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MX354734B - Modulación de dineína en la piel. - Google Patents

Modulación de dineína en la piel.

Info

Publication number
MX354734B
MX354734B MX2013007435A MX2013007435A MX354734B MX 354734 B MX354734 B MX 354734B MX 2013007435 A MX2013007435 A MX 2013007435A MX 2013007435 A MX2013007435 A MX 2013007435A MX 354734 B MX354734 B MX 354734B
Authority
MX
Mexico
Prior art keywords
skin
methods
dynein
modulation
active agents
Prior art date
Application number
MX2013007435A
Other languages
English (en)
Other versions
MX2013007435A (es
Inventor
W Lyga John
Zheng Qian
J Wyborski Russell
Original Assignee
Avon Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Avon Prod Inc filed Critical Avon Prod Inc
Publication of MX2013007435A publication Critical patent/MX2013007435A/es
Publication of MX354734B publication Critical patent/MX354734B/es

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
    • A61K8/466—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur containing sulfonic acid derivatives; Salts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5082—Supracellular entities, e.g. tissue, organisms
    • G01N33/5088—Supracellular entities, e.g. tissue, organisms of vertebrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/74—Biological properties of particular ingredients
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/136—Screening for pharmacological compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/148—Screening for cosmetic compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Hematology (AREA)
  • General Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
  • Medicinal Chemistry (AREA)
  • Mycology (AREA)
  • Food Science & Technology (AREA)
  • Botany (AREA)
  • Gerontology & Geriatric Medicine (AREA)
  • General Physics & Mathematics (AREA)
  • Toxicology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • General Chemical & Material Sciences (AREA)

Abstract

La presente invención se refiere a un método cosmético para mejorar la hiperpigmentación de la piel humana, caracterizado porque comprende aplicar tópicamente a un área de la piel en necesidad del mismo, una cantidad eficaz de un agente activo seleccionado del grupo de extractos botánicos de Amorphophallus campanulatus, Gompherena globose Linn., Fibraretinum resica Pierre (Fibrauretine), Vernonia cinérea Linn. Less, Cayratia japónica, Pteris semipinnata y ácido 5-cloro-salicílico, 3,6-Nanadienol, cis-6-nonenol y los compuestos 6, 7, 8 y combinaciones de los mismos.
MX2013007435A 2010-12-30 2011-11-29 Modulación de dineína en la piel. MX354734B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201061428272P 2010-12-30 2010-12-30
PCT/US2011/062279 WO2012091832A2 (en) 2010-12-30 2011-11-29 Modulation of dynein in skin

Publications (2)

Publication Number Publication Date
MX2013007435A MX2013007435A (es) 2013-09-06
MX354734B true MX354734B (es) 2018-03-16

Family

ID=46380940

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2013007435A MX354734B (es) 2010-12-30 2011-11-29 Modulación de dineína en la piel.

Country Status (11)

Country Link
US (1) US20120171133A1 (es)
EP (2) EP2889384B1 (es)
JP (1) JP6249777B2 (es)
CN (1) CN103561718B (es)
BR (1) BR112013016935A2 (es)
CA (1) CA2822328A1 (es)
ES (1) ES2645011T3 (es)
MX (1) MX354734B (es)
PL (2) PL2659004T3 (es)
TW (1) TWI579002B (es)
WO (1) WO2012091832A2 (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2969823C (en) * 2009-08-26 2022-11-29 Mary Kay Inc. Topical skin care formulations comprising plant extracts
US8815265B2 (en) 2010-06-30 2014-08-26 Avon Products, Inc. Cosmetic use of N-substituted sulfonyloxybenzylamines and related compounds
CN102959077A (zh) 2010-06-30 2013-03-06 雅芳产品公司 用于刺激magp-1以改善皮肤外观的组合物和方法
US8455518B2 (en) * 2010-12-28 2013-06-04 Avon Products, Inc. Method of treating skin with microRNA modulators
US8686013B2 (en) * 2011-08-25 2014-04-01 Avon Products, Inc. Cosmetic use of substituted amino heterocylic carbamoyl analogs and related compounds
WO2014158877A1 (en) * 2013-03-13 2014-10-02 Avon Products, Inc Vernonia cinerea extracts and methods of use
KR101821010B1 (ko) * 2014-11-11 2018-01-23 건국대학교 산학협력단 클리나칸투스 누탄스 추출물을 유효성분으로 포함하는 피부 개선용 화장료 조성물
CN106265211B (zh) * 2015-06-03 2020-03-31 上海家化生物科技有限公司 一种肉苁蓉上清混合物、其制备方法及其皮肤屏障修复作用
CN105147571A (zh) * 2015-10-21 2015-12-16 广东药学院 黑面神提取物及其应用和含该黑面神提取物的美白抗皱霜
CN110551828B (zh) * 2019-09-19 2021-02-26 江苏省家禽科学研究所 一种与鸡背部毛孔密度相关的snp分子标记及其应用
CN114957379B (zh) * 2021-06-28 2024-03-26 河南省人民医院 一种二氢嘧啶硫酮类化合物及其制备方法与应用
CN114149985A (zh) * 2021-12-06 2022-03-08 杭州优玛达生物科技有限公司 一种分子马达的制备方法及其应用
CN114478396B (zh) * 2022-03-18 2023-12-01 河南省人民医院 二氢嘧啶(硫)酮类化合物及其制备方法与应用
CN117257670B (zh) * 2023-05-10 2025-07-25 麦吉丽生物科技有限公司 具有去皱抗衰功效的活性分子马达、面霜组合物及制法和应用

