MX9300482A - Proceso para la preparacion de 2-amino-6-cloropurina. - Google Patents
Proceso para la preparacion de 2-amino-6-cloropurina.Info
- Publication number
- MX9300482A MX9300482A MX9300482A MX9300482A MX9300482A MX 9300482 A MX9300482 A MX 9300482A MX 9300482 A MX9300482 A MX 9300482A MX 9300482 A MX9300482 A MX 9300482A MX 9300482 A MX9300482 A MX 9300482A
- Authority
- MX
- Mexico
- Prior art keywords
- chloropurine
- amino
- preparation
- acyl group
- diacylated
- Prior art date
Links
- RYYIULNRIVUMTQ-UHFFFAOYSA-N 6-chloroguanine Chemical compound NC1=NC(Cl)=C2N=CNC2=N1 RYYIULNRIVUMTQ-UHFFFAOYSA-N 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- WJSVJNDMOQTICG-UHFFFAOYSA-N 2-amino-1-[(2-methyl-4-methylidene-5-oxooxolan-2-yl)methyl]-7h-purin-6-one Chemical class NC1=NC=2N=CNC=2C(=O)N1CC1(C)CC(=C)C(=O)O1 WJSVJNDMOQTICG-UHFFFAOYSA-N 0.000 abstract 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 239000012320 chlorinating reagent Substances 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- 239000003444 phase transfer catalyst Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/40—Heterocyclic compounds containing purine ring systems with halogen atoms or perhalogeno-alkyl radicals directly attached in position 2 or 6
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Se describe un proceso para la preparación de 2-amino-6-cloropurina que comprende la reacción de un derivado 2,9-diacilado de guanina con un agente de cloración, en presencia de un catalizador de transferencia de fase que contienen iones cloruro y después de esto la eliminación del grupo 9-acilo y el grupo 2-acilo mediante hidrólisis.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB929201961A GB9201961D0 (en) | 1992-01-30 | 1992-01-30 | Pharmaceuticals |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX9300482A true MX9300482A (es) | 1994-07-29 |
Family
ID=10709516
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX9300482A MX9300482A (es) | 1992-01-30 | 1993-01-28 | Proceso para la preparacion de 2-amino-6-cloropurina. |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP0625154A1 (es) |
| JP (1) | JPH07503246A (es) |
| KR (1) | KR950700299A (es) |
| AU (1) | AU669874B2 (es) |
| CA (1) | CA2117435A1 (es) |
| GB (1) | GB9201961D0 (es) |
| MX (1) | MX9300482A (es) |
| NZ (1) | NZ246677A (es) |
| WO (1) | WO1993015075A1 (es) |
| ZA (1) | ZA93615B (es) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4231036A1 (de) * | 1992-09-17 | 1994-03-24 | Basf Ag | Verfahren zur Herstellung von 2-Amino-6-halogenpurinen |
| JPH07133276A (ja) * | 1993-09-17 | 1995-05-23 | Jiyuuzen Kagaku Kk | ２−アセチルアミノ−６−クロロプリンの製造方法 |
| DE4415196C1 (de) * | 1994-04-30 | 1995-04-27 | Boehringer Ingelheim Kg | Verbessertes Verfahren zur Herstellung von 2-Amino-6-chlorpurin und 2-Acylamino-6-chlorpurinen |
| CA2189088C (en) | 1995-11-09 | 2005-09-20 | Masatoshi Sakai | 2-amino-6-chloropurine and method for preparing the same |
| US7307167B2 (en) | 2002-04-04 | 2007-12-11 | Sumitomo Chemical Company, Limited | Production method of 2,6-dihalopurine |
| CN102336755B (zh) * | 2011-09-30 | 2013-03-27 | 浙江工业大学 | 一种6-氯嘌呤的化学合成方法 |
| CN113214260B (zh) * | 2021-05-10 | 2022-04-01 | 上海凌凯医药科技有限公司 | 一种2-乙酰氨基-9-乙酰基嘌呤的合成方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0141927B1 (en) | 1983-08-18 | 1991-10-30 | Beecham Group Plc | Antiviral guanine derivatives |
| DE3582399D1 (de) | 1984-09-20 | 1991-05-08 | Beecham Group Plc | Purin-derivate und ihre pharmazeutische verwendung. |
| GB8507606D0 (en) * | 1985-03-23 | 1985-05-01 | Beecham Group Plc | Process |
| DE3941657A1 (de) * | 1989-12-16 | 1991-06-20 | Hoechst Ag | Verfahren zur herstellung von 2-acylamino-6-halogen-purin aus 2,9-diacylguanin |
| DE3941658A1 (de) * | 1989-12-16 | 1991-06-20 | Hoechst Ag | Verfahren zur herstellung von 2-acylamino-9-acyl-6-halogen-purin |
| GB9102127D0 (en) * | 1991-01-31 | 1991-03-13 | Smithkline Beecham Plc | Pharmaceuticals |
-
1992
- 1992-01-30 GB GB929201961A patent/GB9201961D0/en active Pending
-
1993
- 1993-01-28 MX MX9300482A patent/MX9300482A/es unknown
- 1993-01-28 ZA ZA93615A patent/ZA93615B/xx unknown
- 1993-01-28 KR KR1019940702650A patent/KR950700299A/ko not_active Withdrawn
- 1993-01-28 CA CA002117435A patent/CA2117435A1/en not_active Abandoned
- 1993-01-28 JP JP5513055A patent/JPH07503246A/ja active Pending
- 1993-01-28 AU AU33654/93A patent/AU669874B2/en not_active Ceased
- 1993-01-28 EP EP93902481A patent/EP0625154A1/en not_active Withdrawn
- 1993-01-28 WO PCT/GB1993/000185 patent/WO1993015075A1/en not_active Ceased
- 1993-01-28 NZ NZ246677A patent/NZ246677A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NZ246677A (en) | 1996-02-27 |
| CA2117435A1 (en) | 1993-08-05 |
| KR950700299A (ko) | 1995-01-16 |
| GB9201961D0 (en) | 1992-03-18 |
| AU3365493A (en) | 1993-09-01 |
| EP0625154A1 (en) | 1994-11-23 |
| WO1993015075A1 (en) | 1993-08-05 |
| JPH07503246A (ja) | 1995-04-06 |
| AU669874B2 (en) | 1996-06-27 |
| ZA93615B (en) | 1993-11-26 |
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