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MX9703244A - Expresion de lactoferrina recombinante procesada yfragmentos del polipeptido lactoferrina a partir de un producto de fusion en aspergillus. - Google Patents

Expresion de lactoferrina recombinante procesada yfragmentos del polipeptido lactoferrina a partir de un producto de fusion en aspergillus.

Info

Publication number
MX9703244A
MX9703244A MX9703244A MX9703244A MX9703244A MX 9703244 A MX9703244 A MX 9703244A MX 9703244 A MX9703244 A MX 9703244A MX 9703244 A MX9703244 A MX 9703244A MX 9703244 A MX9703244 A MX 9703244A
Authority
MX
Mexico
Prior art keywords
lactoferrin
aspergillus
polypeptide
ragments
expression
Prior art date
Application number
MX9703244A
Other languages
English (en)
Inventor
Orla M Conneely
Denis R Headon
Bert W O'malley
Original Assignee
Agennix Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Agennix Inc filed Critical Agennix Inc
Publication of MX9703244A publication Critical patent/MX9703244A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/79—Transferrins, e.g. lactoferrins, ovotransferrins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Mycology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Cosmetics (AREA)

Abstract

La presente invencion proporciona la produccion de lactoferrinas y fragmentos del polipéptido lactoferrina, usando las células huésped Aspergillus en combinacion con construcciones plasmídicas nuevas. Más especificamente, la presente invencion proporciona construcciones de vectores novedosos capaces de producir lactoferrinas y fragmentos del polipéptido lactoferrina en células huésped Aspergillus. Más particularmente, la presente invencion proporciona construcciones plasmidicas nuevas apropiadas para usarse con las células huésped de Aspergillus y especialmente con Aspergillus awamori, niger y oryzae, las cuales son capaces de producir luego grandes cantidades de lactoferrinas recombinantes y fragmentos del polipéptido de lactoferrina.
MX9703244A 1994-11-02 1997-05-02 Expresion de lactoferrina recombinante procesada yfragmentos del polipeptido lactoferrina a partir de un producto de fusion en aspergillus. MX9703244A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/303,009 US5571697A (en) 1989-05-05 1994-11-02 Expression of processed recombinant lactoferrin and lactoferrin polypeptide fragments from a fusion product in Aspergillus

Publications (1)

Publication Number Publication Date
MX9703244A true MX9703244A (es) 1998-07-31

Family

ID=23170177

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9703244A MX9703244A (es) 1994-11-02 1997-05-02 Expresion de lactoferrina recombinante procesada yfragmentos del polipeptido lactoferrina a partir de un producto de fusion en aspergillus.

Country Status (11)

Country Link
US (3) US5571697A (es)
EP (1) EP0871724A1 (es)
JP (1) JPH10509317A (es)
KR (1) KR100443307B1 (es)
CN (1) CN1230537C (es)
AU (1) AU4279896A (es)
CA (1) CA2204246A1 (es)
DE (1) DE871724T1 (es)
ES (1) ES2127164T1 (es)
MX (1) MX9703244A (es)
WO (1) WO1996014413A1 (es)

