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MX9709475A - Derivados de pirrol y composicion medicinal. - Google Patents

Derivados de pirrol y composicion medicinal.

Info

Publication number
MX9709475A
MX9709475A MX9709475A MX9709475A MX9709475A MX 9709475 A MX9709475 A MX 9709475A MX 9709475 A MX9709475 A MX 9709475A MX 9709475 A MX9709475 A MX 9709475A MX 9709475 A MX9709475 A MX 9709475A
Authority
MX
Mexico
Prior art keywords
optionally substituted
medicinal composition
amino
alkyl
aromatic heterocycle
Prior art date
Application number
MX9709475A
Other languages
English (en)
Inventor
Masami Tsuda
Mitsushi Tanaka
Ayatsugu Nakamura
Original Assignee
Nippon Shinyaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippon Shinyaku Co Ltd filed Critical Nippon Shinyaku Co Ltd
Publication of MX9709475A publication Critical patent/MX9709475A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/335—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
    • C07D207/50—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Urology & Nephrology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Materials For Medical Uses (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

la presente invencion se refiere a una composicion farmacéutica que comprende un derivado de pirrol de la formula [1] siguiente o una sal farmacéuticamente aceptable del mismo, o un solvato de cualesquiera de los mismos, como un ingrediente activo (en donde R1 representa hidrogeno o alcoxicarbonilamino, R2 representa alquilo, arilo que pueden estar sustituidos, heterociclilo aromático que puede estar sustituido, amino no sustituido, monoalquilamino, dialquilamino, o amino cíclico que puede estar sustituido; R3 representa ciano o carbamoilo; R4 representa hidrogeno o alquilo; E representan alquileno; arilo que puede estar sustituido, o heterociclilo aromático que puede estar sustituido). La composicion farmacéutica de la invencion es efectiva para el tratamiento de la polaquiuria o incontinencia urinaria.
MX9709475A 1995-06-07 1996-06-06 Derivados de pirrol y composicion medicinal. MX9709475A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP14069895 1995-06-07
PCT/JP1996/001526 WO1996040634A1 (en) 1995-06-07 1996-06-06 Pyrrole derivatives and medicinal composition

Publications (1)

Publication Number Publication Date
MX9709475A true MX9709475A (es) 1998-02-28

Family

ID=15274666

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9709475A MX9709475A (es) 1995-06-07 1996-06-06 Derivados de pirrol y composicion medicinal.

Country Status (20)

Country Link
US (2) US5998459A (es)
EP (1) EP0842923B1 (es)
JP (1) JP3160910B2 (es)
KR (1) KR100275222B1 (es)
CN (2) CN1090617C (es)
AT (1) ATE318799T1 (es)
AU (1) AU710683B2 (es)
BR (1) BR9608502A (es)
CA (1) CA2223918C (es)
DE (1) DE69635857T2 (es)
DK (1) DK0842923T3 (es)
ES (1) ES2259795T3 (es)
HU (1) HUP9802290A3 (es)
MX (1) MX9709475A (es)
NO (1) NO321606B1 (es)
NZ (1) NZ309151A (es)
PT (1) PT842923E (es)
RU (1) RU2166941C2 (es)
TW (1) TW504503B (es)
WO (1) WO1996040634A1 (es)

Families Citing this family (22)

