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MX9703017A - Inmunizacion oral con plantas transgenicas. - Google Patents

Inmunizacion oral con plantas transgenicas.

Info

Publication number
MX9703017A
MX9703017A MX9703017A MX9703017A MX9703017A MX 9703017 A MX9703017 A MX 9703017A MX 9703017 A MX9703017 A MX 9703017A MX 9703017 A MX9703017 A MX 9703017A MX 9703017 A MX9703017 A MX 9703017A
Authority
MX
Mexico
Prior art keywords
plants
plant
transgenic
animals
transgenic plants
Prior art date
Application number
MX9703017A
Other languages
English (en)
Inventor
Charles J Arntzen
Hugh S Mason
Tariq A Haq
John D Clements
Original Assignee
Texas A & M Univ Sys
Univ Tulane
Educational Fund
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Texas A & M Univ Sys, Univ Tulane, Educational Fund filed Critical Texas A & M Univ Sys
Publication of MX9703017A publication Critical patent/MX9703017A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C07K14/245—Escherichia (G)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
    • C12N15/8258—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon for the production of oral vaccines (antigens) or immunoglobulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/16011—Caliciviridae
    • C12N2770/16022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Cosmetics (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

Las vacunas orales y los auxiliares de vacuna orales de la presente invencion se producen en plantas transgénicas, y luego se administran a través del consumo de la planta transgénica. Se construyen secuencias de ADN que codifican tanto naturalmente como sintéticamente la expresion de agentes inmunogénicos que son capaces de provocar una respuesta inmune en animales cuando se dan como alimento en plantas comestibles, tejidos de plantas, o materiales derivados de plantas, y se transforman plantas para una expresion estable o transitoria en células de plantas. La presente invencion proporciona el primer método funcional conocido para inmunizar animales por medio de plantas transgénicas, en donde las plantas expresan antígenos bacterianos que actuan tanto como inmunogenos como auxiliares, cuando se da como alimento el material de planta transgénica que expresa los antígenos a animales.
MX9703017A 1994-10-24 1995-10-24 Inmunizacion oral con plantas transgenicas. MX9703017A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US32871694A 1994-10-24 1994-10-24
PCT/US1995/013376 WO1996012801A1 (en) 1994-10-24 1995-10-24 Oral immunization with transgenic plants

Publications (1)

Publication Number Publication Date
MX9703017A true MX9703017A (es) 1997-10-31

Family

ID=23282114

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9703017A MX9703017A (es) 1994-10-24 1995-10-24 Inmunizacion oral con plantas transgenicas.

Country Status (11)

Country Link
US (1) US6194560B1 (es)
EP (1) EP0793717B1 (es)
JP (1) JPH10507916A (es)
AT (1) ATE287947T1 (es)
AU (1) AU691707B2 (es)
CA (1) CA2203679C (es)
DE (1) DE69533964T2 (es)
ES (1) ES2235176T3 (es)
MX (1) MX9703017A (es)
NZ (1) NZ297142A (es)
WO (1) WO1996012801A1 (es)

Families Citing this family (48)

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US5484719A (en) 1991-08-26 1996-01-16 Edible Vaccines, Inc. Vaccines produced and administered through edible plants
US5612487A (en) * 1991-08-26 1997-03-18 Edible Vaccines, Inc. Anti-viral vaccines expressed in plants
US6034298A (en) * 1991-08-26 2000-03-07 Prodigene, Inc. Vaccines expressed in plants
CA2232023A1 (en) * 1995-09-15 1997-03-20 John A. Howard Expression cassettes and methods for delivery of animal vaccines
US6261561B1 (en) 1996-04-19 2001-07-17 Henry M. Jackson Foundation For The Advancement Of Military Medicine Method of stimulating an immune response by administration of host organisms that express intimin alone or as a fusion protein with one or more other antigens
JP2000509270A (ja) 1996-04-19 2000-07-25 ヘンリー エム．ジャクソン ファンデーション フォー ザ アドバンスメント オブ ミリタリー メディシン ヒスチジンタグ付きインチミン、ならびに免疫応答を刺激し、標的能力を有する抗原担体としてインチミンを使用する方法
FR2748480B1 (fr) * 1996-05-09 1998-09-04 Biocem Plantes transgeniques exprimant la glycoproteine g de la rage, et glycoproteines ainsi obtenues
US20050032211A1 (en) * 1996-09-26 2005-02-10 Metabogal Ltd. Cell/tissue culturing device, system and method
IL155588A0 (en) * 2003-04-27 2003-11-23 Metabogal Ltd Methods for expression of enzymatically active recombinant lysosomal enzymes in transgenic plant root cells and vectors used thereby
NZ337506A (en) * 1997-04-22 2001-08-31 Bavarian Nordic Res Inst As Detection and differentiation of pathogenic enterobacteria in a sample by providing specific, labelled oligonucleotides probes and optimised primer pairs for amplification using PCR
US20050241024A1 (en) * 1997-10-07 2005-10-27 Langridge William H Transgenic plant-based vaccines
US6777546B2 (en) 1997-10-07 2004-08-17 Loma Linda University Methods and substances for preventing and treating autoimmune disease
US7422747B2 (en) 1997-10-07 2008-09-09 Loma Linda University Transgenic plant-based vaccines
SE9801852D0 (sv) * 1998-05-26 1998-05-26 Sbl Vaccin Ab Method of producing thy A-strains of Vibro cholerae, suck strains and their use
JP2002533068A (ja) * 1998-12-22 2002-10-08 ボイス トンプソン インスティテュート フォア プラント リサーチ トランスジェニック植物に発現される経口で免疫原性の細菌エンテロトキシン
AU776855B2 (en) * 1998-12-23 2004-09-23 Boyce Thompson Institute For Plant Research Inc. Expression of immunogenic hepatitis B surface antigens in transgenic plants
WO2001051080A2 (en) * 2000-01-14 2001-07-19 Prodigene, Inc. Methods and compositions for obtaining disease protection for animals
AUPQ520800A0 (en) * 2000-01-21 2000-02-17 Alfred Hospital Prime-boost vaccination strategy
EP1254156A4 (en) * 2000-01-27 2003-05-21 Univ Loma Linda TRANSGENIC PLANT VACCINES
US7081567B2 (en) * 2000-12-03 2006-07-25 Lexun Xue Transgenic dunaliella salina as a bioreactor
ITRM20010332A1 (it) * 2001-06-11 2002-12-11 Ist Superiore Sanita Vaccini a subunita' e procedimenti per la loro produzione.
US20040003432A1 (en) * 2002-05-06 2004-01-01 Pharmacia Corporation Production of hexosamines and uses thereof
AU2003251604A1 (en) * 2002-06-26 2004-01-19 F. C. Thomas Allnutt Viruses and virus-like particles for multiple antigen and target display
ES2224792B1 (es) * 2002-06-28 2007-02-16 Era Plantech, S.L. Produccion de peptidos y proteinas por acumulacion de cuerpos proteicos derivados de reticulos endoplasmico en plantas.
CA2491568A1 (en) * 2002-08-27 2004-03-11 Dow Agrosciences Llc Use of escherichia coli heat labile toxin as an adjuvant in birds and poultry
US20040117874A1 (en) * 2002-10-15 2004-06-17 Jianjun Yang Methods for accumulating translocated proteins
US7317142B2 (en) * 2002-12-13 2008-01-08 Prodi Gene, Inc. Immunization of fish with plant-expressed recombinant proteins
JP2006522022A (ja) 2003-02-14 2006-09-28 ザ キュレイターズ オブ ザ ユニバーシティー オブ ミズーリ プロテアソーム干渉に関連する避妊法および組成物
US7951557B2 (en) * 2003-04-27 2011-05-31 Protalix Ltd. Human lysosomal proteins from plant cell culture
US20100196345A1 (en) * 2003-04-27 2010-08-05 Protalix Production of high mannose proteins in plant culture
BRPI0410340A (pt) * 2003-05-05 2006-05-30 Dow Agrosciences Llc vetores e células para preparar composições imunoprotetoras derivadas de plantas transgênicas
BRPI0410342A (pt) * 2003-05-05 2006-06-20 Dow Agrosciences Llc composições imunoprofiláticas e terapêuticas estáveis derivadas de células vegetais transgênicas e processos para produção
EP1522585A1 (en) * 2003-10-09 2005-04-13 Plant Research International B.V. Chimeric carrier molecules for the production of mucosal vaccines
WO2005116216A1 (ja) * 2004-05-31 2005-12-08 The Kitasato Institute 遺伝子組換え植物による抗原虫病経口ワクチン
AU2005280896B2 (en) 2004-09-10 2010-08-05 Asahi Glass Company, Limited Vaccine for oral administration
US7723570B2 (en) * 2004-10-12 2010-05-25 Soymeds, Inc. Edible vaccines expressed in soybeans
EP1685848A1 (en) * 2005-01-26 2006-08-02 Plant Research International B.V. Oral vaccines for fish
CA2628308A1 (en) 2005-11-04 2007-05-18 Dow Agrosciences Llc Preparation of vaccine master cell lines using recombinant plant suspension cultures
EP2360175B1 (en) * 2005-11-22 2014-07-16 Novartis Vaccines and Diagnostics, Inc. Norovirus and Sapovirus virus-like particles (VLPs)
WO2007111500A1 (en) * 2006-03-27 2007-10-04 Plant Research International B.V. Immunization with transgenic mushrooms
JP2010525833A (ja) 2007-05-07 2010-07-29 プロタリクス リミテッド 大規模な使い捨て型バイオリアクター
WO2009060440A1 (en) * 2007-11-05 2009-05-14 Mor Research Applications Ltd. Anti-measles cancer immunotherapy
DK2728004T3 (en) 2008-05-02 2018-11-05 Idemitsu Kosan Co Bacterial toxin vaccine
CA2745766C (en) * 2009-03-19 2018-07-03 Kaneka Corporation Method, kit and device for detecting nucleic acid
KR101339703B1 (ko) * 2012-07-23 2013-12-11 전북대학교산학협력단 식물을 이용한 재조합 돼지 유행성 설사병 바이러스 (ｐｅｄｖ) 백신의 제조 방법 및 그에 따른 ｐｅｄｖ 백신
US20160213766A1 (en) * 2013-09-23 2016-07-28 Ventria Bioscience, Inc. OspA Fusion Protein for Vaccination against Lyme Disease
EP3075392A4 (en) 2013-11-26 2017-07-12 Idemitsu Kosan Co., Ltd. Prevention of escherichia coli diarrhea
WO2023229330A1 (ko) * 2022-05-23 2023-11-30 주식회사 백스다임 바이러스 뉴클레오캡시드를 이용한 오량체형 독소 단백질 기반 목적 단백질 융합 오량체 제조 플랫폼

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FR2636842B1 (fr) * 1988-09-27 1994-06-10 Liege Universite Etat Proteine de fusion d'une sequence derivee de la sous-unite b de la toxine cholerique et d'un antigene heterologue doue de proprietes immunogenes, compositions de vaccins les contenant et acides nucleiques recombinants contenant une sequence de nucleotides codant pour ladite proteine de fusion
US5612487A (en) * 1991-08-26 1997-03-18 Edible Vaccines, Inc. Anti-viral vaccines expressed in plants
UA48104C2 (uk) * 1991-10-04 2002-08-15 Новартіс Аг Фрагмент днк, який містить послідовність,що кодує інсектицидний протеїн, оптимізовану для кукурудзи,фрагмент днк, який забезпечує направлену бажану для серцевини стебла експресію зв'язаного з нею структурного гена в рослині, фрагмент днк, який забезпечує специфічну для пилку експресію зв`язаного з нею структурного гена в рослині, рекомбінантна молекула днк, спосіб одержання оптимізованої для кукурудзи кодуючої послідовності інсектицидного протеїну, спосіб захисту рослин кукурудзи щонайменше від однієї комахи-шкідника
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WO1994006465A1 (en) * 1992-09-16 1994-03-31 The University Of Tennessee Research Corporation Antigen of hybrid m protein and carrier for group a streptococcal vaccine

Also Published As

Publication number Publication date
CA2203679C (en) 2010-08-17
US6194560B1 (en) 2001-02-27
NZ297142A (en) 2001-09-28
CA2203679A1 (en) 1996-05-02
JPH10507916A (ja) 1998-08-04
EP0793717B1 (en) 2005-01-26
AU691707B2 (en) 1998-05-21
EP0793717A1 (en) 1997-09-10
ATE287947T1 (de) 2005-02-15
DE69533964T2 (de) 2006-03-30
ES2235176T3 (es) 2005-07-01
AU4194096A (en) 1996-05-15
WO1996012801A1 (en) 1996-05-02
EP0793717A4 (en) 1998-11-25
DE69533964D1 (de) 2005-03-03

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