Families Citing this family (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5571697A (en) * 1989-05-05 1996-11-05 Baylor College Of Medicine Texas Medical Center Expression of processed recombinant lactoferrin and lactoferrin polypeptide fragments from a fusion product in Aspergillus
IL94183A (en) * 1989-05-05 2003-09-17 Baylor College Medicine cDNA SEQUENCE CODING FOR HUMAN LACTOFERRIN PROTEIN OR PORTION THEREOF AND LACTOFERRIN PROTEIN PRODUCED FROM SAID SEQUENCE
US6066469A (en) * 1990-03-08 2000-05-23 Ferro Dynamics, Inc. Cloning, expression, and uses of human lactoferrin
AT404838B (de) * 1995-11-24 1999-03-25 Immuno Ag Herstellung von proteinen aus pro-proteinen durch fusionsproteine abgeleitet von furin oder furinanalogen
US6111081A (en) * 1996-05-31 2000-08-29 Baylor College Of Medicine Lactoferrin variants and uses thereof
US5811381A (en) * 1996-10-10 1998-09-22 Mark A. Emalfarb Cellulase compositions and methods of use
US7883872B2 (en) * 1996-10-10 2011-02-08 Dyadic International (Usa), Inc. Construction of highly efficient cellulase compositions for enzymatic hydrolysis of cellulose
WO2000020555A2 (en) * 1998-10-06 2000-04-13 Aarl Inc Transformation system in the field of filamentous fungal hosts: in chrysosporium
CA2340286C (en) * 1998-08-19 2015-07-14 Monsanto Company Plant expression vector comprising a 5' non-translated leader sequence from a wheat chlorophyll a/b-binding protein gene
US6592814B2 (en) * 1998-10-02 2003-07-15 Johnson & Johnson Vision Care, Inc. Biomedical devices with antimicrobial coatings
US6399570B1 (en) 1999-02-05 2002-06-04 Agennix, Inc. Antimicrobial/endotoxin neutralizing polypeptide
US7417178B2 (en) * 2000-05-02 2008-08-26 Ventria Bioscience Expression of human milk proteins in transgenic plants
US7138150B2 (en) * 2000-05-02 2006-11-21 Ventria Bioscience Method of making an anti-infective composition for treating oral infections
US20080050503A1 (en) * 2000-05-02 2008-02-28 Ning Huang Expression of human milk proteins in transgenic plants
AU2002357934A1 (en) * 2001-12-28 2003-07-24 Campina B.V. Humanized lactoferrin and uses thereof
EP1572908A4 (en) * 2002-02-14 2008-10-22 William J Rutter CHIMERIC MOLECULES FOR ADMINISTERING CLEAVAGE TO A TREATED HOST
ATE453669T1 (de) * 2002-05-10 2010-01-15 New Century Pharmaceuticals Ferritinfusionsproteine zur verwendung für impfstoffe und andere anwendungen
JP4685443B2 (ja) 2002-05-10 2011-05-18 エイジェニックス・インコーポレイテッド 悪性新生物および他の過剰増殖性疾患の治療におけるラクトフェリン
WO2003099207A2 (en) * 2002-05-24 2003-12-04 Agennix Incorporated Oral lactoferrin in the treatment of respiratory disorders
ES2224792B1 (es) * 2002-06-28 2007-02-16 Era Plantech, S.L. Produccion de peptidos y proteinas por acumulacion de cuerpos proteicos derivados de reticulos endoplasmico en plantas.
ATE497778T1 (de) 2002-09-16 2011-02-15 Agennix Inc Lactoferrin-zusammensetzungen und verfahren zur behandlung von diabetischen ulcus
JP4795021B2 (ja) * 2002-12-06 2011-10-19 エイジェニックス インコーポレイテッド 敗血症治療における経口用ラクトフェリン
AU2003296447A1 (en) * 2002-12-10 2004-06-30 Agennix Incorporated Lactoferrin as an agent in the prevention of organ transplant rejection and graft-versus-host-disease
WO2004054608A2 (en) * 2002-12-12 2004-07-01 Agennix Incorporated Lactoferrin in the reduction of pain
WO2004103285A2 (en) * 2003-05-14 2004-12-02 Agennix Incorporated Lactoferrin in the treatment of diabetes mellitus
