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MX9706062A - FORMAS DE DOSIFICACION ORAL CONTENIENDO UN ANTIBIOTICO DE beta -LACTAMA. - Google Patents

FORMAS DE DOSIFICACION ORAL CONTENIENDO UN ANTIBIOTICO DE beta -LACTAMA.

Info

Publication number
MX9706062A
MX9706062A MX9706062A MX9706062A MX9706062A MX 9706062 A MX9706062 A MX 9706062A MX 9706062 A MX9706062 A MX 9706062A MX 9706062 A MX9706062 A MX 9706062A MX 9706062 A MX9706062 A MX 9706062A
Authority
MX
Mexico
Prior art keywords
beta
lactam antibiotic
oral dosage
granulate
forms containing
Prior art date
Application number
MX9706062A
Other languages
English (en)
Inventor
Robertus Cornelis Van Koutrik
Gerrit Jan Sijbrands
Original Assignee
Yamanouchi Europ Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yamanouchi Europ Bv filed Critical Yamanouchi Europ Bv
Publication of MX9706062A publication Critical patent/MX9706062A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
    • A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
    • A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
    • A61K31/431—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems containing further heterocyclic rings, e.g. ticarcillin, azlocillin, oxacillin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Zoology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

Se proporciona un granulado que contiene 50-99,9% en peso de un antibiotico de beta-lactama soluble en agua, 0-50% en peso de un producto de la celulosa el cual es celulosa microcristalina, celulosa microfina o una mezcla de las mismas, y 0-0,5% en peso de un agente aglutinante para la granulacion en humedo. Se describe un proceso para la preparacion de un granulado que comprende un antibiotico de beta-lactama soluble en agua, cuyo proceso comprende humedecer los componentes del granulado con un líquido esencialmente acuoso sin emplear una cantidad importante de un agente aglutinante para la granulacion en humedo (0-0,5% en peso) y tamizar consecutivamente los granulados humedos y secos a través de un tamiz de por lo menos 0,71 mm. Los granulados se mezclan convenientemente con un producto de celulosa, el cual es celulosa microcristalina, celulosa microfina o una mezcla de las mismas, y uno o más desintegrantes para utilizarse en formas de dosificacion oral rápidamente dispersables, cuando se ponen en un ambiente acuoso. El sabor de dichas formas de dosificacion oral se mejora utilizando una combinacion de agentes edulcorantes y sazonantes. También se proporciona un proceso para la preparacion de dichas formas de dosificacion.
MX9706062A 1995-02-08 1996-02-08 FORMAS DE DOSIFICACION ORAL CONTENIENDO UN ANTIBIOTICO DE beta -LACTAMA. MX9706062A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP95200313 1995-02-08
PCT/EP1996/000547 WO1996024337A1 (en) 1995-02-08 1996-02-08 ORAL DOSAGE-FORMS CONTAINING A β-LACTAM ANTIBIOTIC

Publications (1)

Publication Number Publication Date
MX9706062A true MX9706062A (es) 1997-10-31

Family

ID=8220003

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9706062A MX9706062A (es) 1995-02-08 1996-02-08 FORMAS DE DOSIFICACION ORAL CONTENIENDO UN ANTIBIOTICO DE beta -LACTAMA.

Country Status (19)

