MX9704683A - Inhibidores de la escualeno sintetasa. - Google Patents
Inhibidores de la escualeno sintetasa.Info
- Publication number
- MX9704683A MX9704683A MX9704683A MX9704683A MX9704683A MX 9704683 A MX9704683 A MX 9704683A MX 9704683 A MX9704683 A MX 9704683A MX 9704683 A MX9704683 A MX 9704683A MX 9704683 A MX9704683 A MX 9704683A
- Authority
- MX
- Mexico
- Prior art keywords
- benzoxazepines
- benzothiazepines
- naphthyl
- synthetase inhibitors
- squalene synthetase
- Prior art date
Links
- 239000004059 squalene synthase inhibitor Substances 0.000 title 1
- PSYYHKIRDZMRAC-UHFFFAOYSA-N 1$l^{4},2-benzothiazepine 1-oxide Chemical class O=S1N=CC=CC2=CC=CC=C12 PSYYHKIRDZMRAC-UHFFFAOYSA-N 0.000 abstract 1
- HZRJIAKKDMLYFS-UHFFFAOYSA-N 1,2-benzoxazepin-3-one Chemical class C1=CC(=O)NOC2=CC=CC=C21 HZRJIAKKDMLYFS-UHFFFAOYSA-N 0.000 abstract 1
- 230000000879 anti-atherosclerotic effect Effects 0.000 abstract 1
- 239000003529 anticholesteremic agent Substances 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D267/02—Seven-membered rings
- C07D267/08—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D267/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D267/02—Seven-membered rings
- C07D267/08—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D267/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D267/14—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D281/02—Seven-membered rings
- C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D281/10—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Diabetes (AREA)
- Communicable Diseases (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Obesity (AREA)
- Hospice & Palliative Care (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Psychiatry (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Steroid Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
La invencion se refiere a ciertas benzoxazepinonas y benzotiazepinonas utiles como agentes hipocolesterolémicos y agentes antiateroescleroticos.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36271394A | 1994-12-23 | 1994-12-23 | |
| PCT/IB1995/000424 WO1996020184A1 (en) | 1994-12-23 | 1995-06-02 | Naphthyl-benzoxazepines or -benzothiazepines as squalene synthetase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX9704683A true MX9704683A (es) | 1997-09-30 |
Family
ID=23427229
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX9704683A MX9704683A (es) | 1994-12-23 | 1995-06-02 | Inhibidores de la escualeno sintetasa. |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US5770594A (es) |
| JP (1) | JPH10500702A (es) |
| KR (1) | KR960022510A (es) |
| CN (1) | CN1133287A (es) |
| AU (1) | AU4067795A (es) |
| BG (1) | BG100248A (es) |
| BR (1) | BR9505995A (es) |
| CA (1) | CA2207772A1 (es) |
| CZ (1) | CZ344795A3 (es) |
| FI (1) | FI972696A7 (es) |
| GT (1) | GT199500058A (es) |
| HU (1) | HUT74672A (es) |
| IL (1) | IL116399A0 (es) |
| IS (1) | IS4312A (es) |
| LV (1) | LV11325B (es) |
| MA (1) | MA23746A1 (es) |
| MX (1) | MX9704683A (es) |
| NO (1) | NO955288L (es) |
| OA (1) | OA10204A (es) |
| PE (1) | PE60096A1 (es) |
| PL (1) | PL311997A1 (es) |
| SI (1) | SI9500393A (es) |
| SK (1) | SK158795A3 (es) |
| TN (1) | TNSN95133A1 (es) |
| TR (1) | TR199501644A2 (es) |
| WO (1) | WO1996020184A1 (es) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6537987B1 (en) * | 1996-06-20 | 2003-03-25 | Pfizer Inc. | 4,1-benzoxazepines or 4,1-benzothiazepines and their use as squalene synthetase inhibitors |
| US5965553A (en) * | 1996-06-20 | 1999-10-12 | Pfizer Inc. | Squalene synthetase inhibitors |
| DE19716120A1 (de) * | 1997-04-17 | 1998-10-22 | Europ Lab Molekularbiolog | Verwendung von cholesterinsenkenden Mitteln |
| US20060141036A1 (en) * | 1997-12-12 | 2006-06-29 | Andrx Labs Llc | HMG-CoA reductase inhibitor extended release formulation |
| US6403576B1 (en) * | 1998-08-24 | 2002-06-11 | The United States Of America As Represented By The Secretary Of The Navy | Antifungal and antiparasitic compounds |
| US20020054871A1 (en) * | 1999-04-12 | 2002-05-09 | Yadong Huang | Methods and compositions for use in the treatment of hyperlipidemia |
| US20020107173A1 (en) * | 1999-11-04 | 2002-08-08 | Lawrence Friedhoff | Method of treating amyloid beta precursor disorders |
| NZ518822A (en) * | 1999-11-04 | 2004-12-24 | Andrx Corp | Treating a mammal with an APP processing disorder such as Alzheimer's Disease and Down's Syndrome by administering at least one HMG-CoA reductase inhibitor |
| DE60139080D1 (de) | 2000-11-21 | 2009-08-06 | Janssen Pharmaceutica Nv | Farnesyltransferase hemmende benzoheterocyclische derivate |
| WO2008121602A1 (en) * | 2007-03-29 | 2008-10-09 | Smithkline Beecham Corporation | Chemical compounds |
| GB0803747D0 (en) * | 2008-02-29 | 2008-04-09 | Martin | Enzyme and receptor modulation |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE235474T1 (de) * | 1992-04-20 | 2003-04-15 | Takeda Chemical Industries Ltd | 4,1-benzoxazepinderivate als squalen-synthetase inhibitoren und ihre verwendung zur behandlung von hypercholesterämie und als fungizide |
| AU678503B2 (en) * | 1993-09-24 | 1997-05-29 | Takeda Chemical Industries Ltd. | Condensed heterocyclic compounds and their use as squalene synthetase inhibitors |
| AU2453295A (en) * | 1994-09-20 | 1996-04-19 | Pfizer Inc. | Combination of a cholesterol absorption inhibitor and a cholesterol synthesis inhibitor |
-
1995
- 1995-06-02 JP JP8520314A patent/JPH10500702A/ja active Pending
- 1995-06-02 BR BR9505995A patent/BR9505995A/pt not_active Application Discontinuation
- 1995-06-02 WO PCT/IB1995/000424 patent/WO1996020184A1/en not_active Ceased
- 1995-06-02 SK SK1587-95A patent/SK158795A3/sk unknown
- 1995-06-02 CA CA002207772A patent/CA2207772A1/en not_active Abandoned
- 1995-06-02 MX MX9704683A patent/MX9704683A/es not_active IP Right Cessation
- 1995-06-02 US US08/860,155 patent/US5770594A/en not_active Expired - Fee Related
- 1995-06-02 FI FI972696A patent/FI972696A7/fi not_active Application Discontinuation
- 1995-12-13 GT GT199500058A patent/GT199500058A/es unknown
- 1995-12-14 IL IL11639995A patent/IL116399A0/xx unknown
- 1995-12-18 PE PE1995287390A patent/PE60096A1/es not_active Application Discontinuation
- 1995-12-18 MA MA24097A patent/MA23746A1/fr unknown
- 1995-12-19 IS IS4312A patent/IS4312A/is unknown
- 1995-12-21 LV LVP-95-379A patent/LV11325B/en unknown
- 1995-12-21 BG BG100248A patent/BG100248A/xx unknown
- 1995-12-21 PL PL95311997A patent/PL311997A1/xx unknown
- 1995-12-21 TN TNTNSN95133A patent/TNSN95133A1/fr unknown
- 1995-12-22 CN CN95120143A patent/CN1133287A/zh active Pending