CA2527904A1 (en) * 2003-06-06 2005-05-26 Agennix Incorporated Lactoferrin as an adjuvant in cancer vaccines
US20040259770A1 (en) * 2003-06-19 2004-12-23 Rush University Medical Center Method for determining leukocyte activation
WO2005018542A2 (en) * 2003-07-10 2005-03-03 Agennix Incorporated Use of lactoferrin in prophylaxis against infection and/or inflammation in immunosuppressed subjects
ES2368221T3 (es) * 2003-09-11 2011-11-15 Novozymes Adenium Biotech A/S Producción recombinante de agentes antimicrobianos.
WO2005035569A2 (en) * 2003-10-10 2005-04-21 Five Prime Therapeutics, Inc. Kiaa0779, splice variants thereof, and methods of their use
JP2007517504A (ja) * 2003-12-09 2007-07-05 ベントリア バイオサイエンス 融合担体として種子貯蔵蛋白を利用する植物種子中の融合ポリペプチドの高水準発現
US7125963B2 (en) * 2004-03-03 2006-10-24 En N Tech Inc Treatments for contaminant reduction in lactoferrin preparations and lactoferrin containing compositions
WO2006047744A2 (en) 2004-10-26 2006-05-04 Agennix Incorporated Compositions of lactoferrin related peptides and uses thereof
JP4634809B2 (ja) * 2005-01-05 2011-02-16 株式会社アップウェル アポタンパク質の製造方法
US20060211089A1 (en) * 2005-03-16 2006-09-21 Novozymes A/S Expression of defensins in filamentous fungi
WO2007150049A2 (en) 2006-06-22 2007-12-27 Agennix Incorporated Lactoferrin as a radioprotective agent
WO2008073914A2 (en) 2006-12-10 2008-06-19 Dyadic International Inc. Expression and high-throughput screening of complex expressed dna libraries in filamentous fungi
US9862956B2 (en) 2006-12-10 2018-01-09 Danisco Us Inc. Expression and high-throughput screening of complex expressed DNA libraries in filamentous fungi
NZ555163A (en) 2007-05-14 2010-05-28 Fonterra Co Operative Group Methods of immune or hematological enhancement, inhibiting tumour formation or growth, and treating or preventing cancer, cancer symptoms, or the symptoms of cancer treatments
CA2695830A1 (en) 2007-08-08 2009-02-12 Novozymes Biopharma Dk A/S Transferrin variants and conjugates
WO2009033071A2 (en) * 2007-09-07 2009-03-12 Dyadic International, Inc. Novel fungal enzymes
DK2391225T3 (da) * 2009-01-28 2020-07-20 Perraudin Jean Paul Fremgangsmåde til fremstilling af lactoferrin
DK2393834T3 (da) 2009-02-06 2013-06-24 Novozymes Biopharma Dk As Fremgangsmåde til oprensning
ES2630253T3 (es) 2009-02-11 2017-08-18 Albumedix A/S Variantes de albúmina y conjugados
WO2010121933A1 (en) * 2009-04-22 2010-10-28 Dsm Ip Assets B.V. Process for the production of a recombinant polypeptide of interest
WO2011104352A1 (en) 2010-02-25 2011-09-01 Agennix Ag Oral lactoferrin in the treatment of severe sepsis
US10047382B2 (en) 2012-07-03 2018-08-14 Kao Corporation Useful microorganism and method for producing substance of interest
CN103421794B (zh) * 2013-08-08 2014-07-02 华南理工大学 一种黑曲霉组成型表达元件、表达载体、重组黑曲霉及其构建方法和应用
CN108893415B (zh) * 2018-07-31 2022-12-27 上海凯圣生物科技有限公司 曲霉菌株及利用曲霉菌株发酵生产人乳铁蛋白的方法
WO2024056643A1 (en) * 2022-09-15 2024-03-21 Novozymes A/S Fungal signal peptides
WO2025157268A1 (zh) * 2024-01-24 2025-07-31 南京百斯杰生物工程有限公司 一种米曲霉重组菌株的构建方法
WO2025226596A1 (en) * 2024-04-24 2025-10-30 Novozymes A/S Methods for producing secreted polypeptides
CN119776443B (zh) * 2024-12-23 2025-12-02 江苏创健医疗科技股份有限公司 一种多拷贝整合实现高效合成人乳铁蛋白的方法与应用
CN119841906B (zh) * 2025-01-26 2025-09-26 新苡萃(上海)生物科技有限公司 一种淀粉酶信号肽变体及其应用

