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MXPA99001870A - Non-peptide tachykinin receptor antagonists. - Google Patents

Non-peptide tachykinin receptor antagonists.

Info

Publication number
MXPA99001870A
MXPA99001870A MXPA99001870A MX9901870A MXPA99001870A MX PA99001870 A MXPA99001870 A MX PA99001870A MX PA99001870 A MXPA99001870 A MX PA99001870A MX 9901870 A MX9901870 A MX 9901870A MX PA99001870 A MXPA99001870 A MX PA99001870A
Authority
MX
Mexico
Prior art keywords
receptor antagonists
tachykinin receptor
peptide tachykinin
compounds
peptide
Prior art date
Application number
MXPA99001870A
Other languages
Spanish (es)
Inventor
Henry Walker Lunn William
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of MXPA99001870A publication Critical patent/MXPA99001870A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/80—Radicals substituted by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Furan Compounds (AREA)

Abstract

This invention provides a series of substituted benzofurans and indoles useful as non-peptide tachykinin receptor antagonists. This invention also provides methods for treating or preventing conditions associated with an excess of tachykinins which methods comprise administration of one or more of the compounds of the instant invention as well as formulations employing the compounds of this invention.
MXPA99001870A 1993-12-21 1999-02-25 Non-peptide tachykinin receptor antagonists. MXPA99001870A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US17113493A 1993-12-21 1993-12-21

Publications (1)

Publication Number Publication Date
MXPA99001870A true MXPA99001870A (en) 2004-09-06

Family

ID=22622667

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA99001870A MXPA99001870A (en) 1993-12-21 1999-02-25 Non-peptide tachykinin receptor antagonists.

Country Status (7)

Country Link
EP (1) EP0736007A4 (en)
JP (1) JPH09506898A (en)
AU (1) AU1339795A (en)
CA (1) CA2176130A1 (en)
MX (1) MXPA99001870A (en)
WO (1) WO1995017382A1 (en)
ZA (1) ZA9410040B (en)

