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MX9304868A - 27-hidroxirapamicina, derivados de la misma y composicion farmaceutica que la contiene. - Google Patents

27-hidroxirapamicina, derivados de la misma y composicion farmaceutica que la contiene.

Info

Publication number
MX9304868A
MX9304868A MX9304868A MX9304868A MX9304868A MX 9304868 A MX9304868 A MX 9304868A MX 9304868 A MX9304868 A MX 9304868A MX 9304868 A MX9304868 A MX 9304868A MX 9304868 A MX9304868 A MX 9304868A
Authority
MX
Mexico
Prior art keywords
hydroxyrapamicine
derived
same
pharmaceutical composition
hydroxyrapamycin
Prior art date
Application number
MX9304868A
Other languages
English (en)
Inventor
Frances Christy Nelson
Original Assignee
American Home Prod
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/009,605 external-priority patent/US5256790A/en
Application filed by American Home Prod filed Critical American Home Prod
Publication of MX9304868A publication Critical patent/MX9304868A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Transplantation (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

La presente invención proporciona un compuesto de fórmula I, (ver fórmula); y derivados substituidos en la posición 27 del mismo, los cuales son útiles como agentes inmunosupresores, antiinflamatorios, antifúngicos, antitumor, y antiproliferativos. El compuesto representado por la fórmula I es llamado 27-hidroxirapamicina, y también puede ser aludido como 27-desoxo-27-hidroxitrapamicina.
MX9304868A 1992-08-13 1993-08-11 27-hidroxirapamicina, derivados de la misma y composicion farmaceutica que la contiene. MX9304868A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US93012492A 1992-08-13 1992-08-13
US08/009,605 US5256790A (en) 1992-08-13 1993-01-27 27-hydroxyrapamycin and derivatives thereof

Publications (1)

Publication Number Publication Date
MX9304868A true MX9304868A (es) 1994-05-31

Family

ID=26679675

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9304868A MX9304868A (es) 1992-08-13 1993-08-11 27-hidroxirapamicina, derivados de la misma y composicion farmaceutica que la contiene.

Country Status (12)

Country Link
EP (1) EP0655065B1 (es)
JP (1) JPH08501084A (es)
AT (1) ATE146179T1 (es)
AU (1) AU5007193A (es)
CA (1) CA2142288A1 (es)
DE (1) DE69306585T2 (es)
DK (1) DK0655065T3 (es)
ES (1) ES2096941T3 (es)
GR (1) GR3022730T3 (es)
HU (1) HU221499B (es)
MX (1) MX9304868A (es)
WO (1) WO1994004540A1 (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0729471A1 (en) * 1993-11-19 1996-09-04 Abbott Laboratories Semisynthetic analogs of rapamycin (macrolides) being immunomodulators
US5527907A (en) * 1993-11-19 1996-06-18 Abbott Laboratories Macrolide immunomodulators
US6187757B1 (en) 1995-06-07 2001-02-13 Ariad Pharmaceuticals, Inc. Regulation of biological events using novel compounds
CA2219659C (en) * 1995-06-09 2008-03-18 Novartis Ag Rapamycin derivatives
CA2383451A1 (en) 1999-08-24 2001-03-01 Ariad Gene Therapeutics, Inc. 28-epirapalogs
US7067526B1 (en) 1999-08-24 2006-06-27 Ariad Gene Therapeutics, Inc. 28-epirapalogs
EP2407473A3 (en) 2002-02-01 2012-03-21 ARIAD Pharmaceuticals, Inc Method for producing phosphorus-containing compounds
AU2003300076C1 (en) 2002-12-30 2010-03-04 Angiotech International Ag Drug delivery from rapid gelling polymer composition
WO2006115509A2 (en) 2004-06-24 2006-11-02 Novartis Vaccines And Diagnostics Inc. Small molecule immunopotentiators and assays for their detection
CN101583347A (zh) 2006-11-14 2009-11-18 阿里亚德医药股份有限公司 口服制剂
WO2009089549A1 (en) 2008-01-11 2009-07-16 Massachusetts Eye & Ear Infirmary Conditional-stop dimerizable caspase transgenic animals
JP6525971B2 (ja) 2013-06-11 2019-06-05 タカラ バイオ ユーエスエー， インコーポレイテッド タンパク質富化微細小胞、タンパク質富化微細小胞の作製方法及び使用方法
CN118978535A (zh) 2018-05-01 2024-11-19 锐新医药公司 作为mTOR抑制剂的C40-、C28-及C-32连接的雷帕霉素类似物
MX2020011564A (es) 2018-05-01 2021-01-29 Revolution Medicines Inc Analogos de rapamicina unidos a c26 como inhibidores de mtor.
WO2022216900A2 (en) * 2021-04-09 2022-10-13 Revolution Medicines, Inc. Synthesis of rapamycin analog compounds
CA3256390A1 (en) 2022-05-25 2023-11-30 Revolution Medicines, Inc. CANCER TREATMENT METHODS USING AN MTOR INHIBITOR

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH04230389A (ja) * 1990-07-16 1992-08-19 American Home Prod Corp ラパマイシン誘導体
US5102876A (en) * 1991-05-07 1992-04-07 American Home Products Corporation Reduction products of rapamycin

Also Published As

Publication number Publication date
JPH08501084A (ja) 1996-02-06
EP0655065A1 (en) 1995-05-31
CA2142288A1 (en) 1994-03-03
HUT71614A (en) 1996-01-29
HU9500432D0 (en) 1995-04-28
HU221499B (en) 2002-10-28
ES2096941T3 (es) 1997-03-16
DK0655065T3 (es) 1997-02-24
GR3022730T3 (en) 1997-06-30
EP0655065B1 (en) 1996-12-11
WO1994004540A1 (en) 1994-03-03
DE69306585T2 (de) 1997-04-17
ATE146179T1 (de) 1996-12-15
AU5007193A (en) 1994-03-15
DE69306585D1 (de) 1997-01-23

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Legal Events

Date Code Title Description
FG Grant or registration
HC Change of company name or juridical status

Owner name: SILGAN TUBES CORPORATION

MM Annulment or lapse due to non-payment of fees