002-07-03 Microagujas mejoradas y metodos de fabricacion y uso de las mismas. MXPA02006647A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US09/901,535 US6749792B2 (en) 2001-07-09 2001-07-09 Micro-needles and methods of manufacture and use thereof

Publications (1)

Publication Number Publication Date
MXPA02006647A true MXPA02006647A (es) 2004-06-29

Family

ID=25414377

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA02006647A MXPA02006647A (es) 2001-07-09 2002-07-03 Microagujas mejoradas y metodos de fabricacion y uso de las mismas.

Country Status (12)

Country Link
US (2) US6749792B2 (es)
EP (1) EP1287847A1 (es)
JP (1) JP2003088514A (es)
KR (1) KR20030007039A (es)
CN (1) CN1494876A (es)
AR (1) AR034723A1 (es)
CA (1) CA2391810A1 (es)
IL (1) IL150468A0 (es)
MX (1) MXPA02006647A (es)
PL (1) PL354857A1 (es)
RU (1) RU2002118232A (es)
TW (1) TW590782B (es)

Families Citing this family (222)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9704076D0 (sv) * 1997-11-06 1997-11-06 Holdingbolaget Vid Goeteborgs Method for permeabilisation of cell structures and use thereof
WO2003046171A1 (en) * 2001-11-27 2003-06-05 Cellectricon Ab A method for combined sequential agent delivery and electroporation for cell structures and use thereof
US6036924A (en) 1997-12-04 2000-03-14 Hewlett-Packard Company Cassette of lancet cartridges for sampling blood
US6391005B1 (en) 1998-03-30 2002-05-21 Agilent Technologies, Inc. Apparatus and method for penetration with shaft having a sensor for sensing penetration depth
US6884427B1 (en) * 1999-02-08 2005-04-26 Aderans Research Institute, Inc. Filamentary means for introducing agents into tissue of a living host
JP4017977B2 (ja) * 2000-08-08 2007-12-05 アデランス リサーチ インスティテュート インコーポレイテッド 組織工学で処置した毛髪用の台
US6821281B2 (en) 2000-10-16 2004-11-23 The Procter & Gamble Company Microstructures for treating and conditioning skin
US7131987B2 (en) 2000-10-16 2006-11-07 Corium International, Inc. Microstructures and method for treating and conditioning skin which cause less irritation during exfoliation
US7828827B2 (en) 2002-05-24 2010-11-09 Corium International, Inc. Method of exfoliation of skin using closely-packed microstructures
SE0003841D0 (sv) * 2000-10-20 2000-10-20 Daniel Chiu A method and apparatus for penetration of lipid bilayer membranes
US8641644B2 (en) 2000-11-21 2014-02-04 Sanofi-Aventis Deutschland Gmbh Blood testing apparatus having a rotatable cartridge with multiple lancing elements and testing means
WO2002100251A2 (en) 2001-06-12 2002-12-19 Pelikan Technologies, Inc. Self optimizing lancing device with adaptation means to temporal variations in cutaneous properties
US7981056B2 (en) 2002-04-19 2011-07-19 Pelikan Technologies, Inc. Methods and apparatus for lancet actuation
ES2335576T3 (es) 2001-06-12 2010-03-30 Pelikan Technologies Inc. Aparato y procedimiento de toma de muestras de sangre.
US9226699B2 (en) 2002-04-19 2016-01-05 Sanofi-Aventis Deutschland Gmbh Body fluid sampling module with a continuous compression tissue interface surface
WO2002100460A2 (en) 2001-06-12 2002-12-19 Pelikan Technologies, Inc. Electric lancet actuator
US9427532B2 (en) 2001-06-12 2016-08-30 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
ATE494837T1 (de) 2001-06-12 2011-01-15 Pelikan Technologies Inc Integriertes system zur blutprobenanalyse mit mehrfach verwendbarem probennahmemodul
US9795747B2 (en) 2010-06-02 2017-10-24 Sanofi-Aventis Deutschland Gmbh Methods and apparatus for lancet actuation
US8337419B2 (en) 2002-04-19 2012-12-25 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
US7041068B2 (en) 2001-06-12 2006-05-09 Pelikan Technologies, Inc. Sampling module device and method
AU2002344825A1 (en) 2001-06-12 2002-12-23 Pelikan Technologies, Inc. Method and apparatus for improving success rate of blood yield from a fingerstick
EP1404235A4 (en) 2001-06-12 2008-08-20 Pelikan Technologies Inc METHOD AND DEVICE FOR A LANZETTING DEVICE INTEGRATED ON A BLOOD CARTRIDGE CARTRIDGE
