[go: up one dir, main page]

MX9305039A - Ligandos para ga-68 para aplicaciones cardiacas de tep. - Google Patents

Ligandos para ga-68 para aplicaciones cardiacas de tep.

Info

Publication number
MX9305039A
MX9305039A MX9305039A MX9305039A MX9305039A MX 9305039 A MX9305039 A MX 9305039A MX 9305039 A MX9305039 A MX 9305039A MX 9305039 A MX9305039 A MX 9305039A MX 9305039 A MX9305039 A MX 9305039A
Authority
MX
Mexico
Prior art keywords
tep
linked
cardiac applications
ligands
macrobicyclic
Prior art date
Application number
MX9305039A
Other languages
English (en)
Inventor
Dennis A Moore
Original Assignee
Mallinckrodt Medical Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mallinckrodt Medical Inc filed Critical Mallinckrodt Medical Inc
Publication of MX9305039A publication Critical patent/MX9305039A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0482—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group chelates from cyclic ligands, e.g. DOTA
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C215/48—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by hydroxy groups
    • C07C215/50—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by hydroxy groups with amino groups and the six-membered aromatic ring, or the condensed ring system containing that ring, bound to the same carbon atom of the carbon chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
    • C07C225/02—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C225/14—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being unsaturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C07C229/10—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
    • C07C229/16—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of hydrocarbon radicals substituted by amino or carboxyl groups, e.g. ethylenediamine-tetra-acetic acid, iminodiacetic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/76—Metal complexes of amino carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D255/00—Heterocyclic compounds containing rings having three nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D249/00 - C07D253/00
    • C07D255/02—Heterocyclic compounds containing rings having three nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D249/00 - C07D253/00 not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Se describen ligandos y composiciones para galio-68 para formar imágenes cardíacas por TEP. Los ligandos forman complejos estables con Ga-68. La variación de los sustituyentes pendientes o como ramificaciones permite tener como objetivo el órgano con características de perfusión parecidas a una imitación del potasio. Se describen diseños de ligandos macrobicíclicos, macrocíclicos y acíclicos.
MX9305039A 1992-08-19 1993-08-18 Ligandos para ga-68 para aplicaciones cardiacas de tep. MX9305039A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US93215792A 1992-08-19 1992-08-19

Publications (1)

Publication Number Publication Date
MX9305039A true MX9305039A (es) 1994-05-31

Family

ID=25461868

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9305039A MX9305039A (es) 1992-08-19 1993-08-18 Ligandos para ga-68 para aplicaciones cardiacas de tep.

Country Status (3)

Country Link
AU (1) AU5019193A (es)
MX (1) MX9305039A (es)
WO (1) WO1994004485A1 (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6713045B1 (en) 1995-06-02 2004-03-30 Research Corporation Technologies, Inc. Targeted magnetic resonance imaging agents for the detection of physiological processes
US6004529A (en) 1997-04-11 1999-12-21 Nycomed Imaging As Chelating agents
JP4163381B2 (ja) 1997-11-17 2008-10-08 カリフォルニア・インスティテュート・オブ・テクノロジー 生理学的薬剤の検出のための磁気共鳴造影剤
BR0013745A (pt) 1999-09-01 2002-05-14 Unilever Nv Composição alvejante para um têxtil
TR200201278T2 (tr) * 1999-09-01 2002-08-21 Unilever N. V. Bir ürünü katalitik olarak beyazlatmak için ligand ve kompleks.
EP1259588A2 (en) 2000-02-29 2002-11-27 Unilever Plc Composition and method for bleaching a substrate
GB0004962D0 (en) * 2000-03-01 2000-04-19 Univ Cardiff Macrocyclic ligands and complexes thereof
US6673333B1 (en) 2000-05-04 2004-01-06 Research Corporation Technologies, Inc. Functional MRI agents for cancer imaging
AU2001276956A1 (en) * 2000-07-17 2002-01-30 California Institute Of Technology Macrocyclic mri contrast agents
WO2002026748A2 (en) * 2000-09-25 2002-04-04 The Procter & Gamble Company Metal complexes for use in medical and therapeutic applications
US7011816B2 (en) * 2001-12-26 2006-03-14 Immunomedics, Inc. Labeling targeting agents with gallium-68 and gallium-67
US8986650B2 (en) 2005-10-07 2015-03-24 Guerbet Complex folate-NOTA-Ga68
JP5368099B2 (ja) 2005-10-07 2013-12-18 ゲルベ ガリウムと錯体形成することが可能なシグナル部分にカップリングされた、生物学的標的の認識のための部分を含んでなる化合物
KR20080099279A (ko) * 2006-02-24 2008-11-12 말린크로트, 인코포레이티드 이관능성 레조르시놀, 티오레조르시놀, 및 디티오레조르시놀 유도체 금속 킬레이팅 컨쥬게이트

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4957939A (en) * 1981-07-24 1990-09-18 Schering Aktiengesellschaft Sterile pharmaceutical compositions of gadolinium chelates useful enhancing NMR imaging
FR2614020B1 (fr) * 1987-04-14 1989-07-28 Guerbet Sa Nouveaux ligands cycliques azotes, complexes metalliques formes par ces ligands, compositions de diagnostic contenant ces complexes et procede de preparation des ligands.

Also Published As

Publication number Publication date
AU5019193A (en) 1994-03-15
WO1994004485A1 (en) 1994-03-03

Similar Documents

Publication Publication Date Title
MX9305039A (es) Ligandos para ga-68 para aplicaciones cardiacas de tep.
YU56391A (sh) Komponente in katalizatorji za polimerizacijo olefinov
ATE137242T1 (de) Kovalente-ther lipidnukleosid-konjugate
NL166179C (nl) Modulair opgebouwde kast.
FR2361383A1 (fr) Derives de tetrahydrocannabinols
NL183900B (nl) Driedimensioneel constructiesamenstel.
NL7609132A (nl) Werkwijze voor het vervaardigen van uit een aantal lagen bestaande magnetogram-dragers.
IT1134503B (it) Composti della diclorodietilaminofenilalanina ad azione antitumorale
NL7712437A (nl) Bureaumeubel.
DK134258B (da) Rodenticidt præparat omfattende overtrukne partikler af substituerede norbornendicarboximider.
SE7608158L (sv) 6-(alfa-amino-omega-(3,4-metylendioxifenyl)-acylamido) penicillansyraderivat
USD147139S (en) Design for an obphrey or similar article
ES218713Y (es) Pieza para el ensamblaje de partes de muebles.
Flynn Mechanistic and pharmacodynamic studies of ADCT-301, an Antibody Drug Conjugate targeting CD25-expressing haematological malignancies
ES161311U (es) Cuerpo prefabricado para muñecas.
ES213171U (es) Titere digital.
ES169037U (es) Cuerpo perfeccionado para muñecas.
ES182523U (es) Pieza de ensamblaje.
ES178835U (es) Figura publicitaria armable.
ES201609U (es) Perfeccionamientos introducidos en construcciones.
ES116479U (es) Arado monosurco reversible.
ES212327Y (es) Pieza modular para union de partes de muebles.
ES174923U (es) Cuerpo prefabricado para muñecas.
ES182524U (es) Pieza de ensamblaje.
ES163507U (es) Mesa plegable.