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MX9708798A - Baculovirus recombinantes insecticidas. - Google Patents

Baculovirus recombinantes insecticidas.

Info

Publication number
MX9708798A
MX9708798A MX9708798A MX9708798A MX9708798A MX 9708798 A MX9708798 A MX 9708798A MX 9708798 A MX9708798 A MX 9708798A MX 9708798 A MX9708798 A MX 9708798A MX 9708798 A MX9708798 A MX 9708798A
Authority
MX
Mexico
Prior art keywords
insect
optimized
lqhit2
codon
toxin
Prior art date
Application number
MX9708798A
Other languages
English (en)
Inventor
Billy Fred Mccutchen
Original Assignee
Du Pont
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Du Pont filed Critical Du Pont
Publication of MX9708798A publication Critical patent/MX9708798A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N63/00—Biocides, pest repellants or attractants, or plant growth regulators containing microorganisms, viruses, microbial fungi, animals or substances produced by, or obtained from, microorganisms, viruses, microbial fungi or animals, e.g. enzymes or fermentates
    • A01N63/40—Viruses, e.g. bacteriophages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C07K14/43513—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae
    • C07K14/43522—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae from scorpions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/14011—Baculoviridae
    • C12N2710/14111—Nucleopolyhedrovirus, e.g. autographa californica nucleopolyhedrovirus
    • C12N2710/14141—Use of virus, viral particle or viral elements as a vector
    • C12N2710/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Virology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Insects & Arthropods (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Plant Pathology (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Pest Control & Pesticides (AREA)
  • Toxicology (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Agronomy & Crop Science (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Dentistry (AREA)
  • Environmental Sciences (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)

Abstract

Esta invencion pertenece a los baculovirus recombinantes que han sido manipulados por ingeniería genética para producir la expresion optima del gen que codifica para las neurotoxinas selectivas de insectos. Más específicamente, esta invencion pertenece a la secuencia del ácido nucleico aislado que codifica para la toxina de escorpion LghIT2, derivado de Leiurus quinquestriatus hebraeus, en el que la secuencia ha sido optimizada para la expresion del gen en las células infectadas con el virus de polihedrosis nuclear. Esta invencion también se pertenece a los genes quiméricos que comprenden una secuencia de nucleotidos LghIT2 optimizada en el codon, composiciones insecticidas que comprenden los baculovirus recombinantes que expresan un codon optimizado, la neurotoxina selectiva del insecto (por ejemplo el gen de la toxina LghIT2), y los métodos para controlar los insectos en ambos ambientes agronomicos y no agronomicos, que comprende la aplicacion de los baculovirus de insectos que contienen la secuencia de ácido nucleico optimizada en el codon, que codifica para una neurotoxina selectiva del insecto, tal como la toxina LghIT2.
MX9708798A 1995-05-17 1996-05-16 Baculovirus recombinantes insecticidas. MX9708798A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US44329495A 1995-05-17 1995-05-17
PCT/US1996/006988 WO1996036712A1 (en) 1995-05-17 1996-05-16 Recombinant baculovirus insecticides

Publications (1)

Publication Number Publication Date
MX9708798A true MX9708798A (es) 1998-02-28

Family

ID=23760221

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9708798A MX9708798A (es) 1995-05-17 1996-05-16 Baculovirus recombinantes insecticidas.

Country Status (10)

Country Link
US (1) US6096304A (es)
EP (1) EP0826047B1 (es)
JP (1) JP3252854B2 (es)
CN (1) CN1102659C (es)
AU (1) AU723612B2 (es)
BR (1) BR9608741A (es)
MX (1) MX9708798A (es)
NZ (1) NZ308772A (es)
TR (1) TR199701366T1 (es)
WO (1) WO1996036712A1 (es)

