[go: up one dir, main page]

MX9706851A - Variantes de subtilisina carlseberg que tienen adsorcion reducida e hidrolisis incrementada. - Google Patents

Variantes de subtilisina carlseberg que tienen adsorcion reducida e hidrolisis incrementada.

Info

Publication number
MX9706851A
MX9706851A MX9706851A MX9706851A MX9706851A MX 9706851 A MX9706851 A MX 9706851A MX 9706851 A MX9706851 A MX 9706851A MX 9706851 A MX9706851 A MX 9706851A MX 9706851 A MX9706851 A MX 9706851A
Authority
MX
Mexico
Prior art keywords
subtilisin carlsberg
loop region
wild
acid sequence
amino acid
Prior art date
Application number
MX9706851A
Other languages
English (en)
Inventor
Philip Frederik Brode Iii
Bobby Lee Barnett
Donn Nelton Rubingh
Original Assignee
Procter & Gamble
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Procter & Gamble filed Critical Procter & Gamble
Publication of MX9706851A publication Critical patent/MX9706851A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A61K8/66—Enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/0005—Other compounding ingredients characterised by their effect
    • C11D3/0078—Compositions for cleaning contact lenses, spectacles or lenses
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16—Organic compounds
    • C11D3/38—Products with no well-defined composition, e.g. natural products
    • C11D3/386—Preparations containing enzymes, e.g. protease or amylase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
    • C12N9/54—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea bacteria being Bacillus

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Birds (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Detergent Compositions (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

La presente invencion se refiere a variantes de subtilisina Carlsberg que tienen una secuencia de aminoácidos modificada en la secuencia de aminoácidos de subtilisina Carlsberg tipo silvestre, la secuencia de aminoácidos tipo silvestre comprende una primera region de lazo, una segunda region de lazo, una tercera region de lazo, una cuarta region de lazo, y una quinta region de lazo y una sexta region de lazo; en donde la secuencia de aminoácidos modificada comprende diferentes aminoácidos de los que ocurren en la subtilisina Carlsberg de tipo silvestre (es decir, substitucion) en posiciones específicamente identificadas en una o más de las regiones de lazo, por lo que la variante de subtilisina Carlsberg tiene adsorcion reducida a, e hidrolisis incrementada de, un substrato insoluble en comparacion con la subtilisina Carlsberg de tipo silvestre; la presente invencion también se refiere a los genes que codifican dichas variantes de subtilisina Carlsberg; la presente invencion también se refiere a composiciones que comprenden dichas variantes de subtilisina Carlsberg para limpiar una variedad de superficies.
MX9706851A 1995-03-08 1996-02-14 Variantes de subtilisina carlseberg que tienen adsorcion reducida e hidrolisis incrementada. MX9706851A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/400,698 US6455295B1 (en) 1995-03-08 1995-03-08 Subtilisin Carlsberg variants having decreased adsorption and increased hydrolysis
PCT/US1996/002168 WO1996028566A2 (en) 1995-03-08 1996-02-14 Subtilisin carlsberg variants having decreased adsorption and increased hydrolysis

Publications (1)

Publication Number Publication Date
MX9706851A true MX9706851A (es) 1997-11-29

Family

ID=23584644

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9706851A MX9706851A (es) 1995-03-08 1996-02-14 Variantes de subtilisina carlseberg que tienen adsorcion reducida e hidrolisis incrementada.

Country Status (14)

Country Link
US (1) US6455295B1 (es)
EP (1) EP0813596A2 (es)
JP (1) JPH11501812A (es)
CN (1) CN1183119A (es)
AU (1) AU4868896A (es)
BR (1) BR9607356A (es)
CA (1) CA2214348C (es)
CZ (1) CZ279397A3 (es)
HU (1) HUP9800765A3 (es)
IL (1) IL117266A0 (es)
MA (1) MA23818A1 (es)
MX (1) MX9706851A (es)
WO (1) WO1996028566A2 (es)
ZA (1) ZA961631B (es)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6682924B1 (en) * 1995-05-05 2004-01-27 Novozymes A/S Protease variants and compositions
CN1530443A (zh) * 1996-11-04 2004-09-22 ŵ����÷�����޹�˾ 枯草杆菌酶变异体和组合物
JPH10204500A (ja) * 1997-01-20 1998-08-04 Soft Kyukyu Corp:Kk 発泡錠剤洗浄剤
EP0913458B1 (en) * 1997-10-22 2004-06-16 The Procter & Gamble Company Liquid hard-surface cleaning compositions
ES2368718T3 (es) * 1997-10-23 2011-11-21 Danisco Us Inc. Variantes de subtilisina con múltiples sustituciones.
MA25044A1 (fr) * 1997-10-23 2000-10-01 Procter & Gamble Compositions de lavage contenant des variants de proteases multisubstituees.
BR9814236A (pt) * 1997-11-21 2000-10-03 Novo Nordisk As Enzima subtilase, sua variante, sequência de dna isolada, vetor de expressão, célula microbiana hospedeira, processo para produzir uma subtilase ou uma variante de subtilase, composição, e, uso de uma subtilase ou de uma variante de subtilase.
US6780629B2 (en) 1997-11-21 2004-08-24 Novozymes A/S Subtilase enzymes
US6773907B2 (en) 1997-11-21 2004-08-10 Peter Kamp Hansen Subtilase enzymes
US6376450B1 (en) 1998-10-23 2002-04-23 Chanchal Kumar Ghosh Cleaning compositions containing multiply-substituted protease variants
US6831053B1 (en) 1998-10-23 2004-12-14 The Procter & Gamble Company Bleaching compositions comprising multiply-substituted protease variants
AU772347B2 (en) * 1998-12-18 2004-04-22 Novozymes A/S Subtilase enzymes of the I-S1 and I-S2 sub-groups having an additional amino acid residue in an active site loop region
JP4611528B2 (ja) * 1998-12-18 2011-01-12 ノボザイムス アクティーゼルスカブ 活性部位ループ領域中に追加のアミノ酸残基を有するサブチラーゼ酵素サブグループｉ−ｓ１及びｉ−ｓ２
DE69937160T2 (de) * 1998-12-18 2008-06-19 Novozymes A/S Subtilase enzyme der i-s1 und i-s2 untergruppen, mit einem zusätzlichen aminosäurerest in einer aktiven schleifenregion
JP4647788B2 (ja) * 1998-12-18 2011-03-09 ノボザイムス アクティーゼルスカブ 活性部位ループ領域中に追加のアミノ酸残基を有するサブチラーゼ酵素サブグループｉ−ｓ１及びｉ−ｓ２
BRPI9916348B1 (pt) * 1998-12-18 2016-04-12 Novozymes As enzima subtilase isolada, composição, e, uso de uma subtilase ou de uma variante de subtilase ou de uma composição de enzima
CN1333822A (zh) * 1998-12-18 2002-01-30 诺沃奇梅兹有限公司 在活性位点环区具有额外氨基酸残基的i－s1和i－s2亚族枯草杆菌酶
EP1141262B2 (en) * 1998-12-18 2012-09-26 Novozymes A/S Subtilase enzymes of the i-s2 sub-group having an additional amino acid residue in an active site loop region
BRPI9916352B1 (pt) * 1998-12-18 2016-04-19 Novozymes As enzima de subtilase isolada dos subgrupos i-s1 e i-s2, subtilase, seqüência isolada de dna, vetor de expressão, célula hospedeira microbiana, método para produzir uma subtilase ou uma variante de subtilase, composição, e, uso de uma subtilase ou de uma variante de subtilase ou de uma composição de enzima
DE10153792A1 (de) * 2001-10-31 2003-05-22 Henkel Kgaa Neue Alkalische Protease-Varianten und Wasch- und Reinigungsmittel enthaltend diese neuen Alkalischen Protease-Varianten
DE10162728A1 (de) 2001-12-20 2003-07-10 Henkel Kgaa Neue Alkalische Protease aus Bacillus gibsonii (DSM 14393) und Wasch-und Reinigungsmittel enthaltend diese neue Alkalische Protease
DE10162727A1 (de) 2001-12-20 2003-07-10 Henkel Kgaa Neue Alkalische Protease aus Bacillus gibsonii (DSM 14391) und Wasch-und Reinigungsmittel enthaltend diese neue Alkalische Protease
DE10163884A1 (de) 2001-12-22 2003-07-10 Henkel Kgaa Neue Alkalische Protease aus Bacillus sp. (DSM 14392) und Wasch- und Reinigungsmittel enthaltend diese neue Alkalische Protease
US7888093B2 (en) * 2002-11-06 2011-02-15 Novozymes A/S Subtilase variants
DE10260903A1 (de) * 2002-12-20 2004-07-08 Henkel Kgaa Neue Perhydrolasen
US7294499B2 (en) 2003-01-30 2007-11-13 Novozymes A/S Subtilases
DE102004029475A1 (de) * 2004-06-18 2006-01-26 Henkel Kgaa Neues enzymatisches Bleichsystem
DE102007044415A1 (de) 2007-09-17 2009-03-19 Henkel Ag & Co. Kgaa Leistungsverbesserte Proteasen und Wasch- und Reinigungsmittel enthaltend diese Proteasen
KR20110095254A (ko) * 2008-11-11 2011-08-24 다니스코 유에스 인크. 서브틸리신 변이체를 함유하는 조성물 및 방법
US20180112204A1 (en) * 2015-05-13 2018-04-26 Danisco Us Inc. AprL-CLADE PROTEASE VARIANTS AND USES THEREOF
DE102016204815A1 (de) 2016-03-23 2017-09-28 Henkel Ag & Co. Kgaa Proteasen mit verbesserte Enzymstabilität in Waschmittel
DE102016204814A1 (de) * 2016-03-23 2017-09-28 Henkel Ag & Co. Kgaa Verbesserte Reinigungsleistung an Protein sensitiven Anschmutzungen
DE102017215629A1 (de) * 2017-09-05 2019-03-07 Henkel Ag & Co. Kgaa Leistungsverbesserte Proteasevarianten III
EP4525615A2 (en) 2022-05-14 2025-03-26 Novozymes A/S Compositions and methods for preventing, treating, supressing and/or eliminating phytopathogenic infestations and infections