US6782283B2 (en) * 2001-09-07 2004-08-24 Robert N. Schmidt Dry penetrating recording device
US6785569B2 (en) * 2001-09-07 2004-08-31 Orbital Research Dry physiological recording electrode
US8201330B1 (en) * 2001-09-07 2012-06-19 Orbital Research Inc Physiological recording device or electrode
US7286864B1 (en) 2001-09-07 2007-10-23 Orbital Research, Inc. Dry physiological recording device
US7344894B2 (en) 2001-10-16 2008-03-18 Agilent Technologies, Inc. Thermal regulation of fluidic samples within a diagnostic cartridge
US20040068284A1 (en) * 2002-01-29 2004-04-08 Barrows Thomas H. Method for stimulating hair growth and kit for carrying out said method
WO2003074102A2 (en) * 2002-03-04 2003-09-12 Nano Pass Technologies Ltd. Devices and methods for transporting fluid across a biological barrier
US7582099B2 (en) 2002-04-19 2009-09-01 Pelikan Technologies, Inc Method and apparatus for penetrating tissue
WO2003088824A2 (en) 2002-04-19 2003-10-30 Pelikan Technologies, Inc. Device and method for variable speed lancet
US7229458B2 (en) 2002-04-19 2007-06-12 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7175642B2 (en) 2002-04-19 2007-02-13 Pelikan Technologies, Inc. Methods and apparatus for lancet actuation
US7141058B2 (en) 2002-04-19 2006-11-28 Pelikan Technologies, Inc. Method and apparatus for a body fluid sampling device using illumination
US7244265B2 (en) 2002-04-19 2007-07-17 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US8372016B2 (en) 2002-04-19 2013-02-12 Sanofi-Aventis Deutschland Gmbh Method and apparatus for body fluid sampling and analyte sensing
US7371247B2 (en) 2002-04-19 2008-05-13 Pelikan Technologies, Inc Method and apparatus for penetrating tissue
US7976476B2 (en) 2002-04-19 2011-07-12 Pelikan Technologies, Inc. Device and method for variable speed lancet
US7563232B2 (en) 2002-04-19 2009-07-21 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7331931B2 (en) 2002-04-19 2008-02-19 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US9795334B2 (en) 2002-04-19 2017-10-24 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US8221334B2 (en) 2002-04-19 2012-07-17 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US7297122B2 (en) 2002-04-19 2007-11-20 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US8579831B2 (en) 2002-04-19 2013-11-12 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US9314194B2 (en) 2002-04-19 2016-04-19 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
US7648468B2 (en) 2002-04-19 2010-01-19 Pelikon Technologies, Inc. Method and apparatus for penetrating tissue
US8267870B2 (en) 2002-04-19 2012-09-18 Sanofi-Aventis Deutschland Gmbh Method and apparatus for body fluid sampling with hybrid actuation
US8784335B2 (en) 2002-04-19 2014-07-22 Sanofi-Aventis Deutschland Gmbh Body fluid sampling device with a capacitive sensor
US8360992B2 (en) 2002-04-19 2013-01-29 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US7491178B2 (en) 2002-04-19 2009-02-17 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7909778B2 (en) * 2002-04-19 2011-03-22 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7892183B2 (en) 2002-04-19 2011-02-22 Pelikan Technologies, Inc. Method and apparatus for body fluid sampling and analyte sensing
US7291117B2 (en) 2002-04-19 2007-11-06 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US8702624B2 (en) 2006-09-29 2014-04-22 Sanofi-Aventis Deutschland Gmbh Analyte measurement device with a single shot actuator
US9248267B2 (en) 2002-04-19 2016-02-02 Sanofi-Aventis Deustchland Gmbh Tissue penetration device
US7485128B2 (en) 2002-04-19 2009-02-03 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7713214B2 (en) 2002-04-19 2010-05-11 Pelikan Technologies, Inc. Method and apparatus for a multi-use body fluid sampling device with optical analyte sensing
