MX9708278A - Antithrombotic amidinotetrahydropyridylalanine derivatives. - Google Patents
Antithrombotic amidinotetrahydropyridylalanine derivatives.Info
- Publication number
- MX9708278A MX9708278A MX9708278A MX9708278A MX9708278A MX 9708278 A MX9708278 A MX 9708278A MX 9708278 A MX9708278 A MX 9708278A MX 9708278 A MX9708278 A MX 9708278A MX 9708278 A MX9708278 A MX 9708278A
- Authority
- MX
- Mexico
- Prior art keywords
- alkyl
- conr5r6
- alkoxy
- aryl
- nr5r6
- Prior art date
Links
- 239000003146 anticoagulant agent Substances 0.000 title abstract 2
- QNFXNTZVEUTOCV-ZETCQYMHSA-N OC(=O)[C@H](C)N(C(N)=N)N1CCCC=C1 Chemical class OC(=O)[C@H](C)N(C(N)=N)N1CCCC=C1 QNFXNTZVEUTOCV-ZETCQYMHSA-N 0.000 title 1
- 230000002785 anti-thrombosis Effects 0.000 title 1
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 6
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 4
- 125000003118 aryl group Chemical group 0.000 abstract 4
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 2
- 125000001475 halogen functional group Chemical group 0.000 abstract 2
- 206010002388 Angina unstable Diseases 0.000 abstract 1
- 206010003658 Atrial Fibrillation Diseases 0.000 abstract 1
- 206010051055 Deep vein thrombosis Diseases 0.000 abstract 1
- 208000018262 Peripheral vascular disease Diseases 0.000 abstract 1
- 206010038563 Reocclusion Diseases 0.000 abstract 1
- 229940122388 Thrombin inhibitor Drugs 0.000 abstract 1
- 206010043647 Thrombotic Stroke Diseases 0.000 abstract 1
- 208000032109 Transient ischaemic attack Diseases 0.000 abstract 1
- 208000007814 Unstable Angina Diseases 0.000 abstract 1
- 206010047249 Venous thrombosis Diseases 0.000 abstract 1
- 206010000891 acute myocardial infarction Diseases 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 238000002399 angioplasty Methods 0.000 abstract 1
- 208000021328 arterial occlusion Diseases 0.000 abstract 1
- 230000001684 chronic effect Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 201000004332 intermediate coronary syndrome Diseases 0.000 abstract 1
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 abstract 1
- 208000015122 neurodegenerative disease Diseases 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
- 208000037803 restenosis Diseases 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
- 239000003868 thrombin inhibitor Substances 0.000 abstract 1
- 230000002537 thrombolytic effect Effects 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Compounds of formula (I), pharmaceutically acceptable salts thereof, and pharmaceutically acceptable solvates of either entity, wherein Y is optionally monounsaturated C3-C5 alkylene optionally substituted with C1-C4 alkyl or methylene; R1 is H; C1-C4 alkyl optionally substituded with C1-C4 alkoxy, OH, NR5R6, CONR5R6, C3-C6 cycloalkyl or aryl; or C3-C6 alkenyl; R2 is H; C1-C4 alkyl optionally substituted with C1-C4 alkoxy, OH, NR5R6, CONR5R6, C3-C6 cycloalkyl or aryl; or CONR5R6; R3 and R4 are each independently selected from H; C1-C4 alkyl optionally substituded with NR5R6; C1-C4 alkoxy; halo; CONR5R6 and aryl; aryl is phenyl optionally substituted with one, two or three substituents independently selected from C1-C4 alkyl, C1-C4 alkoxy, OH, halo and CF3; R5 and R6 are each independently selected from H and C1-C4 alkyl; and m and n are each independently 1, 2 or 3; are potent and selective thrombin inhibitors useful in the treatment of, inter alia, deep vein thrombosis; reocclusion following thrombolytic therapy; chronic arterial obstruction; peripheral vascular disease; acute myocardial infarction; unstable angina; atrial fibrillation; thrombotic stroke; transient ischaemic attacks; restenosis and occlusion following angioplasty; or neurodegenerative disorders.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/EP1996/001459 WO1996033993A1 (en) | 1995-04-28 | 1996-04-01 | Antithrombotic amidinotetrahydropyridylalanine derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX9708278A true MX9708278A (en) | 1998-01-31 |
Family
ID=39165727
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX9708278A MX9708278A (en) | 1996-04-01 | 1996-04-01 | Antithrombotic amidinotetrahydropyridylalanine derivatives. |
Country Status (1)
| Country | Link |
|---|---|
| MX (1) | MX9708278A (en) |
-
1996
- 1996-04-01 MX MX9708278A patent/MX9708278A/en not_active Application Discontinuation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |