MX9704440A - Method and reagent for treatment of arthritic conditions, induction of graft tolerance and reversal of immune responses. - Google Patents
Method and reagent for treatment of arthritic conditions, induction of graft tolerance and reversal of immune responses.Info
- Publication number
- MX9704440A MX9704440A MX9704440A MX9704440A MX9704440A MX 9704440 A MX9704440 A MX 9704440A MX 9704440 A MX9704440 A MX 9704440A MX 9704440 A MX9704440 A MX 9704440A MX 9704440 A MX9704440 A MX 9704440A
- Authority
- MX
- Mexico
- Prior art keywords
- reversal
- induction
- reagent
- promoter
- treatment
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 4
- 230000002917 arthritic effect Effects 0.000 title abstract 2
- 230000028993 immune response Effects 0.000 title abstract 2
- 230000006698 induction Effects 0.000 title abstract 2
- 239000003153 chemical reaction reagent Substances 0.000 title 1
- 108091032973 (ribonucleotides)n+m Proteins 0.000 abstract 2
- 102000053642 Catalytic RNA Human genes 0.000 abstract 2
- 108090000994 Catalytic RNA Proteins 0.000 abstract 2
- QUSNBJAOOMFDIB-UHFFFAOYSA-N Ethylamine Chemical compound CCN QUSNBJAOOMFDIB-UHFFFAOYSA-N 0.000 abstract 2
- ISAKRJDGNUQOIC-UHFFFAOYSA-N Uracil Chemical compound O=C1C=CNC(=O)N1 ISAKRJDGNUQOIC-UHFFFAOYSA-N 0.000 abstract 2
- 230000015572 biosynthetic process Effects 0.000 abstract 2
- 108091092562 ribozyme Proteins 0.000 abstract 2
- 238000003786 synthesis reaction Methods 0.000 abstract 2
- 101150013553 CD40 gene Proteins 0.000 abstract 1
- NYHBQMYGNKIUIF-UUOKFMHZSA-N Guanosine Chemical compound C1=NC=2C(=O)NC(N)=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O NYHBQMYGNKIUIF-UUOKFMHZSA-N 0.000 abstract 1
- 102000000422 Matrix Metalloproteinase 3 Human genes 0.000 abstract 1
- 102000009572 RNA Polymerase II Human genes 0.000 abstract 1
- 108010009460 RNA Polymerase II Proteins 0.000 abstract 1
- 102100040245 Tumor necrosis factor receptor superfamily member 5 Human genes 0.000 abstract 1
- 230000002255 enzymatic effect Effects 0.000 abstract 1
- 238000012423 maintenance Methods 0.000 abstract 1
- 108020004999 messenger RNA Proteins 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 239000002342 ribonucleoside Substances 0.000 abstract 1
- 108091007196 stromelysin Proteins 0.000 abstract 1
- 238000013518 transcription Methods 0.000 abstract 1
- 230000035897 transcription Effects 0.000 abstract 1
- 241000701161 unidentified adenovirus Species 0.000 abstract 1
- 229940035893 uracil Drugs 0.000 abstract 1
Landscapes
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
An enzymatic nucleic acid molecule which cleaves RNA associated with development or maintenance of an arthritic condition, induction of graft tolerance or reversal of an immune response. In particular, the ribozyme sequences are directed to an mRNA encoding B7-1, B7-2, B7-3, CD40 and/or stromelysin. Also provided are ribozymes where the uracil in positions 4 and/or 7 are substituted, as well as methods for the synthesis of 2'-alkylnucleotides, 2'-O-alkylthioalkyl, or 2'-alkylthioalkylnucleotides. The application further describes a method for diprotection of RNA with aqueous ethylamine, a method for synthesis of a basic ribonucleoside mimetics, and transcription units comprising an RNA polymerase II promoter, a U6 small nuclear promoter, or an adenovirus VA1 promoter system.
