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MX9207685A - Proteina inmunogenica destoxoficada, composicion para vacuna que la contiene y proceso para la formulacion de dicha vacuna. - Google Patents

Proteina inmunogenica destoxoficada, composicion para vacuna que la contiene y proceso para la formulacion de dicha vacuna.

Info

Publication number
MX9207685A
MX9207685A MX9207685A MX9207685A MX9207685A MX 9207685 A MX9207685 A MX 9207685A MX 9207685 A MX9207685 A MX 9207685A MX 9207685 A MX9207685 A MX 9207685A MX 9207685 A MX9207685 A MX 9207685A
Authority
MX
Mexico
Prior art keywords
vaccine
formulation
composition
immunogenic protein
val
Prior art date
Application number
MX9207685A
Other languages
English (en)
Inventor
Wim Hol
Mario Domenighini
Rino Rappuoli
Mariagrazia Pizza
Original Assignee
Sclavo Biocine Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=11361457&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX9207685(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Sclavo Biocine Spa filed Critical Sclavo Biocine Spa
Publication of MX9207685A publication Critical patent/MX9207685A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/164—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C07K14/245—Escherichia (G)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/28—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Vibrionaceae (F)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Se proporciona una proteína destoxificada, inmunogénica, que comprende la secuencia de aminoácidos de la subunidad A de la toxina de cólera (CT-A) o la sibunidad A de una toxina lábil al calor de Escherichia coli (LT-A) o un fragmento de la misma, en la que uno o más aminoácidos en, o en las posiciones que corresponden a Val-53, Ser-63, Val-97, Tir-104 o Pro-106 están remplazados con otro aminoácido o están eliminados. La proteína destoxificada inmunogénica, es útil como vacuna para Vibrio cholerae o una cepa enteroxigénica de Escherichia coli, y es producida por medio del ADN recombinante por la mutagénesis sitio-dirigida.
MX9207685A 1991-12-31 1992-12-31 Proteina inmunogenica destoxoficada, composicion para vacuna que la contiene y proceso para la formulacion de dicha vacuna. MX9207685A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMI913513A IT1253009B (it) 1991-12-31 1991-12-31 Mutanti immunogenici detossificati della tossina colerica e della tossina lt, loro preparazione ed uso per la preparazione di vaccini

Publications (1)

Publication Number Publication Date
MX9207685A true MX9207685A (es) 1994-05-31

Family

ID=11361457

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9207685A MX9207685A (es) 1991-12-31 1992-12-31 Proteina inmunogenica destoxoficada, composicion para vacuna que la contiene y proceso para la formulacion de dicha vacuna.

Country Status (18)

Country Link
US (1) US6149919A (es)
EP (3) EP1484404B1 (es)
JP (2) JP3394774B2 (es)
AT (3) ATE346932T1 (es)
AU (1) AU3347693A (es)
CA (1) CA2127091C (es)
DE (3) DE69233667T2 (es)
DK (3) DK0620850T3 (es)
ES (3) ES2227762T3 (es)
GR (1) GR3029556T3 (es)
IT (1) IT1253009B (es)
MX (1) MX9207685A (es)
MY (1) MY108154A (es)
PT (1) PT1484404E (es)
SA (1) SA93130462B1 (es)
SG (2) SG48217A1 (es)
TW (1) TW239146B (es)
WO (1) WO1993013202A1 (es)

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