- 1995-12-22 CZ CZ953447A patent/CZ344795A3/cs unknown
- 1995-12-22 KR KR1019950054933A patent/KR960022510A/ko not_active Ceased
- 1995-12-22 HU HU9503783A patent/HUT74672A/hu unknown
- 1995-12-22 OA OA60759A patent/OA10204A/en unknown
- 1995-12-22 TR TR95/01644A patent/TR199501644A2/xx unknown
- 1995-12-22 NO NO955288A patent/NO955288L/no unknown
- 1995-12-22 SI SI9500393A patent/SI9500393A/sl unknown
- 1995-12-22 AU AU40677/95A patent/AU4067795A/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| HUT74672A (en) | 1997-01-28 |
| NO955288D0 (no) | 1995-12-22 |
| KR960022510A (ko) | 1996-07-18 |
| FI972696A0 (fi) | 1997-06-23 |
| WO1996020184A1 (en) | 1996-07-04 |
| TNSN95133A1 (fr) | 1996-02-06 |
| OA10204A (en) | 1996-12-18 |
| AU4067795A (en) | 1996-07-04 |
| CN1133287A (zh) | 1996-10-16 |
| NO955288L (no) | 1996-06-24 |
| BG100248A (bg) | 1996-07-31 |
| MA23746A1 (fr) | 1996-07-01 |
| PL311997A1 (en) | 1996-06-24 |
| FI972696L (fi) | 1997-06-23 |
| JPH10500702A (ja) | 1998-01-20 |
| CZ344795A3 (en) | 1996-09-11 |
| HU9503783D0 (en) | 1996-04-29 |
| TR199501644A2 (tr) | 1996-11-21 |
| IS4312A (is) | 1996-06-24 |
| LV11325A (lv) | 1996-06-20 |
| LV11325B (en) | 1997-02-20 |
| US5770594A (en) | 1998-06-23 |
| FI972696A7 (fi) | 1997-06-23 |
| IL116399A0 (en) | 1996-03-31 |
| SI9500393A (en) | 1997-04-30 |
| GT199500058A (es) | 1997-06-05 |
| CA2207772A1 (en) | 1996-07-04 |
| SK158795A3 (en) | 1997-01-08 |
| BR9505995A (pt) | 1997-12-23 |
| PE60096A1 (es) | 1996-12-28 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES2182906T3 (es) | Grapa quirurgica helicoidal. | |
| HN1995009160A (es) | Derivados de cicloalcano indol y azaindol | |
| HN1998000139A (es) | Pirimidin-4-ona y pirimidin-4-tiona novedosas como funguicidas | |
| HN1996000124A (es) | 2-ox y 2- tio - 1, 2 dihidroquinolinil oxazolidinonas | |
| HN1998000124A (es) | Terapia de combinacion | |
| DE60010098D1 (de) | 28-epirapaloge | |
| MX9709875A (es) | N-(indol-2-carbonil)-glicinamidas substituidas y derivados como inhibidores de glicogeno fosforilasa, composiciones que las contienen y uso de las mismas. | |
| HN1997000126A (es) | Derivados de indazol | |
| HN1999000155A (es) | 4-carboxiamino-2-metil-1,2,3,4-tetrahidroquinolinas | |
| HN1998000002A (es) | Compuestos de quinolina y de quinazolina utiles en terapia | |
| HN1998003689A (es) | Azetidinas | |
| MX9704683A (es) | Inhibidores de la escualeno sintetasa. | |
| DE69801200D1 (de) | Stanzwerkzeug | |
| DE69629337D1 (de) | Schweissleistungsquelle | |
| HN1997000153A (es) | Pirazoles plaguicidas y derivados | |
| ES2179908T3 (es) | Acidos sacarosamonocarboxilicos acilados. | |
| HN1999000116A (es) | Isoquinolinas | |
| FI973604L (fi) | Äänilähdejärjestely | |
| ATA202797A (de) | Ambossgartenschere | |
| YU48719B (sh) | Lizin so 6-hloro-5-fluoro-3-(2-tenoil)-2-oksindol-1-karboksamida | |
| EE9900187A (et) | HIV proteaasi inhibiitorina kasulik 1-(3-aminoindasool-5-üül)-3-butüül-tsükliline uurea | |
| TR200103662T2 (tr) | Yeni kalpainler ve bunların kullanılması | |
| HN1998000131A (es) | Terapia de combinación | |
| UA50030A (uk) | Комплексне добриво | |
| HN1997003669A (es) | Quimoxlinodionas |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration | ||
| MM | Annulment or lapse due to non-payment of fees |