MXPA02006093A - Celulas tipo madre o embrionicas producidas por transplante nuclear de especies de cruza. - Google Patents
Celulas tipo madre o embrionicas producidas por transplante nuclear de especies de cruza.Info
- Publication number
- MXPA02006093A MXPA02006093A MXPA02006093A MXPA02006093A MXPA02006093A MX PA02006093 A MXPA02006093 A MX PA02006093A MX PA02006093 A MXPA02006093 A MX PA02006093A MX PA02006093 A MXPA02006093 A MX PA02006093A MX PA02006093 A MXPA02006093 A MX PA02006093A
- Authority
- MX
- Mexico
- Prior art keywords
- cells
- embryonic
- donor
- cell
- nuclear transfer
- Prior art date
Links
- 238000010449 nuclear transplantation Methods 0.000 title 1
- 210000004027 cell Anatomy 0.000 abstract 8
- 210000000805 cytoplasm Anatomy 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 238000002054 transplantation Methods 0.000 abstract 2
- 108020005196 Mitochondrial DNA Proteins 0.000 abstract 1
- 230000006907 apoptotic process Effects 0.000 abstract 1
- 230000022131 cell cycle Effects 0.000 abstract 1
- 230000024245 cell differentiation Effects 0.000 abstract 1
- 210000003855 cell nucleus Anatomy 0.000 abstract 1
- 238000012258 culturing Methods 0.000 abstract 1
- 230000018109 developmental process Effects 0.000 abstract 1
- 210000002308 embryonic cell Anatomy 0.000 abstract 1
- 210000001671 embryonic stem cell Anatomy 0.000 abstract 1
- 230000006801 homologous recombination Effects 0.000 abstract 1
- 238000002744 homologous recombination Methods 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 210000003470 mitochondria Anatomy 0.000 abstract 1
- 238000012986 modification Methods 0.000 abstract 1
- 230000004048 modification Effects 0.000 abstract 1
- 210000004940 nucleus Anatomy 0.000 abstract 1
- 210000000287 oocyte Anatomy 0.000 abstract 1
- 210000000130 stem cell Anatomy 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/873—Techniques for producing new embryos, e.g. nuclear transfer, manipulation of totipotent cells or production of chimeric embryos
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Developmental Biology & Embryology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
Se proporciona un metodo de transferencia nuclear que involucra el transplante o diferenciacion de nucleos de celula donadora en oocitos enucleados de una especie diferente a la celula donadora, en conjunto con un citoplasma y/o mitocondria compatible (de la misma especie del donador). Las unidades de transferencia nuclear resultante son utiles para la produccion de celulas madre embrionicas isogenicas, en particular celulas madre o embrionicas isogenicas humanas. Estas celulas tipo madre o embrionicas son utiles para producir las celulas diferenciadas deseadas y para la introduccion, remocion o modificacion, de los genes deseados, por ejemplo, en sitios especificos del genoma de tales celulas por recombinacion homologa. Estas celulas, que pueden contener un gen heterologo, son especialmente utiles en terapias de transplante celular y para estudio in vitro de diferenciacion celular. La eficiencia de transferencia nuclear se aumenta por la introduccion de citoplasma o ADN mitocondrial compatible (misma especie o similar a la celula o nucleo donador). Tambien, la eficacia de transferencia nuclear puede opcionalmente aumentarse ademas por celulas donadoras geneticamente alteradas para inhibir la apoptosis, seleccionadas para un ciclo celular especifico y/o cultivando bajo condiciones que aumentan el crecimiento y desarrollo embrionico.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US46707699A | 1999-12-20 | 1999-12-20 | |
| PCT/US2000/012631 WO2001046401A1 (en) | 1999-12-20 | 2000-05-10 | Embryonic or stem-like cells produced by cross species nuclear transplantation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MXPA02006093A true MXPA02006093A (es) | 2004-08-23 |
Family
ID=23854253
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MXPA02006093A MXPA02006093A (es) | 1999-12-20 | 2000-05-10 | Celulas tipo madre o embrionicas producidas por transplante nuclear de especies de cruza. |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP1240318A4 (es) |
| JP (1) | JP2004500066A (es) |
| CN (1) | CN1425064A (es) |
| AU (1) | AU784731B2 (es) |
| BR (1) | BR0016561A (es) |
| CA (1) | CA2394614A1 (es) |
| IL (2) | IL150065A0 (es) |
| MX (1) | MXPA02006093A (es) |
| NZ (1) | NZ519346A (es) |
| WO (1) | WO2001046401A1 (es) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7696404B2 (en) | 1996-08-19 | 2010-04-13 | Advanced Cell Technology, Inc. | Embryonic or stem-like cell lines produced by cross species nuclear transplantation and methods for enhancing embryonic development by genetic alteration of donor cells or by tissue culture conditions |
| US7621606B2 (en) | 2001-08-27 | 2009-11-24 | Advanced Cell Technology, Inc. | Trans-differentiation and re-differentiation of somatic cells and production of cells for cell therapies |
| IL147179A0 (en) * | 1999-06-30 | 2002-08-14 | Advanced Cell Tech Inc | Cytoplasmic transfer to de-differentiate recipient cells |
| EP1214404A4 (en) * | 1999-09-14 | 2003-09-03 | Univ Massachusetts | Embryonic or stem-like cell lines produced by cross species nuclear transplantation and methods for enhancing embryonic development by genetic alteration of donor cells or by tissue culture conditions |
| AUPR247901A0 (en) * | 2001-01-10 | 2001-02-01 | Garelag Pty Ltd | Activation of nuclear transfer embryos |
| CN1650007A (zh) * | 2002-02-27 | 2005-08-03 | 长尾恭光 | 胚胎修饰动物及其产生方法 |
| WO2004100773A2 (en) * | 2003-05-13 | 2004-11-25 | The Regents Of The University Of Colorado | Diagnostic and therapeutic treatments related to mitochondrial disorders |
| EP2479256A1 (en) | 2004-11-04 | 2012-07-25 | Advanced Cell Technology, Inc. | Derivation of embryonic stem cells |
| US7893315B2 (en) | 2004-11-04 | 2011-02-22 | Advanced Cell Technology, Inc. | Derivation of embryonic stem cells and embryo-derived cells |
| US20100167404A1 (en) | 2005-08-03 | 2010-07-01 | Advanced Cell Technology, Inc. | Methods of Reprogramming Animal Somatic Cells |
| US8372644B2 (en) * | 2006-02-06 | 2013-02-12 | Transplantation Limited | Method for growing adult cells |
| CN105441385A (zh) | 2007-02-23 | 2016-03-30 | 奥卡塔治疗公司 | 重编程分化细胞和从重编程的细胞产生动物和胚胎干细胞的高效方法 |
| US10865383B2 (en) | 2011-07-12 | 2020-12-15 | Lineage Cell Therapeutics, Inc. | Methods and formulations for orthopedic cell therapy |
| ES2980659T3 (es) | 2015-03-23 | 2024-10-02 | Astellas Inst For Regenerative Medicine | Ensayos mejorados de potencia de células de epitelio pigmentario retiniano (EPR) humano y progenitores de fotorreceptores |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5061620A (en) * | 1990-03-30 | 1991-10-29 | Systemix, Inc. | Human hematopoietic stem cell |
| JP2001500725A (ja) * | 1996-08-19 | 2001-01-23 | ユニヴァーシティー オヴ マサチューセッツ | 種間核移植により製造される胚性または幹細胞様細胞株 |
| AU8587598A (en) * | 1997-07-26 | 1999-02-16 | Wisconsin Alumni Research Foundation | Trans-species nuclear transfer |
| EP1060243A4 (en) * | 1998-03-02 | 2005-03-09 | Univ Massachusetts | EMBRYONIC OR STEM-LIKE CELL LINES PRODUCED BY NUCLEAR TRANSPLANTATION OF CROSS-SPECIES |
| GB9809178D0 (en) * | 1998-04-29 | 1998-07-01 | Univ Edinburgh | Nuclear reprogramming of somatic cells |
| JP2003503044A (ja) * | 1999-06-30 | 2003-01-28 | ワン，ウー−サク | 種間核移植技術を用いたヒトクローン胚の作製方法 |
| EP1214404A4 (en) * | 1999-09-14 | 2003-09-03 | Univ Massachusetts | Embryonic or stem-like cell lines produced by cross species nuclear transplantation and methods for enhancing embryonic development by genetic alteration of donor cells or by tissue culture conditions |
-
2000
- 2000-05-10 NZ NZ519346A patent/NZ519346A/en unknown
- 2000-05-10 IL IL15006500A patent/IL150065A0/xx unknown
- 2000-05-10 WO PCT/US2000/012631 patent/WO2001046401A1/en not_active Ceased
- 2000-05-10 CN CN00818280A patent/CN1425064A/zh active Pending
- 2000-05-10 CA CA002394614A patent/CA2394614A1/en not_active Abandoned
- 2000-05-10 EP EP00930498A patent/EP1240318A4/en not_active Withdrawn
- 2000-05-10 MX MXPA02006093A patent/MXPA02006093A/es not_active Application Discontinuation
- 2000-05-10 BR BR0016561-1A patent/BR0016561A/pt not_active IP Right Cessation
- 2000-05-10 JP JP2001546899A patent/JP2004500066A/ja active Pending
- 2000-05-10 AU AU48309/00A patent/AU784731B2/en not_active Ceased
-
2002
- 2002-06-06 IL IL150065A patent/IL150065A/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| AU784731B2 (en) | 2006-06-08 |
| CA2394614A1 (en) | 2001-06-28 |
| NZ519346A (en) | 2004-02-27 |
| JP2004500066A (ja) | 2004-01-08 |
| IL150065A0 (en) | 2002-12-01 |
| EP1240318A4 (en) | 2004-12-08 |
| WO2001046401A1 (en) | 2001-06-28 |
| EP1240318A1 (en) | 2002-09-18 |
| AU4830900A (en) | 2001-07-03 |
| WO2001046401A8 (en) | 2001-07-26 |
| IL150065A (en) | 2009-09-22 |
| CN1425064A (zh) | 2003-06-18 |
| BR0016561A (pt) | 2002-09-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |