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MX9302883A - Proceso en un solo recipiente para preparar pergolida. - Google Patents

Proceso en un solo recipiente para preparar pergolida.

Info

Publication number
MX9302883A
MX9302883A MX9302883A MX9302883A MX9302883A MX 9302883 A MX9302883 A MX 9302883A MX 9302883 A MX9302883 A MX 9302883A MX 9302883 A MX9302883 A MX 9302883A MX 9302883 A MX9302883 A MX 9302883A
Authority
MX
Mexico
Prior art keywords
pergolide
mixture
prepare
substantially consumed
dilute
Prior art date
Application number
MX9302883A
Other languages
English (en)
Inventor
Jerry Wayne Misner
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of MX9302883A publication Critical patent/MX9302883A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/02—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hydrocarbon or substituted hydrocarbon radicals, attached in position 8

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Esta invención proporciona un proceso en un solo recipiente para preparar pergolida que comprende reaccionar 8, 9-dihidroelimoclavina con 1-yodopropano a elevada temperatura en presencia de un bicarbonato o carbonato de calcio, magnesio o alcalino metálico y un disolvente seleccionado N-metilpirrolidinona, hexametilfosforamida, dimetilpropilenourea y dimetiletilenourea hasta que la 8, 9-dihidroelimoclavina se consume substancialmente para preparar una primera mezcla intermedia; diluir la primera mezcla intermedia con un volumen grande de un disolvente básico seleccionado de piridona, picolina y lutidina, enfriar la mezcla diluida a una temperatura baja, combinarla con un haluro de tolueno o de Cl-C3 alcanosulfonilo, y dejar que la reacción continúe a baja temperatura hasta que el primer intermedio se ha consumido substancialmente para preparar una segunda mezcla intermedia; combinar la segunda mezcla intermedia fría con una solución fría de tiometóxido alcalino metálico y dejar que la reacción continúe a elevada temperatura hasta que el segundo intermedio se consuma substancialmente para preparar una mezcla de pergolida bruta; diluir la mezcla de pergolida bruta con agua para obtener pergolida sólida y lavar la pergolida con agua para obtener pergolida de al menos 90 por ciento de pureza.
MX9302883A 1992-05-21 1993-05-18 Proceso en un solo recipiente para preparar pergolida. MX9302883A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/886,800 US5463060A (en) 1992-05-21 1992-05-21 One-pot process

Publications (1)

Publication Number Publication Date
MX9302883A true MX9302883A (es) 1993-11-01

Family

ID=25389802

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9302883A MX9302883A (es) 1992-05-21 1993-05-18 Proceso en un solo recipiente para preparar pergolida.

Country Status (28)

Country Link
US (1) US5463060A (es)
EP (1) EP0571202B1 (es)
JP (1) JP3580565B2 (es)
KR (1) KR100285971B1 (es)
CN (1) CN1040438C (es)
AR (1) AR248023A1 (es)
AT (1) ATE203750T1 (es)
AU (1) AU656075B2 (es)
BR (1) BR9302016A (es)
CA (1) CA2095593C (es)
CZ (1) CZ283997B6 (es)
DE (1) DE69330506T2 (es)
DK (1) DK0571202T3 (es)
ES (1) ES2160587T3 (es)
FI (1) FI114476B (es)
GR (1) GR3037000T3 (es)
HU (1) HU210324B (es)
IL (1) IL105695A (es)
MX (1) MX9302883A (es)
MY (1) MY108884A (es)
NO (1) NO302416B1 (es)
NZ (1) NZ247545A (es)
PH (1) PH30663A (es)
PL (1) PL173522B1 (es)
PT (1) PT571202E (es)
RU (1) RU2108333C1 (es)
TW (1) TW215438B (es)
YU (1) YU49022B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1307934B1 (it) * 1999-01-27 2001-11-29 Poli Ind Chimica Spa Processo per la preparazione di derivati alchimercaptometilergolinici.
US6388079B1 (en) 2000-08-29 2002-05-14 Scinopharm Singapore Pte Ltd. Process for preparing pergolide
CN1561335A (zh) * 2001-10-02 2005-01-05 日本曹达株式会社 乙烯衍生物的制备方法
US7019140B2 (en) * 2002-03-15 2006-03-28 Antibioticos S.P.A. Process for the synthesis of pergolide
RU2213565C1 (ru) * 2002-06-24 2003-10-10 Общество с ограниченной ответственностью "Паркинфарм" Способ лечебного воздействия на организм пациента при лечении болезни паркинсона
CN110330495A (zh) * 2019-08-08 2019-10-15 重庆大学 一种合成麦角碱的方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4166182A (en) * 1978-02-08 1979-08-28 Eli Lilly And Company 6-n-propyl-8-methoxymethyl or methylmercaptomethylergolines and related compounds
US4782152A (en) * 1985-08-16 1988-11-01 Eli Lilly And Company Decyanation of pergolide intermediate

Also Published As

Publication number Publication date
KR930023365A (ko) 1993-12-18
HU9301460D0 (en) 1993-09-28
TW215438B (en) 1993-11-01
AR248023A1 (es) 1995-05-31
BR9302016A (pt) 1993-11-30
IL105695A (en) 1997-08-14
CZ93793A3 (en) 1994-01-19
CA2095593C (en) 2003-09-30
JPH069630A (ja) 1994-01-18
PT571202E (pt) 2001-11-30
CN1040438C (zh) 1998-10-28
NO931839D0 (no) 1993-05-19
NO302416B1 (no) 1998-03-02
AU3847693A (en) 1993-11-25
EP0571202A1 (en) 1993-11-24
NZ247545A (en) 1995-03-28
RU2108333C1 (ru) 1998-04-10
DK0571202T3 (da) 2001-10-08
HU210324B (en) 1995-03-28
YU34593A (sh) 1996-05-20
US5463060A (en) 1995-10-31
PH30663A (en) 1997-09-16
FI114476B (fi) 2004-10-29
HUT64539A (en) 1994-01-28
NO931839L (no) 1993-11-22
CN1082544A (zh) 1994-02-23
MY108884A (en) 1996-11-30
CZ283997B6 (cs) 1998-07-15
GR3037000T3 (en) 2002-01-31
EP0571202B1 (en) 2001-08-01
FI932281L (fi) 1993-11-22
DE69330506D1 (de) 2001-09-06
JP3580565B2 (ja) 2004-10-27
DE69330506T2 (de) 2002-04-11
PL299010A1 (en) 1993-12-27
PL173522B1 (pl) 1998-03-31
AU656075B2 (en) 1995-01-19
KR100285971B1 (ko) 2001-05-02
YU49022B (sh) 2003-07-07
ES2160587T3 (es) 2001-11-16
IL105695A0 (en) 1993-09-22
ATE203750T1 (de) 2001-08-15
CA2095593A1 (en) 1993-11-22
FI932281A0 (fi) 1993-05-19

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Legal Events

Date Code Title Description
FG Grant or registration
MM Annulment or lapse due to non-payment of fees