[go: up one dir, main page]

MX9805181A - Derivados de lactona a partir de derivados de 17.beta- carboxi, carbotio y amida androstano. - Google Patents

Derivados de lactona a partir de derivados de 17.beta- carboxi, carbotio y amida androstano.

Info

Publication number
MX9805181A
MX9805181A MX9805181A MX9805181A MX9805181A MX 9805181 A MX9805181 A MX 9805181A MX 9805181 A MX9805181 A MX 9805181A MX 9805181 A MX9805181 A MX 9805181A MX 9805181 A MX9805181 A MX 9805181A
Authority
MX
Mexico
Prior art keywords
derivatives
beta
carbothio
carboxy
amide
Prior art date
Application number
MX9805181A
Other languages
English (en)
Inventor
Keith Biggadike
Panayiotis Alexandro Procopiou
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9526651.6A external-priority patent/GB9526651D0/en
Priority claimed from GBGB9613121.4A external-priority patent/GB9613121D0/en
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of MX9805181A publication Critical patent/MX9805181A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0066—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by a carbon atom forming part of an amide group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
    • C07J3/005—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom the carbon atom being part of a carboxylic function
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Los compuestos de la serie androstano se describen que tienen la formula general (I) y los solvatos de estos, en donde R, representa 0, S o NH; R2 individualmente representa OC(=O) alquilo C1-6, R3 individualmente representa hidrogeno, metilo (los cuales pueden estar en la configuracion alfa o beta) o metileno; o R2 y R3 juntos representan (a) donde R6 y R7 son el mismo o diferente y cada uno representa hidrogeno o alquilo C1-6; R4 y R5 son el mismo o diferente y cada uno representa hidrogeno o halogeno; y (b) representa un enlace sencillo o uno doble. Los compuestos de la formula (Y) y sus solvatos tienen usos en medicina como agentes anti-inflamatorios o anti-alérgicos.
MX9805181A 1995-12-29 1998-06-25 Derivados de lactona a partir de derivados de 17.beta- carboxi, carbotio y amida androstano. MX9805181A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9526651.6A GB9526651D0 (en) 1995-12-29 1995-12-29 Compounds
GBGB9613121.4A GB9613121D0 (en) 1996-06-21 1996-06-21 Compounds

Publications (1)

Publication Number Publication Date
MX9805181A true MX9805181A (es) 1998-10-31

Family

ID=26308402

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9805181A MX9805181A (es) 1995-12-29 1998-06-25 Derivados de lactona a partir de derivados de 17.beta- carboxi, carbotio y amida androstano.

Country Status (33)

