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MXPA02002384A - Polipeptidos similares al factor de crecimiento de fibroblastos. - Google Patents

Polipeptidos similares al factor de crecimiento de fibroblastos.

Info

Publication number
MXPA02002384A
MXPA02002384A MXPA02002384A MXPA02002384A MXPA02002384A MX PA02002384 A MXPA02002384 A MX PA02002384A MX PA02002384 A MXPA02002384 A MX PA02002384A MX PA02002384 A MXPA02002384 A MX PA02002384A MX PA02002384 A MXPA02002384 A MX PA02002384A
Authority
MX
Mexico
Prior art keywords
polypeptides
growth factor
fibroblast growth
fgf
methods
Prior art date
Application number
MXPA02002384A
Other languages
English (en)
Inventor
Michael Danilenko Dimitry
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/391,861 external-priority patent/US7408047B1/en
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of MXPA02002384A publication Critical patent/MXPA02002384A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/50—Fibroblast growth factor [FGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/11—Antisense
    • C12N2310/111—Antisense spanning the whole gene, or a large part of it
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/475—Assays involving growth factors
    • G01N2333/50—Fibroblast growth factors [FGF]

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  • Rheumatology (AREA)
  • Dermatology (AREA)
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  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pulmonology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)

Abstract

La presente invencion proporciona los novedosos polipeptidos similares al Factor de Crecimiento de Fibroblastos (similar a FGF) y las moleculas de acido nucleico que codifican los mismos. La invencion tambien proporciona los vectores, las celulas huesped, los anticuerpos y los metodos para producir los polipeptidos similares a FGF. Tambien se proporcionan los metodos para el diagnostico y tratamiento de enfermedades asociadas con los polipeptidos similares a FGF.
MXPA02002384A 1999-09-07 2000-09-05 Polipeptidos similares al factor de crecimiento de fibroblastos. MXPA02002384A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/391,861 US7408047B1 (en) 1999-09-07 1999-09-07 Fibroblast growth factor-like polypeptides
US09/644,052 US7459540B1 (en) 1999-09-07 2000-08-23 Fibroblast growth factor-like polypeptides
PCT/US2000/024373 WO2001018172A2 (en) 1999-09-07 2000-09-05 Fibroblast growth factor-like polypeptides

Publications (1)

Publication Number Publication Date
MXPA02002384A true MXPA02002384A (es) 2004-09-10

Family

ID=27013655

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA02002384A MXPA02002384A (es) 1999-09-07 2000-09-05 Polipeptidos similares al factor de crecimiento de fibroblastos.

Country Status (13)

Country Link
US (10) US7459540B1 (es)
EP (4) EP2189475A3 (es)
JP (4) JP4793836B2 (es)
AT (1) ATE430197T1 (es)
AU (1) AU7350000A (es)
CA (1) CA2383774C (es)
CY (1) CY1109166T1 (es)
DE (1) DE60042122D1 (es)
DK (1) DK1218509T3 (es)
ES (1) ES2326407T3 (es)
MX (1) MXPA02002384A (es)
PT (1) PT1218509E (es)
WO (1) WO2001018172A2 (es)

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ATE444306T1 (de) 2004-05-13 2009-10-15 Lilly Co Eli Fgf-21-fusionsproteine
WO2006014899A2 (en) 2004-07-26 2006-02-09 Dow Global Technologies Inc. Process for improved protein expression by strain engineering
BRPI0514790A (pt) 2004-09-02 2008-06-24 Lilly Co Eli muteìna de fgf-21 de humano, ou um seu peptìdeo biologicamente ativo, método para produzir a muteìna, composição farmacêutica, e, uso da muteìna de fgf-21 de humano
EP1789443A1 (en) 2004-09-02 2007-05-30 Eli Lilly And Company Muteins of fibroblast growth factor 21
US7655627B2 (en) 2004-12-14 2010-02-02 Eli Lilly And Company Muteins of fibroblast growth factor 21
JP2008528487A (ja) * 2005-01-21 2008-07-31 イーライ リリー アンド カンパニー 心臓血管疾患を治療する方法
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