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MXNL04000051A - Proceso para la produccion de un inmunosupresor. - Google Patents

Proceso para la produccion de un inmunosupresor.

Info

Publication number
MXNL04000051A
MXNL04000051A MXNL04000051A MXNL04000051A MXNL04000051A MX NL04000051 A MXNL04000051 A MX NL04000051A MX NL04000051 A MXNL04000051 A MX NL04000051A MX NL04000051 A MXNL04000051 A MX NL04000051A MX NL04000051 A MXNL04000051 A MX NL04000051A
Authority
MX
Mexico
Prior art keywords
immunosuppressant
production
suppressant
immuno
formula
Prior art date
Application number
MXNL04000051A
Other languages
English (en)
Inventor
Gopeekrishnan Sreenilayam
Original Assignee
Biocon Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biocon Ltd filed Critical Biocon Ltd
Publication of MXNL04000051A publication Critical patent/MXNL04000051A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • C07D307/88—Benzo [c] furans; Hydrogenated benzo [c] furans with one oxygen atom directly attached in position 1 or 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Saccharide Compounds (AREA)
  • Furan Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

La presente invencion esta relacionada con un proceso para la preparacion de una sal de sodio de acido micofenolico mediante la reaccion de acido micofenolico con sal de sodio C2-C10 de acido carboxilico seleccionada del grupo que comprende acetato de sodio, hexanoato 2-etil de sodio o caprilato de sodio. Mas particularmente, la invencion esta relacionada con un proceso para preparar sal de sodio de acido mocofenolico en donde el acido carboxilico comprende un acatato de sodio. El acido mocofenolico es convertido a la sal de amonio mediante su reaccion con amoniaco. La sal de amonio del acido micofenolico se hace reaccionar con acetato de sodio, hexanoato 2-etil de sodio o caprilato de sodio para obtener la sal de sodio de acido micofenolico.
MXNL04000051A 2002-08-29 2002-08-29 Proceso para la produccion de un inmunosupresor. MXNL04000051A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/IN2002/000178 WO2004020426A1 (en) 2002-08-29 2002-08-29 Process for the production of an immunosuppressant

Publications (1)

Publication Number Publication Date
MXNL04000051A true MXNL04000051A (es) 2005-02-24

Family

ID=31972038

Family Applications (1)

Application Number Title Priority Date Filing Date
MXNL04000051A MXNL04000051A (es) 2002-08-29 2002-08-29 Proceso para la produccion de un inmunosupresor.

Country Status (12)

Country Link
US (1) US7122687B2 (es)
EP (1) EP1532130B1 (es)
JP (1) JP4275069B2 (es)
KR (1) KR100551617B1 (es)
AT (1) ATE447563T1 (es)
AU (1) AU2002334381B2 (es)
BR (1) BR0214971A (es)
CA (1) CA2468435C (es)
DE (1) DE60234279D1 (es)
ES (1) ES2333207T3 (es)
MX (1) MXNL04000051A (es)
WO (1) WO2004020426A1 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005105768A2 (en) * 2004-04-26 2005-11-10 Teva Gyógyszergyár Zàrtköruen Muködo Rèszvènytàrsasàg Process for preparation of mycophenolic acid and ester derivatives thereof
US20050250773A1 (en) 2004-04-27 2005-11-10 Sandor Molnar Process for preparation of mycophenolate mofetil and other esters of mycophenolic acid
DE602005020014D1 (de) 2004-07-20 2010-04-29 Teva Gyogyszergyar Zartkoeruen Kristallines mycophenolat-natrium
WO2008002665A1 (en) * 2006-06-29 2008-01-03 Teva Pharmaceutical Industries Ltd. Regulation of acid metabolite production
WO2008003637A2 (en) * 2006-07-05 2008-01-10 Dsm Ip Assets B.V. Isolation and use of amine salts of mycophenolic acid
BRPI0803097A2 (pt) * 2007-04-11 2011-11-08 Teva Gyogyszergyar ... método para redução do nìvel de impurezas na fermentação do ácido micofenólico
CN106866594A (zh) * 2017-02-17 2017-06-20 上海华源医药科技发展有限公司 适用于麦考酚钠工业化生产的优化工艺

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA684959B (en) * 1967-11-22 1969-05-22 Lilly Co Eli Agents and methods for inhibiting the growth of malignant tumor cells in warm-blooded mammals
US5177072A (en) * 1987-01-30 1993-01-05 Syntex (U.S.A.) Inc. Treatment of autoimmune inflammatory, and psoriatic diseases with heterocyclic aminoalkyl esters of mycophenolic acid and derivatives
US4727069A (en) * 1987-01-30 1988-02-23 Syntex (U.S.A.) Inc. Heterocyclic aminoalkyl esters of mycophenolic acid, derivatives thereof and pharmaceutical compositions

Also Published As

Publication number Publication date
EP1532130B1 (en) 2009-11-04
KR20040079902A (ko) 2004-09-16
CA2468435A1 (en) 2004-03-11
BR0214971A (pt) 2004-12-14
ATE447563T1 (de) 2009-11-15
CA2468435C (en) 2008-02-19
KR100551617B1 (ko) 2006-02-13
AU2002334381A1 (en) 2004-03-19
DE60234279D1 (de) 2009-12-17
EP1532130A1 (en) 2005-05-25
WO2004020426A1 (en) 2004-03-11
EP1532130A4 (en) 2008-03-19
ES2333207T3 (es) 2010-02-18
AU2002334381B2 (en) 2007-01-04
JP2005539047A (ja) 2005-12-22
JP4275069B2 (ja) 2009-06-10
US7122687B2 (en) 2006-10-17
US20050165243A1 (en) 2005-07-28

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Legal Events

Date Code Title Description
FG Grant or registration