US7674232B2 (en) 2002-04-19 2010-03-09 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7524293B2 (en) 2002-04-19 2009-04-28 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7374544B2 (en) 2002-04-19 2008-05-20 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7232451B2 (en) 2002-04-19 2007-06-19 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7410468B2 (en) 2002-04-19 2008-08-12 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7547287B2 (en) 2002-04-19 2009-06-16 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7901362B2 (en) 2002-04-19 2011-03-08 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7717863B2 (en) 2002-04-19 2010-05-18 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US8574895B2 (en) 2002-12-30 2013-11-05 Sanofi-Aventis Deutschland Gmbh Method and apparatus using optical techniques to measure analyte levels
DE10305831B4 (de) * 2003-02-12 2007-01-04 Siemens Ag Diagnosegerät
US7578954B2 (en) 2003-02-24 2009-08-25 Corium International, Inc. Method for manufacturing microstructures having multiple microelements with through-holes
US7415299B2 (en) * 2003-04-18 2008-08-19 The Regents Of The University Of California Monitoring method and/or apparatus
CN1321706C (zh) * 2003-05-29 2007-06-20 财团法人工业技术研究院 一种数组式微针软质基材结构及其制造方法
DE602004028463D1 (de) 2003-05-30 2010-09-16 Pelikan Technologies Inc Verfahren und vorrichtung zur injektion von flüssigkeit
EP1633235B1 (en) 2003-06-06 2014-05-21 Sanofi-Aventis Deutschland GmbH Apparatus for body fluid sampling and analyte sensing
WO2006001797A1 (en) 2004-06-14 2006-01-05 Pelikan Technologies, Inc. Low pain penetrating
EP1635700B1 (en) 2003-06-13 2016-03-09 Sanofi-Aventis Deutschland GmbH Apparatus for a point of care device
US8282576B2 (en) 2003-09-29 2012-10-09 Sanofi-Aventis Deutschland Gmbh Method and apparatus for an improved sample capture device
GB2406794B (en) 2003-10-06 2008-03-05 Inverness Medical Ltd A lancing device using a piezoelectric actuator
US9351680B2 (en) 2003-10-14 2016-05-31 Sanofi-Aventis Deutschland Gmbh Method and apparatus for a variable user interface
US7497980B2 (en) * 2003-11-10 2009-03-03 Agency For Science, Technology And Research Microneedles and microneedle fabrication
US7753888B2 (en) * 2003-11-21 2010-07-13 The Regents Of The University Of California Method and/or apparatus for puncturing a surface for extraction, in situ analysis, and/or substance delivery using microneedles
US7822454B1 (en) 2005-01-03 2010-10-26 Pelikan Technologies, Inc. Fluid sampling device with improved analyte detecting member configuration
WO2005065414A2 (en) 2003-12-31 2005-07-21 Pelikan Technologies, Inc. Method and apparatus for improving fluidic flow and sample capture
WO2005082593A1 (en) * 2004-02-17 2005-09-09 Avery Dennison Corporation Method of making microneedles
WO2005087305A1 (en) * 2004-03-12 2005-09-22 Agency For Science, Technology And Research Methods and moulds for use in fabricating side-ported microneedles
WO2005094526A2 (en) 2004-03-24 2005-10-13 Corium International, Inc. Transdermal delivery device
US7597885B2 (en) * 2004-03-26 2009-10-06 Aderans Research Institute, Inc. Tissue engineered biomimetic hair follicle graft
EP1751546A2 (en) 2004-05-20 2007-02-14 Albatros Technologies GmbH & Co. KG Printable hydrogel for biosensors
US9775553B2 (en) 2004-06-03 2017-10-03 Sanofi-Aventis Deutschland Gmbh Method and apparatus for a fluid sampling device
EP1765194A4 (en) 2004-06-03 2010-09-29 Pelikan Technologies Inc METHOD AND DEVICE FOR A LIQUID DETECTION DEVICE
US7086266B2 (en) 2004-08-05 2006-08-08 Becton, Dickinson And Company Method of producing tapered or pointed cannula
US7076987B2 (en) 2004-08-05 2006-07-18 Becton, Dickinson And Company Method of producing tapered or pointed cannula
AR050212A1 (es) * 2004-08-13 2006-10-04 Aderans Res Inst Inc Organogenesis a partir de celulas disociadas
SE0402100D0 (sv) * 2004-08-30 2004-08-30 Bonsens Ab Molded micro-needles
US7132054B1 (en) 2004-09-08 2006-11-07 Sandia Corporation Method to fabricate hollow microneedle arrays
US7097776B2 (en) * 2004-10-22 2006-08-29 Hewlett-Packard Development Company, L.P. Method of fabricating microneedles
US7785459B2 (en) 2004-10-22 2010-08-31 Hewlett-Packard Development Company, L.P. Microneedles and methods of fabricating
JP2008522875A (ja) * 2004-12-07 2008-07-03 スリーエム イノベイティブ プロパティズ カンパニー マイクロニードルの成形方法
US8652831B2 (en) 2004-12-30 2014-02-18 Sanofi-Aventis Deutschland Gmbh Method and apparatus for analyte measurement test time
WO2006075716A1 (ja) * 2005-01-14 2006-07-20 Fujikura Ltd. 医薬物運搬用器具とその製造方法
US8280476B2 (en) * 2005-03-29 2012-10-02 Arkal Medical, Inc. Devices, systems, methods and tools for continuous glucose monitoring
JP4826711B2 (ja) * 2005-03-31 2011-11-30 ニプロ株式会社 注射針
CA2626199A1 (en) * 2005-10-17 2007-04-26 Aderans Research Institute, Inc. Method of delivering hair follicle progenitor cells to the skin
WO2007062386A2 (en) * 2005-11-22 2007-05-31 Aderans Research Institute, Inc. Hair follicle graft from tissue engineered skin
WO2007062387A2 (en) * 2005-11-22 2007-05-31 Aderans Research Institute, Inc. Hair grafts derived from plucked hair
US9636035B2 (en) * 2005-12-14 2017-05-02 Scibase Ab Medical apparatus for determination of biological conditions using impedance measurements
EP1959828B1 (en) * 2005-12-14 2013-02-27 SciBase AB Diagnosing of a diseased condition of the skin using impedance
JP4910002B2 (ja) * 2006-02-09 2012-04-04 アデランス リサーチ インスティテュート インコーポレイテッド 被験体へと流体および材料を送達するための装置および方法
US20070202186A1 (en) 2006-02-22 2007-08-30 Iscience Interventional Corporation Apparatus and formulations for suprachoroidal drug delivery
US20100049021A1 (en) * 2006-03-28 2010-02-25 Jina Arvind N Devices, systems, methods and tools for continuous analyte monitoring
US20090131778A1 (en) * 2006-03-28 2009-05-21 Jina Arvind N Devices, systems, methods and tools for continuous glucose monitoring
US20080154107A1 (en) * 2006-12-20 2008-06-26 Jina Arvind N Device, systems, methods and tools for continuous glucose monitoring
US8197435B2 (en) 2006-05-02 2012-06-12 Emory University Methods and devices for drug delivery to ocular tissue using microneedle
TWI300055B (en) * 2006-05-26 2008-08-21 Nat Univ Tsing Hua Method of manufacturing hollow micro-needle structures
US20070276330A1 (en) * 2006-05-28 2007-11-29 Beck Patricia A Microneedles and methods of fabricating thereof
US8250729B2 (en) * 2006-07-12 2012-08-28 University Of Utah Research Foundation 3D fabrication of needle tip geometry and knife blade
US8012566B2 (en) * 2006-07-12 2011-09-06 Hewlett-Packard Development Company, L.P. Microneedles formed by electroplating and selectively releasing temperature sensitive layers
US8865288B2 (en) * 2006-07-17 2014-10-21 University Of Utah Research Foundation Micro-needle arrays having non-planar tips and methods of manufacture thereof
US20080138581A1 (en) * 2006-07-17 2008-06-12 Rajmohan Bhandari Masking high-aspect aspect ratio structures
EP2073888A4 (en) * 2006-08-28 2011-01-19 Agency Science Tech & Res MICRONED NEEDLES AND METHOD FOR PRODUCING MICRONED NEEDLES
US20080058726A1 (en) * 2006-08-30 2008-03-06 Arvind Jina Methods and Apparatus Incorporating a Surface Penetration Device
US20080097352A1 (en) * 2006-09-12 2008-04-24 Beck Patricia A Methods of fabricating microneedles with bio-sensory functionality
JP2010503454A (ja) * 2006-09-18 2010-02-04 エージェンシー フォー サイエンス、テクノロジー アンド リサーチ 針構造および針構造を製作するための方法
KR100869277B1 (ko) * 2006-12-22 2008-11-18 호남석유화학 주식회사 마이크로니들 어레이와 그의 성형 몰드
WO2008089344A2 (en) * 2007-01-19 2008-07-24 Joseph Neev Devices and methods for generation of subsurface micro-disruptions for biomedical applications
WO2008091602A2 (en) 2007-01-22 2008-07-31 Corium International, Inc. Applicators for microneedle arrays
CN100431487C (zh) * 2007-01-25 2008-11-12 中国科学院上海微系统与信息技术研究所 一种三维植入式微电极阵列的制作方法
USD606190S1 (en) 2007-02-08 2009-12-15 Aderans Research Institute, Inc. Device for delivering cellular material and physiologic fluids to a subject
US20080234562A1 (en) * 2007-03-19 2008-09-25 Jina Arvind N Continuous analyte monitor with multi-point self-calibration
AU2008241470B2 (en) 2007-04-16 2013-11-07 Corium Pharma Solutions, Inc. Solvent-cast microneedle arrays containing active
