MX9602034A - Retinoid-like compounds. - Google Patents
Retinoid-like compounds.Info
- Publication number
- MX9602034A MX9602034A MX9602034A MX9602034A MX9602034A MX 9602034 A MX9602034 A MX 9602034A MX 9602034 A MX9602034 A MX 9602034A MX 9602034 A MX9602034 A MX 9602034A MX 9602034 A MX9602034 A MX 9602034A
- Authority
- MX
- Mexico
- Prior art keywords
- alkyl
- formula
- independently hydrogen
- compound
- nhcs
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 7
- 229910052739 hydrogen Inorganic materials 0.000 abstract 5
- 239000001257 hydrogen Substances 0.000 abstract 5
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 4
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 150000003254 radicals Chemical class 0.000 abstract 2
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 1
- -1 -CONHRy Chemical group 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 206010003246 arthritis Diseases 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- CBOIHMRHGLHBPB-UHFFFAOYSA-N hydroxymethyl Chemical compound O[CH2] CBOIHMRHGLHBPB-UHFFFAOYSA-N 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 125000001624 naphthyl group Chemical group 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 231100000252 nontoxic Toxicity 0.000 abstract 1
- 230000003000 nontoxic effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 208000017520 skin disease Diseases 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The present invention relates to a compound of formula (see formula) or a nontoxic pharmaceutically acceptable salt, physiologically hydrolyzable ester or solvate thereof, in which X is -O-CO-, -NH-CO-, -CS-NH-, -CO-O-, -CO-O-, -CO-NH-, -COS-, -SCO-, -SCH2-, -CH2-CH2-, -C(C-, -CH2,-NH-, -COCH2-, -NHCS-, -NHCS-, -CH2S-; -CH2O-, -OCH2-, -NHCH2- or -CR5=CR6-; Rm and Rk are independently hydrogen, halogen, C1-6 alkyl, hydroxy, C1-6 alkyloxy or nitro; n is zero or one; R4 is -(CH2)t-Y, C1-6 alkyl, or C3-6 cycloalkyl; R1 is -CO2Z, C1-6alkyl, CH2OH, -CONHRy , or CHO; R2 and R3 are independently hydrogen or C1-6 alkyl alkyl; Ra and Rb are independently hydrogen or C1-6 alkyl; but when n is one, Ra and Rb together can form a radical of the formula (see formula); Y is naphthyl or phenyl, both radicals can be optionally substituted with one to three same or different C1-6 alkyl or halogen; Z is hydrogen or C1-6 alkyl;R5, R6 and Ry are independently hydrogen or C1-6 alkyl; and t is zero to six. Also porivided by this invention are methods for preventing and/or treating tumors, arthritis and nonmalignant skin disorders comprising administering a compound of formula Y to a mammal. Further provided is a pharmaceutical formulation (composition) comprising a compound of formula Y in admixture with (a) pharmaceutically acceptable excipient (s).
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/464,186 US5648385A (en) | 1994-01-03 | 1995-06-05 | Retinoid-like compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX9602034A true MX9602034A (en) | 1997-08-30 |
Family
ID=23842896
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX9602034A MX9602034A (en) | 1995-06-05 | 1996-05-29 | Retinoid-like compounds. |
Country Status (11)
| Country | Link |
|---|---|
| KR (1) | KR970000224A (en) |
| CN (1) | CN1144217A (en) |
| CZ (1) | CZ160996A3 (en) |
| HU (1) | HU218963B (en) |
| IL (1) | IL118528A (en) |
| MX (1) | MX9602034A (en) |
| NO (1) | NO305946B1 (en) |
| RU (1) | RU2163590C2 (en) |
| SG (1) | SG42412A1 (en) |
| TW (1) | TW418186B (en) |
| ZA (1) | ZA964264B (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JO2178B1 (en) * | 1999-10-19 | 2003-04-23 | اف . هوفمان لاروش ايه جي | Treatment of emphysema using rar selective retinoid antagonists |
| GB0215978D0 (en) * | 2002-07-10 | 2002-08-21 | Karobio Ab | Novel compounds |
| RU2274453C1 (en) * | 2004-12-07 | 2006-04-20 | Алам Джан | Pharmaceutical composition for homeostasis stabilization and arresting pathological process in body |
| CN112004798A (en) * | 2019-01-07 | 2020-11-27 | 江苏凯迪恩医药科技有限公司 | A kind of benzamide compound, intermediate, preparation method and application |
| RU2714932C1 (en) * | 2019-09-26 | 2020-02-21 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Саратовский национальный исследовательский государственный университет имени Н.Г. Чернышевского" | Agent possessing cytotoxic activity |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| LU85558A1 (en) * | 1984-09-28 | 1986-04-03 | Oreal | NOVEL RETINOICALLY ACTIVE NAPHTHALENIC DERIVATIVES, PREPARATION METHODS THEREOF, AND MEDICINAL AND COSMETIC COMPOSITIONS CONTAINING THEM |
-
1996
- 1996-05-15 TW TW085105756A patent/TW418186B/en active
- 1996-05-27 ZA ZA9604264A patent/ZA964264B/en unknown
- 1996-05-29 NO NO962168A patent/NO305946B1/en not_active IP Right Cessation
- 1996-05-29 MX MX9602034A patent/MX9602034A/en unknown
- 1996-06-02 IL IL11852896A patent/IL118528A/en active IP Right Grant
- 1996-06-03 CZ CZ961609A patent/CZ160996A3/en unknown
- 1996-06-04 SG SG1996009977A patent/SG42412A1/en unknown
- 1996-06-04 HU HU9601518A patent/HU218963B/en not_active IP Right Cessation
- 1996-06-04 RU RU96111015/04A patent/RU2163590C2/en active
- 1996-06-05 CN CN96105345A patent/CN1144217A/en active Pending
- 1996-06-05 KR KR1019960020024A patent/KR970000224A/en not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| IL118528A (en) | 2001-04-30 |
| HU9601518D0 (en) | 1996-07-29 |
| CZ160996A3 (en) | 1997-02-12 |
| TW418186B (en) | 2001-01-11 |
| IL118528A0 (en) | 1996-06-02 |
| HUP9601518A2 (en) | 1997-05-28 |
| HUP9601518A3 (en) | 1997-06-30 |
| HU218963B (en) | 2001-01-29 |
| RU2163590C2 (en) | 2001-02-27 |
| NO305946B1 (en) | 1999-08-23 |
| CN1144217A (en) | 1997-03-05 |
| NO962168D0 (en) | 1996-05-29 |
| KR970000224A (en) | 1997-01-21 |
| ZA964264B (en) | 1997-11-27 |
| SG42412A1 (en) | 1997-08-15 |
| NO962168L (en) | 1996-12-06 |
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