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MXJL06000006A - Derivados de naftiridina sustituidos como inhibidores del factor inhibidor de la migracion de macrofagos y su uso en el tratamiento de enfermedades en el hombre. - Google Patents

Derivados de naftiridina sustituidos como inhibidores del factor inhibidor de la migracion de macrofagos y su uso en el tratamiento de enfermedades en el hombre.

Info

Publication number
MXJL06000006A
MXJL06000006A MXJL06000006A MXJL06000006A MXJL06000006A MX JL06000006 A MXJL06000006 A MX JL06000006A MX JL06000006 A MXJL06000006 A MX JL06000006A MX JL06000006 A MXJL06000006 A MX JL06000006A MX JL06000006 A MXJL06000006 A MX JL06000006A
Authority
MX
Mexico
Prior art keywords
inhibitors
treatment
inhibitory factor
human diseases
macrophage migration
Prior art date
Application number
MXJL06000006A
Other languages
English (en)
Inventor
Timothy James Davis
Original Assignee
Avanir Pharmaceuticals
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34272569&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MXJL06000006(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Avanir Pharmaceuticals filed Critical Avanir Pharmaceuticals
Publication of MXJL06000006A publication Critical patent/MXJL06000006A/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
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    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Obesity (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Child & Adolescent Psychology (AREA)
  • Psychology (AREA)
  • Virology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Psychiatry (AREA)
  • Dermatology (AREA)
  • Transplantation (AREA)

Abstract

Se proveen inhibidores del factor inhibidor de la migracion de macrofagos (MIF) con una estructura principal de naftiridina que son de utilidad en el tratamiento de una variedad de trastornos, incluyendo el tratamiento de afecciones patologicas asociadas con la actividad del MIF. Los inhibidores MIF tienen las siguientes estructuras:Que incluyen estereoisomeros, prodrogas y sales aceptables parea uso farmaceutico de los mismos donde n, R, R1, R2, X, Y y Z tiene los valores que se describen en la memoria descriptiva: Tambien se proveen composiciones que contienen un inhibidor de MIF en combinacion con un vehiculo aceptable para uso farmaceutico, asi como metodos para utilizarlos.
MXJL06000006A 2003-08-22 2004-08-09 Derivados de naftiridina sustituidos como inhibidores del factor inhibidor de la migracion de macrofagos y su uso en el tratamiento de enfermedades en el hombre. MXJL06000006A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US49744303P 2003-08-22 2003-08-22
PCT/US2004/025683 WO2005021546A1 (en) 2003-08-22 2004-08-09 Substituted naphthyridine derivatives as inhibitors of macrophage migration inhibitory factor and their use in the treatment of human diseases

Publications (1)

Publication Number Publication Date
MXJL06000006A true MXJL06000006A (es) 2006-05-04

Family

ID=34272569

Family Applications (1)

Application Number Title Priority Date Filing Date
MXJL06000006A MXJL06000006A (es) 2003-08-22 2004-08-09 Derivados de naftiridina sustituidos como inhibidores del factor inhibidor de la migracion de macrofagos y su uso en el tratamiento de enfermedades en el hombre.

Country Status (13)

Country Link
US (2) US20050124604A1 (es)
EP (1) EP1656376A1 (es)
JP (1) JP2007503388A (es)
CN (1) CN1839133A (es)
AR (1) AR045471A1 (es)
AU (1) AU2004268941A1 (es)
BR (1) BRPI0413695A (es)
CA (1) CA2531506A1 (es)
MX (1) MXJL06000006A (es)
PE (1) PE20051112A1 (es)
TW (1) TW200524928A (es)
UY (1) UY28483A1 (es)
WO (1) WO2005021546A1 (es)

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MA52564A (fr) 2018-05-10 2021-03-17 Amgen Inc Inhibiteurs de kras g12c pour le traitement du cancer
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JP7454572B2 (ja) 2018-11-19 2024-03-22 アムジエン・インコーポレーテツド Ｋｒａｓ ｇ１２ｃ阻害剤及びその使用方法
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UY28483A1 (es) 2005-03-31
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CN1839133A (zh) 2006-09-27
CA2531506A1 (en) 2005-03-10
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US7361760B2 (en) 2008-04-22
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