Family Cites Families (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5310675A (en) * 1983-06-24 1994-05-10 Genencor, Inc. Procaryotic carbonyl hydrolases
IE81141B1 (en) * 1983-06-24 2000-04-05 Genencor Int Procaryotic carbonyl hydrolases
US4760025A (en) * 1984-05-29 1988-07-26 Genencor, Inc. Modified enzymes and methods for making same
US5972682A (en) * 1984-05-29 1999-10-26 Genencor International, Inc. Enzymatically active modified subtilisins
US5185258A (en) * 1984-05-29 1993-02-09 Genencor International, Inc. Subtilisin mutants
US5155033A (en) * 1989-01-06 1992-10-13 Genencor, Inc. Subtilisins modified at position 225 resulting in a shift in catalytic activity
US5700676A (en) * 1984-05-29 1997-12-23 Genencor International Inc. Modified subtilisins having amino acid alterations
US5371008A (en) * 1984-05-29 1994-12-06 Genencor International, Inc. Substrate assisted catalysis
US5371190A (en) * 1984-05-29 1994-12-06 Genencor International, Inc. Substrate assisted catalysis
US5244791A (en) * 1984-05-29 1993-09-14 Genecor International, Inc. Methods of ester hydrolysis
US5182204A (en) * 1984-05-29 1993-01-26 Genencor International, Inc. Non-human carbonyl hydrolase mutants, vectors encoding same and hosts transformed with said vectors
US5346823A (en) * 1984-05-29 1994-09-13 Genencor, Inc. Subtilisin modifications to enhance oxidative stability
WO1987004461A1 (en) 1986-01-15 1987-07-30 Amgen THERMALLY STABLE AND pH STABLE SUBTILISIN ANALOGS AND METHOD FOR PRODUCTION THEREOF
US4908773A (en) 1987-04-06 1990-03-13 Genex Corporation Computer designed stabilized proteins and method for producing same
JPS63502959A (ja) 1986-02-12 1988-11-02 ジェネックス、コ−ポレ−ション 突然変異誘発及びスクリ−ニング方法並びに生成物
US4990452A (en) 1986-02-12 1991-02-05 Genex Corporation Combining mutations for stabilization of subtilisin
US5013657A (en) 1988-04-12 1991-05-07 Bryan Philip N Subtilisin mutations
US4980288A (en) 1986-02-12 1990-12-25 Genex Corporation Subtilisin with increased thermal stability
US5240632A (en) * 1986-03-26 1993-08-31 Amway Corporation Machine dishwasher water spot control composition
SG30639G (en) * 1986-04-30 1995-09-01 Genencor Int Non-human carbonyl hydrolase mutants DNA sequences and vectors encoding same and hosts transformed with said vectors
NZ221627A (en) 1986-09-09 1993-04-28 Genencor Inc Preparation of enzymes, modifications, catalytic triads to alter ratios or transesterification/hydrolysis ratios
JP3026567B2 (ja) * 1987-02-27 2000-03-27 ジェネンコー インターナショナル インコーポレイテッド 分子のクローニング及びタンパク分解酵素をコードする遺伝子の発現
US5260207A (en) * 1987-04-06 1993-11-09 Enzon Labs Inc. Engineering of electrostatic interactions at metal ion binding sites for the stabilization of proteins
JP3155984B2 (ja) * 1987-04-06 2001-04-16 ノヴォザイムズ・アクティーゼルスカブ タンパク質の安定化のための金属イオン結合部位における静電的相互作用の操作
US4914031A (en) * 1987-04-10 1990-04-03 Amgen, Inc. Subtilisin analogs
DK6488D0 (da) 1988-01-07 1988-01-07 Novo Industri As Enzymer
US6287841B1 (en) * 1988-02-11 2001-09-11 Genencor International, Inc. High alkaline serine protease
CN1056187C (zh) 1988-02-11 2000-09-06 金克克国际有限公司 新的蛋白水解酶及其在洗涤剂中的应用
US5324653A (en) * 1988-02-11 1994-06-28 Gist-Brocades N.V. Recombinant genetic means for the production of serine protease muteins
WO1994002618A1 (en) 1992-07-17 1994-02-03 Gist-Brocades N.V. High alkaline serine proteases
US5246849A (en) 1988-04-12 1993-09-21 Enzon, Inc. Thermally stable serine proteases
US5116741A (en) 1988-04-12 1992-05-26 Genex Corporation Biosynthetic uses of thermostable proteases
US5118623A (en) * 1988-05-27 1992-06-02 Solvay Enzymes, Inc. Bleach stable enzymes
AU618675B2 (en) 1989-05-17 1992-01-02 Amgen, Inc. Multiply mutated subtilisins
EP0405902A1 (en) 1989-06-26 1991-01-02 Unilever Plc Enymatic detergent compositions
ES2227508T3 (es) 1989-06-26 2005-04-01 Unilever N.V. Composiciones detergentes enzimaticas.
DK316989D0 (da) 1989-06-26 1989-06-26 Novo Nordisk As Enzymer
US5665587A (en) * 1989-06-26 1997-09-09 Novo Nordisk A/S Modified subtilisins and detergent compositions containing same
US5352603A (en) * 1989-08-31 1994-10-04 Kali-Chemie Ag Highly alkaline proteases
US6271012B1 (en) * 1989-10-11 2001-08-07 Genencor International, Inc. Protease muteins and their use in detergents
DE4009534A1 (de) * 1990-03-24 1991-09-26 Henkel Kgaa Fluessiges handreinigungsmittel
DK97190D0 (da) * 1990-04-19 1990-04-19 Novo Nordisk As Oxidationsstabile detergentenzymer
CA2087342C (en) * 1990-08-09 2003-12-23 Lars Abrahmsen Serine protease variants having peptide ligase activity
US5629173A (en) * 1990-08-09 1997-05-13 Genentech, Inc. Methods of use of serine protease variants having peptide ligase activity
DK271490D0 (da) * 1990-11-14 1990-11-14 Novo Nordisk As Detergentkomposition
US5482849A (en) * 1990-12-21 1996-01-09 Novo Nordisk A/S Subtilisin mutants
EP0563169B2 (en) 1990-12-21 2006-04-12 Novozymes A/S ENZYME MUTANTS HAVING A LOW DEGREE OF VARIATION OF THE MOLECULAR CHARGE OVER A pH RANGE
US5340735A (en) * 1991-05-29 1994-08-23 Cognis, Inc. Bacillus lentus alkaline protease variants with increased stability
EP0525610A3 (en) * 1991-07-27 1993-03-24 Solvay Enzymes Gmbh & Co. Kg Process for increasing the stability of enzymes and stabilized enzymes
US5275945A (en) * 1991-10-08 1994-01-04 Vista Chemical Company Alkaline proteases stable in heavy-duty detergent liquids
US5567601A (en) * 1993-06-01 1996-10-22 University Of Maryland Subtilisin mutants lacking a primary calcium binding site
US5470733A (en) * 1993-06-01 1995-11-28 University Of Maryland Calcium free subtilisin mutants
HUT74222A (en) 1993-09-15 1996-11-28 Procter & Gamble Subtilisin bpn' variants with decreased adsorption and increased hydrolysis
US6436690B1 (en) * 1993-09-15 2002-08-20 The Procter & Gamble Company BPN′ variants having decreased adsorption and increased hydrolysis wherein one or more loop regions are substituted
CA2173105C (en) * 1993-10-14 2003-05-27 Andre Baeck Protease-containing cleaning compositions
AU1253695A (en) * 1993-10-14 1995-05-04 Procter & Gamble Company, The Bleaching compositions comprising protease enzymes
ES2364774T3 (es) * 1994-02-24 2011-09-14 HENKEL AG & CO. KGAA Enzimas mejoradas y detergentes que las contienen.
US6599730B1 (en) * 1994-05-02 2003-07-29 Procter & Gamble Company Subtilisin 309 variants having decreased adsorption and increased hydrolysis
US5780285A (en) * 1995-03-03 1998-07-14 Genentech, Inc. Subtilisin variants capable of cleaving substrates containing dibasic residues

