[go: up one dir, main page]

MXPA94009086A - Guanidinas sustituidas terapeuticas. - Google Patents

Guanidinas sustituidas terapeuticas.

Info

Publication number
MXPA94009086A
MXPA94009086A MXPA94009086A MX9409086A MXPA94009086A MX PA94009086 A MXPA94009086 A MX PA94009086A MX PA94009086 A MXPA94009086 A MX PA94009086A MX 9409086 A MX9409086 A MX 9409086A MX PA94009086 A MXPA94009086 A MX PA94009086A
Authority
MX
Mexico
Prior art keywords
substituted guanidines
guanidines
therapeutic substituted
therapeutic
utilize
Prior art date
Application number
MXPA94009086A
Other languages
English (en)
Inventor
Lain-Yen Hu
Original Assignee
Cambridge Neuroscience Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cambridge Neuroscience Inc filed Critical Cambridge Neuroscience Inc
Publication of MXPA94009086A publication Critical patent/MXPA94009086A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/18—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to carbon atoms of six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
    • C07C323/43—Y being a hetero atom
    • C07C323/44—X or Y being nitrogen atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

La presente invencion proporciona guanidinas sustituidas terapeuticamente utiles, y metodos de tratamiento y composiciones farmaceuticas que utilizan o comprenden una o mas de estas guanidinas.
MXPA94009086A 1993-11-23 1994-11-23 Guanidinas sustituidas terapeuticas. MXPA94009086A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US15677393A 1993-11-23 1993-11-23

Publications (1)

Publication Number Publication Date
MXPA94009086A true MXPA94009086A (es) 2006-02-14

Family

ID=22561031

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA94009086A MXPA94009086A (es) 1993-11-23 1994-11-23 Guanidinas sustituidas terapeuticas.

Country Status (9)

Country Link
US (4) US5922772A (es)
EP (1) EP0739200A4 (es)
JP (1) JPH09505591A (es)
KR (1) KR100424523B1 (es)
AU (1) AU705487B2 (es)
CA (1) CA2177081A1 (es)
MX (1) MXPA94009086A (es)
WO (1) WO1995014461A1 (es)
ZA (1) ZA949294B (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6143791A (en) * 1994-02-03 2000-11-07 Cambridge Neuroscience, Inc. Therapeutic guanidines
JPH09509156A (ja) * 1994-02-03 1997-09-16 ケンブリッジ・ニューロサイエンス・インコーポレーテッド 治療用グアニジン類
US6787569B1 (en) 1994-02-03 2004-09-07 Cambridge Neuroscience, Inc. Therapeutic guanidines
US7351743B1 (en) 1994-02-03 2008-04-01 Wyeth Therapeutic guanidines
US6756389B2 (en) 1996-08-09 2004-06-29 Cambridge Neuroscience, Inc. Pharmaceutically active compounds and methods of use
US6774263B1 (en) 1997-10-10 2004-08-10 Cambridge Neuroscience, Inc. Pharmaceutically active compound and methods of use
US7041702B1 (en) * 1997-10-21 2006-05-09 Scion Pharmaceuticals, Inc. Pharmaceutically active compounds and methods of use
US6741575B1 (en) 1999-02-26 2004-05-25 Hughes Electronics Corporation Apparatus and method for efficient delivery of multicast data over personal access communications system (PACS)
US20030199574A1 (en) 2000-03-02 2003-10-23 Vitreo-Retinal Technologies, Inc. Treatment of ophthalmic disorders using urea and urea derivatives
MXPA04007802A (es) * 2002-02-13 2005-04-19 Vitreo Retinal Technologies In Tratamiento de desordenes oftalmicos utilizando urea o derivados de urea.
GB0216621D0 (en) 2002-07-17 2002-08-28 Imaging Res Solutions Ltd Imaging compounds
US20040258742A1 (en) * 2003-04-11 2004-12-23 Van Osdol William Woodson Transdermal administration of N-(2,5-disubstituted phenyl)-N'-(3-substituted phenyl)-N'-methyl guanidines
EP1787679A1 (en) * 2005-07-29 2007-05-23 Laboratorios Del Dr. Esteve, S.A. Use of compounds binding to the sigma receptor for the treatment of diabetes-associated pain
CN101970427A (zh) 2008-02-29 2011-02-09 Vm生物医药公司 治疗疼痛症状及其它失调的方法
KR101885503B1 (ko) * 2009-12-24 2018-08-07 사우디 아람코 테크놀로지스 컴퍼니 폴리사이클릭 구아니딘 화합물의 합성방법
AU2019349935B2 (en) 2018-09-27 2023-01-12 BioPhysics Pharma, Inc. Transdermal drug delivery system
US12246098B2 (en) 2018-09-27 2025-03-11 BioPhysics Pharma, Inc. Trans-epithelial membrane drug delivery system

