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MX9505063A - Tetralina- e indano-1h-imidazoles. - Google Patents

Tetralina- e indano-1h-imidazoles.

Info

Publication number
MX9505063A
MX9505063A MX9505063A MX9505063A MX9505063A MX 9505063 A MX9505063 A MX 9505063A MX 9505063 A MX9505063 A MX 9505063A MX 9505063 A MX9505063 A MX 9505063A MX 9505063 A MX9505063 A MX 9505063A
Authority
MX
Mexico
Prior art keywords
imidazoles
hydrogen
indano
tetraline
substituted
Prior art date
Application number
MX9505063A
Other languages
English (en)
Inventor
Jean-Pierre Geerts
Genevieve Motte
Edmond Differding
Jean-Pierre Henichart
Original Assignee
Ucb Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ucb Sa filed Critical Ucb Sa
Publication of MX9505063A publication Critical patent/MX9505063A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C07D233/58—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Los 4-(1,2,3,4-tetrahidro-1-naftalenil)-1H-imidazoles sustituidos y los 4-(2,3-dihidro-1H-inden-1-il)-1H-imidazoles sustituidos, sus isomeros opticos y sus mezclas racémicas, sus sales, métodos para prepararlos y composiciones terapéuticas que los contienen. Estos compuestos tienen la formula general (I) en la que n=1 o 2, R1, R2, R3 y R4 = hidrogeno, halogeno, hidroxilo, alquilo de C1-C4 o alcoxi de C1-C4, R5 = hidrogeno o alquilo de C1-C4, con ser simultáneamente hidrogeno cuando n es igual a 2. Estos nuevos compuestos presentan actividades anti-isquémica y anti-hipertensora.
MX9505063A 1994-12-14 1995-12-05 Tetralina- e indano-1h-imidazoles. MX9505063A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9425211.1A GB9425211D0 (en) 1994-12-14 1994-12-14 Substituted 1H-imidazoles

Publications (1)

Publication Number Publication Date
MX9505063A true MX9505063A (es) 1997-01-31

Family

ID=10765918

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9505063A MX9505063A (es) 1994-12-14 1995-12-05 Tetralina- e indano-1h-imidazoles.

Country Status (26)

Country Link
US (1) US5658938A (es)
EP (1) EP0717037A1 (es)
JP (1) JPH08208622A (es)
KR (1) KR960022474A (es)
CN (1) CN1054376C (es)
AR (1) AR002257A1 (es)
AU (1) AU693614B2 (es)
BG (1) BG63043B1 (es)
BR (1) BR9505815A (es)
CA (1) CA2165133A1 (es)
CZ (1) CZ327195A3 (es)
EE (1) EE9500064A (es)
FI (1) FI955927A7 (es)
GB (1) GB9425211D0 (es)
HU (1) HUT73980A (es)
IL (1) IL116325A (es)
IS (1) IS4311A (es)
MX (1) MX9505063A (es)
NO (1) NO305316B1 (es)
NZ (1) NZ280646A (es)
PL (1) PL311736A1 (es)
RO (1) RO113346B1 (es)
RU (1) RU2156239C2 (es)
SK (1) SK155095A3 (es)
TW (1) TW303362B (es)
ZA (1) ZA9510554B (es)

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GB9425211D0 (en) * 1994-12-14 1995-02-15 Ucb Sa Substituted 1H-imidazoles
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ZA981080B (en) 1997-02-11 1998-08-12 Warner Lambert Co Bicyclic inhibitors of protein farnesyl transferase
US6503935B1 (en) 1998-08-07 2003-01-07 Abbott Laboratories Imidazoles and related compounds as α1A agonists
US20030073850A1 (en) * 1998-08-07 2003-04-17 Altenbach Robert J. 4-Imidazole derivatives of benzyl and restricted benzyl sulfonamides, sulfamides, ureas, carbamates, and amides and their use
US6388090B2 (en) 2000-01-14 2002-05-14 Orion Corporation Imidazole derivatives
NZ522274A (en) 2000-05-08 2004-11-26 Orion Corp New polycyclic indanylimidazoles with alpha2 adrenergic activity
TW200930291A (en) * 2002-04-29 2009-07-16 Bayer Cropscience Ag Pesticidal heterocycles
US20040266776A1 (en) * 2003-06-25 2004-12-30 Gil Daniel W. Methods of preventing and reducing the severity of stress-associated conditions
FI20022007A0 (fi) * 2002-11-08 2002-11-08 Juvantia Pharma Ltd Oy Oromukosaalinen valmiste ja menetelmä sen valmistamiseksi
FI20022159A0 (fi) * 2002-12-05 2002-12-05 Orion Corp Uusia farmaseuttisia yhdisteitä
AU2007209382A1 (en) * 2006-01-27 2007-08-02 F. Hoffmann-La Roche Ag Use of 2-imidazoles for the treatment of CNS disorders
BRPI0718059A2 (pt) * 2006-10-19 2013-11-05 Holffmann La Roche Ag F Aminometil-2-imidazóis com afinidade com os receptores amina-associado traço
EP2076497B1 (en) * 2006-10-19 2012-02-22 F. Hoffmann-La Roche AG Aminomethyl-4-imidazoles
WO2008052907A1 (en) * 2006-11-02 2008-05-08 F. Hoffmann-La Roche Ag Substituted 2-imidazoles as modulators of the trace amine associated receptors
CA2669112A1 (en) * 2006-11-16 2008-05-22 F. Hoffmann-La Roche Ag Substituted 4-imidazoles
EP2101762B1 (en) * 2006-12-13 2011-05-18 F. Hoffmann-La Roche AG Novel 2 -imidazoles as ligands for trace amine associated receptors (taar)
US20080146523A1 (en) * 2006-12-18 2008-06-19 Guido Galley Imidazole derivatives
CA2675221C (en) * 2007-02-02 2016-02-23 F. Hoffmann-La Roche Ag Novel 2-aminooxazolines as taar1 ligands
CL2008000431A1 (es) * 2007-02-13 2008-08-18 Schering Corp Compuestos derivados de biciclos o heterociclos condensados; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar afecciones relacionadas con los a2c adrenegicos, tales como congestion relacionada con rinitis, polipos o re
EP2125749A2 (en) * 2007-02-13 2009-12-02 Schering Corporation Functionally selective alpha2c adrenoreceptor agonists
WO2008100459A1 (en) * 2007-02-13 2008-08-21 Schering Corporation Derivatives and analogs of chroman as functionally selective alpha2c adrenoreceptor agonists
EP2121641B1 (en) * 2007-02-15 2014-09-24 F. Hoffmann-La Roche AG 2-aminooxazolines as taar1 ligands
MX2009013742A (es) 2007-07-02 2010-01-26 Hoffmann La Roche 2-imidazolinas.
WO2009003867A1 (en) * 2007-07-03 2009-01-08 F. Hoffmann-La Roche Ag 4-imidazolines and their use as antidepressants
WO2009016048A1 (en) * 2007-07-27 2009-02-05 F. Hoffmann-La Roche Ag 2-azetidinemethaneamines and 2-pyrrolidinemethaneamines as taar-ligands
BRPI0815038A2 (pt) * 2007-08-02 2015-03-17 Hoffmann La Roche Uso de derivados de benzamida para o tratamento de transtornos do cns
CA2695331A1 (en) * 2007-08-03 2009-02-12 F. Hoffmann-La Roche Ag Pyridinecarboxamide and benzamide derivatives as taar1 ligands
CL2008003553A1 (es) * 2007-12-05 2009-11-27 Grindeks Jsc Proceso para preparar atipamezol o clorhidrato de 5-(2-etil-2,3-dihidro-1h-inden-2-il)-1h-imidazol: y loa compuestos intermediarios considerados en el proceso
US8383818B2 (en) 2008-02-21 2013-02-26 Merck Sharp & Dohme Corp. Functionally selective alpha2C adrenoreceptor agonists
US8242153B2 (en) * 2008-07-24 2012-08-14 Hoffmann-La Roche Inc. 4,5-dihydro-oxazol-2YL derivatives
PE20110215A1 (es) * 2008-07-24 2011-03-31 Hoffmann La Roche Derivados de 4,5-dihidro-oxazol-2-ilo
WO2010017120A1 (en) * 2008-08-04 2010-02-11 Schering Corporation Cyclopropylchromene derivatives as modulators of the alpha-2c receptor
AR073628A1 (es) 2008-10-07 2010-11-17 Schering Corp Analogos de biaril espiroaminooxazolina y espiroaminodiazolina moduladores de receptores adrenergicos alfa2c, composiciones farmaceuticas que los comprenden y uso de los mismos en rinitis alergica,trastornos cardiacos y otras enfermedades
US20100311798A1 (en) * 2009-06-05 2010-12-09 Decoret Guillaume 2-aminooxazolines as taar1 ligands
US8354441B2 (en) * 2009-11-11 2013-01-15 Hoffmann-La Roche Inc. Oxazoline derivatives
US9452980B2 (en) 2009-12-22 2016-09-27 Hoffmann-La Roche Inc. Substituted benzamides
US8673950B2 (en) 2010-11-02 2014-03-18 Hoffmann-Laroche Inc. Dihydrooxazol-2-amine derivatives
US8802673B2 (en) 2011-03-24 2014-08-12 Hoffmann-La Roche Inc Heterocyclic amine derivatives
US9073911B2 (en) 2011-06-09 2015-07-07 Hoffmann-La Roche Inc. Pyrazole derivatives
US9029370B2 (en) 2011-06-10 2015-05-12 Hoffmann-La Roche Inc. Substituted benzamide derivatives
RU2621050C2 (ru) 2012-01-12 2017-05-31 Ф. Хоффманн-Ля Рош Аг Гетероциклические производные в качестве рецепторов, ассоциированных со следовыми аминами (taars)
AU2013314388B2 (en) 2012-09-14 2016-07-14 F. Hoffmann-La Roche Ag Pyrazole carboxamide derivatives as TAAR modulators for use in the treatment of several disorders, such as depression, diabetes and Parkinson's disease
BR112015001771B1 (pt) * 2012-09-17 2022-08-16 F. Hoffmann-La Roche Ag Derivados de carboxamida de triazol, seu uso e composição farmacêutica que os compreende
WO2015165085A1 (en) 2014-04-30 2015-11-05 F.Hoffmann-La Roche Ag Morpholin-pyridine derivatives
BR112017000160A2 (pt) 2014-08-27 2017-10-31 Hoffmann La Roche derivados de azetidina substituidos como ligantes de taar
WO2016030306A1 (en) 2014-08-27 2016-03-03 F. Hoffmann-La Roche Ag Substituted pyrazino[2,1-a]isoquinoline derivatives for the treatment of cns disorders
PT3430010T (pt) 2016-03-17 2020-09-10 Hoffmann La Roche Derivado de 5-etiol-4-metil-pirazol-3-carboxamida com atividade de agonista de taar
EA039557B1 (ru) * 2016-03-17 2022-02-10 Фмк Корпорейшн Способ превращения s-энантиомера в его рацемическую форму
CN116496261B (zh) * 2023-03-09 2025-06-27 中国人民解放军军事科学院军事医学研究院 4-(1h)-咪唑类衍生物及其医药用途
CN118684628B (zh) * 2024-05-20 2025-06-17 中国人民解放军军事科学院军事医学研究院 取代二氢茚基咪唑类化合物及其制备方法和用途

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JPS6048972A (ja) * 1983-08-25 1985-03-16 Dai Ichi Seiyaku Co Ltd テトラヒドロナフタレン誘導体
GB2167408B (en) * 1984-11-23 1988-05-25 Farmos Oy Substituted imidazole derivatives and their preparation and use
GB8626287D0 (en) * 1986-11-04 1986-12-03 Ucb Sa Substituted 1h-imidazoles
GB2206880B (en) * 1987-07-16 1991-04-24 Farmos Oy Optical isomers of an imidazole derivative
US5151526A (en) * 1990-10-11 1992-09-29 The United States Of America As Represented By The Secretary Of The Army 4-[1-(1-naphthalenyl)ethyl]-1H-imidazole, method of making and use as an anesthetic
JPH04210680A (ja) * 1990-12-01 1992-07-31 Nissan Chem Ind Ltd イミダゾール誘導体および植物生長調節剤
GB9425211D0 (en) * 1994-12-14 1995-02-15 Ucb Sa Substituted 1H-imidazoles

Also Published As

Publication number Publication date
EE9500064A (et) 1996-06-17
HU9503549D0 (en) 1996-02-28
CA2165133A1 (en) 1996-06-15
SK155095A3 (en) 1997-02-05
KR960022474A (ko) 1996-07-18
JPH08208622A (ja) 1996-08-13
US5658938A (en) 1997-08-19
BR9505815A (pt) 1998-01-06
FI955927L (fi) 1996-06-15
IL116325A (en) 1999-10-28
HUT73980A (en) 1996-10-28
CZ327195A3 (en) 1996-07-17
TW303362B (es) 1997-04-21
PL311736A1 (en) 1996-06-24
IL116325A0 (en) 1996-03-31
BG100208A (bg) 1996-07-31
NZ280646A (en) 1996-08-27
AU4036895A (en) 1996-06-20
IS4311A (is) 1996-06-15
RO113346B1 (ro) 1998-06-30
CN1133837A (zh) 1996-10-23
FI955927A7 (fi) 1996-06-15
NO955034D0 (no) 1995-12-12
BG63043B1 (bg) 2001-02-28
NO305316B1 (no) 1999-05-10
AU693614B2 (en) 1998-07-02
NO955034L (no) 1996-06-17
RU2156239C2 (ru) 2000-09-20
GB9425211D0 (en) 1995-02-15
FI955927A0 (fi) 1995-12-11
AR002257A1 (es) 1998-03-11
ZA9510554B (en) 1996-06-13
CN1054376C (zh) 2000-07-12
EP0717037A1 (fr) 1996-06-19

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Legal Events

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FG Grant or registration
MM Annulment or lapse due to non-payment of fees