[go: up one dir, main page]

MXPA02005717A - High throughput or capillary-based screening for a bioactivity or biomolecule. - Google Patents

High throughput or capillary-based screening for a bioactivity or biomolecule.

Info

Publication number
MXPA02005717A
MXPA02005717A MXPA02005717A MXPA02005717A MXPA02005717A MX PA02005717 A MXPA02005717 A MX PA02005717A MX PA02005717 A MXPA02005717 A MX PA02005717A MX PA02005717 A MXPA02005717 A MX PA02005717A MX PA02005717 A MXPA02005717 A MX PA02005717A
Authority
MX
Mexico
Prior art keywords
biomolecule
bioactivity
capillary
high throughput
based screening
Prior art date
Application number
MXPA02005717A
Other languages
Spanish (es)
Inventor
Jay M Short
Original Assignee
Diversa Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/738,871 external-priority patent/US20010041333A1/en
Priority claimed from US09/790,321 external-priority patent/US20020048809A1/en
Priority claimed from US09/894,956 external-priority patent/US20020015997A1/en
Application filed by Diversa Corp filed Critical Diversa Corp
Publication of MXPA02005717A publication Critical patent/MXPA02005717A/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/10Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034Isolating an individual clone by screening libraries
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • C12Q1/6834Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • C12Q1/6837Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips

Landscapes

  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Plant Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
MXPA02005717A 2000-10-10 2001-10-10 High throughput or capillary-based screening for a bioactivity or biomolecule. MXPA02005717A (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US68543200A 2000-10-10 2000-10-10
US09/738,871 US20010041333A1 (en) 1997-06-16 2000-12-15 High throughput screening for a bioactivity or biomolecule
US09/790,321 US20020048809A1 (en) 1997-06-16 2001-02-21 Capillary array-based sample screening
US09/894,956 US20020015997A1 (en) 1997-06-16 2001-06-27 Capillary array-based sample screening
US30910101P 2001-07-31 2001-07-31
PCT/US2001/031806 WO2002031203A2 (en) 2000-10-10 2001-10-10 High throughput or capillary-based screening for a bioactivity or biomolecule

Publications (1)

Publication Number Publication Date
MXPA02005717A true MXPA02005717A (en) 2003-10-14

Family

ID=27540945

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA02005717A MXPA02005717A (en) 2000-10-10 2001-10-10 High throughput or capillary-based screening for a bioactivity or biomolecule.

Country Status (7)

Country Link
EP (1) EP1364052A2 (en)
JP (1) JP2005501217A (en)
AU (1) AU1164202A (en)
CA (1) CA2393374A1 (en)
IL (1) IL150020A0 (en)
MX (1) MXPA02005717A (en)
WO (1) WO2002031203A2 (en)

Families Citing this family (109)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0307428D0 (en) 2003-03-31 2003-05-07 Medical Res Council Compartmentalised combinatorial chemistry
GB0307403D0 (en) 2003-03-31 2003-05-07 Medical Res Council Selection by compartmentalised screening
US20060078893A1 (en) 2004-10-12 2006-04-13 Medical Research Council Compartmentalised combinatorial chemistry by microfluidic control
US7960148B2 (en) 2003-07-02 2011-06-14 Verenium Corporation Glucanases, nucleic acids encoding them and methods for making and using them
WO2005021714A2 (en) 2003-08-11 2005-03-10 Diversa Corporation Laccases, nucleic acids encoding them and methods for making and using them
WO2005034736A2 (en) * 2003-10-10 2005-04-21 Biophysical Corporation Generation of biochemical images and methods of use
US20050221339A1 (en) * 2004-03-31 2005-10-06 Medical Research Council Harvard University Compartmentalised screening by microfluidic control
JP2008505619A (en) 2004-06-16 2008-02-28 ヴェレニウム コーポレイション Compositions and methods for enzymatic decolorization of chlorophyll
US20080070291A1 (en) 2004-06-16 2008-03-20 David Lam Compositions and Methods for Enzymatic Decolorization of Chlorophyll
US7968287B2 (en) 2004-10-08 2011-06-28 Medical Research Council Harvard University In vitro evolution in microfluidic systems
US20090038023A1 (en) 2005-03-10 2009-02-05 Verenium Corporation Lyase Enzymes, Nucleic Acids Encoding Them and Methods For Making and Using Them
CN102943085A (en) 2005-03-15 2013-02-27 维莱尼姆公司 Cellulases, nucleic acids encoding them and methods for making and using them
EP2363205A3 (en) 2006-01-11 2014-06-04 Raindance Technologies, Inc. Microfluidic Devices And Methods Of Use In The Formation And Control Of Nanoreactors
MY160756A (en) 2006-02-10 2017-03-15 Verenium Corp Cellulolytic enzymes, nucleic acids encoding them and methods for making and using them
EP1989302B1 (en) 2006-02-14 2018-04-11 BP Corporation North America Inc. Xylanases, nucleic acids encoding them and methods for making and using them
EP2112227B1 (en) 2006-03-07 2013-05-15 Cargill, Incorporated Aldolases, nucleic acids encoding them and methods for making and using them
EP3153580A3 (en) 2006-03-07 2017-04-19 BASF Enzymes LLC Aldolases, nucleic acids encoding them and methods for making and using them
US9562837B2 (en) 2006-05-11 2017-02-07 Raindance Technologies, Inc. Systems for handling microfludic droplets
EP3782722B1 (en) 2006-05-11 2022-07-06 Bio-Rad Laboratories, Inc. Microfluidic devices
MX369001B (en) 2006-08-04 2019-10-24 Basf Enzymes Llc Glucanases, nucleic acids encoding them and methods for making and using them.
EP3536396B1 (en) 2006-08-07 2022-03-30 The President and Fellows of Harvard College Fluorocarbon emulsion stabilizing surfactants
US20100189706A1 (en) 2007-01-30 2010-07-29 Cathy Chang Enzymes for the treatment of lignocellulosics, nucleic acids encoding them and methods for making and using them
US8772046B2 (en) 2007-02-06 2014-07-08 Brandeis University Manipulation of fluids and reactions in microfluidic systems
US9029085B2 (en) 2007-03-07 2015-05-12 President And Fellows Of Harvard College Assays and other reactions involving droplets
US8592221B2 (en) 2007-04-19 2013-11-26 Brandeis University Manipulation of fluids, fluid components and reactions in microfluidic systems
CN103757036B (en) 2007-10-03 2019-10-01 维莱尼姆公司 Zytase, the nucleic acid and its methods for making and using same for encoding them
US9797010B2 (en) 2007-12-21 2017-10-24 President And Fellows Of Harvard College Systems and methods for nucleic acid sequencing
WO2009088949A1 (en) 2008-01-03 2009-07-16 Verenium Corporation Transferases and oxidoreductases, nucleic acids encoding them and methods for making and using them
US12038438B2 (en) 2008-07-18 2024-07-16 Bio-Rad Laboratories, Inc. Enzyme quantification
WO2010009365A1 (en) 2008-07-18 2010-01-21 Raindance Technologies, Inc. Droplet libraries
WO2010033200A2 (en) 2008-09-19 2010-03-25 President And Fellows Of Harvard College Creation of libraries of droplets and related species
EP2373812B1 (en) 2008-12-19 2016-11-09 President and Fellows of Harvard College Particle-assisted nucleic acid sequencing
EP3415235B1 (en) 2009-03-23 2025-11-12 Bio-Rad Laboratories, Inc. Manipulation of microfluidic droplets