Family Cites Families (99)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2422889A (en) * 1947-06-24 Pyrimidine compounds and process
US1730388A (en) * 1929-10-08 Winfield scott
US2145214A (en) * 1939-01-24 Parasiticide
US1677235A (en) * 1928-07-17 Balph v
US1411731A (en) * 1920-11-03 1922-04-04 Charles W Kemper Cable clamp
US1422506A (en) * 1921-07-02 1922-07-11 Dovan Chemical Corp Process of making diphenylguanidine
US1642180A (en) * 1922-11-27 1927-09-13 Du Pont Di-para-xylylguanidine
US1597233A (en) * 1923-02-27 1926-08-24 Albert C Burrage Vulcanization of rubber
GB223410A (en) * 1923-11-01 1924-10-23 British Dyestuffs Corp Ltd Improvements in the manufacture of diarylguanidines
GB224376A (en) * 1923-11-01 1924-11-13 British Dyestuffs Corp Ltd Improvements in the manufacture of triarylguanidines
GB258203A (en) * 1925-09-23 1926-09-16 Silesia Ver Chemischer Fabrike An improved process for the production of symmetrical di-arylguanidines
US1672431A (en) * 1925-11-30 1928-06-05 Firm Chem Fab Auf Actien Vorma Symmetrical diarylized guanidine compounds
US1795398A (en) * 1925-12-21 1931-03-10 Huguenin Albert Elevator for boats with constant draft
US1850682A (en) * 1927-01-10 1932-03-22 Ig Farbenindustrie Ag Substituted guanidines
DE514248C (de) * 1927-09-13 1930-12-10 Schering Kahlbaum Akt Ges Verfahren zur Darstellung substituierter Guanidine
US1756315A (en) * 1927-11-28 1930-04-29 Rubber Service Lab Co Rubber vulcanization process
US1915922A (en) * 1931-03-02 1933-06-27 American Cyanamid Co Mothproofing
GB478525A (en) * 1936-02-13 1938-01-20 Georg Knoth Process for the preparation of diphenylguanidine
US2145514A (en) * 1938-03-23 1939-01-31 Kennedy Stella Dunn Garment support
US2254009A (en) * 1940-04-24 1941-08-26 American Cyanamid Co Symmetrical di-2-octyl-guanidine
US2274476A (en) * 1940-08-23 1942-02-24 American Cyanamid Co Insecticide and moth larvae repellent
US2362915A (en) * 1940-12-24 1944-11-14 Courtaulds Ltd Process for improving the fastness to washing of dyed cellulosic textile materials
US2289541A (en) * 1941-01-18 1942-07-14 American Cyanamid Co Insecticide
US2704710A (en) * 1950-04-18 1955-03-22 Gen Aniline & Film Corp Precipitation of azo dyes in silver halide emulsions by means of guanidine and biguanide compounds containing long alkyl chains
US2633474A (en) * 1951-07-21 1953-03-31 Monsanto Chemicals 1, 3-bis (o-ethylphenyl) guanidine
US3117994A (en) * 1959-12-03 1964-01-14 Monsanto Canada Ltd Nu, nu', nu'-trisubstituted guanidines
US3168562A (en) * 1959-12-23 1965-02-02 Burroughs Wellcome Co Substituted benzylguanidines
GB952194A (en) * 1960-12-23 1964-03-11 Smith Kline French Lab New guanidine derivatives and processes for preparing the same
US3140231A (en) * 1961-08-14 1964-07-07 Rohm & Haas T-octylguanidines as antihypertensive agents
US3159676A (en) * 1962-02-07 1964-12-01 Smith Kline French Lab Naphthyl containing guanidines
US3248426A (en) * 1962-03-01 1966-04-26 American Home Prod Nu-(1-naphthylmethyl)-guanidine and acid addition salt thereof
US3301755A (en) * 1962-04-18 1967-01-31 Ciba Geigy Corp Allylic guanidines
CH433246A (de) * 1962-06-25 1967-04-15 Ciba Geigy Verfahren zur Herstellung von Guanidinverbindungen
US3479437A (en) * 1963-08-26 1969-11-18 Stauffer Chemical Co Guanidine complexes as fungicides
US3320229A (en) * 1963-08-26 1967-05-16 Stauffer Chemical Co Complexes of guanidines with completely halogenated acetones
US3252189A (en) * 1963-10-04 1966-05-24 Seasafe Transp Ab Line tensioning apparatus
GB1110947A (en) * 1963-12-13 1968-04-24 Evans Medical Ltd Guanidines
US3228975A (en) * 1964-04-10 1966-01-11 American Cyanamid Co Akyl-substituted cyclohexyl guanidines and biguanides
NL125066C (es) * 1964-07-31
US3391189A (en) * 1966-01-13 1968-07-02 Ciba Geigy Corp Nu-allyl-guanidines and salts thereof
