MXPA01000076A - The use of an anti-microbial compound for disinfection - Google Patents

Abstract

The present invention relates to the use of a liquid disinfecting solution comprising an anti-microbial having low volatility to provide long lasting disinfection.

Description

THE USE OF AN ANTIMICROBIAL COMPOUND FOR DISINFECTION TECHNICAL FIELD The present invention relates to the use of a liquid disinfectant solution comprising an antimicrobial compound for disinfecting various surfaces and covering inanimate surfaces such as hard surfaces, such as walls, tiles, floors, top countertops, tables, glass, room surfaces, bathroom, kitchen surfaces. Advantageously, the present compositions also provide excellent cleaning performance, excellent gloss.

BACKGROUND The antimicrobial compositions contain materials that have the ability to disinfect. It is generally recognized that a disinfectant material gradually produces or even eliminates microorganisms that exist on a surface. Although disinfectant compositions based on known disinfectant materials bleach, quaternary ammonium compounds, essential oil or the like, provide good immediate disinfecting properties do not have a disinfectant activity of the compositions for prolonged periods after application to a hard surface, . ^. r ^. ? ., S! > .Í ^^^^^^ Ít? ISSÁM .. ^. '^ .. ^ J > .. -. jMitZ, jnc ¿fc ^ Bi *. - > to disinfect. Consumers are also looking for disinfectant compositions that, in addition to the disinfectant properties, also provide excellent cleaning performance, especially in greasy soils which do not leave visible formation / films on the surface 5 at the time of drying. It is therefore an object of the present to provide not only effective disinfecting performance of any treated surface, with maximum efficiency, but also a greatly prolonged disinfecting action after its application. Another object of the present invention is to provide compositions that provide, in addition to immediate and long-lasting disinfecting properties, also excellent cleaning performance which at the same time further enhance the gloss on the treated surface. Advantageously, the effective immediate disinfecting performance as well as the long-term disinfecting performance, 5 using a low total level of disinfectant materials, is provided. An advantage of the present compositions is that they can be used to provide effective and long-lasting immediate disinfection on any surface, even at high dilution surfaces, ie until free from elution of 1: 100 (composition: water). Another advantage of the present invention is that immediate and long-term disinfection is provided over a wide variety of pure bacterial strains including gram-positive and gram-negative bacterial strains. In a preferred aspect of the present invention the combination of a peroxygen bleach and / or an antimicrobial essential oil or active ingredient thereof and an antimicrobial compound as described herein is particularly effective of Gram negative bactericose sepals.

BRIEF DESCRIPTION OF THE INVENTION According to the present invention, the use of a liquid disinfectant solution comprising an antimicrobial compound of low volatility to provide long-lasting disinfection is provided. The present invention also encompasses a method for disinfecting a hard surface in which a liquid disinfectant composition is applied on said surface. The present invention also encompasses also the use of said liquid disinfectant composition as defined herein, packaged in a spray dispenser, as well as a cleaning cloth impregnated with a liquid disinfectant composition as defined herein.

DETAILED DESCRIPTION OF THE INVENTION ANTIMICROBIAL COMPOUND The present invention relates to the use of a liquid disinfectant composition comprising a low antimicrobial compound volatility as an essential ingredient of it. By "antimicrobial compound" is meant any known ingredient that has the ability to reduce or even eliminate killing microorganisms that exist on a surface. In a preferred aspect of the present invention, the liquid disinfectant solution is a composition comprising an antimicrobial compound and those optional ingredients, examples of which are described later. The antimicrobial compound selected for use in the present invention exhibits low volatility. The term "low volatility" as used herein is defined as a compound that does not evaporate immediately and therefore remains on the surface on which it is applied. In a preferred aspect of the present invention, the antimicrobial compound has a vapor pressure of less than 0.1 mm HG when measured at 20 ° C using typical methods of calculating the vapor pressure. In another preferred aspect, the antimicrobial compound of the group consisting of citric acid, benzoic acid, benzophenone or mixtures thereof is selected. The antimicrobial compound may be in solid form, but is preferably in liquid form. Citric acid is a particularly preferred antimicrobial compound. Citric acid is commercially available as an aqueous solution of Jungbunziauer with the name of factory Citric acid®. The antimicrobial compound is preferably present in an effective amount. By effective amount, an amount is implied ^^^^^^ ját ^ gg ^^^^^^^^^^^^^^ K ^^^^^^^^^^^^^^^^^^^^ enough to allow that the antimicrobial compound performs its action, that is, produces the number of microorganisms that exist in a given surface. The effective amount differs depending on the antimicrobial compound. Typically, the compositions of the present invention comprise from 0.001% to 10% by weight of the total composition of an antimicrobial compound, preferably from 0.01% to 5% and more preferably from 0.1% to 3%. The effective disinfecting performance is obtained with the compositions according to the present invention on a variety of microorganisms including Gram negative bacteria such as Pseudomonas aeroginosa, Escherichia coli, Salmonella as well as on Gram positive bacteria such as Enterococcus hirae, Staphylococcus aureus, present on infected surfaces. , it is even used under highly diluted conditions, for example up to a dilution level of 1: 100 (composition: water). The disinfectant properties of a composition according to the present invention, by the bactericidal activity of said composition. A suitable test method for evaluating the bactericidal activity of a composition on infected surfaces is described in the European standard prEN 1040, CEN / TC 216 N 78, dated November 1995, issued by the European Committee for Standardization, Brussels. The European standard prEN 1040, CEN TC 216 N 78, specifies a test method and requirements for the minimum bacterial activity of a disinfectant composition. The compositions according to the present invention pass this test even if it is used under highly diluted conditions. Other suitable methods are the dilution method of AOAC use, in the germicidal expression method of AOAC in cleaning cloth methods with AOAC (EUA) and AFNOR T72-190 (Europe). The disinfection properties can be measured in the present invention. long-lasting compositions by bactericidal activity of said compositions. A suitable test method for evaluating the long-lasting bactericidal activity of a composition can be as follows: firstly, the surfaces (for example glass) to be tested respectively are treated either with a composition in accordance with the present invention or a reference composition, for example a negative control composed of pure water (by spraying the composition directly onto the surface or by first sprinkling the composition on a sponge used to clean the surface or when the composition of the present invention is executed in the form of cleaning cloth rubbing the surface with it). After a variable type frame (for example 12-24 hours) the surface was inoculated respectively with bacteria (105"7 cfu / slides) grown for example in TSB (Tryptone / Soybean) and is typically left in a few seconds. 2 hours before evaluating the remaining living bacteria, then live bacteria (if any) are recovered on the surface (but suspending the bacteria in the neutralization cloth and growing on an agar plate) and incubated at the appropriate temperature, for example 37 ° C to let them grow typically during the night Finally, an evaluation of the residual antibacterial effectiveness of the composition is made, cultivating the cultures and / or the dilutions thereof (for example 10 ~ 2 or 10). * 1) resulting from the 5 surfaces treated with the compositions according to the present invention and the reference composition.