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FR2744724B1 (fr) * 1996-02-14 2002-08-02 Pasteur Institut Proteine recombinante contenant un fragment c-terminal de la proteine msp-1 d'un plasmodium infectieux pour l'homme pour la production de vaccins anti-paludiques
US6596271B2 (en) * 1996-07-12 2003-07-22 The Regents Of The University Of California Insect control method with genetically engineered biopesticides
US5891431A (en) * 1997-01-22 1999-04-06 Her Majesty The Queen In Right Of Canada, As Represented By The Minister Of Natural Resources Transgenic virus
WO2000024772A2 (en) * 1998-10-23 2000-05-04 E.I. Du Pont De Nemours And Company Scorpion toxins
BR0017604B1 (pt) 1999-03-12 2013-03-05 composiÇço inseticida sinÉrgica, processo para controle de insetos e processo para proteger plantas contra infestaÇço e ataque de insetos.
ATE406442T1 (de) * 1999-06-22 2008-09-15 Du Pont Skorpionstoxine aus buthotus judaicus
US6768002B1 (en) 1999-06-22 2004-07-27 E. I. Du Pont De Nemours And Company Scorpion toxins
US6326193B1 (en) 1999-11-05 2001-12-04 Cambria Biosciences, Llc Insect control agent
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NZ548255A (en) 2004-02-02 2010-10-29 Ambrx Inc Modified human interferon polypeptides and their uses
CN102603895B (zh) 2004-06-18 2016-09-28 Ambrx公司 新颖抗原结合多肽和其用途
BRPI0512396A (pt) 2004-07-21 2008-03-11 Ambrx Inc polipeptìdeos biossintéticos utilizando aminoácidos codificados não naturalmente
ATE410445T1 (de) * 2004-11-04 2008-10-15 Univ Connecticut Insektizide polypeptide und deren verwendung
BRPI0519170A8 (pt) 2004-12-22 2018-05-08 Ambrx Inc formulações de hormônio de crescimento humano que compreendem um aminoácido não naturalmente codificado
CN102732588B (zh) * 2004-12-22 2015-01-07 Ambrx公司 氨酰基-tRNA合成酶的组合物及其用途
NZ555308A (en) 2004-12-22 2010-10-29 Ambrx Inc Compositions containing, methods involving, and uses of non-natural amino acids and polypeptides
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KR20070090023A (ko) 2004-12-22 2007-09-04 암브룩스, 인코포레이티드 변형 인간 성장 호르몬
CN101238215A (zh) * 2005-04-05 2008-08-06 先锋高级育种国际公司 利用植物病毒密码子偏爱性设计用于在植物中的多肽表达的核酸分子的方法和组合物
JP2008541769A (ja) * 2005-06-03 2008-11-27 アンブレツクス・インコーポレイテツド 改善されたヒトインターフェロン分子及びそれらの使用
CN103103238B (zh) 2005-08-18 2016-08-10 Ambrx公司 一种在细胞中制造在特定位置处具有所选氨基酸的抗体或抗体片段多肽的方法
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EP2061878B1 (en) * 2006-09-08 2014-01-08 Ambrx, Inc. Hybrid suppressor trna for vertebrate cells
MX2009002523A (es) 2006-09-08 2009-03-20 Ambrx Inc Polipeptido de plasma humano modificado o andamios fc y sus usos.
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AU2008232937B2 (en) 2007-03-30 2012-09-27 Ambrx, Inc. Modified FGF-21 polypeptides and their uses
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KR101597695B1 (ko) 2007-07-26 2016-02-25 유니큐어 아이피 비.브이. 차등 코돈 바이어스를 갖는 반복 암호 서열을 포함하는 배큘로바이러스 벡터
EP2217265B1 (en) 2007-11-20 2017-05-10 Ambrx, Inc. Modified insulin polypeptides and their uses
NZ586947A (en) 2008-02-08 2012-11-30 Ambrx Inc Modified leptin polypeptides and their uses
UA103774C2 (uk) 2008-07-23 2013-11-25 Амбркс, Інк. Модифіковані поліпептиди бичачого гранулоцитарного колонієстимулювального фактора (g-csf) та їх застосування
MX357314B (es) 2008-09-26 2018-07-04 Ambrx Inc Microorganismos y vacunas dependientes de replicacion de aminoacidos no naturales.
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Also Published As

Publication number Publication date
AU5865196A (en) 1996-11-29
EP0826047B1 (en) 2002-04-17
WO1996036712A1 (en) 1996-11-21
BR9608741A (pt) 1999-07-06
CN1102659C (zh) 2003-03-05
EP0826047A1 (en) 1998-03-04
AU723612B2 (en) 2000-08-31
JPH10509596A (ja) 1998-09-22
US6096304A (en) 2000-08-01
JP3252854B2 (ja) 2002-02-04
TR199701366T1 (xx) 1998-03-21
CN1184504A (zh) 1998-06-10
NZ308772A (en) 1999-04-29

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