Applications Claiming Priority (12)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US35492094A | 1994-12-13 | 1994-12-13 | |
| US08/363,254 US5891684A (en) | 1992-10-15 | 1994-12-23 | Base-modified enzymatic nucleic acid |
| US08/363,253 US5891683A (en) | 1993-09-02 | 1994-12-23 | Non-nucleotide containing enzymatic nucleic acid |
| US08/390,850 US5612215A (en) | 1992-12-07 | 1995-02-17 | Stromelysin targeted ribozymes |
| US08/426,124 US5716824A (en) | 1995-04-20 | 1995-04-20 | 2'-O-alkylthioalkyl and 2-C-alkylthioalkyl-containing enzymatic nucleic acids (ribozymes) |
| US08/432,874 US5627053A (en) | 1994-03-29 | 1995-05-02 | 2'deoxy-2'-alkylnucleotide containing nucleic acid |
| US43450995A | 1995-05-04 | 1995-05-04 | |
| US95195P | 1995-07-07 | 1995-07-07 | |
| US97495P | 1995-07-07 | 1995-07-07 | |
| US08/512,861 US6146886A (en) | 1994-08-19 | 1995-08-07 | RNA polymerase III-based expression of therapeutic RNAs |
| US08/541,365 US5672501A (en) | 1994-12-23 | 1995-10-05 | Base-modified enzymatic nucleic acid |
| PCT/US1995/015516 WO1996018736A2 (en) | 1994-12-13 | 1995-11-22 | Method and reagent for treatment of arthritic conditions, induction of graft tolerance and reversal of immune responses |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX9704440A true MX9704440A (en) | 1997-10-31 |
Family
ID=56289668
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX9704440A MX9704440A (en) | 1994-12-13 | 1995-11-22 | Method and reagent for treatment of arthritic conditions, induction of graft tolerance and reversal of immune responses. |
Country Status (2)
| Country | Link |
|---|---|
| EP (1) | EP0799313A2 (en) |
| MX (1) | MX9704440A (en) |
-
1995
- 1995-11-22 EP EP95942944A patent/EP0799313A2/en not_active Withdrawn
- 1995-11-22 MX MX9704440A patent/MX9704440A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP0799313A2 (en) | 1997-10-08 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| WO1996018736A3 (en) | Method and reagent for treatment of arthritic conditions, induction of graft tolerance and reversal of immune responses | |
| DE60037938D1 (en) | ANTISENSE THERAPY FOR TRPM-2 | |
| MX9605716A (en) | Methods and compositions for treatment of restenosis and cancer using ribozymes. | |
| GR3024597T3 (en) | 7-deazapurine modified oligonucleotides | |
| WO2001089583A3 (en) | Glutamic acid decarboxylase (gad)_delivery system for treating neurodegenerative diseases | |
| EP0654077A4 (en) | Method and reagent for treatment of animal diseases. | |
| DE69736598D1 (en) | Ribonucleic acid RNA preparation and its use | |
| PT1053313E (en) | OLIGONUCLEOTIDOS '' ANTISENSE '' OPTIMIZED COMPLEMENTARY SEQUENCES OF DNA METHYLTRANSFERASE | |
| ES8504458A1 (en) | Preparation of DNA sequences and DNA recombinant molecules coding for the cholera toxine units A and B, the products obtained and compositions containing the unit(s) obtained. | |
| WO2001025488A3 (en) | Method for enrichment of natural antisense messenger rna | |
| MY109486A (en) | Method employing type ii endoglycosidase | |
| DK0665882T3 (en) | DNA compounds comprising sequences encoding mannuronan C-5 epimerase | |
| EP1621545A3 (en) | Oligoribonucleotides and ribonucleases for cleaving RNA | |
| WO1998054313A3 (en) | Dna methyltransferase genomic sequences and antisense oligonucleotides | |
| WO1996018733A3 (en) | Ribozyme-mediated inactivation of leukemia-associated rna | |
| EP0794256A3 (en) | Method for culturing microorganisms having methanol metabolic pathway | |
| MX9704440A (en) | Method and reagent for treatment of arthritic conditions, induction of graft tolerance and reversal of immune responses. | |
| ZA947059B (en) | Grb3-3 gene its variants and their uses | |
| EP1118667A4 (en) | Novel enzyme compositions, process for producing the same and utilization of the same | |
| ZA200101737B (en) | Nucleic acid molecules which code for enzymes with fructosyltransferase activity and use thereof. | |
| NZ330290A (en) | Purified proteins, recombinant DNA sequences and processes for producing caffeine free beverages | |
| WO2001088124A3 (en) | Method and reagent for the inhibition of erg | |
| GB9028107D0 (en) | System for isolating and producing new genes,gene products and dna sequences | |
| ZA99236B (en) | Orotidine-5'-phosphate decarboxylase gene, gene construct comprising this gene and its use. | |
| BG103672A (en) | Acarbose acb group, isolation of acarbose biosynthesis and acarbose metabolism from actinoplanes sp. se 50/110 and their application |