US8911749B2 (en) 2007-04-16 2014-12-16 Corium International, Inc. Vaccine delivery via microneedle arrays
US7985537B2 (en) * 2007-06-12 2011-07-26 Aderans Research Institute, Inc. Methods for determining the hair follicle inductive properties of a composition
US20080312518A1 (en) * 2007-06-14 2008-12-18 Arkal Medical, Inc On-demand analyte monitor and method of use
US20100196446A1 (en) 2007-07-10 2010-08-05 Morteza Gharib Drug delivery and substance transfer facilitated by nano-enhanced device having aligned carbon nanotubes protruding from device surface
US7959969B2 (en) 2007-07-10 2011-06-14 California Institute Of Technology Fabrication of anchored carbon nanotube array devices for integrated light collection and energy conversion
US20090053673A1 (en) * 2007-08-23 2009-02-26 Zimmer, Inc. Method for localized treatment of periodontal tissue
CN101808588B (zh) * 2007-09-28 2012-12-19 贝尔法斯特女王大学 递送装置及方法
US20090099427A1 (en) * 2007-10-12 2009-04-16 Arkal Medical, Inc. Microneedle array with diverse needle configurations
US8398397B2 (en) * 2008-03-12 2013-03-19 Ultradent Products, Inc. Dental intraligamentary injection needles and related methods of manufacture
US9386944B2 (en) 2008-04-11 2016-07-12 Sanofi-Aventis Deutschland Gmbh Method and apparatus for analyte detecting device
US20090301994A1 (en) * 2008-05-12 2009-12-10 Rajmohan Bhandari Methods for Wafer Scale Processing of Needle Array Devices
EP2294216A4 (en) 2008-05-14 2011-11-23 Dermtech Int DIAGNOSIS OF MELANOMA AND SOLAR LENTIGO BY ANALYSIS OF NUCLEIC ACIDS
WO2009149197A2 (en) 2008-06-03 2009-12-10 University Of Utah Research Foundation High aspect ratio microelectrode arrays enabled to have customizable lengths and methods of making the same
WO2010013598A1 (ja) * 2008-08-01 2010-02-04 株式会社ライトニックス 流路形成微細針付きセンサ
US9375169B2 (en) 2009-01-30 2016-06-28 Sanofi-Aventis Deutschland Gmbh Cam drive for managing disposable penetrating member actions with a single motor and motor and control system
US9041541B2 (en) 2010-01-28 2015-05-26 Seventh Sense Biosystems, Inc. Monitoring or feedback systems and methods
WO2012018486A2 (en) 2010-07-26 2012-02-09 Seventh Sense Biosystems, Inc. Rapid delivery and/or receiving of fluids
EP2408372B1 (en) 2009-03-02 2019-01-09 Seventh Sense Biosystems, Inc. Devices associated with blood sampling
CN102458559B (zh) 2009-04-10 2014-06-04 3M创新有限公司 制造中空微针阵列的方法以及由其制得的制品和用途
EP2260764A1 (de) * 2009-06-10 2010-12-15 F. Hoffmann-La Roche AG Mikronadel und Verfahren zu deren Herstellung
KR101213223B1 (ko) * 2009-07-07 2013-01-09 한국전자통신연구원 할로우를 가지는 미세 바늘 및 미세 바늘 구조체의 제조 방법
JP5568324B2 (ja) * 2010-01-15 2014-08-06 凸版印刷株式会社 マイクロニードル製造方法
WO2011127207A2 (en) 2010-04-07 2011-10-13 California Institute Of Technology Simple method for producing superhydrophobic carbon nanotube array
US8965476B2 (en) 2010-04-16 2015-02-24 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
AU2011248108B2 (en) 2010-05-04 2016-05-26 Corium Pharma Solutions, Inc. Method and device for transdermal delivery of parathyroid hormone using a microprojection array
WO2011163347A2 (en) * 2010-06-23 2011-12-29 Seventh Sense Biosystems, Inc. Sampling devices and methods involving relatively little pain
WO2012009613A1 (en) 2010-07-16 2012-01-19 Seventh Sense Biosystems, Inc. Low-pressure environment for fluid transfer devices
US20120039809A1 (en) 2010-08-13 2012-02-16 Seventh Sense Biosystems, Inc. Systems and techniques for monitoring subjects
CN104758118B (zh) 2010-10-15 2018-04-06 科尼尔赛德生物医学公司 用于进入眼睛的装置
EP2992827B1 (en) 2010-11-09 2017-04-19 Seventh Sense Biosystems, Inc. Systems and interfaces for blood sampling
WO2012079066A2 (en) 2010-12-10 2012-06-14 California Institute Of Technology Method for producing graphene oxide with tunable gap
EP2686058A1 (en) * 2011-03-18 2014-01-22 Université Libre de Bruxelles Devices for puncturing a human or animal body's membrane
US20120245445A1 (en) * 2011-03-21 2012-09-27 Michael Darryl Black Glucose Monitoring System
WO2012135238A1 (en) 2011-03-29 2012-10-04 California Institute Of Technology Method to increase the capacitance of electrochemical carbon nanotube capacitors by conformal deposition of nanoparticles
AU2012249683A1 (en) 2011-04-29 2013-11-14 Seventh Sense Biosystems, Inc. Devices and methods for collection and/or manipulation of blood spots or other bodily fluids
EP2701598A1 (en) 2011-04-29 2014-03-05 Seventh Sense Biosystems, Inc. Systems and methods for collecting fluid from a subject
AU2012249692A1 (en) 2011-04-29 2013-11-14 Seventh Sense Biosystems, Inc. Delivering and/or receiving fluids
US20130158468A1 (en) 2011-12-19 2013-06-20 Seventh Sense Biosystems, Inc. Delivering and/or receiving material with respect to a subject surface
JP2013090837A (ja) * 2011-10-26 2013-05-16 Toppan Printing Co Ltd 針状体の製造方法および針状体
US8764681B2 (en) 2011-12-14 2014-07-01 California Institute Of Technology Sharp tip carbon nanotube microneedle devices and their fabrication
JP5856475B2 (ja) * 2011-12-28 2016-02-09 Ａｓｔｉ株式会社 マイクロニードルの製造方法
CN102526870B (zh) * 2012-01-09 2013-08-28 上海交通大学 基于表面微细加工工艺的异平面空心微针及其制备方法
EP2806940B1 (en) * 2012-01-24 2019-05-22 International Scientific PTY Ltd Delivery device
JP2013166363A (ja) * 2012-02-17 2013-08-29 Toppan Printing Co Ltd 微細針チップ射出成形用金型及びその微細針チップを射出成形する方法
USD690004S1 (en) 2012-03-16 2013-09-17 Aderans Research Institute, Inc. Holder for a device for delivering cellular material and physiologic fluids
WO2013170171A1 (en) * 2012-05-11 2013-11-14 10X Technology Llc Hollow silica glass microneedle arrays and method and apparatus for manufacturing same
US9349543B2 (en) 2012-07-30 2016-05-24 California Institute Of Technology Nano tri-carbon composite systems and manufacture
CA2882184C (en) * 2012-08-27 2021-09-07 Clearside Biomedical, Inc. Apparatus and methods for drug delivery using microneedles
EP4566672A3 (en) 2012-11-08 2025-08-13 Clearside Biomedical Inc. Methods for the treatment of ocular disease in human subjects
CA2896188C (en) 2012-12-21 2021-02-23 Corium International, Inc. Microarray for delivery of therapeutic agent and methods of use
ES2921481T3 (es) 2013-03-12 2022-08-26 Corium Inc Aplicadores para microproyecciones
US10820860B2 (en) 2013-03-14 2020-11-03 One Drop Biosensor Technologies, Llc On-body microsensor for biomonitoring
US9192313B1 (en) 2013-03-14 2015-11-24 Orbital Research Inc. Dry physiological recording device and method of manufacturing
EP2972264A4 (en) 2013-03-14 2016-12-07 Sano Intelligence Inc ON THE BODY BORN MICROSENSOR FOR BIO SURVEILLANCE
US10195409B2 (en) 2013-03-15 2019-02-05 Corium International, Inc. Multiple impact microprojection applicators and methods of use
CA2903763C (en) 2013-03-15 2021-11-16 Corium International, Inc. Microarray with polymer-free microstructures, methods of making, and methods of use
US10384046B2 (en) 2013-03-15 2019-08-20 Corium, Inc. Microarray for delivery of therapeutic agent and methods of use
WO2014144973A1 (en) 2013-03-15 2014-09-18 Corium International, Inc. Microarray for delivery of therapeutic agent, methods of use, and methods of making
US9539139B2 (en) 2013-05-03 2017-01-10 Clearside Biomedical, Inc. Apparatus and methods for ocular injection
WO2014197317A1 (en) 2013-06-03 2014-12-11 Clearside Biomedical, Inc. Apparatus and methods for drug delivery using multiple reservoirs
BR112015031162A2 (pt) * 2013-06-13 2017-07-25 Microdermics Inc microagulhas metálicas
SG11201600331YA (en) * 2013-07-16 2016-02-26 3M Innovative Properties Co Hollow microneedle with bevel opening
EP3021930B1 (en) * 2013-07-16 2020-10-07 3M Innovative Properties Company Hollow microneedle with beveled tip
US10595754B2 (en) 2014-03-13 2020-03-24 Sano Intelligence, Inc. System for monitoring body chemistry
CN106102578A (zh) 2014-03-13 2016-11-09 萨诺智能公司 用于监控身体化学性质的系统
JP2017524419A (ja) 2014-06-20 2017-08-31 クリアサイド バイオメディカル，インコーポレイテッド 薬剤送達のための挿入深さを制御するための可変径カニューレ及び方法
EP3188714A1 (en) 2014-09-04 2017-07-12 Corium International, Inc. Microstructure array, methods of making, and methods of use
JP6906885B2 (ja) 2014-11-14 2021-07-21 ロレアル しわを減少させるためのマイクロニードルシート