Country Link
US (1) US5948422A (es)
EP (1) EP0801559B1 (es)
CN (1) CN1125636C (es)
AT (1) ATE216576T1 (es)
AU (1) AU4789696A (es)
BG (1) BG63528B1 (es)
BR (1) BR9607189A (es)
CZ (1) CZ293718B6 (es)
DE (1) DE69620866T2 (es)
DK (1) DK0801559T3 (es)
EA (2) EA000361B1 (es)
ES (1) ES2175073T3 (es)
HU (1) HU227938B1 (es)
MX (1) MX9706062A (es)
NO (1) NO319993B1 (es)
PL (1) PL186386B1 (es)
PT (1) PT801559E (es)
WO (1) WO1996024337A1 (es)
ZA (1) ZA961018B (es)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI225402B (en) * 1996-03-13 2004-12-21 Biochemie Gmbh Auxiliary-free agglomerates
EP0912169A2 (en) * 1996-07-16 1999-05-06 Gist-Brocades B.V. $g(b)-LACTAM GRANULES FREE OF ORGANIC SOLVENTS
US6080427A (en) * 1997-04-17 2000-06-27 Bristol-Myers Squibb Company Cefadroxil monohydrate tablet formulation
JP2002505269A (ja) * 1998-03-06 2002-02-19 エウランド インターナショナル ソシエタ ペル アチオニ 急速崩壊錠剤
US7399751B2 (en) * 1999-11-04 2008-07-15 Sertoli Technologies, Inc. Production of a biological factor and creation of an immunologically privileged environment using genetically altered Sertoli cells
DE19922537A1 (de) * 1999-05-10 2000-11-16 Roland Bodmeier Darreichungsform zur Applikation in Körperöffnungen
EP1319409A4 (en) * 2000-09-22 2006-05-03 Takeda Pharmaceutical SOLID PREPARATIONS
GB0102342D0 (en) * 2001-01-30 2001-03-14 Smithkline Beecham Plc Pharmaceutical formulation
EP1368003A4 (en) * 2001-02-05 2004-05-12 Scherer Technologies Inc R P METHODS AND COMPOSITIONS FOR REDUCING THE TASTE OF PHARMACEUTICAL ACTIVE SUBSTANCES
RU2190403C1 (ru) * 2001-09-27 2002-10-10 Нестерук Владимир Викторович Фармацевтическая композиция, обладающая антибактериальным действием, и способ ее получения
MXPA04008720A (es) * 2002-03-12 2004-12-06 Squibb Bristol Myers Co Suspension oral de sabor agradable y metodo.
ES2358470T3 (es) * 2002-10-02 2011-05-11 Meiji Seika Kaisha Ltd. Composición medicinal antibacteriana con absorptividad oral mejorada.
CA2511185C (en) * 2002-12-20 2012-09-18 Niconovum Ab A physically and chemically stable nicotine-containing particulate material
JP4926703B2 (ja) * 2003-07-03 2012-05-09 セルトリ・テクノロジーズ・エルエルシー セルトリ細胞および筋様細胞を含有する組成物、並びに細胞性移植における該組成物の使用
WO2005021056A1 (en) * 2003-08-21 2005-03-10 Cns, Inc. Effervescent delivery system
CN101309674A (zh) * 2005-11-17 2008-11-19 诺瓦提斯公司 药物组合物
WO2007104573A2 (en) 2006-03-16 2007-09-20 Niconovum Ab Improved snuff composition
US8617597B2 (en) 2006-07-06 2013-12-31 Bayer Intellectual Property Gmbh Pharmaceutical composition containing a tetrahydrofolic acid
AU2007278850B2 (en) * 2006-07-28 2013-06-06 Sertocell Biotechnology (Us) Corp. Adult sertoli cells and uses thereof
WO2010031552A1 (en) * 2008-09-17 2010-03-25 Niconovum Ab Process for preparing snuff composition
WO2010077911A1 (en) * 2008-12-17 2010-07-08 Altheus Therapeutics, Inc. Enema formulations
WO2023204773A1 (en) * 2022-04-20 2023-10-26 Bilim Ilac Sanayii Ve Ticaret A.S. Tablet formulations for the treatment of urinary system infections and method for the preparation of such formulations

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3344030A (en) * 1964-06-15 1967-09-26 American Home Prod Reinforced directly compressed nongranulated pharmaceutical crystalline lactose tables
DE2251249A1 (de) * 1972-10-19 1974-05-02 Hoechst Ag Verfahren zur herstellung von penicillin-verbindungen enthaltenden tabletten
DE2251250C3 (de) * 1972-10-19 1981-06-25 Hoechst Ag, 6230 Frankfurt Verfahren zur Herstellung hochdosierter Antibiotica-Tabletten
DE3887179T2 (de) * 1987-03-02 1994-06-16 Brocades Pharma Bv Pharmazeutische Zusammensetzung, pharmazeutisches Granulat und Verfahren zu ihrer Herstellung.
US5049394A (en) * 1987-09-11 1991-09-17 E. R. Squibb & Sons, Inc. Pharmaceutical composition containing high drug load and method for preparing same
ATE108996T1 (de) * 1988-02-25 1994-08-15 Brocades Pharma Bv Verfahren zur herstellung eines pharmazeutischen granulats.
US5643591A (en) * 1991-01-16 1997-07-01 Fmc Corporation Solid dosage forms
EP0755258B1 (en) * 1994-04-13 2002-01-23 Research Corporation Technologies, Inc Methods of treating disease using sertoli cells and allografts or xenografts
US5605889A (en) * 1994-04-29 1997-02-25 Pfizer Inc. Method of administering azithromycin

Also Published As

Publication number Publication date
DE69620866T2 (de) 2003-02-27
HU227938B1 (en) 2012-06-28
EP0801559B1 (en) 2002-04-24
US5948422A (en) 1999-09-07
EA199700093A1 (ru) 1998-02-26
HUP9801677A2 (hu) 1998-11-30
BG101822A (en) 1998-04-30
NO319993B1 (no) 2005-10-10
NO973646L (no) 1997-09-11
PL321567A1 (en) 1997-12-08
ATE216576T1 (de) 2002-05-15
DE69620866D1 (de) 2002-05-29
WO1996024337A1 (en) 1996-08-15
AU4789696A (en) 1996-08-27
BG63528B1 (bg) 2002-04-30
HUP9801677A3 (en) 1999-05-28
PT801559E (pt) 2002-09-30
EA199900205A1 (ru) 2000-06-26
EA000361B1 (ru) 1999-06-24
CZ230297A3 (en) 1997-11-12
EA003736B1 (ru) 2003-08-28
ES2175073T3 (es) 2002-11-16
BR9607189A (pt) 1997-11-11
EP0801559A1 (en) 1997-10-22
CN1125636C (zh) 2003-10-29
DK0801559T3 (da) 2002-06-17
CN1173816A (zh) 1998-02-18
ZA961018B (en) 1997-08-08
CZ293718B6 (cs) 2004-07-14
PL186386B1 (pl) 2004-01-30
NO973646D0 (no) 1997-08-07

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