EP2486409A1 (en) 2009-10-09 2012-08-15 Universite De Strasbourg Labelled silica-based nanomaterial with enhanced properties and uses thereof
EP3842150A1 (en) 2009-10-27 2021-06-30 President and Fellows of Harvard College Droplet creation techniques
WO2011079176A2 (en) 2009-12-23 2011-06-30 Raindance Technologies, Inc. Microfluidic systems and methods for reducing the exchange of molecules between droplets
US9399797B2 (en) 2010-02-12 2016-07-26 Raindance Technologies, Inc. Digital analyte analysis
US9366632B2 (en) 2010-02-12 2016-06-14 Raindance Technologies, Inc. Digital analyte analysis
US10351905B2 (en) 2010-02-12 2019-07-16 Bio-Rad Laboratories, Inc. Digital analyte analysis
JP5934657B2 (en) 2010-02-12 2016-06-15 レインダンス テクノロジーズ, インコーポレイテッド Digital specimen analysis
EP2539450B1 (en) * 2010-02-25 2016-02-17 Advanced Liquid Logic, Inc. Method of making nucleic acid libraries
WO2011149272A2 (en) * 2010-05-25 2011-12-01 주식회사 나노엔텍 Qualitative and quantitative analytical method for analyzing the activity type of an enzyme that is activated by proteolysis
US9562897B2 (en) 2010-09-30 2017-02-07 Raindance Technologies, Inc. Sandwich assays in droplets
EP3859011A1 (en) 2011-02-11 2021-08-04 Bio-Rad Laboratories, Inc. Methods for forming mixed droplets
EP2675819B1 (en) 2011-02-18 2020-04-08 Bio-Rad Laboratories, Inc. Compositions and methods for molecular labeling
US20140154184A1 (en) * 2011-04-28 2014-06-05 The Regents Of The University Of California Time-gated fluorescence imaging with si-containing particles
US8841071B2 (en) 2011-06-02 2014-09-23 Raindance Technologies, Inc. Sample multiplexing
EP3216872B1 (en) 2011-06-02 2020-04-01 Bio-Rad Laboratories, Inc. Enzyme quantification
US8658430B2 (en) 2011-07-20 2014-02-25 Raindance Technologies, Inc. Manipulating droplet size
EP2831587B1 (en) 2012-03-27 2018-05-16 Ventana Medical Systems, Inc. Signaling conjugates and methods of use
US9657290B2 (en) * 2012-07-03 2017-05-23 The Board Of Trustees Of The Leland Stanford Junior University Scalable bio-element analysis
US10323279B2 (en) 2012-08-14 2019-06-18 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10752949B2 (en) 2012-08-14 2020-08-25 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10221442B2 (en) 2012-08-14 2019-03-05 10X Genomics, Inc. Compositions and methods for sample processing
US9701998B2 (en) 2012-12-14 2017-07-11 10X Genomics, Inc. Methods and systems for processing polynucleotides
EP2885418A4 (en) 2012-08-14 2016-03-02 10X Genomics Inc MICROCAPSULE COMPOSITIONS AND METHODS
US10273541B2 (en) 2012-08-14 2019-04-30 10X Genomics, Inc. Methods and systems for processing polynucleotides
US9951386B2 (en) 2014-06-26 2018-04-24 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10584381B2 (en) 2012-08-14 2020-03-10 10X Genomics, Inc. Methods and systems for processing polynucleotides
US11591637B2 (en) 2012-08-14 2023-02-28 10X Genomics, Inc. Compositions and methods for sample processing
WO2014093676A1 (en) 2012-12-14 2014-06-19 10X Technologies, Inc. Methods and systems for processing polynucleotides
US10533221B2 (en) 2012-12-14 2020-01-14 10X Genomics, Inc. Methods and systems for processing polynucleotides
CA2900481A1 (en) 2013-02-08 2014-08-14 10X Genomics, Inc. Polynucleotide barcode generation
US10395758B2 (en) 2013-08-30 2019-08-27 10X Genomics, Inc. Sequencing methods
US11901041B2 (en) 2013-10-04 2024-02-13 Bio-Rad Laboratories, Inc. Digital analysis of nucleic acid modification
WO2015069634A1 (en) 2013-11-08 2015-05-14 President And Fellows Of Harvard College Microparticles, methods for their preparation and use
US9944977B2 (en) 2013-12-12 2018-04-17 Raindance Technologies, Inc. Distinguishing rare variations in a nucleic acid sequence from a sample
US9824068B2 (en) 2013-12-16 2017-11-21 10X Genomics, Inc. Methods and apparatus for sorting data
EP3090063B1 (en) 2013-12-31 2019-11-06 Bio-Rad Laboratories, Inc. Method for detection of latent retrovirus
US9694361B2 (en) 2014-04-10 2017-07-04 10X Genomics, Inc. Fluidic devices, systems, and methods for encapsulating and partitioning reagents, and applications of same
US10839939B2 (en) 2014-06-26 2020-11-17 10X Genomics, Inc. Processes and systems for nucleic acid sequence assembly
US12312640B2 (en) 2014-06-26 2025-05-27 10X Genomics, Inc. Analysis of nucleic acid sequences
CN106536756A (en) 2014-06-26 2017-03-22 10X基因组学有限公司 Analysis of nucleic acid sequences
EP3161160B1 (en) 2014-06-26 2021-10-13 10X Genomics, Inc. Methods of analyzing nucleic acids from individual cells or cell populations
CA2964472A1 (en) 2014-10-29 2016-05-06 10X Genomics, Inc. Methods and compositions for targeted nucleic acid sequencing
US9975122B2 (en) 2014-11-05 2018-05-22 10X Genomics, Inc. Instrument systems for integrated sample processing
CN107427808B (en) 2015-01-12 2020-10-23 10X基因组学有限公司 Method and system for preparing nucleic acid sequencing library and library prepared by using same
KR20170106979A (en) 2015-01-13 2017-09-22 10엑스 제노믹스, 인크. System and method for visualizing structure variation and phase adjustment information
MX2017010142A (en) 2015-02-09 2017-12-11 10X Genomics Inc Systems and methods for determining structural variation and phasing using variant call data.
CN114277081A (en) 2015-02-22 2022-04-05 里兰斯坦福初级大学理事会 Micro-screening apparatus, method and product
WO2016137973A1 (en) 2015-02-24 2016-09-01 10X Genomics Inc Partition processing methods and systems
BR112017018054A2 (en) 2015-02-24 2018-07-24 10X Genomics Inc Methods for Covering Targeted Nucleic Acid Sequences
US10647981B1 (en) 2015-09-08 2020-05-12 Bio-Rad Laboratories, Inc. Nucleic acid library generation methods and compositions
AU2016338907B2 (en) 2015-10-13 2022-07-07 President And Fellows Of Harvard College Systems and methods for making and using gel microspheres
PT3882357T (en) 2015-12-04 2022-09-05 10X Genomics Inc Methods and compositions for nucleic acid analysis
JP6735348B2 (en) 2016-02-11 2020-08-05 10エックス ジェノミクス, インコーポレイテッド Systems, methods and media for de novo assembly of whole genome sequence data
WO2017197343A2 (en) 2016-05-12 2017-11-16 10X Genomics, Inc. Microfluidic on-chip filters
WO2017197338A1 (en) 2016-05-13 2017-11-16 10X Genomics, Inc. Microfluidic systems and methods of use
EP3538277B1 (en) 2016-11-14 2024-05-29 Orca Biosystems, Inc. Apparatuses for sorting target particles
US11085039B2 (en) 2016-12-12 2021-08-10 xCella Biosciences, Inc. Methods and systems for screening using microcapillary arrays
EP3551745A4 (en) 2016-12-12 2020-07-15 Xcella Biosciences, Inc. METHODS AND SYSTEMS FOR SCREENING USING MICROCAPILLAR ARRAYS
US10815525B2 (en) 2016-12-22 2020-10-27 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10011872B1 (en) 2016-12-22 2018-07-03 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10550429B2 (en) 2016-12-22 2020-02-04 10X Genomics, Inc. Methods and systems for processing polynucleotides
CN110382439A (en) 2016-12-30 2019-10-25 埃克切拉生物科学公司 Multistage sample retrieval system
CN117512066A (en) 2017-01-30 2024-02-06 10X基因组学有限公司 Methods and systems for droplet-based single cell barcoding
US12264411B2 (en) 2017-01-30 2025-04-01 10X Genomics, Inc. Methods and systems for analysis
EP3625715A4 (en) 2017-05-19 2021-03-17 10X Genomics, Inc. SYSTEMS AND PROCEDURES FOR THE ANALYSIS OF DATA SETS
EP3445876B1 (en) 2017-05-26 2023-07-05 10X Genomics, Inc. Single cell analysis of transposase accessible chromatin
US20180340169A1 (en) 2017-05-26 2018-11-29 10X Genomics, Inc. Single cell analysis of transposase accessible chromatin
EP3625361A1 (en) 2017-11-15 2020-03-25 10X Genomics, Inc. Functionalized gel beads
US10829815B2 (en) 2017-11-17 2020-11-10 10X Genomics, Inc. Methods and systems for associating physical and genetic properties of biological particles
CN112262218B (en) 2018-04-06 2024-11-08 10X基因组学有限公司 Systems and methods for quality control in single cell processing
DK3890876T3 (en) 2018-12-06 2024-07-22 Xcella Biosciences Inc LATERAL FILLING OF MICROCAPILLAR ARRAYS
CN109682786B (en) * 2019-01-16 2021-11-12 四川省畜牧科学研究院 Method for identifying haemonchus contortus eggs and application thereof
CN110047572A (en) * 2019-03-14 2019-07-23 周军河 A kind of intelligence warm spring system and application method
CN115428088A (en) 2020-02-13 2022-12-02 10X基因组学有限公司 Systems and methods for joint interactive visualization of gene expression and DNA chromatin accessibility
CN115595354B (en) * 2022-10-28 2025-10-17 陕西科技大学 Method for visually and rapidly detecting nitrilase
CN116675285B (en) * 2023-05-15 2023-11-10 苏州科技大学 A kind of degradation method of perfluorinated compounds

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5853984A (en) * 1990-06-11 1998-12-29 Nexstar Pharmaceuticals, Inc. Use of nucleic acid ligands in flow cytometry
EP0636186B1 (en) * 1992-04-03 1998-11-25 The Perkin-Elmer Corporation Probe composition and method
US5958672A (en) * 1995-07-18 1999-09-28 Diversa Corporation Protein activity screening of clones having DNA from uncultivated microorganisms
US6057103A (en) * 1995-07-18 2000-05-02 Diversa Corporation Screening for novel bioactivities
US20030215798A1 (en) * 1997-06-16 2003-11-20 Diversa Corporation High throughput fluorescence-based screening for novel enzymes
AU2053197A (en) * 1996-02-23 1997-09-10 Ariad Pharmaceuticals, Inc. Cell-based assay
ATE327345T1 (en) * 1998-08-07 2006-06-15 Cellay Llc GEL MICRO DROPS FOR GENETIC ANALYSIS

Also Published As

Publication number Publication date
WO2002031203A9 (en) 2003-07-03
JP2005501217A (en) 2005-01-13
AU1164202A (en) 2002-04-22
IL150020A0 (en) 2002-12-01
EP1364052A2 (en) 2003-11-26
CA2393374A1 (en) 2002-04-18
WO2002031203A2 (en) 2002-04-18
WO2002031203A3 (en) 2003-09-25

Similar Documents

Publication Publication Date Title
MXPA02005717A (en) High throughput or capillary-based screening for a bioactivity or biomolecule.
MXPA02007609A (en) Screening arrangement.
ZA997582B (en) Vented container for produce.
ZA200203744B (en) Process for selectively producing light olefins.
MX259234B (en) Process for sizing paper.
ZA200204582B (en) Immunoassay for neonicotinyl insecticides.
AUPQ931100A0 (en) Screening apparatus
ZA200004959B (en) High bulk paper.
MXPA02012537A (en) Method for manufacturing plastic-substitute goods by using natural materials.
ZA992772B (en) Substituted tricyclics.
MXPA03008436A (en) Process for manufacturing transparent tints.
ZA200109611B (en) Process for making a pipa-polyol.
ZA200003519B (en) Inspection machine by compression.
ZA200108623B (en) Process for preparing imidachloprid.
GB0111004D0 (en) Screening method
MXPA03002517A (en) Hydrocracking process.
ZA992628B (en) Process for preparing phenoxyphenylsulfonyl halides.
MXPA02005346A (en) Cryptosporidium.
ZA200202553B (en) Screening Apparatus.
ZA200206617B (en) Screening apparatus.
ZA200005040B (en) Screening device.
ZA200204485B (en) Fused tri-heterocyclic compounds.
ZA200205516B (en) Process.
ZA200101803B (en) A screening device.
ZA200108818B (en) A sieve for sizing particulate material.