US3639477A (en) * 1968-06-17 1972-02-01 Parke Davis & Co Novel propoxyguanidine compounds and means of producing the same
US3803324A (en) * 1968-07-09 1974-04-09 Boehringer Mannheim Gmbh Amino-guanidine derivatives useful for regulating blood pressure
GB1208252A (en) * 1969-01-01 1970-10-14 American Cyanamid Co Use of alkylguanidine salts as viricides
AU1592270A (en) * 1969-06-17 1971-12-09 Imperial Chemical Industries Limited Antiviral processes and compositions
US3547951A (en) * 1969-06-17 1970-12-15 Waldo R Hardie 1,3-dioxolan-4-yl-alkyl guanidines
US3949089A (en) * 1969-06-23 1976-04-06 Burroughs Wellcome Co. Substituted guanidine compounds as antifibrillatory agents
US4060640A (en) * 1970-04-29 1977-11-29 Shell Oil Company Therapeutic agents
US3975533A (en) * 1970-04-29 1976-08-17 Shell Oil Company Therapeutic agents
US3968243A (en) * 1970-06-05 1976-07-06 Burroughs Wellcome Co. Substituted guanidine compounds in the treating of arrythmias
GB1340957A (en) * 1970-07-03 1973-12-19 Sigma Lutin Multi-spindle rotary pumps
NL7011683A (es) * 1970-08-07 1972-02-09
US3908013A (en) * 1970-09-17 1975-09-23 Armour Pharma Pharmaceutical aromatic guanidine compositions and methods of using same
US3769427A (en) * 1970-10-01 1973-10-30 Armour Pharma Pharmaceutical compositions and methods of using same
US3681459A (en) * 1970-10-01 1972-08-01 Armour Pharma Guanidine compounds and use of same
US3976787A (en) * 1970-11-10 1976-08-24 Armour Pharmaceutical Company Pharmaceutical guanidine preparations and methods of using same
US3784643A (en) * 1970-12-11 1974-01-08 Colgate Palmolive Co Aryloxyalkylguanidines
DE2133056C3 (de) * 1971-07-02 1980-10-23 Vsesojuznyj Nautschno-Issledovatelskij Institut Chimitscheskich Sredstv Zaschtschity Rastenij, Moskau Verwendung von NJS-di-alkyl-N'arylsubstituierten Guanidinen zur Bekämpfung von Mehltaupilzen und Grauschimmel der Pflanzen
US3795533A (en) * 1971-11-24 1974-03-05 Research Corp Preservation and strengthening of porous solids
US3976643A (en) * 1973-07-13 1976-08-24 William H. Rorer, Inc. Guanidines
NL7315350A (nl) * 1973-11-09 1975-05-13 Akzo Nv Nieuwe aminoguanidine verbindingen.
US4007181A (en) * 1974-02-11 1977-02-08 The Upjohn Company Adamantyl containing guanidines
US4052455A (en) * 1974-04-08 1977-10-04 Mead Johnson & Company Styrylamidines
US4014934A (en) * 1974-04-15 1977-03-29 Armour Pharmaceutical Company Substituted 4'-hydroxyphenyl guanidines and methods of using the same
US4109014A (en) * 1974-10-29 1978-08-22 Armour Pharmaceutical Company Pharmaceutical, compositions containing substituted 4'-hydroxyphenyl guanidines and methods of using same
US4130663A (en) * 1975-08-04 1978-12-19 Mead Johnson & Company Styrylamidines
US4169154A (en) * 1976-04-15 1979-09-25 Hoffmann-La Roche Inc. Method of treating depression with thiourea derivatives
US4051256A (en) * 1976-09-19 1977-09-27 Imperial Chemical Industries Limited Guanidine derivatives
US4101659A (en) * 1977-08-29 1978-07-18 Mcneil Laboratories, Incorporated Benzhydryl guanidines
US4172204A (en) * 1977-10-07 1979-10-23 Syntex (U.S.A.) Inc. Method for preparing 4,5-dihydro-2-alkoxycarbonylamino-5-carbocyclic aryl imidazoles and intermediates thereof
IL62200A (en) * 1980-03-01 1984-09-30 Wyeth John & Brother Ltd Piperidine derivatives,their preparation and pharmaceutical compositions containing them
DE3108564A1 (de) * 1981-03-06 1982-11-18 Bayer Ag, 5090 Leverkusen N-tert-butyl-phenyl-n'-cyclohexyl-quanidine, verfahren zu ihrer herstellung sowie ihre verwendung als fungizide
US4393077A (en) * 1981-07-02 1983-07-12 William H. Rorer, Inc. 1-Methylene-1-phenylguanidine compounds
FR2509724B1 (fr) * 1981-07-15 1985-10-25 Centre Nat Rech Scient Nouvelles guanidines a fort encombrement sterique et procedes pour leur preparation