SG10201809690VA (en) * 2015-01-21 2018-12-28 3M Innovative Properties Co Microneedle array and method of use
CN107206220A (zh) * 2015-02-16 2017-09-26 凸版印刷株式会社 微针
JP6482323B2 (ja) 2015-03-03 2019-03-13 富士フイルム株式会社 経皮吸収シート
JP6317690B2 (ja) * 2015-03-03 2018-04-25 富士フイルム株式会社 経皮吸収シート、及びその製造方法
WO2016147476A1 (ja) * 2015-03-18 2016-09-22 凸版印刷株式会社 薬剤投与装置および薬剤投与装置の製造方法
US10857093B2 (en) 2015-06-29 2020-12-08 Corium, Inc. Microarray for delivery of therapeutic agent, methods of use, and methods of making
EP3413851B1 (en) 2016-02-10 2023-09-27 Clearside Biomedical, Inc. Packaging
JP2019514581A (ja) 2016-05-02 2019-06-06 クリアサイド バイオメディカル，インコーポレイテッド 眼の薬物送達のためのシステムおよび方法
WO2018031913A1 (en) 2016-08-12 2018-02-15 Clearside Biomedical, Inc. Devices and methods for adjusting the insertion depth of a needle for medicament delivery
US12090294B2 (en) 2017-05-02 2024-09-17 Georgia Tech Research Corporation Targeted drug delivery methods using a microneedle
CN109091728A (zh) * 2017-08-01 2018-12-28 中国科学院深圳先进技术研究院 一种微量液体注射器及对薄壁组织进行注射的方法
EP3752645A4 (en) 2018-02-14 2022-04-13 Dermtech, Inc. NEW GENE CLASSIFIERS AND THEIR USE IN NON-MELANOMA SKIN CANCER
IT201800006526A1 (it) * 2018-06-20 2019-12-20 Microago cavo per la somministrazione transdermica di molecole attive e/o per il campionamento di fluidi biologici e metodo di fabbricazione di tale microago cavo
US11213667B2 (en) * 2018-07-11 2022-01-04 Santa Clara University 3D printed microneedles for microencapsulated mammalian cell extrusion
JP6737460B1 (ja) * 2019-02-12 2020-08-12 近畿精工株式会社 マイクロニードル
EP3948290A4 (en) 2019-03-26 2023-08-09 Dermtech, Inc. NEW GENE CLASSIFIERS AND THEIR USES FOR SKIN CANCERS
AU2021265743A1 (en) 2020-04-28 2022-11-03 Ticona Llc Microneedle assembly
KR102531521B1 (ko) 2021-01-05 2023-05-15 인싸이토(주) 마이크로 니들을 이용한 경사 주사침 세트 및 경사 주사침
WO2022174040A1 (en) * 2021-02-11 2022-08-18 10X Technology Llc Method and apparatus for fabricating brittle microneedle
US20240167102A1 (en) * 2021-03-02 2024-05-23 Dermtech, Inc. Predicting therapeutic response
USD1086030S1 (en) 2021-04-21 2025-07-29 One Health Biosensing Inc. Charging station
USD988882S1 (en) 2021-04-21 2023-06-13 Informed Data Systems Inc. Sensor assembly
USD1076079S1 (en) 2021-04-21 2025-05-20 One Health Biosensing Inc. Applicator assembly
US20250283847A1 (en) * 2022-04-29 2025-09-11 Board Of Regents, The University Of Texas System Microneedle-based plant sensors and methods of making and using thereof
WO2024040387A1 (en) * 2022-08-22 2024-02-29 Wenzhou Institute, University Of Chinese Academy Of Sciences (Wiucas) Microneedle arrays and method of making

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3964482A (en) 1971-05-17 1976-06-22 Alza Corporation Drug delivery device
US4838877A (en) * 1985-08-06 1989-06-13 Massau Bruce A Polymeric hypodermic device
US5217671A (en) * 1988-09-22 1993-06-08 Terumo Kabushiki Kaisha Method of making a tubular body
US5250066A (en) * 1990-03-19 1993-10-05 Becton Dickinson And Company Plastic pointed articles and method for their preparation
US5078700A (en) * 1990-03-19 1992-01-07 Becton, Dickinson And Company Liquid crystalline catheter
US5620639A (en) * 1993-03-09 1997-04-15 Stevens; John F. Method of manufacturing needles
US5403291A (en) * 1993-08-02 1995-04-04 Quinton Instrument Company Catheter with elongated side holes
US5733266A (en) 1996-07-26 1998-03-31 Gravlee, Jr.; Joseph F. Hypodermic needle
US5928207A (en) * 1997-06-30 1999-07-27 The Regents Of The University Of California Microneedle with isotropically etched tip, and method of fabricating such a device
US6310886B1 (en) * 1997-08-28 2001-10-30 Tivo, Inc. Method and apparatus implementing a multimedia digital network
US6077462A (en) * 1998-02-20 2000-06-20 3M Innovative Properties Company Method and apparatus for seamless microreplication using an expandable mold
US6117386A (en) * 1998-04-30 2000-09-12 Medronic Inc. Centering perfusion delivery catheter and method of manufacture
US6233389B1 (en) * 1998-07-30 2001-05-15 Tivo, Inc. Multimedia time warping system