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IL115582A0 (en) * 1994-10-14 1996-01-19 Lilly Co Eli Methods for treating resistant tumors
IL115613A0 (en) * 1994-10-20 1996-01-19 Lilly Co Eli Bicyclic neuropeptide y receptor antagonists
WO1996012488A1 (en) * 1994-10-20 1996-05-02 Eli Lilly And Company Bicyclic bradykinin receptor antagonists
US6458811B1 (en) 1996-03-26 2002-10-01 Eli Lilly And Company Benzothiophenes formulations containing same and methods
PT910369E (en) * 1996-03-26 2010-06-04 Lilly Co Eli Benzothiophenes, formulations containing same, and methods
CA2206752A1 (en) 1996-07-02 1998-01-02 George Joseph Cullinan Benzothiophene compounds, intermediates, processes, and methods of use
DE69824410T2 (en) 1997-04-30 2005-06-02 Eli Lilly And Co., Indianapolis Antithrombotic agents
JP2002514217A (en) 1997-04-30 2002-05-14 イーライ・リリー・アンド・カンパニー Antithrombotic substance
CA2287993A1 (en) 1997-04-30 1998-11-05 Mary George Johnson Antithrombotic agents
EP1027051B1 (en) 1997-04-30 2005-01-05 Eli Lilly And Company Antithrombotic agents
US6284756B1 (en) 1998-04-30 2001-09-04 Eli Lilly And Company Antithrombotic agents
DE69904427T2 (en) * 1998-10-28 2003-07-17 Eli Lilly And Co., Indianapolis Benzothiophene derivatives as antithrombotic agents and intermediates
WO2001032625A1 (en) 1999-11-03 2001-05-10 Du Pont Pharmaceuticals Company Aryl- and heteroaryl-substituted tetrahydroisoquinolines and use thereof to block reuptake of norepinephrine, dopamine and serotonin
US7163949B1 (en) 1999-11-03 2007-01-16 Amr Technology, Inc. 4-phenyl substituted tetrahydroisoquinolines and use thereof
CA2415532C (en) 2000-07-11 2010-05-11 Albany Molecular Research, Inc. Novel 4-phenyl substituted tetrahydroisoquinolines therapeutic use thereof
ES2259376T3 (en) 2001-05-22 2006-10-01 Eli Lilly And Company 1,2,3,4-TETRAHYDROQUINOLINS 2-SUBSTITUTES AND THEIR DERIVATIVES, COMPOSITIONS AND PROCEDURES.
ES2236536T3 (en) 2001-05-22 2005-07-16 Eli Lilly And Company TETRAHYDROQUINOLINE DERIVATIVES FOR THE INHIBITION OF DISEASES ASSOCIATED WITH THE PRIVACY OF STROGENS OR WITH AN OPEN PHYSIOLOGICAL RESPONSE TO ENDOGENOUS STROGENS.
GB0130305D0 (en) * 2001-12-19 2002-02-06 Amersham Plc Compounds for imaging alzheimers disease
UA91341C2 (en) 2004-07-15 2010-07-26 Амр Текнолоджи, Інк. Aryl-and heteroaryl-substituted tetrahydroisoquinolines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin
WO2006123182A2 (en) 2005-05-17 2006-11-23 Merck Sharp & Dohme Limited Cyclohexyl sulphones for treatment of cancer
NZ565111A (en) 2005-07-15 2011-10-28 Amr Technology Inc Aryl-and heteroaryl-substituted tetrahydrobenzazepines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin
WO2007041052A2 (en) 2005-09-29 2007-04-12 Merck & Co., Inc. Acylated spiropiperidine derivatives as melanocortin-4 receptor modulators
GB0603041D0 (en) 2006-02-15 2006-03-29 Angeletti P Ist Richerche Bio Therapeutic compounds
WO2008039327A2 (en) 2006-09-22 2008-04-03 Merck & Co., Inc. Method of treatment using fatty acid synthesis inhibitors
US20110218176A1 (en) 2006-11-01 2011-09-08 Barbara Brooke Jennings-Spring Compounds, methods, and treatments for abnormal signaling pathways for prenatal and postnatal development
EP2805945B1 (en) 2007-01-10 2019-04-03 MSD Italia S.r.l. Amide substituted indazoles as poly(ADP-ribose)polymerase (PARP) inhibitors
JP5319518B2 (en) 2007-04-02 2013-10-16 Ｍｓｄ株式会社 Indoledione derivative
AU2008269154B2 (en) 2007-06-27 2014-06-12 Merck Sharp & Dohme Llc 4-carboxybenzylamino derivatives as histone deacetylase inhibitors
CA2717509A1 (en) 2008-03-03 2009-09-11 Tiger Pharmatech Tyrosine kinase inhibitors
US9156812B2 (en) 2008-06-04 2015-10-13 Bristol-Myers Squibb Company Crystalline form of 6-[(4S)-2-methyl-4-(2-naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine
US8691825B2 (en) 2009-04-01 2014-04-08 Merck Sharp & Dohme Corp. Inhibitors of AKT activity
EP2429295B1 (en) 2009-05-12 2013-12-25 Albany Molecular Research, Inc. Aryl, heteroaryl, and heterocycle substituted tetrahydroisoquinolines and use thereof
EA020553B1 (en) 2009-05-12 2014-12-30 Олбани Молекьюлар Рисерч, Инк. 7-([1,2,4]TRIAZOLO[1,5-α]PYRIDIN-6-YL)-4-(3,4-DICHLOROPHENYL)-1,2,3,4-TETRAHYDROISOQUINOLINE, PHARMACEUTICAL COMPOSITION BASED THEREON AND METHODS OF TREATING NEUROLOGICAL AND MENTAL DISORDERS
KR20120023072A (en) 2009-05-12 2012-03-12 브리스톨-마이어스 스큅 컴퍼니 Crystalline forms of (s)-7-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-4-(3,4-dichlorohphenyl)-1,2,3,4-tetrahydroisoquinoline and use thereof
CN102638981B (en) 2009-10-14 2015-07-22 默沙东公司 Substituted piperidines for enhancing p53 activity and uses thereof
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US3975537A (en) * 1973-09-21 1976-08-17 Smith Kline Pharmaceutical compositions and methods of producing coronary vasodilation
US3880891A (en) * 1973-09-21 1975-04-29 Smithkline Corp Substituted benzofurans
US3947470A (en) * 1974-06-20 1976-03-30 Smithkline Corporation Substituted benzofurans and benzothiophenes
US4024273A (en) * 1974-06-20 1977-05-17 Smithkline Corporation Coronary vasodilator and anti-anginal compositions comprising substituted benzofurans and benzothiophenes and methods of producing coronary vasodilation and anti-anginal activity
US4133814A (en) * 1975-10-28 1979-01-09 Eli Lilly And Company 2-Phenyl-3-aroylbenzothiophenes useful as antifertility agents
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Also Published As

Publication number Publication date
WO1995017382A1 (en) 1995-06-29
JPH09506898A (en) 1997-07-08
ZA9410040B (en) 1996-06-18
AU1339795A (en) 1995-07-10
EP0736007A4 (en) 1997-03-19
CA2176130A1 (en) 1995-06-29
EP0736007A1 (en) 1996-10-09

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