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MX9606171A - Procedimiento para eliminar sales biliares de un paciente y composiciones alquilatadas de las mismas. - Google Patents

Procedimiento para eliminar sales biliares de un paciente y composiciones alquilatadas de las mismas.

Info

Publication number
MX9606171A
MX9606171A MX9606171A MX9606171A MX9606171A MX 9606171 A MX9606171 A MX 9606171A MX 9606171 A MX9606171 A MX 9606171A MX 9606171 A MX9606171 A MX 9606171A MX 9606171 A MX9606171 A MX 9606171A
Authority
MX
Mexico
Prior art keywords
patient
reaction product
alkylating agent
bile salts
removing bile
Prior art date
Application number
MX9606171A
Other languages
English (en)
Inventor
W Harry Mandeville Iii
Stephen Randall Holmes-Farley
Original Assignee
Geltex Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22980525&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX9606171(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Geltex Pharma Inc filed Critical Geltex Pharma Inc
Publication of MX9606171A publication Critical patent/MX9606171A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
    • C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
    • C08F220/52—Amides or imides
    • C08F220/54—Amides, e.g. N,N-dimethylacrylamide or N-isopropylacrylamide
    • C08F220/60—Amides, e.g. N,N-dimethylacrylamide or N-isopropylacrylamide containing nitrogen in addition to the carbonamido nitrogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/785—Polymers containing nitrogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/785—Polymers containing nitrogen
    • A61K31/787—Polymers containing nitrogen containing heterocyclic rings having nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F26/00—Homopolymers and copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00—Chemical modification by after-treatment
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00—Chemical modification by after-treatment
    • C08F8/02—Alkylation
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00—Chemical modification by after-treatment
    • C08F8/44—Preparation of metal salts or ammonium salts
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L39/00—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen; Compositions of derivatives of such polymers
    • C08L39/02—Homopolymers or copolymers of vinylamine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Obesity (AREA)
  • Nutrition Science (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Un método para eliminar sales billares de un paciente, que incluye administrar al paciente una cantidad terapéuticamente efectiva del producto de reaccion de: a) uno o más polímeros altamente entrelazados, caracterizados por una unidad de repeticion seleccionada del grupo que consiste esencialmente en: (1), (2), (3): (NR-CH2-CH2)n, (4): (NR-CH2CH2-NR-CH2CH2-NR-CH2-CHOH-CH2)n y sales y copolímeros de los mismos, en donde n es un entero y cada R, de manera independiente, es H o un grupo alquilo C1-C8, y b) al menos algunos de los átomos de nitrogeno en dichas unidades de repeticion no se reaccionan con dicho agente alquilante; (ii) menos del 10% en moles de los átomos de nitrogeno en las unidades de repeticion, que reaccionan con el agente alquilante, forman unidades de amonio cuaternario; y (iii) el producto de reaccion no es toxico y es estable una vez que se ingiere.
MX9606171A 1994-06-10 1996-12-06 Procedimiento para eliminar sales biliares de un paciente y composiciones alquilatadas de las mismas. MX9606171A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US25843194A 1994-06-10 1994-06-10

Publications (1)

Publication Number Publication Date
MX9606171A true MX9606171A (es) 1998-07-31

Family

ID=22980525

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9606171A MX9606171A (es) 1994-06-10 1996-12-06 Procedimiento para eliminar sales biliares de un paciente y composiciones alquilatadas de las mismas.

Country Status (21)

Country Link
US (12) US5679717A (es)
EP (2) EP0909768A3 (es)
JP (1) JP3931217B2 (es)
KR (1) KR100271693B1 (es)
CN (1) CN1150217C (es)
AT (1) ATE184027T1 (es)
AU (1) AU698752C (es)
CA (1) CA2191478C (es)
DE (3) DE122004000034I2 (es)
DK (1) DK0764174T3 (es)
ES (1) ES2135743T3 (es)
FR (1) FR04C0021I2 (es)
GR (1) GR3031702T3 (es)
IL (2) IL114073A (es)
LU (1) LU91100I2 (es)
MX (1) MX9606171A (es)
NL (1) NL300159I2 (es)
NZ (1) NZ288076A (es)
RU (1) RU2160742C2 (es)
TW (1) TW474813B (es)
WO (1) WO1995034585A1 (es)

Families Citing this family (131)

* Cited by examiner, † Cited by third party
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US5917007A (en) 1999-06-29
DE69511861T2 (de) 2000-02-10
US20070155950A1 (en) 2007-07-05
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AU2699095A (en) 1996-01-05
US5679717A (en) 1997-10-21
ES2135743T3 (es) 1999-11-01
EP0764174B1 (en) 1999-09-01
GR3031702T3 (en) 2000-02-29
DE122004000034I1 (de) 2005-02-24
TW474813B (en) 2002-02-01
US6225355B1 (en) 2001-05-01
CA2191478C (en) 2007-10-16
AU698752C (en) 2002-08-08
LU91100I9 (es) 2019-01-29
US20010044519A1 (en) 2001-11-22
ATE184027T1 (de) 1999-09-15
CN1150435A (zh) 1997-05-21
LU91100I2 (fr) 2004-11-08
US20050131161A1 (en) 2005-06-16
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US5693675A (en) 1997-12-02
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US6066678A (en) 2000-05-23
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