Country Link
US (1) US6197761B1 (es)
EP (1) EP0876392B1 (es)
JP (1) JP2947944B2 (es)
KR (1) KR19990076859A (es)
CN (1) CN1133643C (es)
AP (1) AP9801274A0 (es)
AT (1) ATE194356T1 (es)
AU (1) AU721865B2 (es)
BG (1) BG102625A (es)
BR (1) BR9612309A (es)
CA (1) CA2241728A1 (es)
CZ (1) CZ207498A3 (es)
DE (1) DE69609199T2 (es)
DK (1) DK0876392T3 (es)
EA (1) EA001401B1 (es)
EE (1) EE9800227A (es)
ES (1) ES2150150T3 (es)
GR (1) GR3034564T3 (es)
HU (1) HUP9903707A3 (es)
IL (1) IL124938A0 (es)
IS (1) IS4781A (es)
MX (1) MX9805181A (es)
NO (1) NO311022B1 (es)
NZ (1) NZ324373A (es)
OA (1) OA10701A (es)
PE (1) PE87598A1 (es)
PL (1) PL327629A1 (es)
PT (1) PT876392E (es)
SI (1) SI0876392T1 (es)
SK (1) SK89198A3 (es)
TR (1) TR199801247T2 (es)
TW (1) TW498072B (es)
WO (1) WO1997024365A1 (es)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE260931T1 (de) * 1997-06-30 2004-03-15 Glaxo Group Ltd Verfahren zur identifizierung von verbindungen mit verminderter systemischer aktivität
GB9909229D0 (en) * 1999-04-23 1999-06-16 Glaxo Group Ltd Enantiomers of mercapto lactones and processes for their synthesis
GB0017988D0 (en) * 2000-07-21 2000-09-13 Glaxo Group Ltd Novel process
KR100889426B1 (ko) 2000-08-05 2009-03-23 글락소 그룹 리미티드 항염증제로서의 6.알파.,9.알파.-디플루오로-17.알파.-'(2-푸라닐카르복실)옥시-11.베타.-히드록시-16.알파.-메틸-3-옥소-안드로스트-1,4-디엔-17-카르보티오산 ｓ-플루오로메틸 에스테르
US6858593B2 (en) 2000-08-05 2005-02-22 Smithkline Beecham Corporation Anti-inflammatory androstane derivative compositions
US6777400B2 (en) 2000-08-05 2004-08-17 Smithkline Beecham Corporation Anti-inflammatory androstane derivative compositions
US6858596B2 (en) * 2000-08-05 2005-02-22 Smithkline Beecham Corporation Formulation containing anti-inflammatory androstane derivative
US6759398B2 (en) 2000-08-05 2004-07-06 Smithkline Beecham Corporation Anti-inflammatory androstane derivative
US6777399B2 (en) * 2000-08-05 2004-08-17 Smithkline Beecham Corporation Anti-inflammatory androstane derivative compositions
US6787532B2 (en) 2000-08-05 2004-09-07 Smithkline Beecham Corporation Formulation containing anti-inflammatory androstane derivatives
US6750210B2 (en) 2000-08-05 2004-06-15 Smithkline Beecham Corporation Formulation containing novel anti-inflammatory androstane derivative
GB0019172D0 (en) * 2000-08-05 2000-09-27 Glaxo Group Ltd Novel compounds
UA77656C2 (en) 2001-04-07 2007-01-15 Glaxo Group Ltd S-fluoromethyl ester of 6-alpha, 9-alpha-difluoro-17-alpha-[(2-furanylcarbonyl)oxy]-11-beta-hydroxy-16- alpha-methyl-3-oxoandrosta-1,4-dien-17-beta-carbothioacid as anti-inflammatory agent
AU2002253342B2 (en) * 2001-04-30 2007-01-04 Glaxo Group Limited Novel anti-inflammatory androstane derivatives
JP2005500290A (ja) * 2001-06-12 2005-01-06 グラクソ　グループ　リミテッド 抗炎症性の、１７β−カルボチオアートアンドロスタン誘導体である１７α複素環エステル
WO2003018575A1 (en) * 2001-08-24 2003-03-06 Wyeth Holdings Corporation 5-substituted-3(2h)-furanones useful for inhibition of farnesyl-protein transferase
GB0125259D0 (en) 2001-10-20 2001-12-12 Glaxo Group Ltd Novel compounds
GB0127160D0 (en) * 2001-11-12 2002-01-02 Glaxo Group Ltd Novel compounds
WO2003042229A1 (en) * 2001-11-12 2003-05-22 Glaxo Group Limited Non-aromatic heterocyclic esters of furan-2-one-esters of 17.beta.-carboxyl or 17.beta.-carbothio glucocorticoids
US20050175545A1 (en) * 2002-02-04 2005-08-11 Keith Biggadike Formulation for inhalation comprising a glucocorticoid and a beta 2-adrenoreceptor agonist
GB0202635D0 (en) * 2002-02-05 2002-03-20 Glaxo Wellcome Mfg Pte Ltd Formulation containing novel anti-inflammatory androstane derivative
GB2389530B (en) 2002-06-14 2007-01-10 Cipla Ltd Pharmaceutical compositions
WO2004087731A1 (en) * 2003-04-04 2004-10-14 Alpharma Aps Process for the preparation of steroidal carbothioic acid derivatives and intermediates
EP1466920A1 (en) * 2003-04-04 2004-10-13 Alpharma APS Process for the preparation of steroidal 17 beta-carbothioates
JP4584981B2 (ja) * 2004-04-01 2010-11-24 ユニベルシテ・ド・リエージュ 気管支炎症疾患の処置および予防のためのトリオキソピリミジンの使用
PT103202B (pt) 2004-10-19 2011-01-27 Hovione Farmaciencia S A Processo para a esterificação de um ácido carbotiótico
GB0507165D0 (en) * 2005-04-08 2005-05-18 Glaxo Group Ltd Novel crystalline pharmaceutical product
AR059216A1 (es) * 2006-01-27 2008-03-19 Sun Pharmaceutical Ind Ltd 11b-hidroxiandrosta-4-eno-3-onas
GB0615108D0 (en) * 2006-07-28 2006-09-06 Glaxo Group Ltd Novel formulations
CN103087137A (zh) * 2011-11-07 2013-05-08 天津金耀集团有限公司 一种21位为硫代烃基的糖皮质激素
US20250296918A1 (en) 2022-04-28 2025-09-25 Resonac Corporation Method for producing mercapto heterocyclic compound and method for testing the same
CN120344545A (zh) * 2022-12-16 2025-07-18 津药生物科技（天津）有限公司 新型糖皮质激素、其制备方法及用途
WO2025256615A1 (zh) * 2024-06-14 2025-12-18 津药药业股份有限公司 新型糖皮质激素的晶型

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4093721A (en) * 1974-08-30 1978-06-06 Glaxo Laboratories Limited Pharmaceutical compositions of 6α,9α-difluoro-androst-4-ene-17β-carboxylates and derivatives thereof
US4188385A (en) 1978-04-05 1980-02-12 Syntex (U.S.A.) Inc. Thioetianic acid derivatives
SE8306370D0 (sv) 1983-11-18 1983-11-18 Draco Ab Novel androstane-17beta-carboxylic acid esters, a process and intermediates for their preparation, compositions and method for the treatment of inflammatory conditions
IL78144A0 (en) 1985-04-04 1986-07-31 Draco Ab Novel androstane-17beta-carboxylic acid esters
US5767113A (en) * 1995-05-10 1998-06-16 The Salk Institute For Biological Studies Compounds useful for concurrently activating glucocorticoid-induced response and reducing multidrug resistance