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4766075A (en) * 1982-07-14 1988-08-23 Genentech, Inc. Human tissue plasminogen activator
US4652639A (en) * 1982-05-06 1987-03-24 Amgen Manufacture and expression of structural genes
US4703008A (en) * 1983-12-13 1987-10-27 Kiren-Amgen, Inc. DNA sequences encoding erythropoietin
US4710465A (en) * 1984-04-19 1987-12-01 Yale University Junction-fragment DNA probes and probe clusters
US4886747A (en) * 1985-03-22 1989-12-12 Genentech, Inc. Nucleic acid encoding TGF-β and its uses
US4959318A (en) * 1985-06-27 1990-09-25 Zymogenetics, Inc. Expression of protein C
US4965190A (en) * 1986-07-31 1990-10-23 Howard Hughes Medical Institute Methods for the identification of mutations in the human phenylalanine hydroxylase gene using DNA probes
US5019508A (en) * 1987-08-27 1991-05-28 Biotechnology Research Partners, Ltd. Synovial phospholipases
US5081227A (en) * 1988-03-04 1992-01-14 La Jolla Cancer Research Foundation Germ cell alkaline phosphatase
IL94183A (en) * 1989-05-05 2003-09-17 Baylor College Medicine cDNA SEQUENCE CODING FOR HUMAN LACTOFERRIN PROTEIN OR PORTION THEREOF AND LACTOFERRIN PROTEIN PRODUCED FROM SAID SEQUENCE
US5571691A (en) * 1989-05-05 1996-11-05 Baylor College Of Medicine Production of recombinant lactoferrin and lactoferrin polypeptides using CDNA sequences in various organisms
US5571697A (en) * 1989-05-05 1996-11-05 Baylor College Of Medicine Texas Medical Center Expression of processed recombinant lactoferrin and lactoferrin polypeptide fragments from a fusion product in Aspergillus
CA2034487C (en) * 1989-06-16 2000-08-29 Virgil B. Lawlis Dna sequences, vectors, and fusion polypeptides to increase secretion of desired polypeptides from filamentous fungi
UA27702C2 (uk) * 1989-09-27 2000-10-16 Гіст-Брокейдс Н.В. Фрагмент геномної днк, що кодує фітазу aspergillus niger,фрагмент кднк, що кодує фітазу aspergillus niger, рекомбінантна плазмідна днк для експресії фітази в aspergillus (варіанти), штам aspergillus-продуцент фітази aspergillus (варіанти), спосіб одержання фітази, рекомбінанта фітаза aspergillus niger
WO1991005045A1 (en) * 1989-09-28 1991-04-18 Granada Biosciences, Inc. PORCINE LACTOFERRIN AMINO ACID AND cDNA SEQUENCE
WO1991013982A1 (en) * 1990-03-08 1991-09-19 Ferrodynamics, Inc. Genetically engineered human lactoferrin
JP2818056B2 (ja) * 1990-09-07 1998-10-30 森永乳業株式会社 抗菌性ペプチドおよび抗菌剤
EP0724633A1 (en) * 1991-02-08 1996-08-07 The University Of Vermont And State Agricultural College Recombinant transferrins, transferrin half-molecules and mutants thereof
CA2123416C (en) * 1991-12-09 2003-05-20 Robertus J. Gouka Process for producing/secreting a protein by a transformed mould using expression/secretion regulating regions derived from an aspergillus endoxylanase ii gene
ZA932568B (en) * 1992-04-24 1993-11-12 Baylor College Midecine A Non Production of recombinant human lactoferrin

Also Published As

Publication number Publication date
WO1996014413A1 (en) 1996-05-17
AU4279896A (en) 1996-05-31
DE871724T1 (de) 1999-06-02
CA2204246A1 (en) 1996-05-17
CN1171815A (zh) 1998-01-28
US6080559A (en) 2000-06-27
JPH10509317A (ja) 1998-09-14
EP0871724A1 (en) 1998-10-21
CN1230537C (zh) 2005-12-07
ES2127164T1 (es) 1999-04-16
KR970707283A (ko) 1997-12-01
EP0871724A4 (es) 1998-10-21
KR100443307B1 (ko) 2004-11-08
US5955316A (en) 1999-09-21
US5571697A (en) 1996-11-05

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