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS53136506A (en) * 1977-05-02 1978-11-29 Mototaka Ueno Production of bathing agent being nontoxious to human and animal used in squeezed towell and bath waer to wipe body of0patient * old man and disabled parson
JP3695472B2 (ja) * 1995-03-20 2005-09-14 株式会社コーセー メイラード反応阻害剤
JP2000095663A (ja) * 1998-09-24 2000-04-04 Kose Corp 植物抽出物を含有する外用剤
US6143303A (en) * 1999-08-14 2000-11-07 Janakiram; Chodavarapu Analgesic anti-inflammatory composition and method of preparing from dodonaea sp
US20030032771A1 (en) * 2001-02-14 2003-02-13 Sharp David J. Peptide inhibitors of cellular proliferation
JP2002322076A (ja) * 2001-02-26 2002-11-08 Oji Paper Co Ltd トリプシン阻害剤
JP4808365B2 (ja) 2001-03-02 2011-11-02 ユニバーシティ オブ ピッツバーグ オブ ザ コモンウェルス システム オブ ハイヤー エデュケイション Ｐｃｒ法
US20070010657A1 (en) * 2002-09-13 2007-01-11 Rainer Klocke Cytoplasmic dynein heavy chain 1 genes, expression products, non-human animal model uses in human neurological diseases
JP2006504932A (ja) * 2002-09-20 2006-02-09 ザ ジェネラル ホスピタル コーポレーション 皮膚損傷を予防するための方法および組成物
JP4224387B2 (ja) * 2003-12-04 2009-02-12 日本メナード化粧品株式会社 皮膚外用剤
US20050136028A1 (en) * 2003-12-19 2005-06-23 Dmitri Ptchelintsev Cosmetic compositions having extracts of Amomum melegueta and methods of treating skin
MXPA06013705A (es) * 2004-05-28 2007-02-13 Unigen Pharmaceuticals Inc Diarilalcanos como potentes inhibidores de enzimas binucleares.
EP2272987A3 (en) 2004-07-09 2012-04-11 University of Pittsburgh of the Commonwealth System of Higher Education Identification of markers in esophageal cancer, colon cancer, head and neck cancer and melanoma
JP4777738B2 (ja) * 2004-10-14 2011-09-21 株式会社 資生堂 Ａｄａｍ活性阻害物質によるしわの防止または改善
GB0426255D0 (en) * 2004-11-30 2004-12-29 Younger Skin Ltd Improvements in and relating to products for skin treatment
AU2007215822B2 (en) * 2006-02-15 2012-10-25 Pola Chemical Industries Inc. External preparation for skin containing flavanone derivative
CN100475189C (zh) * 2006-10-17 2009-04-08 王海龙 一种化妆品组合物及其制备方法和应用
KR100999261B1 (ko) * 2007-10-09 2010-12-07 (주)아모레퍼시픽 여성호르몬 결핍으로 초래되는 여성 피부의 노화 억제제 스크리닝 방법
JP2009209063A (ja) * 2008-03-03 2009-09-17 Univ Kinki 皮膚外用剤または皮膚化粧料
KR20110000745A (ko) * 2008-03-28 2011-01-05 너스킨 인터어내셔날 인코포레이팃드 활성산소종의 억제를 위한 ａｒＮＯＸ-억제제를 포함하는 조성물
MX2010011853A (es) * 2008-04-30 2011-02-21 Univ New York Compuestos esteroidales como modificadores de melanogenesis y usos de los mismos.
US7592024B1 (en) * 2008-12-29 2009-09-22 Avon Products, Inc. Topical compositions containing melicope hayselii and a method of treating skin
JP5867981B2 (ja) * 2009-06-05 2016-02-24 丸善製薬株式会社 マトリックスメタロプロテアーゼ−１（ｍｍｐ−１）活性阻害剤、エストロゲン様作用剤、ｉ型コラーゲン産生促進剤、ヒアルロン酸産生促進剤、及びｕｖ−ｂダメージからの回復剤
US20110044920A1 (en) * 2009-08-07 2011-02-24 Mary Kay Inc. Topical skin care formulations
CA2969823C (en) * 2009-08-26 2022-11-29 Mary Kay Inc. Topical skin care formulations comprising plant extracts
MX339842B (es) * 2009-12-22 2016-06-14 Avon Prod Inc Composiciones estimuladoras de paxilina y usos cosmeticos de las mismas.
US8815265B2 (en) * 2010-06-30 2014-08-26 Avon Products, Inc. Cosmetic use of N-substituted sulfonyloxybenzylamines and related compounds
CN102959077A (zh) * 2010-06-30 2013-03-06 雅芳产品公司 用于刺激magp-1以改善皮肤外观的组合物和方法
CA2799083C (en) * 2010-06-30 2018-04-24 Avon Products, Inc. Use of tiliacora triandra in cosmetics and compositions thereof
CN101973853B (zh) * 2010-09-29 2013-04-03 桂林莱茵生物科技股份有限公司 羟基酪醇的提取方法

Also Published As

Publication number Publication date
EP2659004A2 (en) 2013-11-06
EP2889384B1 (en) 2016-09-28
WO2012091832A2 (en) 2012-07-05
CA2822328A1 (en) 2012-07-05
PL2659004T3 (pl) 2017-12-29
PL2889384T3 (pl) 2017-07-31
EP2659004B1 (en) 2017-08-30
JP2014507132A (ja) 2014-03-27
CN103561718B (zh) 2020-06-16
BR112013016935A2 (pt) 2016-08-30
EP2659004A4 (en) 2014-05-14
CN103561718A (zh) 2014-02-05
ES2645011T3 (es) 2017-12-01
US20120171133A1 (en) 2012-07-05
MX2013007435A (es) 2013-09-06
TWI579002B (zh) 2017-04-21
EP2889384A1 (en) 2015-07-01
WO2012091832A3 (en) 2012-09-07
JP6249777B2 (ja) 2017-12-20
TW201304816A (zh) 2013-02-01

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