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MX9701783A - Proteinas c3 humanas modificadas. - Google Patents

Proteinas c3 humanas modificadas.

Info

Publication number
MX9701783A
MX9701783A MX9701783A MX9701783A MX9701783A MX 9701783 A MX9701783 A MX 9701783A MX 9701783 A MX9701783 A MX 9701783A MX 9701783 A MX9701783 A MX 9701783A MX 9701783 A MX9701783 A MX 9701783A
Authority
MX
Mexico
Prior art keywords
proteins
protein
modified
modified human
conjugates
Prior art date
Application number
MX9701783A
Other languages
English (en)
Other versions
MXPA97001783A (es
Inventor
Richard Alexander Harrison
Timothy Charles Farries
Original Assignee
Imutran Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB9418147A external-priority patent/GB9418147D0/en
Priority claimed from GBGB9509102.1A external-priority patent/GB9509102D0/en
Application filed by Imutran Ltd filed Critical Imutran Ltd
Publication of MX9701783A publication Critical patent/MX9701783A/es
Publication of MXPA97001783A publication Critical patent/MXPA97001783A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/472—Complement proteins, e.g. anaphylatoxin, C3a, C5a
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Proteínas de trayectoria de complemento nativas modificadas, de tal manera que la proteína es capaz de formar una convertasa C3 estable. De preferencia, la proteína modificada es una proteína C3 humana modificada. También se proporcionan secuencias de ADN que codifican estas proteínas, junto con construcciones de ADN. También se describen conjugados que comprenden a estas proteínas y una fraccion fijadora específica, por ejemplo un anticuerpo, así como usos de estas proteínas y/o conjugados en terapia.
MXPA/A/1997/001783A 1994-09-08 1995-09-08 Proteinas c3 humanas modificadas MXPA97001783A (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB9418147.6 1994-09-08
GB9418147A GB9418147D0 (en) 1994-09-08 1994-09-08 Modified proteins
GBGB9509102.1A GB9509102D0 (en) 1995-05-04 1995-05-04 Modified proteins
GB9509102.1 1995-05-04
PCT/GB1995/002121 WO1996007738A2 (en) 1994-09-08 1995-09-08 Modified human c3 proteins

Publications (2)

Publication Number Publication Date
MX9701783A true MX9701783A (es) 1997-10-31
MXPA97001783A MXPA97001783A (es) 1998-07-03

Family

ID=

Also Published As

Publication number Publication date
NZ292565A (en) 1999-03-29
NO971059D0 (no) 1997-03-07
NZ333949A (en) 2000-06-23
BR9509172A (pt) 1997-11-25
US5849297A (en) 1998-12-15
BG101295A (bg) 1997-12-30
CN1162335A (zh) 1997-10-15
RO117189B1 (ro) 2001-11-30
EP0779922B1 (en) 2004-08-11
WO1996007738A3 (en) 1996-03-28
DE69533359D1 (de) 2004-09-16
FI970979A7 (fi) 1997-03-07
CN1104501C (zh) 2003-04-02
CA2197888A1 (en) 1996-03-14
AU3477295A (en) 1996-03-27
ES2224133T3 (es) 2005-03-01
JPH10505241A (ja) 1998-05-26
PL319040A1 (en) 1997-07-21
RU2194713C2 (ru) 2002-12-20
WO1996007738A2 (en) 1996-03-14
NO971059L (no) 1997-05-07
BG63606B1 (bg) 2002-06-28
EP0779922A2 (en) 1997-06-25
AU707004B2 (en) 1999-07-01
CZ68597A3 (en) 1997-11-12
FI970979A0 (fi) 1997-03-07
SK29697A3 (en) 1998-01-14
CZ290596B6 (cs) 2002-08-14
HUT77874A (hu) 1998-09-28
FI970979L (fi) 1997-03-07
ATE273388T1 (de) 2004-08-15
DE69533359T2 (de) 2005-07-28

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Legal Events

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FG Grant or registration
MM Annulment or lapse due to non-payment of fees