US4742054A (en) * 1982-11-23 1988-05-03 Naftchi Nosrat E Treatment of mammals suffering from damage to the central nervous system
US4723029A (en) * 1983-09-23 1988-02-02 Schering Corporation Organic acid-substituted guanidine anthelmintics
EP0147537A1 (en) * 1983-09-23 1985-07-10 Schering Corporation Phenylguanidines
US4663263A (en) * 1984-10-19 1987-05-05 Canon Kabushiki Kaisha Toner, charge-imparting material and composition containing substituted guanidine compound for electrophotography
JPS61104354A (ja) * 1984-10-20 1986-05-22 Sony Corp テ−プレコ−ダ
DE3501383A1 (de) * 1985-01-17 1986-07-17 Akzo Gmbh, 5600 Wuppertal Verfahren zur herstellung von n,n'-disubstituierten guanidinen
WO1987004433A1 (en) * 1986-01-28 1987-07-30 A.H. Robins Company Limited Preparation of 3-dimethylamino-7-methyl-1,2,4-benzotriazine-1-oxide and azapropazone
US5190976A (en) * 1986-07-10 1993-03-02 State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And University Of Oregon N,N'-disubstituted guanidines and their use as excitatory amino acid antagonists
US5385946A (en) * 1986-07-10 1995-01-31 State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon Method for treating hypertension with disubstituted granidine compounds
US5312840A (en) * 1986-07-10 1994-05-17 State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education Substituted guanidines having high binding to the sigma receptor and the use thereof
US4709094A (en) * 1986-07-10 1987-11-24 State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon Sigma brain receptor ligands and their use
US4906779A (en) * 1986-07-10 1990-03-06 State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University N,N'-disubstituted guanidines and their use as excitatory amino acid antagonists
US5093525A (en) * 1986-07-10 1992-03-03 State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University N,N'-disubstituted guanidines and their use as excitatory amino acid antagonists
US4837218A (en) * 1987-10-23 1989-06-06 Washington University Alkylated bicycloalkaneamines for treatment of neurotoxic injury
US4891185A (en) * 1988-01-22 1990-01-02 Goldin Stanley M High resolution monitoring device
US5011834A (en) * 1989-04-14 1991-04-30 State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon PCP receptor ligands and the use thereof
WO1990014067A2 (en) * 1989-05-02 1990-11-29 State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon Methods for treating anxiety with sigma receptor ligands
US5262568A (en) * 1990-03-02 1993-11-16 State Of Oregon Tri- and tetra-substituted guanidines and their use as excitatory amino acid antagonists
PT96930B (pt) * 1990-03-02 1998-06-30 Univ Oregon Metodo para a utilizacao de guanidinas tri- e tetra-substituidas como antagonistas de amino-acidos excitadores
US5336689A (en) * 1990-03-02 1994-08-09 State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon Tri- and tetra-substituted guanidines and their use as excitatory amino acid antagonists
JPH05508836A (ja) * 1990-05-25 1993-12-09 オレゴン州 シグマ受容体に対して高い結合性を有する置換グアニジンおよびその使用
WO1992004054A1 (en) * 1990-08-30 1992-03-19 STATE OF OREGON, acting by and through THE OREGON STATE BOARD OF HIGHER EDUCATION, acting for and on behalf of THE OREGON HEALTH SCIENCES UNIVERSITY, PORTLAND, OREGON, and THE UNIVERSITY OF OREGON, EUGENE, OREGON, Johnson Hall, University of Oregon Substituted amidines having high binding to the sigma receptor and the use thereof
IE20030530A1 (en) * 1991-02-08 2003-10-01 Cambridge Neuroscience Inc Guanidines and derivatives
US5298657A (en) * 1992-03-20 1994-03-29 Cambridge Neuroscience Inc. Preparation of substituted guanidines
DK41193D0 (da) * 1993-04-07 1993-04-07 Neurosearch As Ionkanalaabnere
JPH09509156A (ja) * 1994-02-03 1997-09-16 ケンブリッジ・ニューロサイエンス・インコーポレーテッド 治療用グアニジン類

Also Published As

Publication number Publication date
EP0739200A4 (en) 1997-12-17
EP0739200A1 (en) 1996-10-30
KR100424523B1 (ko) 2004-09-30
JPH09505591A (ja) 1997-06-03
US6013675A (en) 2000-01-11
AU705487B2 (en) 1999-05-20
AU1290095A (en) 1995-06-13
ZA949294B (en) 1995-12-27
US6156741A (en) 2000-12-05
US5955507A (en) 1999-09-21
US5922772A (en) 1999-07-13
WO1995014461A1 (en) 1995-06-01
CA2177081A1 (en) 1995-06-01

Similar Documents

Publication Publication Date Title
ZA943744B (en) Therapeutic substituted guanidines
FI941826A0 (fi) Menetelmät ja koostumukset elimen hypofunktion ennaltaehkäisemiseksi ja/tai terapeuttiseksi hoitamiseksi
UA26213C2 (uk) Засіб для профілактики та лікуваhhя остеопорозу та фармацевтичhа композиція hа їх осhові
MXPA94009086A (es) Guanidinas sustituidas terapeuticas.
BG104599A (en) Inhibition of raf kinase using symmetrical and unsymmetrical substituted diphenyl ureas
UA39158C2 (uk) Похідні n4-оксикарбоніл-5'-дезокси-5-фторцитидину та фармацевтичний препарат на їх основі
DK0760848T3 (da) Lactobacillusstammer af menneskelig oprindelse, deres sammensætninger og anvendelse deraf
MX9705235A (es) Inhibidores de calpaina y/o catepsina b de oxazolidina substituida.
MX9709238A (es) Formulaciones farmaceuticas y de dieta para la profilaxis y tratamiento de trastornos gastrointestinales.
ZA98214B (en) Treatment of multiple sclerosis through ingestion or inhalation of copolymer-1.
UA41355C2 (uk) Засіб для лікування нейро-сніду
ZA948B (en) Endothelin converting enzyme inhibitors
TW268937B (es)
EP0813544A4 (es)
BG102250A (en) The use of marigold-extracted glycosides for the treatment of psoriasis
DK1032556T3 (da) Farmaceutisk aktive forbindelser og anvendelsesfremgangsmåder
DE69420229D1 (de) Pharmazeutische Zusammensetzung zur Behandlung von AIDS
BG102667A (en) Diosgenine-containing composition
NO961226L (no) Blandinger for forebyggelse og behandling av viralinduserte tumorer
RU94041028A (ru) Применение производных мелатонина для лечения десинхронизационных нарушений, фармацевтическая композиция
NO20001758D0 (no) Fremgangsmåter og blandinger for behandling av leddgikt
ZA966953B (en) Pharmaceutical composition.
IL105061A (en) Pharmaceutical compositions for the treatment of neurodegenerative diseases comprising VIP analogues and fragments thereof
FI961494L (fi) Farmaseuttisia koostumuksia ja niiden käyttö, etenkin hermoston rappeutumissairauksien hoitamiseksi
TWI226833B (en) Pharmaceutical composition for inhibiting bone resorption

Legal Events

Date Code Title Description
FA Abandonment or withdrawal