MX9300361A - Derivado de 4-aril-3-heteroarilureidoquinolina como agentes antihipercolesterolemicos y antiateroscleroticos. - Google Patents
Derivado de 4-aril-3-heteroarilureidoquinolina como agentes antihipercolesterolemicos y antiateroscleroticos.Info
- Publication number
- MX9300361A MX9300361A MX9300361A MX9300361A MX9300361A MX 9300361 A MX9300361 A MX 9300361A MX 9300361 A MX9300361 A MX 9300361A MX 9300361 A MX9300361 A MX 9300361A MX 9300361 A MX9300361 A MX 9300361A
- Authority
- MX
- Mexico
- Prior art keywords
- heteroarilureidoquinoline
- hypercholesterolemic
- aryl
- derived
- atherosclerotic agents
- Prior art date
Links
- 230000000879 anti-atherosclerotic effect Effects 0.000 title abstract 2
- 230000000326 anti-hypercholesterolaemic effect Effects 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 102100030817 Liver carboxylesterase 1 Human genes 0.000 abstract 1
- 101710181187 Liver carboxylesterase 1 Proteins 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 230000000055 hyoplipidemic effect Effects 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Steroid Compounds (AREA)
- Quinoline Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Compuesto de la fórmula (I), las sales farmacéuticamente aceptables del mismo, en donde R2, R3, R4, m, X y Q son como se define más adelante, e intermediarios novedosos usados en la síntesis de dichos compuestos. Los compuestos de la fórmula (I) son inhibidores de acilcoenzima A: aciltransferasa de colesterol (ACAT) y son útiles como agentes hipolipidémicos y antiateroscleróticos.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US82463992A | 1992-01-23 | 1992-01-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX9300361A true MX9300361A (es) | 1994-06-30 |
Family
ID=25241935
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX9300361A MX9300361A (es) | 1992-01-23 | 1993-01-22 | Derivado de 4-aril-3-heteroarilureidoquinolina como agentes antihipercolesterolemicos y antiateroscleroticos. |
Country Status (16)
| Country | Link |
|---|---|
| EP (1) | EP0623112B1 (es) |
| JP (1) | JP2668163B2 (es) |
| KR (1) | KR950700284A (es) |
| AT (1) | ATE175196T1 (es) |
| AU (1) | AU3323393A (es) |
| CA (1) | CA2128093C (es) |
| DE (1) | DE69228069T2 (es) |
| DK (1) | DK0623112T3 (es) |
| ES (1) | ES2125325T3 (es) |
| FI (2) | FI930264A7 (es) |
| HU (1) | HUT63625A (es) |
| IL (1) | IL104420A0 (es) |
| MX (1) | MX9300361A (es) |
| NO (1) | NO942757D0 (es) |
| WO (1) | WO1993015058A1 (es) |
| ZA (1) | ZA93482B (es) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6133326A (en) | 1994-08-31 | 2000-10-17 | Pfizer Inc | Compositions and methods for decreasing sebum production |
| WO1999043659A1 (en) * | 1998-02-25 | 1999-09-02 | Sumitomo Pharmaceuticals Co., Ltd. | Pyridone derivatives and process for producing the same |
| US6452008B2 (en) | 1998-02-25 | 2002-09-17 | Sumitomo Pharmaceuticals Company, Limited | Pyridone derivatives and process for preparing the same |
| EA004255B1 (ru) | 2000-02-02 | 2004-02-26 | Уорнер-Ламберт Компани | Применение 2,6-диизопропилфенилового эфира [(2,4,6-триизопропилфенил)ацетил]сульфаминовой кислоты в качестве ингибитора секреции сальных желез, в частности, для лечения акне и композиции и способы на основе данного соединения |
| KR101218213B1 (ko) | 2003-07-03 | 2013-01-04 | 시토비아 인크. | 카스파제의 활성인자 및 세포자멸사의 유도인자로서의4-아릴아미노-퀴나졸린 |
| US8309562B2 (en) | 2003-07-03 | 2012-11-13 | Myrexis, Inc. | Compounds and therapeutical use thereof |
| JP2008508243A (ja) * | 2004-07-30 | 2008-03-21 | パルメド・ソシエテ・アノニム | アミノキノリンをｑとし、抗生物質残基をａとする混成分子ｑａ、その合成及び抗菌剤としての使用 |
| FR2874922A1 (fr) * | 2004-07-30 | 2006-03-10 | Palumed Sa | Molecules hybrides qa ou q est une aminoquinoleine et a est un residu antibiotique, leur synthese et leurs utilisations en tant qu'agent antibacterien |
| EP1833482A4 (en) | 2005-01-03 | 2011-02-16 | Myriad Genetics Inc | COMPOUNDS AND ITS THERAPEUTIC USE |
| US8258145B2 (en) | 2005-01-03 | 2012-09-04 | Myrexis, Inc. | Method of treating brain cancer |
| US11618751B1 (en) | 2022-03-25 | 2023-04-04 | Ventus Therapeutics U.S., Inc. | Pyrido-[3,4-d]pyridazine amine derivatives useful as NLRP3 derivatives |
| US11319319B1 (en) | 2021-04-07 | 2022-05-03 | Ventus Therapeutics U.S., Inc. | Compounds for inhibiting NLRP3 and uses thereof |
| US12331048B2 (en) | 2022-10-31 | 2025-06-17 | Ventus Therapeutics U.S., Inc. | Pyrido-[3,4-d]pyridazine amine derivatives useful as NLRP3 inhibitors |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IE892088L (en) * | 1988-07-12 | 1990-01-12 | William Henry Deryk Morris | Quinoline derivatives, their production and use |
| MX22406A (es) * | 1989-09-15 | 1994-01-31 | Pfizer | Nuevos derivados de n-aril y n-heteroarilamidas y urea como inhibidores de acil coenzima a: acil transferasa del colesterol (acat). |
| TW205037B (es) * | 1989-10-06 | 1993-05-01 | Takeda Pharm Industry Co Ltd | |
| DE69106499T2 (de) * | 1990-02-10 | 1995-06-29 | Takeda Chemical Industries, Ltd., Osaka | Chromenderivate, deren herstellung und verwendung. |
| CZ395592A3 (en) * | 1991-04-26 | 1994-02-16 | Pfizer | 4-aryl-3-(heteroarylureido)quinoline derivatives, process of their preparation and use |
-
1992
- 1992-12-21 CA CA002128093A patent/CA2128093C/en not_active Expired - Fee Related
- 1992-12-21 AU AU33233/93A patent/AU3323393A/en not_active Abandoned
- 1992-12-21 DE DE69228069T patent/DE69228069T2/de not_active Expired - Fee Related
- 1992-12-21 ES ES93901257T patent/ES2125325T3/es not_active Expired - Lifetime
- 1992-12-21 DK DK93901257T patent/DK0623112T3/da active
- 1992-12-21 AT AT93901257T patent/ATE175196T1/de not_active IP Right Cessation
- 1992-12-21 JP JP5513207A patent/JP2668163B2/ja not_active Expired - Fee Related
- 1992-12-21 EP EP93901257A patent/EP0623112B1/en not_active Expired - Lifetime
- 1992-12-21 WO PCT/US1992/010886 patent/WO1993015058A1/en not_active Ceased
-
1993
- 1993-01-18 IL IL104420A patent/IL104420A0/xx unknown
- 1993-01-22 ZA ZA93482A patent/ZA93482B/xx unknown
- 1993-01-22 HU HU9300197A patent/HUT63625A/hu unknown
- 1993-01-22 MX MX9300361A patent/MX9300361A/es unknown
- 1993-01-22 FI FI930264A patent/FI930264A7/fi unknown
-
1994
- 1994-07-22 NO NO942757A patent/NO942757D0/no unknown
- 1994-07-22 KR KR1019940702519A patent/KR950700284A/ko not_active Ceased
-
2001
- 2001-01-12 FI FI20010074A patent/FI20010074A7/fi unknown
Also Published As
| Publication number | Publication date |
|---|---|
| FI20010074A7 (fi) | 2001-01-12 |
| NO942757L (no) | 1994-07-22 |
| DK0623112T3 (da) | 1999-08-30 |
| HU9300197D0 (en) | 1993-04-28 |
| JP2668163B2 (ja) | 1997-10-27 |
| ZA93482B (en) | 1994-07-22 |
| JPH07503712A (ja) | 1995-04-20 |
| DE69228069T2 (de) | 1999-05-20 |
| FI930264A0 (fi) | 1993-01-22 |
| FI930264A7 (fi) | 1993-07-24 |
| ES2125325T3 (es) | 1999-03-01 |
| ATE175196T1 (de) | 1999-01-15 |
| WO1993015058A1 (en) | 1993-08-05 |
| NO942757D0 (no) | 1994-07-22 |
| KR950700284A (ko) | 1995-01-16 |
| CA2128093A1 (en) | 1993-08-05 |
| CA2128093C (en) | 1998-02-03 |
| HUT63625A (en) | 1993-09-28 |
| IL104420A0 (en) | 1993-05-13 |
| EP0623112B1 (en) | 1998-12-30 |
| EP0623112A1 (en) | 1994-11-09 |
| DE69228069D1 (de) | 1999-02-11 |
| AU3323393A (en) | 1993-09-01 |
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