MX9800281A - Novel heterocyclic compounds for the treatment of pain and use thereof. - Google Patents
Novel heterocyclic compounds for the treatment of pain and use thereof.Info
- Publication number
- MX9800281A MX9800281A MX9800281A MX9800281A MX9800281A MX 9800281 A MX9800281 A MX 9800281A MX 9800281 A MX9800281 A MX 9800281A MX 9800281 A MX9800281 A MX 9800281A MX 9800281 A MX9800281 A MX 9800281A
- Authority
- MX
- Mexico
- Prior art keywords
- alkyl
- pain
- treatment
- independently
- heterocyclic compounds
- Prior art date
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Polycyclic alkaloids of formula (I), wherein R1 is H, C1-6 alkyl, or C6-12 aryl optionally substituted with polar groups; R2 and R3 are independently H, OH, C1-6 alkyl, -C(NH)-NH2, a positively charged group, or C7-13 aralkyl optionally substituted with NH2, OH, C1-6 alkyl, or halogen; or R2 and R3 together form a 5 to 6 member ring optionally incorporating a heteroatom; R4 is H, C1-6 alkyl, OR6, SR6 or N(R6)2, wherein each R6 is independently H, C1-3 alkyl, or halogen; X is O, S, SO, SO2, N-R5, or C-(R5)2, wherein each R5 is independently H, C1-6 alkyl, or C7-13 aralkyl optionally interrupted with one or more heteroatom; n is an integer from 0 to 2; m is an integer from 0 to 3; with the proviso that when X is CH2 then R1 is not CH3, R2 and R3 are not both H, R4 is not OH, m is not 3 and n is not 0. For the treatment of pain and pharmaceutically acceptable compositions comprising those compounds. The compounds of this invention act as agonists at the opiate receptor.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB95144176 | 1995-07-14 | ||
| GB95144176 | 1995-07-14 | ||
| PCT/CA1996/000467 WO1997003978A1 (en) | 1995-07-14 | 1996-07-12 | Novel heterocyclic compounds for the treatment of pain and use thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX9800281A true MX9800281A (en) | 1998-07-31 |
| MXPA98000281A MXPA98000281A (en) | 1998-11-09 |
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