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MX9300268A - Nuevas 4-cinolinil-y 4-naftiridinil-dihidropiridinas, procedimiento para su obtencion y medicamentos que las contienen. - Google Patents

Nuevas 4-cinolinil-y 4-naftiridinil-dihidropiridinas, procedimiento para su obtencion y medicamentos que las contienen.

Info

Publication number
MX9300268A
MX9300268A MX9300268A MX9300268A MX9300268A MX 9300268 A MX9300268 A MX 9300268A MX 9300268 A MX9300268 A MX 9300268A MX 9300268 A MX9300268 A MX 9300268A MX 9300268 A MX9300268 A MX 9300268A
Authority
MX
Mexico
Prior art keywords
medicines
procedure
obtaining
new
naftiridinil
Prior art date
Application number
MX9300268A
Other languages
English (en)
Inventor
Alexander Straub
Jurgen Stoltefuss
Siegfried Goldmann
Rainer Gross
Martin Bechem
Siegbert Hebisch
Joachim Hutter
Howard-Paul Rounding
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of MX9300268A publication Critical patent/MX9300268A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La invención se refiere a nuevas 4-cinolinil- y 4-naftiridinil-dihidropiridinas de fórmula general I en la cual R1 a R5 tienen el significado mencionado en la descripción, procedimiento para su obtención y su empleo en medicamentos, en especial en medios con actividad inotrópica positiva.
MX9300268A 1992-01-30 1993-01-20 Nuevas 4-cinolinil-y 4-naftiridinil-dihidropiridinas, procedimiento para su obtencion y medicamentos que las contienen. MX9300268A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4202526A DE4202526A1 (de) 1992-01-30 1992-01-30 Neue 4-cinnolinyl- und 4-naphthyridinyl-dihydropyridine, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln

Publications (1)

Publication Number Publication Date
MX9300268A true MX9300268A (es) 1993-07-01

Family

ID=6450545

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9300268A MX9300268A (es) 1992-01-30 1993-01-20 Nuevas 4-cinolinil-y 4-naftiridinil-dihidropiridinas, procedimiento para su obtencion y medicamentos que las contienen.

Country Status (15)

Country Link
US (2) US5364855A (es)
EP (1) EP0555657A1 (es)
JP (1) JPH05286968A (es)
KR (1) KR930016414A (es)
CN (1) CN1074906A (es)
AU (1) AU664406B2 (es)
CA (1) CA2088209A1 (es)
CZ (1) CZ372192A3 (es)
DE (1) DE4202526A1 (es)
HU (1) HUT65938A (es)
IL (1) IL104525A0 (es)
MX (1) MX9300268A (es)
NZ (1) NZ245781A (es)
PL (1) PL297561A1 (es)
ZA (1) ZA93639B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4313696A1 (de) * 1993-04-27 1994-11-03 Bayer Ag 2-Amino-4-heteroaryl-1,4-dihydropyridine, Verfahren zu ihrer Herstellung und ihre Verwendung in Arzneimitteln
DE4321030A1 (de) * 1993-06-24 1995-01-05 Bayer Ag 4-bicyclisch substituierte Dihydropyridine, Verfahren zu ihrer Herstellung und ihre Verwendung in Arzneimittel
US20050203119A1 (en) * 2003-09-10 2005-09-15 Mitsunori Ono Dihydropyridine compounds for treating or preventing metabolic disorders
WO2009149837A1 (en) * 2008-06-09 2009-12-17 Bayer Schering Pharma Aktiengesellschaft Substituted 4- (indazolyl) -1,4-dihydropyridines and methods of use thereof
KR102700664B1 (ko) * 2017-08-07 2024-08-29 조인트 스탁 컴퍼니 “바이오케드” Cdk8/19 저해제로서 새로운 헤테로사이클릭 화합물

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1670827C3 (de) * 1967-03-20 1974-10-24 Bayer Ag, 5090 Leverkusen 4-(2'-Nitrophenyl)-2,6-dimethyl-3,5-dicarbmethoxy-1,4-dihydropyridin
US3932645A (en) * 1971-04-10 1976-01-13 Farbenfabriken Bayer Ag Pharmaceutical compositions containing unsymmetrical esters of 1,4-dihydropyridine 3,5-dicarboxylic acid
US4038399A (en) * 1972-04-18 1977-07-26 Bayer Aktiengesellschaft 1,4-dihydropyridine carboxylic acid esters useful as coronary vessel dilators and anti-hypertensives
GB1552911A (en) * 1975-07-02 1979-09-19 Fujisawa Pharmaceutical Co 1,4 dihydropyridine derivatives and the preparation thereof
US4284634A (en) * 1975-07-02 1981-08-18 Fujisawa Pharmaceutical Co., Ltd. 1,4-Dihydropyridine derivatives, and pharmaceutical method of the same
DE2752820A1 (de) * 1977-11-26 1979-05-31 Bayer Ag Neue nitrosubstituierte 1,4-dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
DE3431303A1 (de) * 1984-08-25 1986-02-27 Goedecke Ag 1,6-naphthyridin-derivate, verfahren zu deren herstellung und deren verwendung
DE3445852A1 (de) * 1984-12-15 1986-06-19 Bayer Ag, 5090 Leverkusen Dihydropyridin-carbonsaeureamide, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln
DE3447169A1 (de) * 1984-12-22 1986-07-03 Bayer Ag, 5090 Leverkusen Optisch aktive nitrodihydropyridine, verfahren zur herstellung und ihre verwendung in arzneimitteln
US4820842A (en) * 1986-11-19 1989-04-11 Warner-Lambert Company 2-substituted-1,4-dihydropyridines
DE4011105A1 (de) * 1990-04-06 1991-10-10 Bayer Ag Neue 4-chinolyl-dihydropyridine, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln
HU212435B (en) * 1990-06-07 1996-06-28 Sandoz Ag Herbicidal compositions containing substituted phthalides and heterocyclic phthalides as active ingredient and process for preparation of their active ingredients.
MX9200299A (es) * 1991-02-07 1992-12-01 Roussel Uclaf Nuevos derivados biciclicos nitrogenados, su procedimiento de preparacion los nuevos compuestos intermedios obtenidos su aplicacion como medicamentos y las composiciones farmaceuticas que los contienen.

Also Published As

Publication number Publication date
IL104525A0 (en) 1993-05-13
KR930016414A (ko) 1993-08-26
HU9300247D0 (en) 1993-04-28
HUT65938A (en) 1994-08-29
NZ245781A (en) 1995-08-28
CA2088209A1 (en) 1993-07-31
US5410055A (en) 1995-04-25
EP0555657A1 (de) 1993-08-18
AU664406B2 (en) 1995-11-16
PL297561A1 (en) 1993-10-18
CN1074906A (zh) 1993-08-04
CZ372192A3 (en) 1993-12-15
US5364855A (en) 1994-11-15
ZA93639B (en) 1993-08-30
DE4202526A1 (de) 1993-08-05
AU3205893A (en) 1993-08-05
JPH05286968A (ja) 1993-11-02

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