EP1187653B1 (en) 1999-06-04 2010-03-31 Georgia Tech Research Corporation Devices for enhanced microneedle penetration of biological barriers
US6312612B1 (en) * 1999-06-09 2001-11-06 The Procter & Gamble Company Apparatus and method for manufacturing an intracutaneous microneedle array
US6379324B1 (en) 1999-06-09 2002-04-30 The Procter & Gamble Company Intracutaneous microneedle array apparatus
US6256533B1 (en) 1999-06-09 2001-07-03 The Procter & Gamble Company Apparatus and method for using an intracutaneous microneedle array
US6406638B1 (en) 2000-01-06 2002-06-18 The Regents Of The University Of California Method of forming vertical, hollow needles within a semiconductor substrate, and needles formed thereby
US6558361B1 (en) * 2000-03-09 2003-05-06 Nanopass Ltd. Systems and methods for the transport of fluids through a biological barrier and production techniques for such systems
US6612111B1 (en) * 2000-03-27 2003-09-02 Lifescan, Inc. Method and device for sampling and analyzing interstitial fluid and whole blood samples
US6607513B1 (en) * 2000-06-08 2003-08-19 Becton, Dickinson And Company Device for withdrawing or administering a substance and method of manufacturing a device
US7310543B2 (en) * 2001-03-26 2007-12-18 Kumetrix, Inc. Silicon microprobe with integrated biosensor
US6501976B1 (en) * 2001-06-12 2002-12-31 Lifescan, Inc. Percutaneous biological fluid sampling and analyte measurement devices and methods
US6875613B2 (en) * 2001-06-12 2005-04-05 Lifescan, Inc. Biological fluid constituent sampling and measurement devices and methods
US6721586B2 (en) * 2001-06-12 2004-04-13 Lifescan, Inc. Percutaneous biological fluid sampling and analyte measurement devices and methods
US6767341B2 (en) * 2001-06-13 2004-07-27 Abbott Laboratories Microneedles for minimally invasive drug delivery

Also Published As

Publication number Publication date
IL150468A0 (en) 2002-12-01
CN1494876A (zh) 2004-05-12
US20030208138A1 (en) 2003-11-06
RU2002118232A (ru) 2004-01-27
AR034723A1 (es) 2004-03-17
US20030009113A1 (en) 2003-01-09
US6749792B2 (en) 2004-06-15
PL354857A1 (en) 2003-01-13
CA2391810A1 (en) 2003-01-09
EP1287847A1 (en) 2003-03-05
KR20030007039A (ko) 2003-01-23
TW590782B (en) 2004-06-11
JP2003088514A (ja) 2003-03-25

Similar Documents

Publication Publication Date Title
MXPA02006647A (es) Microagujas mejoradas y metodos de fabricacion y uso de las mismas.
EP1266607A3 (en) Percutaneous biological fluid constituent sampling and measurement devices and methods
WO2005018728A3 (en) Expandable sheath tubing
WO2005007219A3 (en) Valvuloplasty devices and methods
WO2004073500A3 (en) Bone access system
EP2380512A3 (en) Obturator tips
AU2001245501A1 (en) Device for connecting a catheter onto a guide-wire
WO2008079812A3 (en) Dermal and transdermal cryogenic microprobe systems and methods
ATE466615T1 (de) Längliches intrakorporales medizinprodukt
EP2275163A3 (en) Deflectable catheter with a high modulus fiber puller element
DE69427465D1 (de) Führungsdraht aus superelastischer legierung
WO2002055135A3 (en) Device for delivery of liquid and gel-like surgical materials and methods for use thereof
BRPI0605167A (pt) dispositivo, sistema e método para distribuir um material curável dentro do osso
WO2005048812A3 (en) Cannula delivery and support system
EP2441489A3 (en) Apparatus for treatment of sinusitis
ATE518508T1 (de) Tiefen- und punktionskontrolle für ein blutgefäss-hämostasesystem
DE60225303D1 (de) Vorrichtung für eine herzklappenreperatur
TW200626193A (en) Catheter for medical treatment
ATE463202T1 (de) Kapillarrohr-spitzen-design zur unterstützung des blutflusses
EP1834589A3 (en) Micropore forming system, micropore forming device, chip container, and chip container kit
EP1138275A3 (en) Multiple solution dental irrigator
WO2002060312A3 (en) Flexible tip medical instrument
BR0210011A (pt) Cateter com septo de arrasto reduzido
CA2376285A1 (en) Intracutaneous microneedle array apparatus
WO2007079375A3 (en) Active fixation cardiac vein medical lead