Optional ingredients The liquid disinfectant solution as described herein may in fact be a component of a disinfectant composition. A disinfectant composition may comprise a variety of ingredients, for example an additional disinfectant material, surfactant, chelating agents, preferably radicals, solvents and pH regulators as described in more detail below. 15 Additional Disinfectant Materials Suitable disinfectant materials are those known to those skilled in the art for the purpose of disinfecting and may include bleaching agents such as peroxygen bleach and / or chlorine-type bleaches, antimicrobial essential oils or active ingredients thereof. , quaternary ammonium compounds, phenolic compounds, aldehydes such as glutaldehyde, formaldehyde, glyoxal, - - »---" - ^ - * - = • '* - ~ "« r ". _ ^ _ -JS - A-.. ^, .. ^. * Me m» «^ ..,. "..., ... .... ^. ^" ^ ^^ - parabens such as ethylparaben, propylparaben, methylparaben, organic acids and peroxyacids, alcohols and mixtures thereof Preferred disinfectant materials for use herein include a peroxygen bleach, or an antimicrobial essential oil, an active ingredient thereof, or a mixture of a peroxygen bleach and such an antimicrobial essential oil or an active ingredient thereof A preferred disinfectant material for use herein is a peroxygen bleach or a mixture thereof A preferred peroxygen bleach is hydrogen peroxide, or a water soluble source thereof, or mixtures thereof Hydrogen peroxide is most preferred to be used herein The presence of peroxygen bleach, especially hydrogen peroxide in the compositions according to the to present invention, contributes to the disinfecting properties of said compositions. Indeed, said peroxygen bleach can attack the vital function of the cells of the microorganisms, for example, it can inhibit the assembly of ribosome units within the cytoplasm of the cells of the microorganisms. Also peroxygen bleach, such as hydrogen peroxide is an oxidant that generates hydroxyl free radicals that attack proteins and nucleic acids. In addition, the presence of peroxygen bleach, especially hydrogen peroxide, provides good stain removal benefits when used in any application on hard surfaces. As used herein, a source of hydrogen peroxide refers to any compound that produces hydrogen peroxide when said compound is in contact with water. Suitable water-soluble sources of hydrogen peroxide for use herein include percarbonates, persilicates, persulfates, such as monopersulfate, perborates and peroxyacids such as diperoxydodecanoic acid (DPDA), magnesium-perphthalic acid and mixtures thereof. In addition, other classes of peroxide may be used as an alternative to hydrogen peroxide and sources thereof or in combination with hydrogen peroxide and sources thereof. Suitable classes include dialkyl peroxides, diacyl peroxides, preformed percarboxylic acids, peroxides and / or organic and inorganic hydroperoxides. Typically, it is present in peroxygen bleach compositions or a mixture thereof according to the present invention at a level of up to 20% by weight of the total composition, preferably from 0.1% to 15% and more preferably 0.5% to 10%. Another particularly preferred disinfectant material for use herein is an antimicrobial essential oil or an active ingredient thereof, or a mixture thereof.

The antimicrobial essential oils suitable for use herein are those essential oils that exhibit antimicrobial activity. By "active ingredients of essential oils", herein is meant any essential oil ingredient exhibiting antimicrobial activity. It is speculated that said antimicrobial essential oils and active ingredients thereof act as protein denaturing agents. Such antimicrobial essential oils include, but are not limited to, those obtained from thyme, lemon verbena, cider, lemons, orange, anise, clove, anise seed, pine, cinnamon, geranium, roses, mint, lavender, lemon balm, eucalyptus, peppermint, camphor, ajowan, sandalwood, rosemary, verbena, pulguera, luisa grass, ratanhiae, cedar and mixtures thereof. Preferred antimicrobial essential oils to be used herein are thyme oil, clove oil, cinnamon oil, geranium oil, eucalyptus oil, peppermint oil, lemon balm oil, ajowan oil, peppermint oil or mixtures thereof. same. The active ingredients of the essential oils to be used herein include, but are not limited to the same rudder (present for example in thyme, ajowan), eugenol (present for example in cinnamon and cloves), menthol (present for example in mint), geraniol (present for example in the geranium and rose, lemon balm), verbenone (present for example in verbena), eucalyptol and pinocarbona (present in eucalyptus), cedrol (present for example in cedar), anethole (present for example in anise), carvacrol , hinoquitiol, berberine, ferulic acid, cinnamic acid, methylsalicylic acid, methylsalicylate, terpinol, limonene and mixtures thereof. The preferred active ingredients of essential oils to be used herein are thymol, eugenol, verbenone, eucalyptol, terpinol, cinnamic acid, methylsalicylic acid, limonene, geraniol or mixtures thereof. Thymol can be commercially available for example from Aldrich-Manheimer Inc., eugenol can be commercially available for example from Sigma, System-Bioindustries (SBI) -Manheimer Inc. Typically, the antimicrobial essential oil or the active ingredient thereof or the mixture thereof is present in the composition at a level of up to 20% by weight of the total composition, preferably at a level of at least from 0.03% to 10%, more preferably from 0.006% to 10%, even more preferably 0.01 % to 8% and most preferably from 0.03% to 3%. A highly preferred embodiment of the compositions herein combines said antimicrobial essential oil or an active ingredient thereof or a mixture thereof with peroxygen bleach. The quaternary ammonium compounds suitable for use herein are quaternary ammonium compounds containing alkyl or substituted alkyl groups, alkylamide or carboxylic acid groups, ether groups, unsaturated alkyl groups and cyclic quaternary ammonium compounds, which may be chlorides, dichlorides , bromides, methylsulfates, chlorphenatos, cycloalkylsulfonates or salts of the other acids. Among the possible cyclic quaternary ammonium compounds are the following: alkylpyridinium chloride and / or sulfates, the alkyl group preferably being ethyl, dodecyl or hexadecyl groups; 5-alkyl isoquinolyl chlorides and / or bromides, the alkyl group preferably being a dodecyl group. Particularly suitable quaternary ammonium compounds for use herein include alkyldimethylbenzylammonium chloride, octyldecyldimethylammonium chloride, dioctyldimethylammonium chloride, didecyldimethylammonium chloride, alkyldimethylammonium saccharinate, cetylpyridinium, and mixtures thereof. Suitable phenolic compounds for use herein include o-phenyl-phenol, or benzyl (p-chlorophenol), 4-teramylphenol and mixtures thereof. Other disinfectant materials suitable for use herein include bleach type chlorine such as hypochlorite.

Surfactants The compositions according to the present invention may further comprise a surfactant or mixtures thereof. The 20 surfactants suitable for use herein may be any surfactant known to those skilled in the art, including anionic, nonionic, cationic, amphoteric surfactants . "" ^^ .T ^ ... ... -. * ^ .. ^. - ,. - -. _ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^^^^^^^^^^^ ~ .. í ^. ^. - ^ ^ i ^. and / or zwitterionics. The surfactants contribute to cleaning performance of the disinfectant compositions of the present invention. Particularly suitable anionic surfactants for use herein include water soluble salts or acids of the formula ROS03M where R is preferably a C6-C2 hydrocarbyl, preferably an alkyl or hydroxyalkyl having a C- or C2o alkyl component, more preferably an alkyl or C 2 -C 2 hydroxyalkyl, and M is H or a cation, for example an alkali metal cation (for example sodium, potassium, lithium), or ammonium or substituted ammonium (for example methyl cations) -, dimethyl-, and trimethylammonium and quaternary ammonium cations, such as tetramethylammonium and dimethylpiperidinium cations and quaternary ammonium cations derived from alkylamines such as ethylamine, diethylamine, triethylamine and mixtures thereof, and the like). Other anionic surfactants suitable for use herein include alkyldiphenylether sulfonates and alkylcarboxylates. Other anionic surfactants may include salts (including, for example, sodium, potassium, ammonium and substituted ammonium salts such as mono-, di- and triethanolamine salts) of soap, C9-C20 linear alkylbenzenesulfonates, primary or secondary alkenesulfonates of Cs-C22 > CB-C2 olefinsulfonates, sulfonated polycarboxylic acids prepared for sulfonation of the pyrolyzed product of alkali metal citrates, for example as described in British Patent Specification No. 1,082,179, alkyl polyglycol ether sulphates (containing up to 10 moles of ethylene oxide) ); riMaariÉrflMa ^ | Glykyl-sulfonates such as methyl-ester sulphonates of Cu-C-iß; acylglycerol sulfonates, oleylglycerol fatty sulfonates, alkylphenolthylene ether sulphates, paraffinsulfonates, alkyl phosphates, and isethionates such as acyl isethionates, N-acyltaurates, alkylsuccinamates and sulfosuccinates, sulfosuccinate monoesters (especially saturated and unsaturated C? 2-C-?? monoesters) , diesters of sulfoccinate (especially diesters of Cß-C-saturated and unsaturated), acyl sarcosinates, sulfates of alkylpolysaccharides such as alkyl polyglycoside sulphates (the non-sulphonated non-ionic compounds are described later), branched primary alkyl sulphates, alkylpolyethoxycarboxylate such as those of the formula RO (CH2CH20) kCH2COO-M + where R is C8-C22 alkyl, k is an integer from 0 to 10 and M is a soluble salt-forming cation. Resin acids and hydrogenated resin acids are also suitable, such as rosin, hydrogenated rosin, and hydrogenated resin acids and resin acids present in the wood oil or derivatives thereof. Other examples are given in "Surface Active Agents and Detergents" (Vol. I and II by Schwartz, Perry and Berch). A variety of such surfactants are also generally described in the E: U.A patent. 3,929,678, issued December 30, 1975 to Laughlin, et al., At column 23, line 58 to column 29 line 23 (incorporated herein by reference). Preferred anionic surfactants for use in the compositions herein are alkylbenzene sulfonates, alkylsulfates, alkoxylated alkylsulfates, parafinsulfonates and mixtures thereof.

^ '^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^ The amphoteric surfactants suitable for use herein include amine oxides having the following formula R1R2R3NO wherein each of R1, R2, R3, is independently a saturated or unsubstituted, straight or branched, hydrocarbon chain, of 1 to 30 carbon atoms. Preferred amine oxide surfactants for use in accordance with the present invention are amine oxides having the following formula R? R2R3NO wherein R1 is a hydrocarbon chain comprising from 1 to 30 carbon atoms, preferably from 6 to 20, more preferably from 8 to 16, most preferably from 8 to 12, and wherein R 2 and R 3 are independently substituted or unsubstituted, straight or branched hydrocarbon chains, of 1 to 4 carbon atoms, preferably 1 to 3 carbon atoms, and more preferably are methyl groups. R1 can be a saturated or unsubstituted, straight or branched hydrocarbon chain. Amine oxides suitable for use herein are for example a natural mixture of C-iß-C-to amine oxide as well as C? 2-C? B amine oxides commercially obtained from Hoechst. The zwitterionic surfactants suitable for use herein contain both cationic and anionic hydrophilic groups on the same molecule in a relatively broad pH range. The typical cationic group is a quaternary ammonium group, although other positively charged groups can be used such as phosphonium, imidazolium and sulfonium groups. Typical anionic hydrophilic groups are carboxylates and sulfates, although other groups such as sulfates, phosphonates and the like can be used. A generic formula for some zwitterionic surfactants to be used herein is where R1 is a hydrophobic group; R2 and R3 are in each case C1-C4 alkyl, hydroxyalkyl or another substituted alkyl group which can also be linked to form ring structures with the N; R4 is a moiety joining the cationic nitrogen atom to the hydrophilic group and is typically an alkylene, hydroxyalkylene or polyalkoxy group containing from 10 carbon atoms; and X is the hydrophilic group which is preferably a carboxylate or sulfate group. Preferred hydrophobic groups R1 are alkyl groups containing from 1 to 24, preferably less than 18, more preferably less than 16 carbon atoms. The hydrophobic group may contain unsaturation and / or substituents and / or linking groups such as aryl groups, amido groups, ester groups and the like. In general, simple alkyl groups are referred for reasons of cost and stability. Highly preferred zwitterionic surfactants include betaine and sulfobetaine surfactants, derivatives thereof or mixtures thereof. Such betaine or sulfobetaine surfactants are preferred herein, as they aid in disinfection by increasing the permeability of the bacterial cell wall, thereby allowing other active ingredients to enter the cell.

In addition, due to the mild action profile of said betaine or sulfobetaine surfactants, they are particularly suitable for cleaning delicate surfaces, for example surfaces in contact with food and / or babies. The betaine or sulfobetaine 5 surfactants are also extremely mild to the skin and / or the surfaces to be treated. The betaine and sulphobetaine surfactants to be used herein are the betaine / sulfobetaine or betaine-like detergents in which the molecule contains alkali and acid groups which form an internal salt giving the molecule hydrophilic groups as cationic as anionic on a wide range of pH values. Some common examples of such detergents are described in US Patents 2,082,275, 2,702,279 and 2,255,082, incorporated herein by reference. The preferred betaine and sulfobetaine surfactants herein are according to the formula: wherein R1 is a hydrocarbon chain containing from 1 to 24 carbon atoms, preferably from 8 to 18, more preferably from 12 to 14, wherein R2 and R3 are hydrocarbon chains containing from 1 to 3 carbon atoms , preferably a carbon atom, wherein n is an integer from 1 to 10, preferably from 1 to 6, more preferably is 1, and Mfa ^ w¿HutHriar ^ | i | BM_Hj3 || £ H ^^ selects from the group consisting of carboxyl and sulfonyl radicals and wherein the sum of the hydrocarbon chains R1, R2 and R3 is from 14 to 24 carbon atoms, or mixtures thereof. Examples of particularly suitable betaine surfactants include C12-C18 alkyldimethylbetaine such as coco-betaine and C10-C16 alkyldimethylbetaine such as laurylbetaine. Coco-betaine is commercially available under the trade name of Amonyl 265®. Laurylbetaine is commercially available from Albright & Wilson with the factory name Empigen BB / L®. Other specific zwitterionic surfactants have the generic formula: R1-C (0) -N (R2) - (C (R3) 2) nN (R2) 2 (+) - (C (R3) 2) n-S03 (- ) or R? -C (O) -N (R2) - (C (R3) 2) nN (R2) 2 (+) - (C (R3) 2) n -COO (-) wherein each Ri is a hydrocarbon, for example an alkyl group containing from 8 to 20, preferably up to 18, more preferably up to 16 carbon atoms, each R 2 is either a hydrogen (when attached to the nitrogen amide), short chain alkyl or substituted alkyl which contains from 1 to 4 carbon atoms, preferably groups selected from the group consisting of ethyl, propyl, ethyl or hydroxy-substituted propyl and mixtures thereof, preferably methyl, each R3 is selected from the group consisting of hydrogen and hydroxy groups, and each n is a number from 1 to 4, preferably from 2 to 3, more preferably 3, with no more than one hydroxy group in any portion (C (R3) 2). The R- groups can be branched , - - ». «^» > - _, .. ^^. ¿¿¿^ AdáS * ^ and / or unsaturated. The groups R2 can also be connected to form ring structures. Such a surfactant is a C10-C14 fatty acid acylamidopropylene (hydroxypropylene) sulfobetaine obtainable from Sherex Company under the trade name "Varion CAS sulfobetaine" ®. Suitable nonionic surfactants for use herein are fatty alcohol ethoxylates and / or propoxylates which are commercially obtainable with a variety of fatty alcohol chain lengths and a variety of degrees of ethoxylation. In fact, the HLB values of such alkoxylated nonionic surfactants depend essentially on the chain length of the fatty alcohol, the nature of the alkoxylation and the degree of alkoxylation. These available catalogs of surfactants that list a number of surfactants, including nonionic surfactants, together with their respective HLB values. Particularly suitable for use herein as nonionic surfactants, states of non-ionic hydrophobic surfactants having a HLB (hydrophilic-lipophilic balance) less than 16, preferably less than 15, more preferably less than 12, and most preferably less than 10. It has been found that these hydrophobic nonionic surfactants provide good fat cutting properties. Preferred hydrophobic nonionic surfactants for use in the compositions according to the present invention are surfactants having an HLB less than 16 and which are in accordance with the formula RO- (C2H40) n (C3H6O) mH, in where R is an alkyl chain of C6 to C22 or an alkylbenzene chain of CQ to C2s and wherein n + m is from 0 to 20 and n is from 0 to 15 and m is from 0 to 20, preferably n + m is from 1 to 20 15 and n + m is from 0.5 to 15, more preferably n + m is from 1 to 10 and n + m is from 0 to 10. Preferred R chains for use herein are C C to C22 alquilo alkyl chains. In accordance, the hydrophobic nonionic surfactants suitable for use herein are Dobanol R 91-2.5 (HLB = 8.1; R is a mixture of alkyl chains from Cg to Cu, n is 2.5 and m is 0), or Lutensol R T03 (HLB = 8, R is an alkyl chain of C? 3, n is 3 and m is 0) or Lutensol R AO3 (HLB = 8; R is a mixture of C ?3 to C15 alkyl chains, n is 3 and m is 0) or Tergitol R 25L3 (HLB = 7.7; R is in the lengths of alkyl chains of C-? 2 to C15, n is 3 and m is 0) or Dobanol R 23-3 (HLB = 8.1, R is a mixture of alkyl chains of C-? 2 to C-? 3, n is 3 and m is 0) or Dobanol R 23- 2 (HLB = 6.2, R is a mixture of C 2 to C 13 alkyl chains, n is 2 and m is 0) or Dobanol R 45-7 (HLB = 11.6, R is a mixture of C to C15 alkyl chains, n is 7 and m is 0) Dobanol R 23-6.5 (HLB = 11.9, R is a mixture of C-? 2 to C13 alkyl chains, n is 6.5 and m is 0) or Dobanol R 25-7 (HLB = 12; R is a mixture of alkyl chains of C 2 to Cis, n is 7 and m is 0) or Dobanol R 91-5 (HLB = 11.6, R is a mixture of alkyl chains from Cg to Cu, n is 5 and m is 0 ) or Dobanol R 91-5 (HLB = 12.5, R is a mixture of alkyl chains from Cg to Cu, n is 6 and m is 0) o Dobanol R 91-8 (HLB = 13.7; R is a mixture of alkyl chains of C9 to Cu, n is 8 and m is 0), Dobanol R 91-10 (HLB = 14.2, R is a mixture of alkyl chains from Cg to Cu, n is 10 and m is 0), or mixtures thereof. Preferred in the present are Dobanol R 91-2.5, or Lutensol R TO3, or Lutensol R AO3, or Tergitol R 25L3, or Dobanol R 23-3, or Dobanol R 23-2, or mixtures thereof. These Dobanol R surfactants are commercially obtainable from SHELL. These Lutansol R surfactants are commercially obtainable from BASF and those Tergitol R surfactants are commercially available from CARBIDE UNION. Typically, the surfactant or mixtures thereof may be present in the composition of the present invention at a level of from 0.01% to 50% by weight of the total composition, preferably from 0.01% to 30% and more preferably from 0.05% to 20%. %.

Polyalkylene glycol alkyl ether The compositions described herein may comprise a polyalkylene glycol alkyl ether, as hereinafter defined, or mixtures thereof. Typically, if present, the composition may comprise a polyalkylene glycol alkyl ether or a mixture thereof even at 0. 001% to 10%, preferably from 0.005% to 2%, and more preferably from 0.01% to 1%, even more preferably from 0.05% to 0.5% and most preferably from 0.08% to 0.4% by weight of the total composition. The polyalkylene glycol alkyl ethers suitable for use herein are according to the following formula: RrO- (CH2-CHR20) n -R3 wherein Ri and R2 are independently in each case hydrogen or a substituted or unsubstituted, saturated or unsaturated, linear or branched hydrocarbon chain, having from 1 to 30 carbon atoms or a linear or branched hydrocarbon chain, including hydroxy, having 1 to 30 carbon atoms, R3 is a substituted or unsubstituted, saturated or unsaturated, straight or branched hydrocarbon chain having from 1 to 30 carbon atoms, or a linear or branched hydrocarbon chain including hydroxy, having 1 to 30 carbon atoms, n is a number greater than 2, or a mixture thereof. Preferably, R1 and R2 are independently in each case hydrogen, or an alkyl group or substituted or unsubstituted, linear or branched alkylene group having 1 to 30 carbon atoms, preferably 1 to 16 carbon atoms, more preferably 1 to 8 and most preferably from 1 to 4, or a linear or branched alkyl or alkenyl group including hydroxy, having from 1 to 30 carbon atoms more preferably from 1 to 16, still more preferably from 1 to 4 and most preferably R1 and R2 are methyl or hydrogen. Preferably, R3 is an alkyl group or substituted or unsubstituted alkenyl group, linear or branched, having from 1 to 30 carbon atoms, preferably from 1 to 16 carbon atoms, more preferably from 1 to 8 and most preferably from 1 to 4, or a substituted or unsubstituted, saturated or unsaturated, linear or branched aryl group, have up to 30 atoms .,. *. . . - ^ - ^^ ?. The carbon atom, preferably from 3 to 16, more preferably from 4 to 8 carbon atoms, or linear or branched alkyl or alkenyl group including hydroxy, having from 1 to 30 carbon atoms more preferably from 1 to 16, still more preferably from 1 to 8 and most likely R3 is butyl, Preferably, n is a number of 3, preferably from 3 to 2300, more preferably from 3 to 100, more preferably from 3 to 20 and most preferably from 3 to 10. The polyalkylene glycol alkyl ethers for use herein preferably have an average molecular weight of 164 to 100 000, more preferably from 180 to 10,000 and most preferably from 200 to 1,000. Polyalkylene glycol alkyl ethers suitable for use herein include polypropylene glycol monobutyl ether, polyethylene glycol copropylene glycol monobutyl ether, polyethylene glycol dimethyl ether, polyethylene glycol propylene glycol dimethylether, polyether stearate. tilenglicol or mixtures thereof. The polypropylene glycol monobutyl ether (average molecular weight 340) is commercially available from Aldrich or Union Carbide as Ucon-lb 65®.

Chelating Agents The compositions herein may further comprise a chelating agent as a preferred optional ingredient. Suitable chelating agents can be any of the known chelating agents. skilled in the art such as those selected from the group comprising phosphonate chelating agents, aminocarboxylate chelating agents or other carboxylate chelating agents, or polyfunctionally substituted aromatic chelating agents or mixtures thereof. Such phosphonate chelating agents can include etidronic acid (1-hydroxymethylene bisphosphonic acid or HEDP) as well as aminophosphonate compounds, including aminoalkylenepolyalkylenephosphonate, ethane-1-hydroxydisphosphonates, nitrilotrimethylenephosphonates, ethylenediaminetetramethylene phosphonates, and diethylenetriaminpentamethylenephosphonates of alkali metals. The phosphonate compounds can be present either in their acid form or as salts of different cations on some or all acidic functionalities. Preferred phosphonate chelating agents to be used herein are diethylenetriaminpentamethylenephosphonates. Such phosphonate chelators are commercially available from Monsanto under the trade name DEQUEST®. Polyfunctionally substituted aromatic chelating agents may also be useful in the compositions herein. See the patent of E.U.A. 3,812,044, issued May 21, 1974 to Connor et al. Preferred compounds of that type in acid form are dihydroxydisulfobenzenes such as 1,2-dihydroxy-3,5-disulfobenzene. A preferred biodegradable chelating agent for use herein is ethylene diamine N, N'-disuccinic acid, or alkaline or alkaline earth metal salts, ammonium or substituted ammonium thereof or mixtures thereof.

^ ¿^ ^ G ^ ^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^ * l ^^ ^ & ^ themselves. Ethylene diamine-N'-disuccinic acids, especially the (S, S) isomer, have been extensively described in the U.S.A. 4,704,233, issued November 3, 1987 to Hartman and Perkins. Ethylenediamine-N, N'-disuccinic acid is commercially available, for example, under the ssEDDS® factory name from Palmer Research Laboratories. Suitable aminocarboxylate chelating agents useful herein include ethylenediaminetetraacetates, diethylenetriaminpetaacetates, diethylenetriaminpentoacetate (DTPA), N-hydroxyethylenediaminetriacetates, nitrilotriacetates, ethylenediaminetetraproprionates, triethylenetetraminehexaacetates, ethanoldiglicines, propylenediaminetetraacetic acid (PDTA), and methylglycylaceaietic acid (MGDA), both in their acid form, as in its alkali metal, ammonium and substituted ammonium salt forms. Particularly suitable for use in the present are diethylenetriaminpentaacetic acid (DTPA), propylene diamine tetraacetic acid (PDTA) which is commercially obtainable, for example from BASF under the trade name Trilon FS® and methylglycliciacetic acid (MGDA). Other carboxylate chelating agents to be used herein include malonic acid, salicylic acid, glycine, aspartic acid, glutamic acid or mixtures thereof. Such chelating agents, especially phosphonate chelating agents such as diethylenetriaminpentamethylene phosphonates, are particularly preferred in the compositions according to the present invention. invention, since they have been found to further contribute to the disinfeg properties of the compositions herein. Typically, the compositions according to the present invention comprise up to 5% by weight of the total composition of a chelating agent, or mixtures thereof, preferably from 0.002% to 3% by weight and more preferably 0.002% to 1.5%.

Radical scavengers The compositions herein may further comprise a radical scavenger as a preferred optional ingredient. Radical scavengers suitable for use herein include the well-known substituted mono- and dihydroxybenzenes and derivatives thereof, alkyl- and arylcarboxylates and mixtures thereof. Preferred radical scavengers for use herein include diterbutylhydroxytoluene, hydroquinone, diterbutylhydroquinone, monoterbutylhydroquinone, tert-butylhydroxyanisole, benzoic acid, toluic acid, catechol, t-butylcatechol, 2-methoxy-phenol, 2-ethoxy-phenol, 4-allyl- catechol, 2-methoxy-4- (2-propenyl) phenol, benzylamine, 1, 1) 3-tris (2-methyl-4-hydroxy-5-t-butylphenyl) butane, as well as n-propyl gallate. It is highly preferred for use in the present di-tert-butylhydroxytoluene, which is commercially available from SHELL under the trade name IONOL CP®. Typically, the compositions according to the present invention comprise up to 5% by weight of the total composition of a * iéti:? .. ??? iá?. ^ áSáitsíSé® & * t .. 4cSr «radical scavenger, or mixtures thereof, preferably from 0.01% to 1.5% by weight and more preferably from 0.01% by weight 1 %.

Solvents The compositions herein may comprise as an optional ingredient a solvent or mixtures thereof. When used, the solvents will advantageously give enhanced cleaning to the compositions of the present invention, solvents suitable for incorporation into the compositions according to the present invention include propylene glycol derivatives such as n-butoxypropanol or n-butoxypropoxypropanol, or CARBITOL® solvents soluble in water or CELLOSOLVE® solvents soluble in water. CARBITOL® solvents are compounds of the 2- (2-alkoxyethoxy) ethanol class among the alkoxy group derived from ethyl, propyl or butyl. A preferred water-soluble carbitol is 2- (2-butoxyethoxy) ethanol) also known as butylcarbitol. Water-soluble CELLOSOLVE® solvents are compounds of the 2-alkoxyethoxyethanol class, with 2-butoxyethoxyethanol being preferred. Other suitable solvents are benzyl alcohol, methanol, ethanol, isopropyl alcohol and diols such as 2-ethyl-1,3-hexanediol and 2,2,4-trimethyl-1,3-pentanediol and mixtures thereof. Preferred solvents for use herein are n-butoxypropoxypropanol, butyl carbitol® and mixture thereof. A very preferred solvent for use herein is carbitol®.

Solvents may typically be present within the compositions of the invention at a level of up to 15% by weight and preferably from 1% to 7% by weight of the composition.

PH Regulators Typically, the liquid compositions of the present invention have a pH such as less than 14.0, more preferably 1 to 10, and most preferably 2 to 9. The pH of the compositions can be adjusted using organic and inorganic acids , alkalizing agents as pH regulators, that is to say a system constituted of a compound or a combination of compounds, whose pH changes only slightly when a strong acid or base is added. PH regulators suitable for use herein in a neutral to alkaline condition include a pH buffer of borate, phosphonate, silicate and mixtures thereof. Borate pH regulators suitable for use herein include alkali metal salts of borates and alkylborates and mixtures thereof. Borate pH regulators suitable for use herein are alkali metal salts of borate, metaborate, tetraborate, octoborate, pentaborate, dodecaboro, boron trifluoride and / or alkyl borate containing from 1 to 12 carbon atoms and preferably from 1 to 12 carbon atoms. 4. The suitable alkylborate includes methylborate, ethylborate and propylborate. Particularly preferred here are the alkali metal salts of metaborate (for example sodium metaborate), A *;. ^ - * - ^,, -, - '- ^. ^^ j ^^^ aC ^. - - • -. ^, fct > ^ "... ^ tetraborate (for example, sodium tetraborate decahydrate) or mixtures thereof. Boron salts such as sodium metaborate and sodium tetraborate are commercially available from Bórax and Societa Chimica Larderello under the name of manufactures sodium metaborate® and Bórax®. In the embodiment of the present invention in which the compositions are formulated in the acid pH range (ie less than 7), preferably from 2 to 6, more preferably from 2 to 4, the compositions according to the present invention may comprise in addition a pH regulator or a mixture thereof, that is to say a system constituted of a compound or a combination of compounds, whose pH changes only slightly when a strong acid or base is added. PH regulators suitable for use herein in the acidic condition include organic acids and mixtures thereof. Organic acids suitable for use herein include monocarboxylic acids, dicarboxylic acids and tricarboxylic acids or mixtures thereof. Preferred organic acids for use herein include acetic acid, citric acid, malonic acid, maleic acid, malic acid, lactic acid, glutaric acid, glutamic acid, aspartic acid, methylisuccinic acid, succinic acid, or mixtures thereof. Particularly preferred here is succinic acid. Typically, the compositions according to the present invention may comprise up to 15% by weight of the total composition of - «• '< • '* - & & amp; amp; < - A pH regulator, or mixtures thereof, preferably from 0.01% to 10%, more preferably from 0.01% to 5% and most preferably from 0.1% to 3% %. The compositions herein may further comprise a variety of other optional ingredients such as builders, stabilizers, bleach activators, soil suspending agents, dye transfer agents, brighteners, perfumes, anti-dusting agents, enzymes, dispersants, inhibitors. of transfer of dyes, pigments, perfumes and dyes.

Form of treatment of the disinfectant compositions The compositions herein can be packaged in a suitable packaging variety for detergents known to those skilled in the art. The solution and / or disinfectant composition used herein is in liquid form and may be desirably packaged to manually operated spray dispenser containers. In accordance, the present invention also encompasses liquid compositions of the invention packaged in a post-spray dispenser, preferably in a trigger spray dispenser or in a pump spray dispenser. For example, said spraying type jets allow uniformly applying to a relatively large area of a surface to be disinfected the liquid compositions suitable for its use. r according to the present invention; thus contributing to the disinfecting properties of said compositions. Such spraying type jets are particularly suitable for disinfecting vertical surfaces. Spray-type dispensers suitable for use in accordance with the present invention include hand-operated foam trigger-type dispensers, sold for example by Specialty Packaging Products, Inc. or Continental Sprayers, Inc., these types of dispensers are disclosed, for example in US-4,701, 311 of Dunnining et al. and US-4,646,973 and US-4,538,745 both from Focarracci. Particularly preferred to be used herein are spray type sprays such as T 8500® or T8900® commercially available from Continental Sprayers International or T 8100® commercially available from Canyon, Northern Ireland. In such assortment the liquid composition is divided into fine liquid droplets resulting in a spray that is directed on the surface to be treated. In fact, in such sprayer type jet the composition obtained in the body of said dispenser is directed through the sprayer head of the spraying type by energy communicated to a pumping mechanism by the user, as said user activates said mechanism pumping. More particularly, in said sprinkler head of the sprinkler type, the composition is forced against an obstacle, for example against a grid or a cone or the like, thus providing shocks to help atomize the liquid composition, ie to assist in the formation of Droplets of liquid. -. ' ¿. »> ",:" The solutions / compositions of the present invention can also be attached in the form of cleaning cloths. By "wiping cloths", disposable wipes incorporating a disinfectant composition according to the present invention are intended herein. Preferably, such cleaning cloths are packed in a plastic box. In accordance, the present invention also encompasses cleaning wipes incorporating a composition as described hereinbefore. Preferably, said wipes are impregnated / moistened with a liquid disinfectant composition as described herein. The advantage of this embodiment is a faster use of a disinfectant composition by the user, even outside the home, ie there is no need to pour, for example, the liquid compositions according to the present invention onto the surfaces to be disinfected. and dry it with a cloth. In other words, the cleaning cloths 15 allows the disinfection of surfaces in one step.

PROCESS FOR DISINFECTING A HARD SURFACE The present invention relates to the use of a solution and / or disinfectant composition to provide long-lasting disinfection. These results are achieved by applying the disinfection solution / composition as described above to a hard surface by optionally equalizing said hard surface after application. 'rrttt n- t-' tf? nw- '- -nriifrihWitr r - -. ..r, *, * ^ ** ** »* ^. .. ».-, ja *. - - - .-, -. - :. «, ..

Hard surfaces include those typically found in homes such as kitchens, bathrooms, such as tiles, walls, floors, chrome, glass, smooth vinyl, any plastic, laminated wood, table tops, sinks, stove tops, dishes , sanitary facilities such as dumps, showers, shower curtains, toilets, toilets and the like. Hard surfaces also include household appliances including, but not limited to, refrigerators, freezers, washing machines, automatic dryers, ovens, microwave ovens, dishwashers, etc. The disinfectant solution / composition as described herein can be applied in liquid form to the surface to be disinfected in its pure form or in its diluted form typically at a dilution level up to 100 times its weight of water, preferably of 80 to 2 times its weight of water, and more preferably 60 to 10 times. In a preferred use, the liquid disinfectant solution / composition is applied to a hard surface in its diluted form, where it is not necessary to rinse the surface after the composition has been applied thereto, as no visible residue is left on the surface. the surface. • r 'JHWp »~. ^. ?? tm * »s- ~ * to ?? é &e *! L- *. - ^ ». .., -_. ^^, «A ^".

EXAMPLES The present invention will be further illustrated with the following examples. In the following examples, all levels are cited in percent by weight of the composition.

Claims (5)

NOVELTY OF THE INVENTION CLAIMS

1. - The use of a liquid disinfectant solution comprising an antimicrobial compound that has low volatility to provide long-lasting disinfection.

2. The use according to claim 1, wherein the antimicrobial compound has a vapor pressure of less than 0.1 mm Hg when measured at 20 ° C.

3. The use according to any of the preceding claims, wherein the antimicrobial compound of the group consisting of citric acid, benzoic acid, benzophenone or mixtures thereof is selected.

4. A disinfectant solution according to any of the preceding claims.

5. A disinfectant composition comprising a disinfectant solution according to any of the preceding claims and an additional ingredient selected from the group consisting of additional disinfectant material, surfactant, chelating agent, radical scavenger, pH regulator and mixtures thereof. same.