MXPA01009174A - Antagonistas de endotelina novedosos derivados de piridazina. - Google Patents
Antagonistas de endotelina novedosos derivados de piridazina.Info
- Publication number
- MXPA01009174A MXPA01009174A MXPA01009174A MXPA01009174A MXPA01009174A MX PA01009174 A MXPA01009174 A MX PA01009174A MX PA01009174 A MXPA01009174 A MX PA01009174A MX PA01009174 A MXPA01009174 A MX PA01009174A MX PA01009174 A MXPA01009174 A MX PA01009174A
- Authority
- MX
- Mexico
- Prior art keywords
- endothelin
- endothelin antagonists
- compounds
- new pyridazine
- pyridazine
- Prior art date
Links
- 102000002045 Endothelin Human genes 0.000 title abstract 3
- 108050009340 Endothelin Proteins 0.000 title abstract 3
- ZUBDGKVDJUIMQQ-UBFCDGJISA-N endothelin-1 Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(O)=O)NC(=O)[C@H]1NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@@H](CC=2C=CC(O)=CC=2)NC(=O)[C@H](C(C)C)NC(=O)[C@H]2CSSC[C@@H](C(N[C@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N2)=O)NC(=O)[C@@H](CO)NC(=O)[C@H](N)CSSC1)C1=CNC=N1 ZUBDGKVDJUIMQQ-UBFCDGJISA-N 0.000 title abstract 3
- 239000005557 antagonist Substances 0.000 title 1
- PBMFSQRYOILNGV-UHFFFAOYSA-N pyridazine Chemical compound C1=CC=NN=C1 PBMFSQRYOILNGV-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 230000001404 mediated effect Effects 0.000 abstract 2
- 102000010180 Endothelin receptor Human genes 0.000 abstract 1
- 108050001739 Endothelin receptor Proteins 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Gynecology & Obstetrics (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Diaphragms For Electromechanical Transducers (AREA)
Abstract
Compuestos de formula (I): (ver formula) tienen afinidad por receptores de endotelina, son selectivos por ETA sobre ETB, y son potencialmente utiles en el tratamiento de condiciones mediadas por endotelina.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0023074.8A GB0023074D0 (en) | 2000-09-20 | 2000-09-20 | Pyridazines |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MXPA01009174A true MXPA01009174A (es) | 2004-10-15 |
Family
ID=9899818
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MXPA01009174A MXPA01009174A (es) | 2000-09-20 | 2001-09-11 | Antagonistas de endotelina novedosos derivados de piridazina. |
Country Status (12)
| Country | Link |
|---|---|
| EP (1) | EP1191026B1 (es) |
| JP (1) | JP3545735B2 (es) |
| AT (1) | ATE267193T1 (es) |
| BR (1) | BR0104141A (es) |
| CA (1) | CA2357687C (es) |
| DE (1) | DE60103342T2 (es) |
| DK (1) | DK1191026T3 (es) |
| ES (1) | ES2220677T3 (es) |
| GB (1) | GB0023074D0 (es) |
| MX (1) | MXPA01009174A (es) |
| PT (1) | PT1191026E (es) |
| TR (1) | TR200401185T4 (es) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2297040T3 (es) | 2002-01-02 | 2008-05-01 | Actelion Pharmaceuticals Ltd. | Nuevas alcanosulfonamidas como antagonistas endoteliales. |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3379544D1 (en) * | 1982-06-08 | 1989-05-11 | Ciba Geigy Ag | 2-phenyl-2-naphthyl and 2-heterocyclic pyrimidines as antidotes for protecting cultured plants before phytotoxic damages caused by herbicides |
| US5707966A (en) * | 1994-03-04 | 1998-01-13 | Eli Lilly And Company | Antithrombotic agents |
| DE19537548A1 (de) * | 1995-10-09 | 1997-04-10 | Merck Patent Gmbh | Endothelin-Rezeptor-Antagonisten |
| CN1102580C (zh) * | 1995-12-20 | 2003-03-05 | 山之内制药株式会社 | 芳基乙烯基磺酰胺衍生物及其医药组合物 |
-
2000
- 2000-09-20 GB GBGB0023074.8A patent/GB0023074D0/en not_active Ceased
-
2001
- 2001-09-05 DK DK01307528T patent/DK1191026T3/da active
- 2001-09-05 EP EP01307528A patent/EP1191026B1/en not_active Expired - Lifetime
- 2001-09-05 TR TR2004/01185T patent/TR200401185T4/xx unknown
- 2001-09-05 PT PT01307528T patent/PT1191026E/pt unknown
- 2001-09-05 AT AT01307528T patent/ATE267193T1/de not_active IP Right Cessation
- 2001-09-05 ES ES01307528T patent/ES2220677T3/es not_active Expired - Lifetime
- 2001-09-05 DE DE60103342T patent/DE60103342T2/de not_active Expired - Fee Related
- 2001-09-11 MX MXPA01009174A patent/MXPA01009174A/es active IP Right Grant
- 2001-09-18 CA CA002357687A patent/CA2357687C/en not_active Expired - Fee Related
- 2001-09-19 BR BR0104141-0A patent/BR0104141A/pt not_active IP Right Cessation
- 2001-09-19 JP JP2001285183A patent/JP3545735B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| ATE267193T1 (de) | 2004-06-15 |
| DE60103342D1 (de) | 2004-06-24 |
| CA2357687C (en) | 2006-03-14 |
| ES2220677T3 (es) | 2004-12-16 |
| GB0023074D0 (en) | 2000-11-01 |
| PT1191026E (pt) | 2004-10-29 |
| EP1191026B1 (en) | 2004-05-19 |
| JP3545735B2 (ja) | 2004-07-21 |
| TR200401185T4 (tr) | 2004-06-21 |
| BR0104141A (pt) | 2002-07-09 |
| JP2002128780A (ja) | 2002-05-09 |
| DE60103342T2 (de) | 2004-09-23 |
| EP1191026A1 (en) | 2002-03-27 |
| CA2357687A1 (en) | 2002-03-20 |
| DK1191026T3 (da) | 2004-06-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |