MX9204008A - Derivados de metilen-oxindol y proceso para su preparacion. - Google Patents
Derivados de metilen-oxindol y proceso para su preparacion.Info
- Publication number
- MX9204008A MX9204008A MX9204008A MX9204008A MX9204008A MX 9204008 A MX9204008 A MX 9204008A MX 9204008 A MX9204008 A MX 9204008A MX 9204008 A MX9204008 A MX 9204008A MX 9204008 A MX9204008 A MX 9204008A
- Authority
- MX
- Mexico
- Prior art keywords
- hydrogen
- alkyl
- halogen
- derivatives
- oxindol
- Prior art date
Links
- IGXUUWYVUGBMFT-UHFFFAOYSA-N 3-methyleneoxindole Chemical class C1=CC=C2C(=C)C(=O)NC2=C1 IGXUUWYVUGBMFT-UHFFFAOYSA-N 0.000 title 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 10
- 239000001257 hydrogen Substances 0.000 abstract 10
- 150000002431 hydrogen Chemical class 0.000 abstract 8
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 7
- 229910052736 halogen Inorganic materials 0.000 abstract 3
- 150000002367 halogens Chemical class 0.000 abstract 3
- 125000001589 carboacyl group Chemical group 0.000 abstract 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 2
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 1
- DQNVJWKDCCSMLW-UHFFFAOYSA-N 2-methylideneindole Chemical class C1=CC=CC2=NC(=C)C=C21 DQNVJWKDCCSMLW-UHFFFAOYSA-N 0.000 abstract 1
- 101100516568 Caenorhabditis elegans nhr-7 gene Proteins 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000004423 acyloxy group Chemical group 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- -1 cyano, carboxyl Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229940121358 tyrosine kinase inhibitor Drugs 0.000 abstract 1
- 239000005483 tyrosine kinase inhibitor Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Indole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB919115160A GB9115160D0 (en) | 1991-07-12 | 1991-07-12 | Methylen-oxindole derivatives and process for their preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX9204008A true MX9204008A (es) | 1993-01-01 |
Family
ID=10698323
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX9204008A MX9204008A (es) | 1991-07-12 | 1992-07-08 | Derivados de metilen-oxindol y proceso para su preparacion. |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US5409949A (es) |
| EP (2) | EP0552329B1 (es) |
| JP (1) | JP3188701B2 (es) |
| KR (1) | KR930702337A (es) |
| AT (1) | ATE206420T1 (es) |
| AU (1) | AU656015B2 (es) |
| CA (1) | CA2091058C (es) |
| DE (1) | DE69232093T2 (es) |
| DK (1) | DK0552329T3 (es) |
| ES (1) | ES2165357T3 (es) |
| FI (1) | FI931061A0 (es) |
| GB (1) | GB9115160D0 (es) |
| HU (1) | HUT67496A (es) |
| IE (1) | IE922253A1 (es) |
| IL (1) | IL102383A (es) |
| MX (1) | MX9204008A (es) |
| NZ (1) | NZ243454A (es) |
| PT (1) | PT552329E (es) |
| RU (1) | RU2072989C1 (es) |
| TW (1) | TW202444B (es) |
| WO (1) | WO1993001182A1 (es) |
| ZA (1) | ZA925169B (es) |
Families Citing this family (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9004483D0 (en) * | 1990-02-28 | 1990-04-25 | Erba Carlo Spa | New aryl-and heteroarylethenylene derivatives and process for their preparation |
| US5587385A (en) * | 1991-12-24 | 1996-12-24 | Farmitalia Carlo Erba S.R.L. | Arylidene-heterocyclic derivatives and process for their preparation |
| GB9313638D0 (en) * | 1993-07-01 | 1993-08-18 | Erba Carlo Spa | Arylidene and heteroarylidene oxindole derivatives and process for their preparation |
| GB9326136D0 (en) * | 1993-12-22 | 1994-02-23 | Erba Carlo Spa | Biologically active 3-substituted oxindole derivatives useful as anti-angiogenic agents |
| GB9406137D0 (en) * | 1994-03-28 | 1994-05-18 | Erba Carlo Spa | N-substituted beta-aryl- and betaheteroaryl-alpha-cyanoacrylamide derivatives and process for their preparation |
| GB9412719D0 (en) * | 1994-06-24 | 1994-08-17 | Erba Carlo Spa | Substituted azaindolylidene compounds and process for their preparation |
| GB9501567D0 (en) * | 1995-01-26 | 1995-03-15 | Pharmacia Spa | Hydrosoluble 3-arylidene-2-oxindole derivatives as tyrosine kinase inhibitors |
| GB9507298D0 (en) * | 1995-04-07 | 1995-05-31 | Pharmacia Spa | Substituted indolylmethylene-oxindale analogues as tyrosine kinase inhibitors |
| US6147106A (en) | 1997-08-20 | 2000-11-14 | Sugen, Inc. | Indolinone combinatorial libraries and related products and methods for the treatment of disease |
| US5880141A (en) * | 1995-06-07 | 1999-03-09 | Sugen, Inc. | Benzylidene-Z-indoline compounds for the treatment of disease |
| US6906093B2 (en) | 1995-06-07 | 2005-06-14 | Sugen, Inc. | Indolinone combinatorial libraries and related products and methods for the treatment of disease |
| GB9610964D0 (en) * | 1996-05-24 | 1996-07-31 | Pharmacia & Upjohn Spa | Substituted tetralylmethylen-oxindole analogues as tyrosine kinase inhibitors |
| ATE308520T1 (de) * | 1996-08-23 | 2005-11-15 | Sugen Inc | Kombinatorische bibliotheken von indolinone und verwandte produkte und verfahren zur behandlung von krankheiten |
| WO1998024432A2 (en) * | 1996-12-05 | 1998-06-11 | Sugen, Inc. | Use of indolinone compounds as modulators of protein kinases |
| US6051597A (en) * | 1997-06-13 | 2000-04-18 | Merck & Co., Inc. | Indolylquinones as antidiabetic agents |
| US20040067531A1 (en) * | 1997-08-20 | 2004-04-08 | Sugen, Inc. | Methods of modulating protein tyrosine kinase function with substituted indolinone compounds |
| GB9718913D0 (en) | 1997-09-05 | 1997-11-12 | Glaxo Group Ltd | Substituted oxindole derivatives |
| US6531502B1 (en) | 1998-01-21 | 2003-03-11 | Sugen, Inc. | 3-Methylidenyl-2-indolinone modulators of protein kinase |
| EP1060160A2 (en) | 1998-02-27 | 2000-12-20 | THE UNITED STATES GOVERNMENT as represented by THE DEPARTMENT OF HEALTH AND HUMAN SERVICES | Disubstituted lavendustin a analogs and pharmaceutical compositions comprising the analogs |
| US6102942A (en) | 1998-03-30 | 2000-08-15 | Endovascular Technologies, Inc. | Stent/graft deployment catheter with a stent/graft attachment mechanism |
| US6569868B2 (en) | 1998-04-16 | 2003-05-27 | Sugen, Inc. | 2-indolinone derivatives as modulators of protein kinase activity |
| DE19826517B4 (de) * | 1998-06-15 | 2006-03-23 | Baxter Healthcare S.A. | Verfahren zur Herstellung von Filmtabletten mit Cyclophosphamid als Wirkstoff und daraus hergestellte Cyclophosphamid-Filmtablette |
| JP2002522452A (ja) * | 1998-08-04 | 2002-07-23 | スージェン・インコーポレーテッド | 蛋白質キナーゼの調節剤３−メチリデニル−２−インドリノン |
| US6680335B2 (en) | 1998-09-28 | 2004-01-20 | Sugen, Inc. | Methods of modulating protein tyrosine kinase function with substituted indolinone compounds |
| US6153634A (en) * | 1998-12-17 | 2000-11-28 | Hoffmann-La Roche Inc. | 4,5-azolo-oxindoles |
| AU767138B2 (en) | 1998-12-17 | 2003-10-30 | F. Hoffmann-La Roche Ag | 4,5-pyrazinoxindoles as protein kinase inhibitors |
| CA2354591A1 (en) | 1998-12-17 | 2000-06-22 | F. Hoffmann-La Roche Ag | 4-aryloxindoles as inhibitors of jnk protein kinases |
| AU770375B2 (en) * | 1998-12-17 | 2004-02-19 | F. Hoffmann-La Roche Ag | 4-alkenyl (and alkynyl) oxindoles as inhibitors of cyclin-dependent kinases, in particular CDK2 |
| JP2000247949A (ja) * | 1999-02-26 | 2000-09-12 | Eisai Co Ltd | スルホンアミド含有インドール化合物 |
| GB9904933D0 (en) | 1999-03-04 | 1999-04-28 | Glaxo Group Ltd | Compounds |
| US6492398B1 (en) | 1999-03-04 | 2002-12-10 | Smithkline Beechman Corporation | Thiazoloindolinone compounds |
| US6624171B1 (en) | 1999-03-04 | 2003-09-23 | Smithkline Beecham Corporation | Substituted aza-oxindole derivatives |
| CA2368041A1 (en) * | 1999-03-24 | 2000-09-28 | Sugen, Inc. | Indolinone compounds as kinase inhibitors |
| US6689806B1 (en) | 1999-03-24 | 2004-02-10 | Sugen, Inc. | Indolinone compounds as kinase inhibitors |
| US6878733B1 (en) | 1999-11-24 | 2005-04-12 | Sugen, Inc. | Formulations for pharmaceutical agents ionizable as free acids or free bases |
| US6313310B1 (en) | 1999-12-15 | 2001-11-06 | Hoffmann-La Roche Inc. | 4-and 5-alkynyloxindoles and 4-and 5-alkenyloxindoles |
| RU2240826C2 (ru) | 2000-02-03 | 2004-11-27 | Эйсай Ко., Лтд. | Ингибитор экспрессии интегрина |
| MY130363A (en) | 2000-02-15 | 2007-06-29 | Sugen Inc | "pyrrole substituted 2-indolinone protein kinase inhibitors" |
| US6620818B1 (en) | 2000-03-01 | 2003-09-16 | Smithkline Beecham Corporation | Method for reducing the severity of side effects of chemotherapy and/or radiation therapy |
| MY128450A (en) | 2000-05-24 | 2007-02-28 | Upjohn Co | 1-(pyrrolidin-1-ylmethyl)-3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives |
| US6706709B2 (en) | 2000-06-02 | 2004-03-16 | Sugen, Inc. | Indolinone derivatives as protein kinase/phosphatase inhibitors |
| AR042586A1 (es) | 2001-02-15 | 2005-06-29 | Sugen Inc | 3-(4-amidopirrol-2-ilmetiliden)-2-indolinona como inhibidores de la protein quinasa; sus composiciones farmaceuticas; un metodo para la modulacion de la actividad catalitica de la proteinquinasa; un metodo para tratar o prevenir una afeccion relacionada con la proteinquinasa |
| AU2002303892A1 (en) | 2001-05-30 | 2002-12-09 | Jingrong Cui | 5-aralkylsulfonyl-3- (pyrrol-2-ylmethylidene)-2-indolinone derivatives as kinase inhibitors |
| AR038957A1 (es) * | 2001-08-15 | 2005-02-02 | Pharmacia Corp | Terapia de combinacion para el tratamiento del cancer |
| MXPA04003385A (es) | 2001-10-10 | 2005-04-11 | Sugen Inc | Derivados de 3-?4-substituido con heterociclilo)-pirrol-2-ilmetilidene?-2-indolinona como inhibidores de cinasa. |
| JP4542783B2 (ja) * | 2002-03-05 | 2010-09-15 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | スルホンアミド含有複素環化合物及び血管新生抑制剤とを組み合わせてなる抗腫瘍剤 |
| US20050107819A1 (en) * | 2003-11-14 | 2005-05-19 | Medtronic Vascular, Inc. | Catheter with a sectional guidewire shaft |
| US8772269B2 (en) * | 2004-09-13 | 2014-07-08 | Eisai R&D Management Co., Ltd. | Use of sulfonamide-including compounds in combination with angiogenesis inhibitors |
| WO2010149943A1 (en) * | 2009-06-25 | 2010-12-29 | Oncorel Ab | New compounds and medical use |