Also Published As

Publication number Publication date
CA2214348A1 (en) 1996-09-19
IL117266A0 (en) 1996-06-18
WO1996028566A3 (en) 1997-07-10
US6455295B1 (en) 2002-09-24
EP0813596A2 (en) 1997-12-29
HUP9800765A2 (hu) 1998-07-28
JPH11501812A (ja) 1999-02-16
WO1996028566A2 (en) 1996-09-19
HUP9800765A3 (en) 2001-01-29
CA2214348C (en) 2001-10-30
CN1183119A (zh) 1998-05-27
CZ279397A3 (en) 1997-11-12
ZA961631B (en) 1996-09-06
AU4868896A (en) 1996-10-02
MA23818A1 (fr) 1996-10-01
BR9607356A (pt) 1999-06-15

Similar Documents

Publication Publication Date Title
MX9706851A (es) Variantes de subtilisina carlseberg que tienen adsorcion reducida e hidrolisis incrementada.
MX9605357A (es) Variantes de subtilisina bpn' que tiene absorcion reducida e hidrolisis incrementada.
MX9605358A (es) Variantes de subtilicina 309 con absorcion disminuida e hidrolisis aumentada.
MX9706841A (es) Variantes de proteinasa k que tienen adsorcion reducida e hidrolisis incrementada.
MX9706847A (es) Variantes de subtilisina dy que tienen adsorcion reducida e hidrolisis incrementada.
HU9600667D0 (en) Subtilisin bpn' variants with decreased adsorption and increased hydrolysis
NO964590L (no) Töyvaskemidler omfattende subtilisin BPN'-varianter
AU6424394A (en) Protease variants
EP1538155A3 (en) Amylase variants
CA2173106A1 (en) Bleaching Compositions Comprising Protease Enzymes
CA2173105A1 (en) Protease-containing cleaning compositions
MX9706846A (es) Variantes de termitasa que tienen adsorcion reducida e hidrolisis incrementada.
WO1999005291A3 (en) Aggrecan degrading metallo proteases
WO2000001831A3 (en) Proteases fused with variants of streptomyces subtilisin inhibitor
NZ527971A (en) Nucleic acid molecules encoding a transmembrane serine protease 9, the encoded polypeptides and methods based thereon
WO2000001826A3 (en) Stabilized variants of streptomyces subtilisin inhibitor
AU7655994A (en) Cloning of a member of the serine-threonine-kinase family
PT722457E (pt) Compostos modificadores da transmissao serotoninergica aplicacoes em diagnostico e em terapia
EP1158052A4 (en) BETA-PRIMEVEROSIDASDE GENE