Also Published As

Publication number Publication date
DE69609199D1 (de) 2000-08-10
PE87598A1 (es) 1999-01-15
DK0876392T3 (da) 2000-11-06
PL327629A1 (en) 1998-12-21
CN1133643C (zh) 2004-01-07
NO983004D0 (no) 1998-06-26
NO983004L (no) 1998-08-26
EA001401B1 (ru) 2001-02-26
WO1997024365A1 (en) 1997-07-10
ATE194356T1 (de) 2000-07-15
ES2150150T3 (es) 2000-11-16
BR9612309A (pt) 1999-07-13
AP9801274A0 (en) 1998-06-30
HUP9903707A2 (hu) 2000-03-28
BG102625A (en) 1999-04-30
JPH11501675A (ja) 1999-02-09
EA199800484A1 (ru) 1999-02-25
US6197761B1 (en) 2001-03-06
SI0876392T1 (en) 2000-12-31
SK89198A3 (en) 1999-03-12
TW498072B (en) 2002-08-11
TR199801247T2 (xx) 1998-11-23
EP0876392A1 (en) 1998-11-11
IS4781A (is) 1998-06-23
CN1209135A (zh) 1999-02-24
DE69609199T2 (de) 2001-03-01
NO311022B1 (no) 2001-10-01
PT876392E (pt) 2000-12-29
AU1140997A (en) 1997-07-28
GR3034564T3 (en) 2001-01-31
HUP9903707A3 (en) 2000-04-28
HK1012193A1 (en) 1999-07-30
EP0876392B1 (en) 2000-07-05
AU721865B2 (en) 2000-07-13
CZ207498A3 (cs) 1998-11-11
JP2947944B2 (ja) 1999-09-13
CA2241728A1 (en) 1997-07-10
KR19990076859A (ko) 1999-10-25
NZ324373A (en) 1999-10-28
OA10701A (en) 2002-05-21
EE9800227A (et) 1998-12-15
IL124938A0 (en) 1999-01-26

Similar Documents

Publication Publication Date Title
MX9805181A (es) Derivados de lactona a partir de derivados de 17.beta- carboxi, carbotio y amida androstano.
NZ233735A (en) Heterocyclic substituted aminophenol derivatives
YU11997A (sh) Laktamski derivati i njihove farmaceutske kompozicije
ES8401032A1 (es) Procedimiento para la obtencion de 1,4-dihidropiridinas.
MY116845A (en) New 19-nor-pregnene derivatives
BG103399A (en) New heterocycle-substituted benzamides and their application for the treatment of diseases
TR199801268T2 (xx) Ta�ikinin antagonistleri olarak 3-Azetidinilalkilpiperidinler veya pirolidinler.
CA2138289A1 (en) N-substituted azabicycloheptane derivatives, the preparation and use thereof
CA2449679A1 (en) Androstenones
MX9700807A (es) Derivados de 3-azabiciclo (3.2.0)heptano n-sustituidos utiles como neurolepticos.
MY132057A (en) Quinoxalinones, a process for their preparation and their use
MY114282A (en) Anthracycline derivatives
MX9700813A (es) Nuevos derivados 3-substituidos de 3h-2,3-benzodiazepina, su preparacion y su uso como medicamentos.
BG103271A (en) Derivatives of n-(benzothiazol-2-yl) piperidine-1-ethaneamines, method for their preparation and application as therapeutical means
GEP20043225B (en) 1-Trifluoromethyl-4-Hydroxy-7- Piperidinyl-Aminomethylchroman Derivatives
SE9603285D0 (sv) New compounds
PL308349A1 (en) 4-estrenes bridged at positions 19, 11 and exhibiting gestagenic effectiveness
HUP0002457A1 (hu) 4-Halogénezett szteroidszármazékok, eljárás előállításukra, ezek intermedierjei, és ezeket tartalmazó gyógyszerkészítmények
GEP20032975B (en) Echinocandin Derivatives, Preparation Method and Pharmaceutical Composition
DK0876393T3 (da) 21-(2-oxo-tetrahydrofuran)-thio-pregnanderivater, fremgangsmåde til fremstilling deraf og farmaceutiske præparater indehold
MY133140A (en) N-substituted azabicycloheptane derivatives, their preparation and use
IL117497A (en) 17-difluoromethylene estratriene derivatives and pharmaceutical compositions containing the same
ATE195529T1 (de) 17beta-(2-oxo-tetrahydrofuran-4-yl)-thio- androstane derivate (17beta-(gamma-buttersäure- lacton)-thio derivate) zur behandlung von entzündungen, pharmazeutische präparate davon und ein verfahren zu ihrer herstellung
MX9804068A (es) Nuevos derivados de quinoxalindiona, su preparacion y empleo en medicamentos.
ZA941334B (en) Amide derivative .