| CN103274988B (zh) * | 2013-06-20 | 2016-04-13 | 河北大学 | 3-(氰基-p-硝基苯甲撑基)-2-吲哚酮衍生物及其合成方法和用途 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3310891A1 (de) * | 1983-03-25 | 1984-09-27 | Boehringer Mannheim Gmbh, 6800 Mannheim | Neue indolinon-(2)-derivate, verfahren zu ihrer herstellung, diese verbindungen enthaltende arzneimittel und zwischenprodukte |
| JPH03213847A (ja) * | 1990-01-18 | 1991-09-19 | Konica Corp | ハロゲン化銀写真感光材料 |
| GB9004483D0 (en) | 1990-02-28 | 1990-04-25 | Erba Carlo Spa | New aryl-and heteroarylethenylene derivatives and process for their preparation |
-
1991
- 1991-07-12 GB GB919115160A patent/GB9115160D0/en active Pending
-
1992
- 1992-07-02 IL IL102383A patent/IL102383A/xx not_active IP Right Cessation
- 1992-07-06 TW TW081105346A patent/TW202444B/zh active
- 1992-07-06 NZ NZ243454A patent/NZ243454A/en unknown
- 1992-07-08 MX MX9204008A patent/MX9204008A/es not_active IP Right Cessation
- 1992-07-10 HU HU9300723A patent/HUT67496A/hu unknown
- 1992-07-10 EP EP92914619A patent/EP0552329B1/en not_active Expired - Lifetime
- 1992-07-10 DK DK92914619T patent/DK0552329T3/da active
- 1992-07-10 AU AU22777/92A patent/AU656015B2/en not_active Ceased
- 1992-07-10 ES ES92914619T patent/ES2165357T3/es not_active Expired - Lifetime
- 1992-07-10 EP EP19920111757 patent/EP0525472A3/en active Pending
- 1992-07-10 CA CA002091058A patent/CA2091058C/en not_active Expired - Fee Related
- 1992-07-10 PT PT92914619T patent/PT552329E/pt unknown
- 1992-07-10 RU RU9293004893A patent/RU2072989C1/ru active
- 1992-07-10 DE DE69232093T patent/DE69232093T2/de not_active Expired - Fee Related
- 1992-07-10 AT AT92914619T patent/ATE206420T1/de not_active IP Right Cessation
- 1992-07-10 IE IE225392A patent/IE922253A1/en not_active Application Discontinuation
- 1992-07-10 WO PCT/EP1992/001569 patent/WO1993001182A1/en not_active Ceased
- 1992-07-10 US US07/987,280 patent/US5409949A/en not_active Expired - Lifetime
- 1992-07-10 JP JP50198193A patent/JP3188701B2/ja not_active Expired - Fee Related
- 1992-07-10 ZA ZA925169A patent/ZA925169B/xx unknown
-
1993
- 1993-03-10 FI FI931061A patent/FI931061A0/fi not_active Application Discontinuation
- 1993-03-12 KR KR1019930700756A patent/KR930702337A/ko not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| RU2072989C1 (ru) | 1997-02-10 |
| IL102383A0 (en) | 1993-01-14 |
| DE69232093T2 (de) | 2002-05-16 |
| US5409949A (en) | 1995-04-25 |
| ATE206420T1 (de) | 2001-10-15 |
| AU2277792A (en) | 1993-02-11 |
| WO1993001182A1 (en) | 1993-01-21 |
| NZ243454A (en) | 1995-02-24 |
| HUT67496A (en) | 1995-04-28 |
| KR930702337A (ko) | 1993-09-08 |
| EP0552329B1 (en) | 2001-10-04 |
| TW202444B (es) | 1993-03-21 |
| EP0525472A2 (en) | 1993-02-03 |
| FI931061A7 (fi) | 1993-03-10 |
| IE922253A1 (en) | 1993-01-13 |
| HU9300723D0 (en) | 1993-06-28 |
| CA2091058A1 (en) | 1993-01-13 |
| AU656015B2 (en) | 1995-01-19 |
| ES2165357T3 (es) | 2002-03-16 |
| ZA925169B (en) | 1993-04-28 |
| JPH06501494A (ja) | 1994-02-17 |
| GB9115160D0 (en) | 1991-08-28 |
| EP0525472A3 (en) | 1993-02-24 |
| FI931061A0 (fi) | 1993-03-10 |
| EP0552329A1 (en) | 1993-07-28 |
| DE69232093D1 (de) | 2001-11-08 |
| IL102383A (en) | 1997-09-30 |
| CA2091058C (en) | 2004-03-30 |
| PT552329E (pt) | 2002-02-28 |
| DK0552329T3 (da) | 2001-11-12 |
| JP3188701B2 (ja) | 2001-07-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration | ||
| MM | Annulment or lapse due to non-payment of fees |