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Publication number Priority date Publication date Assignee Title
RU2166941C2 (ru) * 1995-06-07 2001-05-20 Ниппон Синяку Ко., Лтд. Производные пиррола и фармацевтическая композиция на их основе
EP0889032A4 (en) * 1996-03-18 2000-01-05 Eisai Co Ltd CARBOXYLIC ACID DERIVATIVES WITH FUSED CYCLES
US6353016B1 (en) * 1998-01-14 2002-03-05 Nippon Shinyaku Co., Ltd. Potassium channel activators
WO1999061016A1 (fr) * 1998-05-27 1999-12-02 Nippon Shinyaku Co., Ltd. Inhibiteurs de cyclo-oxygenase-2
AU2001241187A1 (en) * 2000-03-21 2001-10-03 Nippon Shinyaku Co. Ltd. Sustained release oral preparations
WO2002004409A2 (en) * 2000-07-06 2002-01-17 Us Gov Health & Human Serv Tetrahydrobenzothiazole analogues as neuroprotective agents
TWI239952B (en) * 2001-03-14 2005-09-21 Nippon Shinyaku Co Ltd Stable crystals of pyrrole compound
KR100863659B1 (ko) * 2001-04-16 2008-10-15 미쓰비시 타나베 파마 코퍼레이션 질소-함유 헤테로시클릭 화합물 및 이를 포함하는 제약 조성물
TWI271402B (en) 2002-10-15 2007-01-21 Tanabe Seiyaku Co Large conductance calcium-activated K channel opener
DE602004024374D1 (de) * 2003-03-13 2010-01-14 Vertex Pharma Zusammensetzungen zur verwendung als protein-kinase-inhibitoren
US20050075359A1 (en) * 2003-03-14 2005-04-07 Rikako Kono Large conductance calcium-activated K channel opener
GB0321509D0 (en) * 2003-09-13 2003-10-15 Astrazeneca Ab Chemical compounds
EP1675585A2 (en) * 2003-10-17 2006-07-05 Tanabe Seiyaku Co., Ltd. Large conductance calcium-activated k channel opener
US7118801B2 (en) * 2003-11-10 2006-10-10 Gore Enterprise Holdings, Inc. Aerogel/PTFE composite insulating material
ITTO20040125A1 (it) * 2004-03-01 2004-06-01 Rotta Research Lab Nuove amidine eterocicliche inibitrici la produzione di ossido d'azoto (no) ad attivita' antinfiammatoria ed analgesica
JP2005325103A (ja) * 2004-04-13 2005-11-24 Tanabe Seiyaku Co Ltd 医薬組成物
EP1904491A2 (en) * 2005-05-31 2008-04-02 Vertex Pharmaceuticals Incorporated Heterocycles useful as modulators of ion channels
PE20070404A1 (es) * 2005-07-29 2007-05-10 Wyeth Corp Compuestos derivados de cianopirrol-sulfonamida como moduladores del receptor de progesterona
PE20070341A1 (es) * 2005-07-29 2007-04-13 Wyeth Corp Derivados de pirrol como moduladores del receptor de progesterona
JP5277256B2 (ja) 2008-04-09 2013-08-28 田辺三菱製薬株式会社 ｍａｘｉ−Ｋチャネル開口薬としてのピリミジン、ピリジン及びトリアジン誘導体
EP3233842B1 (en) 2014-12-17 2025-03-26 King's College London Bicycloheteroaryl-heteroaryl-benzoic acid compounds as retinoic acid receptor beta (rarb) agonists
GB201610867D0 (en) 2016-06-22 2016-08-03 King S College London Crystalline forms of a therapeutic compound and processes for their preparation

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Also Published As

Publication number Publication date
NO975666D0 (no) 1997-12-05
CN1186485A (zh) 1998-07-01
CN1090617C (zh) 2002-09-11
EP0842923B1 (en) 2006-03-01
ATE318799T1 (de) 2006-03-15
RU2166941C2 (ru) 2001-05-20
NO321606B1 (no) 2006-06-12
DE69635857D1 (de) 2006-04-27
CA2223918A1 (en) 1996-12-19
HUP9802290A2 (hu) 1999-10-28
KR19990022329A (ko) 1999-03-25
HUP9802290A3 (en) 2002-02-28
AU710683B2 (en) 1999-09-30
TW504503B (en) 2002-10-01
CN1349796A (zh) 2002-05-22
NZ309151A (en) 2000-01-28
EP0842923A1 (en) 1998-05-20
DK0842923T3 (da) 2006-06-19
BR9608502A (pt) 1999-07-06
US6172102B1 (en) 2001-01-09
DE69635857T2 (de) 2006-10-19
JP3160910B2 (ja) 2001-04-25
US5998459A (en) 1999-12-07
AU5910996A (en) 1996-12-30
CA2223918C (en) 2006-01-10
NO975666L (no) 1998-02-09
PT842923E (pt) 2006-07-31
KR100275222B1 (ko) 2001-02-01
ES2259795T3 (es) 2006-10-16
WO1996040634A1 (en) 1996-12-19
EP0842923A4 (en) 1999-12-29

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Legal Events

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